| $150,000–350,000 | RUMPKE MANAGEMENT CORPORATION | CINCINNATI, OH | WesBanco Bank, Inc. |
| $350,000–1 million | RUSSELL NESBITT SERVICES, INC. | WHEELING, WV | WesBanco Bank, Inc. |
| $1–2 million | RXP OHIO, LLC | COLUMBUS, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | S & L ELECTRIC, INC. | AUSTIN, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | S E DAVIS CONSTRUCTION LLC | LAPLATA, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | S&J PRECISION, INC. | NEW ALBANY, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | S&P CLEANING SERVICE, INC | BARDSTOWN, KY | WesBanco Bank, Inc. |
| $350,000–1 million | S&R TRUCK TIRE CENTER INC | JEFFERSONVILLE, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | SACRED HEART CATHOLIC CHURCH, JEFFERSONVILLE, INC. | JEFFERSONVILLE, IN | WesBanco Bank, Inc. |
| $350,000–1 million | SACRED HEART CO-CATHEDRAL | CHARLESTON, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | SADASHIVA, LLC | LOUISVILLE, KY | WesBanco Bank, Inc. |
| $150,000–350,000 | SAGAMORE MECHANICAL SERVICES, INC | WESTMINSTER, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SAJAKS INVESTMENTS, INC. | GROVE CITY, OH | WesBanco Bank, Inc. |
| $350,000–1 million | SAL CHEMICAL COMPANY INC. | WEIRTON, WV | WesBanco Bank, Inc. |
| $350,000–1 million | SANDAB COMMUNICATIONS LP | PIKESVILLE, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SASI, INC | RIPLEY, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | SASSCER CLAGETT & BUCHER | UPPER MARLBORO, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SAT, LLC | LEXINGTON, KY | WesBanco Bank, Inc. |
| $350,000–1 million | SATURN ELECTRIC, INC. | DAYTON, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SAUL GOOD #3 LLC | NICHOLASVILLE, KY | WesBanco Bank, Inc. |
| $350,000–1 million | SAVAGE CONSTRUCTION CO. | WHEELING, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | SCHAD & SCHAD, P.C. | NEW ALBANY, IN | WesBanco Bank, Inc. |
| $350,000–1 million | SCHIPPER ENTERPRISES, LLC | LOUISVILLE, KY | WesBanco Bank, Inc. |
| $350,000–1 million | SCHIPPER MOTORSPORTS INDIANA, LLC | FORT WAYNE, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | SCHMITT FURNITURE CO., INC | NEW ALBANY, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | SCHULER MACHINE & TOOL CO. | LOUISVILLE, KY | WesBanco Bank, Inc. |
| $350,000–1 million | SCHWENDEMAN AGENCY INC | MARIETTA, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SCORE ENTERTAINMENT LLC | PITTSBURGH, PA | WesBanco Bank, Inc. |
| $350,000–1 million | SCOTT COUNTY RESTAURANTS INC. | SCOTTSBURG, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | SCOTTS HARDWARE INC | SCOTTSBURG, IN | WesBanco Bank, Inc. |
| $1–2 million | SEAL CAULKING & WATERPROOFING LLC | UPPER MARLBORO, MD | WesBanco Bank, Inc. |
| $350,000–1 million | SEBALY, SHILLITO & DYER A LEGAL PROFESSIONAL | DAYTON, OH | WesBanco Bank, Inc. |
| $1–2 million | SELECTIVE DEMOLITION, LLC | GAITHERSBURG, MD | WesBanco Bank, Inc. |
| $350,000–1 million | SELECTIVE HAULING, LLC | GAITHERSBURG, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SENIOR NETWORK, INC. | WALDORF, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SENSORY LINK LLC | GIBSONIA, PA | WesBanco Bank, Inc. |
| $150,000–350,000 | SENTRY FIRE PROTECTION, INC. | HUNTINGTON, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | SHARONVILLE HILLS, LLC | CINCINNATI, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SHETLER-DERBY MOVING & STORAGE | LOUISVILLE, KY | WesBanco Bank, Inc. |
| $150,000–350,000 | SHIPLEY & HORNE, P.A. | LARGO, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SHRI SUDHA LLC | BEL AIR, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SHRIVER BROTHERS SEAFOOD, LLC | LEONARDTOWN, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SHUPECO, LLC | LOUISVILLE, KY | WesBanco Bank, Inc. |
| $150,000–350,000 | SILICON PROCESSORS, INC. | PARKERSBURG, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | SILVER HOSPITALITY, INC. | SILVER SPRING, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SIMPSON ALLOY SERVICES, INC. | ELIZABETH, IN | WesBanco Bank, Inc. |
| $350,000–1 million | SINGLE POINT CONSTRUCTION LLC | HYATTSVILLE, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SISSONVILLE FOODLAND, INC. | CHARLESTON, WV | WesBanco Bank, Inc. |
| $350,000–1 million | SMARTBOX, LLC | NEW ALBANY, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | SMILE LOFT GLEN BURNIE | CROWNSVILLE, MD | WesBanco Bank, Inc. |
| $350,000–1 million | SMITH BROTHERS AGENCY, LLC | PITTSBURGH, PA | WesBanco Bank, Inc. |
| $150,000–350,000 | SMITH DOT, LLC | THURMAN, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SMITH DRUG COMPANY, INC. DBA MINFORD PHARMACY | PORTSMOUTH, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SMITH'S LAMINATING SHOP, INC. | MOUNT WASHINGTON, KY | WesBanco Bank, Inc. |
| $150,000–350,000 | SNMJ, INC. | GROVE CITY, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SOBE, LLC | LANHAM, MD | WesBanco Bank, Inc. |
| $350,000–1 million | SOJOURN COMMUNITY CHURCH, INC. | LOUISVILLE, KY | WesBanco Bank, Inc. |
| $350,000–1 million | SOUTH COUNTY CONSTRUCTION COMPANY, INC | CLINTON, MD | WesBanco Bank, Inc. |
| $2–5 million | SOUTH MOON SALES, INC. | ANNAPOLIS, MD | WesBanco Bank, Inc. |
| $350,000–1 million | SOUTHERN MARYLAND CHRISTIAN ACADEMY | WHITE PLAINS, MD | WesBanco Bank, Inc. |
| $350,000–1 million | SOUTHERN MARYLAND ORAL AND MAXILLOFACIAL SURGERY, P.A. | DUNKIRK, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SOUTHERN MARYLAND RECYCLING, INC. | OWINGS, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SOUTHWESTERN PENNSYLVANIA LEGAL SERVICES | WASHINGTON, PA | WesBanco Bank, Inc. |
| $150,000–350,000 | SPA ROMA INC. | MORGANTOWN, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | SPADE CORPORATION | GEORGETOWN, KY | WesBanco Bank, Inc. |
| $2–5 million | SPARTAN WAREHOUSE AND DISTRIBUTION COMPANY INCORPORATED | COLUMBUS, OH | WesBanco Bank, Inc. |
| $350,000–1 million | SPECIAL INSTALLATIONS, INC. | STEUBENVILLE, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SPRIGLER DOOR SERVICE INC | NEW ALBANY, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | SPRINGHURST ANIMAL CLINIC, PLLC | LOUISVILLE, KY | WesBanco Bank, Inc. |
| $350,000–1 million | SPROUSE BUILDING PRODUCTS, INC. | NEW MARTINSVILLE, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. ANTHONY OF PADUA, CATHOLIC CHURCH, CLARKSVILLE, INC. | CLARKSVILLE, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. CLAIR 60 MINUTE CLEANERS, INC | ST CLAIRSVILLE, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. ELIZABETH CATHOLIC CHARITIES, INC. | NEW ALBANY, IN | WesBanco Bank, Inc. |
| $350,000–1 million | ST. FRANCIS CENTRAL CATHOLIC SCHOOL | MORGANTOWN, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. FRANCIS DE SALES SCHOOL | BECKLEY, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. GREGORY PARISH & SCHOOL | ZELIENOPLE, PA | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. JOSEPH CENTRAL HIGH SCHOOL | HUNTINGTON, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. JOSEPH CHURCH | MARTINSBURG, WV | WesBanco Bank, Inc. |
| $350,000–1 million | ST. JOSEPH GRADE SCHOOL | HUNTINGTON, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. JOSEPH PARISH GRADE SCHOOL | WEIRTON, WV | WesBanco Bank, Inc. |
| $1–2 million | ST. MARY'S RYKEN, INC. | LEONARDTOWN, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. MARY-OF-THE-KNOBS CATHOLIC CHURCH, FLOYDS KNOBS, INC. | FLOYDS KNOBS, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. MATTHEW'S UNITED METHODIST CHURCH EARLY EDUCATION CENTER CORPORATION | BOWIE, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. MATTHEWS ANIMAL CLINIC, P.S.C | LOUISVILLE, KY | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. MICHAEL CHURCH AND SCHOOL | WHEELING, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. PAUL'S CHURCH | WEIRTON, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. VINCENT DE PAUL CHURCH | WHEELING, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | STANDARD HYDRAULICS, INC. | HURRICANE, WV | WesBanco Bank, Inc. |
| $350,000–1 million | STANLEY CONCRETE, L.L.C. | ANNAPOLIS JUNCTION, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | STAR INC | PORTSMOUTH, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | STAR TECHNOLOGIES LIMITED LIABILITY COMPANY | HUNTINGTON, WV | WesBanco Bank, Inc. |
| $350,000–1 million | STARK & KNOLL CO., LPA | FAIRLAWN, OH | WesBanco Bank, Inc. |
| $350,000–1 million | STARVAGGI INDUSTRIES INCORPORATED | WEIRTON, WV | WesBanco Bank, Inc. |
| $350,000–1 million | STATEWIDE HEATING & AIR CONDITIONING SERVICE, INC. | NITRO, WV | WesBanco Bank, Inc. |
| $350,000–1 million | STAY AT HOME HEALTH CARE INC. | SCOTTSBURG, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | STEEL VALLEY EMERGENCY PHYSICIANS, LLC | STEUBENVILLE, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | STEEL VALLEY HOSPITALIST, INC. | STEUBENVILLE, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | STEELEFISH GRILLE NORTH, LLC | BEL AIR, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | STEINMAN HOLDINGS, LLC | GAITHERSBURG, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | STEP BY STEP, INC. | CHARLESTON, WV | WesBanco Bank, Inc. |