| $350,000–1 million | SOL SCHWARTZ & ASSOCIATES, P.C. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SOLARCRAFT INC. | Sugar Land, TX | Frost Bank |
| $350,000–1 million | SOLARCRAFT, INC. | SUGAR LAND, TX | Frost Bank |
| $350,000–1 million | SOLID IT NETWORKS INC. | Houston, TX | Frost Bank |
| $350,000–1 million | SOLID IT NETWORKS, INC. | HOUSTON, TX | Frost Bank |
| $2–5 million | SOLON, INC. | DESOTO, TX | Frost Bank |
| $150,000–350,000 | SONLIGHT CLEANING SERVICE, INC | HALTOM CITY, TX | Frost Bank |
| $150,000–350,000 | SONOVET, INC | NEW BRAUNFELS, TX | Frost Bank |
| $150,000–350,000 | SONTERRA DERMATOLOGY, PLLC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SORT-RITE INTERNATIONAL INC. | Harlingen, TX | Frost Bank |
| $150,000–350,000 | SORT-RITE INTERNATIONAL, INC. | HARLINGEN, TX | Frost Bank |
| $350,000–1 million | SOUR DUCK HOSPITALITY LLC | Austin, TX | Frost Bank |
| $350,000–1 million | SOUR DUCK HOSPITALITY LLC | AUSTIN, TX | Frost Bank |
| $350,000–1 million | SOUTH ALAMO MEDICAL GROUP PA | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SOUTH AUSTIN MARINE II, INC. | AUSTIN, TX | Frost Bank |
| $150,000–350,000 | SOUTH CENTRAL TEXAS MANAGEMENT INC. | San Antonio, TX | Frost Bank |
| $150,000–350,000 | SOUTH CENTRAL TEXAS MANAGEMENT, INC. | San Antonio, TX | Frost Bank |
| $350,000–1 million | SOUTH COAST FIRE & SAFETY INC. | Houston, TX | Frost Bank |
| $350,000–1 million | SOUTH COAST FIRE & SAFETY INC. | HOUSTON, TX | Frost Bank |
| $150,000–350,000 | SOUTH PADRE ISLAND PEDIATRIC CENTER P.A. | CORPUS CHRISTI, TX | Frost Bank |
| $350,000–1 million | SOUTH PARK FAMILY DENTAL CARE LLC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SOUTH PARK FAMILY DENTAL CARE PLLC | San Antonio, TX | Frost Bank |
| $350,000–1 million | SOUTH TEXAS BRAIN & SPINE INSTITUTE, P.A. | CORPUS CHRISTI, TX | Frost Bank |
| $350,000–1 million | SOUTH TEXAS BRAIN & SPINE INSTITUTE, P.A. | Corpus Christi, TX | Frost Bank |
| $150,000–350,000 | SOUTH TEXAS CLINIC FOR PAIN MANAGEMENT PA | McAllen, TX | Frost Bank |
| $150,000–350,000 | SOUTH TEXAS CLINIC FOR PAIN MANAGEMENT, PA | MCALLEN, TX | Frost Bank |
| $150,000–350,000 | SOUTH TEXAS DRYWALL & CONSTRUCTION INC | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SOUTH TEXAS EMERGENCY CARE FOUNDATION INC. | Harlingen, TX | Frost Bank |
| $350,000–1 million | SOUTH TEXAS EMERGENCY CARE FOUNDATION INC. | HARLINGEN, TX | Frost Bank |
| $150,000–350,000 | SOUTH TEXAS ENT CONSULTANTS, PA | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SOUTH TEXAS KIDNEY SPECIALISTS, P.A. | MCALLEN, TX | Frost Bank |
| $5–10 million | SOUTH TEXAS ONCOLOGY & HEMATOLOGY PLLC | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SOUTH TEXAS ORTHOPEDIC SPECIALTY GROUP | San Antonio, TX | Frost Bank |
| $150,000–350,000 | SOUTH TEXAS PATHOLOGY ASSOCIATES, LLP | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SOUTH TEXAS SKIN CANCER CENTER, LLC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SOUTH TEXAS SPIRITS, INC. | ARANSAS PASS, TX | Frost Bank |
| $350,000–1 million | SOUTH TEXAS TRUCK CENTERS LLC | CORPUS CHRISTI, TX | Frost Bank |
| $150,000–350,000 | SOUTH TEXAS VISION ASSOCIATES PA | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SOUTHAMPTON MONTESSORI LP | Houston, TX | Frost Bank |
| $350,000–1 million | SOUTHAMPTON MONTESSORI SCHOOL | HOUSTON, TX | Frost Bank |
| $1–2 million | SOUTHEAST FIRE PROTECTION, L.P. | HOUSTON, TX | Frost Bank |
| $150,000–350,000 | SOUTHEAST SOUTH TEXAS CENTER FOR PEDIATRIC CARE, PA | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SOUTHER EQUIPMENT SALES, INC. | DALLAS, TX | Frost Bank |
| $1–2 million | SOUTHERN BLEACHER HOLDINGS | GRAHAM, TX | Frost Bank |
| $350,000–1 million | SOUTHSIDE CHILDREN'S DENTAL CENTER PC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SOUTHTEX STEEL CONSTRUCTION, INC | NEW BRAUNFELS, TX | Frost Bank |
| $150,000–350,000 | SOUTHWEST AIR EQUIPMENT, INC. | FORT WORTH, TX | Frost Bank |
| $1–2 million | SOUTHWEST ASTHMA & ALLERGY ASSOCIATES | HOUSTON, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST AUSTIN CATHOLIC SCHOOL | AUSTIN, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST AUTOMATED SECURITY, INC. | DALLAS, TX | Frost Bank |
| $150,000–350,000 | SOUTHWEST BUSINESS CAPITAL INC | Houston, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST CHILDREN'S CENTER, P.A. | SAN ANTONIO, TX | Frost Bank |
| $1–2 million | SOUTHWEST CHRISTIAN SCHOOL, INC | FORT WORTH, TX | Frost Bank |
| $150,000–350,000 | SOUTHWEST COMMUNITY BAPTIST CHURCH INC | Houston, TX | Frost Bank |
| $150,000–350,000 | SOUTHWEST COMMUNITY BAPTIST CHURCH, INC. | HOUSTON, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST COMPANIES LTD. | SAN ANTONIO, TX | Frost Bank |
| $5–10 million | SOUTHWEST ELECTRICAL CONTRACTING SERVICES LTD | CONVERSE, TX | Frost Bank |
| $150,000–350,000 | SOUTHWEST MATERIALS HANDLING CO | Dallas, TX | Frost Bank |
| $150,000–350,000 | SOUTHWEST MATERIALS HANDLING CO | DALLAS, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST MATTRESS SALES, INC. | AUSTIN, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST OFFICE SYSTEMS INC | Euless, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST OFFICE SYSTEMS, INC. | EULESS, TX | Frost Bank |
| $150,000–350,000 | SOUTHWEST PAIN CLINIC PA | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SOUTHWEST PAIN CLINIC PA | San Antonio, TX | Frost Bank |
| $150,000–350,000 | SOUTHWEST PAPER STOCK, INC. | FORT WORTH, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST PHARMACY SOLUTIONS, INC. | CORPUS CHRISTI, TX | Frost Bank |
| $150,000–350,000 | SOUTHWEST RECOVERY SERVICES INC. | ADDISON, TX | Frost Bank |
| $150,000–350,000 | SOUTHWEST RECOVERY SERVICES LLC | Addison, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST SALES, INC. | COPPELL, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST SAW CORPORATION | HOUSTON, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST SCHOOL OF ART | San Antonio, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST SCHOOL OF ART | SAN ANTONIO, TX | Frost Bank |
| $2–5 million | SOUTHWEST TEXAS EQUIPMENT DISTRIBUTORS, INC. | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SOUTHWEST UNOS INC. | Garland, TX | Frost Bank |
| $2–5 million | SPA HAVENS LP | Vista, CA | Frost Bank |
| $1–2 million | SPA HAVENS, LP | VISTA, CA | Frost Bank |
| $150,000–350,000 | SPARK SURPLUS LLC | Sugarland, TX | Frost Bank |
| $150,000–350,000 | SPARKLE ASSET MANAGEMENT, LLC | DALLAS, TX | Frost Bank |
| $350,000–1 million | SPECIAL INSURANCE SERVICES INC. | PLANO, TX | Frost Bank |
| $150,000–350,000 | SPECIALIZED MANUFACTURING LTD | Pearland, TX | Frost Bank |
| $150,000–350,000 | SPECIALIZED MANUFACTURING LTD | PEARLAND, TX | Frost Bank |
| $1–2 million | SPECIALTY PACKAGING, INC. | FORT WORTH, TX | Frost Bank |
| $350,000–1 million | SPECTRUM LIGHTING INC. SAN ANTONIO | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SPECTRUM LIGHTING INC. SAN ANTONIO | San Antonio, TX | Frost Bank |
| $350,000–1 million | SPECTRUM PROPERTIES, LTD | DALLAS, TX | Frost Bank |
| $150,000–350,000 | SPEECH LANGUAGE AND BEHAVIOR LP | MIDLAND, TX | Frost Bank |
| $150,000–350,000 | SPEECH LANGUAGE AND BEHAVIOR LP | Midland, TX | Frost Bank |
| $150,000–350,000 | SPEED OF LIGHT BROADBAND, INC. | KELLER, TX | Frost Bank |
| $150,000–350,000 | SPG VENDING SOLUTIONS LLC | Arlington, TX | Frost Bank |
| $150,000–350,000 | SPG VENDING SOLUTIONS, LLC | ARLINGTON, TX | Frost Bank |
| $2–5 million | SPINE TEAM TEXAS MANAGEMENT COMPANY, LLC | SOUTHLAKE, TX | Frost Bank |
| $350,000–1 million | SPIRAL PIPE OF TEXAS, INC. | FORT WORTH, TX | Frost Bank |
| $150,000–350,000 | SPIRIT DSP LLC | SOUTHLAKE, TX | Frost Bank |
| $150,000–350,000 | SPORTS EVENT MARKETING LLC | AUSTIN, TX | Frost Bank |
| $150,000–350,000 | SPORTS EVENT MARKETING LLC | Austin, TX | Frost Bank |
| $150,000–350,000 | SPOT ON PRINT SERVICES LLC | HOUSTON, TX | Frost Bank |
| $150,000–350,000 | SPRINGBACH CONSULTING, LLC | DALLAS, TX | Frost Bank |
| $350,000–1 million | SPRINGTOWN ENTERTAINMENT LLC | SAN MARCOS, TX | Frost Bank |
| $150,000–350,000 | SPRINGTOWN ENTERTAINMENT LLC | San Marcos, TX | Frost Bank |
| $350,000–1 million | SPROLES WOODARD LLP | FORT WORTH, TX | Frost Bank |