| $150,000–350,000 | SMITH DOT LLC | Thurman, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SMITH DOT, LLC | THURMAN, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SMITH DRUG COMPANY, INC. DBA MINFORD PHARMACY | PORTSMOUTH, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SMITH'S LAMINATING SHOP INC. | Mount Washington, KY | WesBanco Bank, Inc. |
| $150,000–350,000 | SMITH'S LAMINATING SHOP, INC. | MOUNT WASHINGTON, KY | WesBanco Bank, Inc. |
| $150,000–350,000 | SNMJ, INC. | GROVE CITY, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SNS OF PIKEVILLE INC | Ashland, KY | WesBanco Bank, Inc. |
| $150,000–350,000 | SOBE, LLC | LANHAM, MD | WesBanco Bank, Inc. |
| $350,000–1 million | SOJOURN COMMUNITY CHURCH, INC. | LOUISVILLE, KY | WesBanco Bank, Inc. |
| $350,000–1 million | SOUTH COUNTY CONSTRUCTION COMPANY INC | Clinton, MD | WesBanco Bank, Inc. |
| $350,000–1 million | SOUTH COUNTY CONSTRUCTION COMPANY, INC | CLINTON, MD | WesBanco Bank, Inc. |
| $2–5 million | SOUTH MOON SALES INC. | Annapolis, MD | WesBanco Bank, Inc. |
| $2–5 million | SOUTH MOON SALES, INC. | ANNAPOLIS, MD | WesBanco Bank, Inc. |
| $350,000–1 million | SOUTHERN MARYLAND CHRISTIAN ACADEMY | WHITE PLAINS, MD | WesBanco Bank, Inc. |
| $350,000–1 million | SOUTHERN MARYLAND CHRISTIAN ACADEMY | White Plains, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SOUTHERN MARYLAND MARINA LLC | Port Tobacco, MD | WesBanco Bank, Inc. |
| $350,000–1 million | SOUTHERN MARYLAND ORAL AND MAXILLOFACIAL SURGERY P.A. | Dunkirk, MD | WesBanco Bank, Inc. |
| $350,000–1 million | SOUTHERN MARYLAND ORAL AND MAXILLOFACIAL SURGERY, P.A. | DUNKIRK, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SOUTHERN MARYLAND RECYCLING, INC. | OWINGS, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SOUTHWESTERN PENNSYLVANIA LEGAL SERVICES | WASHINGTON, PA | WesBanco Bank, Inc. |
| $150,000–350,000 | SPA ROMA INC. | Morgantown, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | SPA ROMA INC. | MORGANTOWN, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | SPADE CORPORATION | GEORGETOWN, KY | WesBanco Bank, Inc. |
| $150,000–350,000 | SPADE CORPORATION | Georgetown, KY | WesBanco Bank, Inc. |
| $2–5 million | SPARTAN WAREHOUSE AND DISTRIBUTION COMPANY INCORPORATED | COLUMBUS, OH | WesBanco Bank, Inc. |
| $350,000–1 million | SPECIAL INSTALLATIONS, INC. | STEUBENVILLE, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SPECTRUM OUTREACH SERVICES LTD | Ironton, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SPRIGLER DOOR SERVICE INC | NEW ALBANY, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | SPRINGHURST ANIMAL CLINIC, PLLC | LOUISVILLE, KY | WesBanco Bank, Inc. |
| $350,000–1 million | SPROUSE BUILDING PRODUCTS, INC. | NEW MARTINSVILLE, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST CLEMENT CHURCH | CINCINNATI, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | ST MONICA PARISH | BEAVER FALLS, PA | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. ANTHONY OF PADUA, CATHOLIC CHURCH, CLARKSVILLE, INC. | CLARKSVILLE, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. CLAIR 60 MINUTE CLEANERS, INC | ST CLAIRSVILLE, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. ELIZABETH CATHOLIC CHARITIES, INC. | NEW ALBANY, IN | WesBanco Bank, Inc. |
| $350,000–1 million | ST. FRANCIS CENTRAL CATHOLIC SCHOOL | MORGANTOWN, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. FRANCIS DE SALES SCHOOL | BECKLEY, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. GREGORY PARISH & SCHOOL | ZELIENOPLE, PA | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. GREGORY PARISH & SCHOOL | Zelienople, PA | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. JOSEPH CENTRAL HIGH SCHOOL | HUNTINGTON, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. JOSEPH CENTRAL HIGH SCHOOL | Huntington, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. JOSEPH CHURCH | MARTINSBURG, WV | WesBanco Bank, Inc. |
| $350,000–1 million | ST. JOSEPH GRADE SCHOOL | HUNTINGTON, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. JOSEPH PARISH GRADE SCHOOL | WEIRTON, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. JOSEPH PARISH GRADE SCHOOL | Weirton, WV | WesBanco Bank, Inc. |
| $1–2 million | ST. MARY'S RYKEN, INC. | LEONARDTOWN, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. MARY-OF-THE-KNOBS CATHOLIC CHURCH, FLOYDS KNOBS, INC. | FLOYDS KNOBS, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. MATTHEW'S UNITED METHODIST CHURCH EARLY EDUCATION CENTER | BOWIE, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. MATTHEW'S UNITED METHODIST CHURCH EARLY EDUCATION CENTER | Bowie, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. MATTHEWS ANIMAL CLINIC, P.S.C | LOUISVILLE, KY | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. MICHAEL CHURCH AND SCHOOL | WHEELING, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. MICHAEL CHURCH AND SCHOOL | Wheeling, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. PAUL'S CHURCH | WEIRTON, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. VINCENT DE PAUL CHURCH | WHEELING, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | ST. VINCENT DE PAUL CHURCH | Wheeling, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | STAFFCO CONSTRUCTION INC | Fairborn, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | STANDARD HYDRAULICS, INC. | HURRICANE, WV | WesBanco Bank, Inc. |
| $350,000–1 million | STANLEY CONCRETE L.L.C. | Annapolis Junction, MD | WesBanco Bank, Inc. |
| $350,000–1 million | STANLEY CONCRETE, L.L.C. | ANNAPOLIS JUNCTION, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | STAR INC | PORTSMOUTH, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | STAR INC | Portsmouth, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | STAR TECHNOLOGIES LIMITED LIABILITY COMPANY | HUNTINGTON, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | STAR TECHNOLOGIES LIMITED LIABILITY COMPANY | Huntington, WV | WesBanco Bank, Inc. |
| $350,000–1 million | STARK & KNOLL CO., LPA | FAIRLAWN, OH | WesBanco Bank, Inc. |
| $350,000–1 million | STARVAGGI INDUSTRIES INCORPORATED | WEIRTON, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | STATEWIDE HEATING & AIR CONDITIONING SERVICE INC. | Nitro, WV | WesBanco Bank, Inc. |
| $350,000–1 million | STATEWIDE HEATING & AIR CONDITIONING SERVICE, INC. | NITRO, WV | WesBanco Bank, Inc. |
| $350,000–1 million | STAY AT HOME HEALTH CARE INC. | SCOTTSBURG, IN | WesBanco Bank, Inc. |
| $150,000–350,000 | STEEL VALLEY EMERGENCY PHYSICIANS, LLC | STEUBENVILLE, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | STEEL VALLEY HOSPITALIST, INC. | STEUBENVILLE, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | STEELEFISH GRILLE NORTH LLC | Bel Air, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | STEELEFISH GRILLE NORTH, LLC | BEL AIR, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | STEINMAN HOLDINGS, LLC | GAITHERSBURG, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | STEP BY STEP, INC. | CHARLESTON, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | STEPPING STONE HEALTH SERVICES LLC | REYNOLDSBURG, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | STERLING SUPPLY CO. | HUNTINGTON, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | STERLING SUPPLY CO. | HUNTINGTON, WV | WesBanco Bank, Inc. |
| $350,000–1 million | STEUBENVILLE AMBULANCE SERVICE DBA | Steubenville, OH | WesBanco Bank, Inc. |
| $350,000–1 million | STEUBENVILLE AMBULANCE SERVICE DBA | STEUBENVILLE, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | STEUBENVILLE COUNTRY CLUB MANOR | STEUBENVILLE, OH | WesBanco Bank, Inc. |
| $1–2 million | STEWART HOME & SCHOOL LLC | Frankfort, KY | WesBanco Bank, Inc. |
| $1–2 million | STEWART HOME & SCHOOL, LLC | FRANKFORT, KY | WesBanco Bank, Inc. |
| $350,000–1 million | STEWART LAWN AND LANDSCAPE MGMNT INC | LOTHIAN, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | STINGRAY WELDING LLC | La Plata, MD | WesBanco Bank, Inc. |
| $350,000–1 million | STONEY HOLLOW TIRE, INC. | MARTINS FERRY, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | STORM WATER MANAGEMENT FACILITIES REPAIR GROUP INC | GAITHERSBURG, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | STRAIGHT TRANSPORTATION SERVICES INC | SAINT ALBANS, WV | WesBanco Bank, Inc. |
| $350,000–1 million | STRICTLY BUSINESS COMPUTER SYS | HUNTINGTON, WV | WesBanco Bank, Inc. |
| $350,000–1 million | STRICTLY BUSINESS COMPUTER SYS | Huntington, WV | WesBanco Bank, Inc. |
| $150,000–350,000 | STRIP DISTRICT MEATS, INC. | PITTSBURGH, PA | WesBanco Bank, Inc. |
| $150,000–350,000 | STUDIO 7 HAIR & SKIN CLINIC LLC | Washington, PA | WesBanco Bank, Inc. |
| $150,000–350,000 | STUDIO 7 HAIR & SKIN CLINIC LLC | WASHINGTON, PA | WesBanco Bank, Inc. |
| $150,000–350,000 | STUDIO PRODUCTIONS | ROCKVILLE, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | STUDIO SUITES BY CHRISTOPHER LTD | Chillicothe, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SUMA, INC | LAWRENCEBURG, KY | WesBanco Bank, Inc. |
| $150,000–350,000 | SUMMIT SALES & MARKETING, INC. | LOUISVILLE, KY | WesBanco Bank, Inc. |
| $350,000–1 million | SUPER SALVAGE INC | Prince Frederick, MD | WesBanco Bank, Inc. |
| $350,000–1 million | SUPER SALVAGE INC | PRINCE FREDERICK, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | SUPERIOR STEEL SERVICE LLC | Batavia, OH | WesBanco Bank, Inc. |
| $150,000–350,000 | SUPERIOR STEEL SERVICE, LLC | BATAVIA, OH | WesBanco Bank, Inc. |