| $150,000–350,000 | RETAIL SPECIALISTS LLC | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $350,000–1 million | RETAIL STRATEGIES, LLC | BIRMINGHAM, AL | SouthPoint Bank |
| $350,000–1 million | RETINA CONSULTANTS OF ALABAMA PC | BIRMINGHAM, AL | Cadence Bank |
| $150,000–350,000 | RETINA SPECIALISTS OF ALABAMA IN MONTGOMERY, LLC | BIRMINGHAM, AL | First Source Federal Credit Union |
| $350,000–1 million | RETINA SPECIALISTS OF ALABAMA, LLC. | BIRMINGHAM, AL | First Source Federal Credit Union |
| $150,000–350,000 | REV BIRMINGHAM, INC. | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | RICHTER LANDSCAPE COMPANY, LLC | BIRMINGHAM, AL | United Community Bank |
| $150,000–350,000 | RILEY & JACKSON, P. C. | BIRMINGHAM, AL | NobleBank & Trust |
| $1–2 million | RIVES CONSTRUCTION COMPANY INC | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | RM LOGISTICS, INC. | BIRMINGHAM, AL | First Source Federal Credit Union |
| $150,000–350,000 | RM MANAGEMENT, LLC | BIRMINGHAM, AL | Renasant Bank |
| $350,000–1 million | ROBERTSON AND ASSOCIATES INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | ROBINSON TEMPERATURE CONTROLS INC | BIRMINGHAM, AL | First Horizon Bank |
| $150,000–350,000 | ROCKY HEIGHTS PRINT & BINDING LLC | BIRMINGHAM, AL | Bryant Bank |
| $150,000–350,000 | RODNEY SCOTT'S BBQ BIRMINGHAM LLC | BIRMINGHAM, AL | SouthPoint Bank |
| $150,000–350,000 | RODNEY SCOTT'S BBQ CHARLESTON LLC | BIRMINGHAM, AL | SouthPoint Bank |
| $350,000–1 million | ROEBUCK IMPORTED CARS, LLC | BIRMINGHAM, AL | Community Bank of Mississippi |
| $150,000–350,000 | ROHRER AESTHETICS LLC | BIRMINGHAM, AL | Regions Bank |
| $150,000–350,000 | RONALD MCDONALD HOUSE CHARITIES OF ALABAMA INC | BIRMINGHAM, AL | Renasant Bank |
| $350,000–1 million | ROOFERS MART SOUTHEAST INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | ROSS NEELY SYSTEMS, INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | ROUSSO FACIAL PLASTIC SURGERY CLINIC, PC | BIRMINGHAM, AL | SouthState Bank, National Association |
| $150,000–350,000 | ROXBERRY SERVICES, INC | BIRMINGHAM, AL | ServisFirst Bank |
| $1–2 million | ROYAL AUTOMOTIVE, INC | BIRMINGHAM, AL | CB&S Bank |
| $150,000–350,000 | ROYAL RESTORATION, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | ROYAL STREET, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $1–2 million | RURAL URGENT CARE LLC | BIRMINGHAM, AL | Peoples Bank of Alabama |
| $2–5 million | RUSSO CORPORATION | BIRMINGHAM, AL | Bryant Bank |
| $150,000–350,000 | S & W ELECTRIC COMPANY INC | BIRMINGHAM, AL | Alabama Central CU |
| $350,000–1 million | S E MEATS INC. | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | SAI JUNG INC | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | SAIN ASSOCIATES, INC. | BIRMINGHAM, AL | ServisFirst Bank |
| $1–2 million | SAIN ENGINEERING ASSOCIATES, I | BIRMINGHAM, AL | PNC Bank, National Association |
| $150,000–350,000 | SAINT ROSE OF LIMA SCHOOL | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | SAINT STEPHEN'S EPISCOPAL CHURCH | BIRMINGHAM, AL | SouthState Bank, National Association |
| $150,000–350,000 | SALON 43 ONE, LLC | BIRMINGHAM, AL | Pinnacle Bank |
| $150,000–350,000 | SAM-TAY ENTERPRISES | BIRMINGHAM, AL | NobleBank & Trust |
| $150,000–350,000 | SANDI GORNATI, INC. | BIRMINGHAM, AL | SouthState Bank, National Association |
| $350,000–1 million | SANDNER COMMERCIAL REAL ESTATE, INC | BIRMINGHAM, AL | ServisFirst Bank |
| $5–10 million | SATELLITES UNLIMITED LLC | BIRMINGHAM, AL | Cadence Bank |
| $350,000–1 million | SAULS SEISMIC LLC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $1–2 million | SAVELA & ASSOCIATES INC. | BIRMINGHAM, AL | First Source Federal Credit Union |
| $2–5 million | SB HOLDING CORPORATION | BIRMINGHAM, AL | SouthPoint Bank |
| $150,000–350,000 | SCHAFFER PLASTIC SURGERY PC | BIRMINGHAM, AL | ServisFirst Bank |
| $1–2 million | SCHOEL ENGINEERING COMPANY INC | BIRMINGHAM, AL | Truist Bank |
| $2–5 million | SCHOLAR CRAFT PRODUCTS INC | BIRMINGHAM, AL | Valley National Bank |
| $150,000–350,000 | SCOTT DUKES & GEISLER P.C. | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | SCOTT ELECTRIC SIGN COMPANY INC | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $350,000–1 million | SCOTT ENERGY SERVICES LLC | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | SCOTT, SULLIVAN, STREETMAN & FOX PC | BIRMINGHAM, AL | First Source Federal Credit Union |
| $350,000–1 million | SCP COLDWORKS, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SDH PIZZA, INC. | BIRMINGHAM, AL | Millennial Bank |
| $1–2 million | SDS RESOURCES LLC | BIRMINGHAM, AL | SouthPoint Bank |
| $350,000–1 million | SEALE HARRIS CLINIC, PC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SECOND WIND PROGRAMS, INC | BIRMINGHAM, AL | SouthState Bank, National Association |
| $150,000–350,000 | SECURIT360, LLC | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $5–10 million | SECURITY ENGINEERS INC | BIRMINGHAM, AL | First Source Federal Credit Union |
| $150,000–350,000 | SENIORSELECT PARTNERS INC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SERRA CHEVROLET, INC | BIRMINGHAM, AL | Cadence Bank |
| $350,000–1 million | SERRA NISSAN-OLDSMOBILE, INC. | BIRMINGHAM, AL | Cadence Bank |
| $350,000–1 million | SERVICE CONSTRUCTION SUPPLY, INC. | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SHADES CREST BAPTIST CHURCH | BIRMINGHAM, AL | SouthState Bank, National Association |
| $150,000–350,000 | SHAIAS OF HOMEWOOD | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SHARP AND STONE OB/GYN PC | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | SHEFFIELD ELECTRICAL CONTRACTORS, LLC | BIRMINGHAM, AL | United Community Bank |
| $150,000–350,000 | SHEFFIELD RISK MANAGEMENT SERVICES, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SHELBY COMPANY LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SHOEMAKER POOL SERVICE, INC. | BIRMINGHAM, AL | Synovus Bank |
| $1–2 million | SHOOK AND FLETCHER MECHANICAL CONTRACTORS INC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SHUNNARAH INJURY LAWYERS, P.C. | BIRMINGHAM, AL | Community Bank of Mississippi |
| $150,000–350,000 | SIGAO STUDIOS, LLC. | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | SIGN BUILDERS, INC. | BIRMINGHAM, AL | Truist Bank |
| $1–2 million | SIMON-WILLIAMSON CLINIC PC | BIRMINGHAM, AL | First Source Federal Credit Union |
| $150,000–350,000 | SIMPLESHIP HOLDINGS, LLC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | SIMPSON PLASTERING LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $5–10 million | SIROTE & PERMUTT, PC | BIRMINGHAM, AL | Cadence Bank |
| $150,000–350,000 | SIXTH AVENUE BAPTIST CHURCH | BIRMINGHAM, AL | Sixth Avenue Baptist FCU |
| $350,000–1 million | SKIN DIAGNOSTICS GROUP PC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SKIPPER CONSULTING, INC | BIRMINGHAM, AL | United Community Bank |
| $150,000–350,000 | SLEEP DISORDER CENTER OF ALABAMA INC | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | SLICE, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SLS WEST INC | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | SMAO, LLC | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | SMART DIGITAL, LLC | BIRMINGHAM, AL | Renasant Bank |
| $1–2 million | SMW ENGINEERING GROUP, INC | BIRMINGHAM, AL | Regions Bank |
| $150,000–350,000 | SNIDER THERAPY CENTERS, INC. | BIRMINGHAM, AL | Synovus Bank |
| $350,000–1 million | SOURCEPOINTE OF AL, LLC | BIRMINGHAM, AL | SouthState Bank, National Association |
| $150,000–350,000 | SOUTH CYPRESS, INC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $150,000–350,000 | SOUTH HIGHLAND CHILD DEVELOPMENT CENTER | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $350,000–1 million | SOUTH OAK TITLE, LLC | BIRMINGHAM, AL | United Community Bank |
| $150,000–350,000 | SOUTHEAST BUSINESS FURNITURE SERVICES, INC. | BIRMINGHAM, AL | First US Bank |
| $350,000–1 million | SOUTHEAST CLINICAL LABORATORIES, LLC | BIRMINGHAM, AL | Cadence Bank |
| $150,000–350,000 | SOUTHEASTERN COMMERCIAL FINANCE, L.L.C. | BIRMINGHAM, AL | Pinnacle Bank |
| $150,000–350,000 | SOUTHEASTERN CONVEYOR SERVICES,INC. | BIRMINGHAM, AL | Traditions Bank |
| $350,000–1 million | SOUTHEASTERN REFRIGERATION, INC. | BIRMINGHAM, AL | Renasant Bank |
| $350,000–1 million | SOUTHEASTERN SEALCOATING INC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SOUTHERN COFFEE COMPANY | BIRMINGHAM, AL | Truist Bank |
| $150,000–350,000 | SOUTHERN CONSOLIDATED ELECTRICAL SALES, INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SOUTHERN ENT & SINUS CENTER P. C. | BIRMINGHAM, AL | Synovus Bank |
| $350,000–1 million | SOUTHERN EQUIPMENT & CREW LLC | BIRMINGHAM, AL | Cadence Bank |