| $150,000–350,000 | SOUTHERN HEMATOLOGY & ONCOLOGY, P.C. | BIRMINGHAM, AL | SouthState Bank, National Association |
| $350,000–1 million | SOUTHERN LAB PARTNERS, LLC | BIRMINGHAM, AL | Community Bank of Mississippi |
| $150,000–350,000 | SOUTHERN LABEL CO. | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SOUTHERN OVERHEAD DOOR INC | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | SOUTHERN PRECISION STAFFING, INC. | BIRMINGHAM, AL | Bryant Bank |
| $5–10 million | SOUTHERN RESEARCH INSTITUTE | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | SOUTHERN SKY AVIATION, LLC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | SOUTHERN SWEEPERS & SCRUBBERS INC | BIRMINGHAM, AL | Renasant Bank |
| $150,000–350,000 | SOUTHERN TRUCK CENTER, INC. | BIRMINGHAM, AL | Synovus Bank |
| $350,000–1 million | SOUTHLAND ELECTRIC COMPANY INC | BIRMINGHAM, AL | ServisFirst Bank |
| $2–5 million | SOUTHLAND INTERNATIONAL TRUCKS INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SOUTHPACE, INC. | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | SOUTHSIDE APARTMENT COMPANY LLC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | SOUTHSIDE PAIN SPECIALISTS PC | BIRMINGHAM, AL | ServisFirst Bank |
| $2–5 million | SOUTHVIEW MEDICAL GROUP PC | BIRMINGHAM, AL | Regions Bank |
| $150,000–350,000 | SOUTHWESTERN ATHLETIC CONFERENCE | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SPAIN & GILLON LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SPARKS & FAVOR PC | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | SPARTAN VALUE INVESTORS LLC | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | SPLAWN & WARD ASSOC | BIRMINGHAM, AL | First Source Federal Credit Union |
| $150,000–350,000 | SPOT COLOR LLC | BIRMINGHAM, AL | Bryant Bank |
| $350,000–1 million | SPOTSWOOD, SANSOM & SANSBURY, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SPREADRITE, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SPRING VALLEY SCHOOL FOUNDATION | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SPRINGER EQUIPMENT CO. INC. | BIRMINGHAM, AL | SouthState Bank, National Association |
| $150,000–350,000 | SPROUTHOUSE, LLC | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | ST MARYS ON THE HIGHLANDS | BIRMINGHAM, AL | Synovus Bank |
| $350,000–1 million | ST. LUKE'S EPISCOPAL CHURCH, MOUNTAIN BROOK, ALABAMA, INC. | BIRMINGHAM, AL | SouthState Bank, National Association |
| $350,000–1 million | ST. VINCENT'S ORTHOPEDICS, PC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | STANDARD HEATING & AIR CONDITIONING COMPANY INC | BIRMINGHAM, AL | ServisFirst Bank |
| $1–2 million | STAR INSULATION INC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | STARBOARD MANAGEMENT, LLC | BIRMINGHAM, AL | First Source Federal Credit Union |
| $2–5 million | STARNES DAVIS FLORIE LLP | BIRMINGHAM, AL | SouthState Bank, National Association |
| $150,000–350,000 | STARNES HOLDINGS, INC. | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | START TRUCK PARTS | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | STEEL CITY BOLT & SCREW LLC | BIRMINGHAM, AL | Itria Ventures LLC |
| $150,000–350,000 | STEEL CITY BOLT & SCREW LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | STEEL CITY EATERIES LLC | BIRMINGHAM, AL | Synovus Bank |
| $350,000–1 million | STEEL CITY RECYCLING LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | STEGALL MECHANICAL LLC | BIRMINGHAM, AL | Renasant Bank |
| $2–5 million | STELLAR STAFFING LLC | BIRMINGHAM, AL | Renasant Bank |
| $150,000–350,000 | STEPHENS PLUMBING INC | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | STERLING CAPITAL MANAGEMENT INC | BIRMINGHAM, AL | Truist Bank |
| $350,000–1 million | STEVE MORRISON TRUCKING INC. | BIRMINGHAM, AL | Itria Ventures LLC |
| $350,000–1 million | STEVE MORRISON TRUCKING, INC. | BIRMINGHAM, AL | Bryant Bank |
| $2–5 million | STEWARD MACHINE CO., INC. | BIRMINGHAM, AL | Oakworth Capital Bank |
| $150,000–350,000 | STEWART INDUSTRIES INT'L BIRMINGHAM | BIRMINGHAM, AL | Wells Fargo Bank, National Association |
| $150,000–350,000 | STOCKHAM, COOPER & POTTS, P. C. | BIRMINGHAM, AL | Cadence Bank |
| $1–2 million | STONE AND SONS ELECTRICAL CONTRACTORS, INC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | STONE BUILDING LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | STORYTELLER OVERLAND, LLC | BIRMINGHAM, AL | SouthState Bank, National Association |
| $150,000–350,000 | STRADA PROFESSIONAL SERVICES, LLC | BIRMINGHAM, AL | First Source Federal Credit Union |
| $150,000–350,000 | STRATEGYWISE, LLC | BIRMINGHAM, AL | Bryant Bank |
| $150,000–350,000 | STRATFORD ENTERPRISES, INC. | BIRMINGHAM, AL | First Source Federal Credit Union |
| $350,000–1 million | STREET AND AREA LIGHTING COMPANY, INC. | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | STRONG AIR CONDITIONING COMPANY, INC. | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | STRUT SERVICES GROUP, INC | BIRMINGHAM, AL | Bryant Bank |
| $150,000–350,000 | STUDIO 21 SALON INC. | BIRMINGHAM, AL | CB&S Bank |
| $5–10 million | SUMMITMEDIA LLC | BIRMINGHAM, AL | Synovus Bank |
| $350,000–1 million | SUNBELT GLASS, LLC | BIRMINGHAM, AL | SouthPoint Bank |
| $1–2 million | SUPERIOR CLEANING SOLUTIONS, L.L.C. | BIRMINGHAM, AL | Hancock Whitney Bank |
| $150,000–350,000 | SUPERIORSCAPE INC | BIRMINGHAM, AL | Cadence Bank |
| $350,000–1 million | SUPREME PAPER SUPPLIES LLC | BIRMINGHAM, AL | BankUnited, National Association |
| $150,000–350,000 | SURIN 280 LLC | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | SURIN OF THAILAND HUNTSVILLE LLC | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | SURIN WEST INC | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | SW CRE, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SWITCH, INC. | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SYSTEMS ANALYSIS INC/LADCO INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | TACO MAMA 119, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | TACO MAMA CENTRAL CITY LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | TACO MAMA SUMMIT LLC | BIRMINGHAM, AL | First Source Federal Credit Union |
| $150,000–350,000 | TACO MAMA TRUSSVILLE LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | TACO MAMA TUSCALOOSA LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | TALON HIRING SOLUTIONS LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | TANORY MOVING SYSTEMS, INC. | BIRMINGHAM, AL | SmartBank |
| $150,000–350,000 | TAUSTIN LABORATORIES LLC | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $350,000–1 million | TAYLOR & MIREE CONSTRUCTION INC. | BIRMINGHAM, AL | SouthState Bank, National Association |
| $150,000–350,000 | TAYLOR SALES AND SERVICE, INC | BIRMINGHAM, AL | Bryant Bank |
| $150,000–350,000 | TAZIKI'S ATLANTA, LLC | BIRMINGHAM, AL | PNC Bank, National Association |
| $350,000–1 million | TAZIKIS NASHVILLE, LLC | BIRMINGHAM, AL | Pinnacle Bank |
| $350,000–1 million | TBSI, INC. | BIRMINGHAM, AL | Synovus Bank |
| $1–2 million | TE STEVENS CO, INC | BIRMINGHAM, AL | Cadence Bank |
| $1–2 million | TECH PROVIDERS INC | BIRMINGHAM, AL | Renasant Bank |
| $150,000–350,000 | TECHNICAL & EDUCATIONAL TRAINING AIDS, INC. | BIRMINGHAM, AL | Synovus Bank |
| $350,000–1 million | TEMPORARY STAFFING SOLUTIONS, INC. | BIRMINGHAM, AL | Affinity Bank, National Association |
| $150,000–350,000 | THE ALABAMA BAPTIST INC. | BIRMINGHAM, AL | SouthState Bank, National Association |
| $350,000–1 million | THE ALTAMONT SCHOOL | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | THE BELL CENTER FOR EARLY INTERVENTION | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | THE BIRMINGHAM EDUCATION FOUNDATION | BIRMINGHAM, AL | Regions Bank |
| $150,000–350,000 | THE CENTER FOR EXECUTIVE LEADERSHIP | BIRMINGHAM, AL | Oakworth Capital Bank |
| $150,000–350,000 | THE COMMUNITY FOOD BANK OF CENTRAL AL | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | THE COMMUNITY FOUNDATION OF GREATER BIRMINGHAM | BIRMINGHAM, AL | Truist Bank |
| $1–2 million | THE COOKIE PLACE, INC | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | THE DANNON PROJECT | BIRMINGHAM, AL | ServisFirst Bank |
| $2–5 million | THE E GROUP, L.L.C. | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | THE EXCEPTIONAL FOUNDATION | BIRMINGHAM, AL | IberiaBank, A Division of First Horizon Bank |
| $2–5 million | THE HARDY CORPORATION | BIRMINGHAM, AL | First Source Federal Credit Union |
| $150,000–350,000 | THE JOSEPH S. BRUNO EDUCATIONAL FOUNDATION | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | THE KENT CORPORATION | BIRMINGHAM, AL | Renasant Bank |