| $350,000–1 million | RUBE P. HOFFMAN CO. | MISSION VIEJO, CA | US Bank National Association |
| $150,000–350,000 | RUBY'S MV INC. | MISSION VIEJO, CA | Bank of America, National Association |
| $150,000–350,000 | SAB TERRA INC. | MISSION VIEJO, CA | Byline Bank |
| $150,000–350,000 | SAB TERRA INC. | MISSION VIEJO, CA | Byline Bank |
| $150,000–350,000 | SAFE HARBOR TREATMENT CENTER FOR WOMEN, INC. | MISSION VIEJO, CA | City National Bank |
| $150,000–350,000 | SANTA CROWN, INC. | MISSION VIEJO, CA | Nano Banc |
| $150,000–350,000 | SC WINGS MISSION VIEJO, LLC | MISSION VIEJO, CA | Southern Bank and Trust Company |
| $150,000–350,000 | SCHOLTEN ROOFING SERVICE COMPANY | MISSION VIEJO, CA | American Business Bank |
| $350,000–1 million | SETSCHEDULE, LLC | MISSION VIEJO, CA | Bank of America, National Association |
| $150,000–350,000 | SIDNEY JAY WEISS M.D. A PROFESSIONAL CORPORATION DBA SIDNEY | MISSION VIEJO, CA | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | SIDNEY JAY WEISS, M.D. A PROFESSIONAL CORPORATION DBA SIDNEY | MISSION VIEJO, CA | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | SOCIAL HOUSE, INC. | MISSION VIEJO, CA | JPMorgan Chase Bank, National Association |
| $2–5 million | SOUTH COAST CHILDREN'S SOCIETY, INC. | MISSION VIEJO, CA | Pacific Premier Bank |
| $350,000–1 million | SOUTH ORANGE COUNTY EMERGENCY VETERINARY | MISSION VIEJO, CA | Wells Fargo Bank, National Association |
| $150,000–350,000 | SOUTHERN ORANGE COUNTY PEDIATRIC ASSOCIATES II, A MEDICAL CO | MISSION VIEJO, CA | Banc of California |
| $1–2 million | SOVEREIGN SURGICAL HOLDINGS LP | MISSION VIEJO, CA | Zions Bank, A Division of |
| $150,000–350,000 | SR GLOBAL SECURITY AND PROTECTION GROUP INC. | MISSION VIEJO, CA | U.S. Bank, National Association |
| $150,000–350,000 | ST KILIAN CHURCH | MISSION VIEJO, CA | Farmers & Merchants Bank of Long Beach |
| $350,000–1 million | STEEL CITY SCAFFOLD, INC. | MISSION VIEJO, CA | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | STINGER LOGISTICS INC. | MISSION VIEJO, CA | Farmers & Merchants Bank of Long Beach |
| $350,000–1 million | STONEYBROOKE CHRISTIAN SCHOOLS | MISSION VIEJO, CA | Farmers & Merchants Bank of Long Beach |
| $350,000–1 million | STRATEGIC SANITATION SERVICES, INC. | MISSION VIEJO, CA | BMO Bank National Association |
| $150,000–350,000 | SUTTON & MURPHY | MISSION VIEJO, CA | Partners Bank of California |
| $150,000–350,000 | SWISS WATCH GALLERY, INC. | MISSION VIEJO, CA | Bank of America, National Association |
| $2–5 million | TECHNICON DESIGN CORPORATION | MISSION VIEJO, CA | HSBC Bank USA, National Association |
| $150,000–350,000 | THE INCONTINENCE AND PELVIC SUPPORT INSTITUTE, A MEDICAL COR | MISSION VIEJO, CA | US Bank National Association |
| $350,000–1 million | TINNELLY LAW GROUP, INC. | MISSION VIEJO, CA | US Bank National Association |
| $1–2 million | VOCATIONAL VISIONS | MISSION VIEJO, CA | Banc of California |
| $350,000–1 million | WEIRTON MANAGEMENT GROUP INC | MISSION VIEJO, CA | Bank of America, National Association |
| $350,000–1 million | WESTERN ANESTHESIA MEDICL ASSOC INC | MISSION VIEJO, CA | Partners Bank of California |
| $150,000–350,000 | WESTERN COLLOID CONSOLIDATED SALES CORP | MISSION VIEJO, CA | American Business Bank |
| $150,000–350,000 | WHITE LOTUS INVESTMENTS, INC. | MISSION VIEJO, CA | Sunwest Bank |
| $150,000–350,000 | WINEWORKS, INC. | MISSION VIEJO, CA | American Business Bank |
| $350,000–1 million | WOODBRIDGE PACIFIC GROUP LLC | MISSION VIEJO, CA | Flagstar Bank National Association |