| $150,000–350,000 | PYRAMID PHYSICAL THERAPY&WKPLC CON, LLC | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | QUALITY CABINETS AND COUNTERS, INC. | FORT MYERS, FL | First Horizon Bank |
| $150,000–350,000 | QUALITY CONTROL AIR OF SWFL INC | FORT MYERS, FL | Synovus Bank |
| $1–2 million | R L JAMES INC GENERAL CONTRACTOR | FORT MYERS, FL | Truist Bank |
| $150,000–350,000 | R-80 RIB CITY LLC | FORT MYERS, FL | Regions Bank |
| $150,000–350,000 | RAIMEY CORPORATION | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | RALPH GARRAMONE, MD, PA | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | RAZ CONSTRUCTION LLC | FORT MYERS, FL | Busey Bank |
| $150,000–350,000 | REUMAR INC | FORT MYERS, FL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | RG ARCHITECTS, P.A | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | RIVERSIDE BAPTIST CHURCH OF FORT MYERS, INC | FORT MYERS, FL | Busey Bank |
| $150,000–350,000 | RNJ ENTERPRISES LIMITED, INC. | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | ROADHOUSE CAFE, INC | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $2–5 million | ROBB & STUCKY INTERNATIONAL, INC. | FORT MYERS, FL | First Foundation Bank |
| $150,000–350,000 | ROCKSTAR INVESTMENTS OF SOUTHWEST FL LLC | FORT MYERS, FL | City National Bank of Florida |
| $150,000–350,000 | RON & SONS, INC. | FORT MYERS, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | ROOFING & RENOVATION OF FLORIDA, LLC | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | ROYAL AUCTION GROUP INC | FORT MYERS, FL | United Fidelity Bank, FSB |
| $150,000–350,000 | ROYAL PALM CLOSET DESIGN INC | FORT MYERS, FL | Lake Michigan CU |
| $1–2 million | ROYAL SHELL VACATIONS INC | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $350,000–1 million | RS WALSH LANDSCAPING INC | FORT MYERS, FL | Truist Bank |
| $150,000–350,000 | RT & RT OF SOUTH WEST FLORIDA, LLC | FORT MYERS, FL | MidWestOne Bank |
| $150,000–350,000 | RUSS BERNER CONSTRUCTION INC | FORT MYERS, FL | Stearns Bank National Association |
| $350,000–1 million | RYVOR GOLF LLC | FORT MYERS, FL | PNC Bank, National Association |
| $350,000–1 million | S.HOMSI, INC | FORT MYERS, FL | Bremer Bank, National Association |
| $350,000–1 million | SAFE-STRAP COMPANY LLC | FORT MYERS, FL | Bank of America, National Association |
| $350,000–1 million | SAINT MICHAEL EVANGELICAL LUTHERAN CHURCH OF FORT MYERS, FLO | FORT MYERS, FL | BayFirst National Bank |
| $350,000–1 million | SAINT RAPHAEL ROOFING, INC | FORT MYERS, FL | Truist Bank |
| $2–5 million | SALUSCARE, INC. | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $2–5 million | SAM GALLOWAY FORD, INC. | FORT MYERS, FL | Truist Bank |
| $1–2 million | SAMINCO | FORT MYERS, FL | Truist Bank |
| $150,000–350,000 | SAN CARLOS GOLF INC. | FORT MYERS, FL | Truist Bank |
| $150,000–350,000 | SAN CARLOS ROOFING COMPANY | FORT MYERS, FL | Southern Bank |
| $150,000–350,000 | SANIBEL BEACH PLACE HOTEL, LLC | FORT MYERS, FL | BankUnited, National Association |
| $150,000–350,000 | SANIBEL HARBOUR YACHT CLUB CONDOMINIUM ASSOCIATION, INC. | FORT MYERS, FL | Midflorida CU |
| $150,000–350,000 | SCP ENTERPRISES INC | FORT MYERS, FL | Fifth Third Bank |
| $350,000–1 million | SEAGATE DEVELOPMENT GROUP LLC | FORT MYERS, FL | Truist Bank |
| $150,000–350,000 | SELISSA, INC. | FORT MYERS, FL | Synovus Bank |
| $350,000–1 million | SEMINOLE GULF RAILWAY, L.P. | FORT MYERS, FL | Lake Michigan CU |
| $150,000–350,000 | SENSING TECHNOLOGIES, INC | FORT MYERS, FL | First Commonwealth Bank |
| $150,000–350,000 | SERBIN MEDICAL BILLING, LLC | FORT MYERS, FL | Busey Bank |
| $350,000–1 million | SERVICE WORKS OF FT. LAUDERDALE, LLC | FORT MYERS, FL | The Bank of Tampa |
| $150,000–350,000 | SEWER VIEWER INC | FORT MYERS, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | SHIRLEY MATHIS GENERAL CLEANING AND LABOR SERVICES INC | FORT MYERS, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | SHORE TO SHORE FREIGHTLINES, INC | FORT MYERS, FL | Busey Bank |
| $150,000–350,000 | SHORELINE LUMBER INC. | FORT MYERS, FL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | SHS SWFL LLC | FORT MYERS, FL | Fifth Third Bank |
| $150,000–350,000 | SJM PROPERTY MANAGEMENT OF FLORIDA, INC. | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | SOLID SURFACE TOPS OF SOUTHWEST FL INC | FORT MYERS, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | SOLOMON & HOOVER CPAS PLLC | FORT MYERS, FL | Regions Bank |
| $150,000–350,000 | SOUTH FLORIDA GAS COMPANY INC | FORT MYERS, FL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | SOUTHERN LIVING CONTRACTORS, INC. | FORT MYERS, FL | Fifth Third Bank |
| $150,000–350,000 | SOUTHERN OAKS SENIOR LIVING CARE LLC | FORT MYERS, FL | Intracoastal Bank |
| $150,000–350,000 | SOUTHSIDE HARBOR | FORT MYERS, FL | BayFirst National Bank |
| $1–2 million | SOUTHWEST CONSTRUCTION SERVICES OF SW FL INC | FORT MYERS, FL | Bank of America, National Association |
| $350,000–1 million | SOUTHWEST DISPOSAL & CLEAN UP, INC | FORT MYERS, FL | Busey Bank |
| $150,000–350,000 | SOUTHWEST DISPOSAL TRANSFER STATION INC. | FORT MYERS, FL | Busey Bank |
| $150,000–350,000 | SOUTHWEST FLORIDA COMMUNITY FOUNDATION, INC. | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | SOUTHWEST FLORIDA COUNCIL INC BSA | FORT MYERS, FL | Truist Bank |
| $1–2 million | SOUTHWEST FLORIDA HOME CARE INC | FORT MYERS, FL | Bank of America, National Association |
| $350,000–1 million | SOUTHWEST FLORIDA SALONS LLC | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | SOUTHWEST NURSERY LLC | FORT MYERS, FL | Cross River Bank |
| $350,000–1 million | SOUTHWEST UTILITY SYSTEMS, INC. | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | SPECIALISTS IN PRIMARY HEALTH CARE | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | SPIRE CONSTRUCTION LLC | FORT MYERS, FL | United Community Bank |
| $150,000–350,000 | SPIRES AND ASSOCIATES PA | FORT MYERS, FL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | SRA STRUCTURAL CONSULTANTS LLC | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | SS GREY II LLC DBA 10 TWENTY FIVE | FORT MYERS, FL | Wells Fargo Bank, National Association |
| $350,000–1 million | ST. FRANCIS XAVIER PARISH IN FORT MYERS, INC. | FORT MYERS, FL | The Northern Trust Company |
| $350,000–1 million | STANCEL CONCRETE INCORPORATED | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | STANLEY STEEMER OF LEE COUNTY INC | FORT MYERS, FL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | STARLITE ELECTRIC LLC | FORT MYERS, FL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | STEPHEN E SMITH MD PA | FORT MYERS, FL | IberiaBank, A Division of First Horizon Bank |
| $350,000–1 million | STEVENS & LAYTON INC | FORT MYERS, FL | First Bank |
| $350,000–1 million | STEVENS CONSTRUCTION, INC | FORT MYERS, FL | Lake Michigan CU |
| $350,000–1 million | STOKES MARINE, INC. | FORT MYERS, FL | Lake Michigan CU |
| $150,000–350,000 | STRATEGY MARKETING GROUP INC. | FORT MYERS, FL | BankUnited, National Association |
| $150,000–350,000 | STRICKLER BROS UNDERGROUND INC | FORT MYERS, FL | Truist Bank |
| $350,000–1 million | STROEMER AND COMPANY LLC | FORT MYERS, FL | IberiaBank, A Division of First Horizon Bank |
| $350,000–1 million | STUDIO R.K., INC. | FORT MYERS, FL | Busey Bank |
| $350,000–1 million | STUDIOPLUS, LLC | FORT MYERS, FL | ServisFirst Bank |
| $150,000–350,000 | STULTZ INC | FORT MYERS, FL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | SUMMERLIN BEND SURGERY CENTER LLP | FORT MYERS, FL | Wells Fargo Bank, National Association |
| $350,000–1 million | SUN BROADCASTING, INC. | FORT MYERS, FL | Bank of America, National Association |
| $350,000–1 million | SUN SPORTS CYCLE AND WATERCRAFT, INC. | FORT MYERS, FL | IberiaBank, A Division of First Horizon Bank |
| $350,000–1 million | SUNBIZ | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | SUNCOAST ALUMINUM FURNITURE, INC. | FORT MYERS, FL | First Foundation Bank |
| $1–2 million | SUNCOAST CONTRACTORS SUPPLY, INC. | FORT MYERS, FL | Busey Bank |
| $150,000–350,000 | SUNIL MALKANI, M.D., P.A. | FORT MYERS, FL | Busey Bank |
| $1–2 million | SUNNYGROVE LANDSCAPE IRRIGATION & MAINTENANCE LLC | FORT MYERS, FL | Valley National Bank |
| $1–2 million | SUNNYGROVE LANDSCAPING & NURSERY, INC. | FORT MYERS, FL | Valley National Bank |
| $350,000–1 million | SUNSET AIR, INC. | FORT MYERS, FL | First Bank |
| $350,000–1 million | SUNSHINE RECYCLING SERVICES OF SWFL, LLC | FORT MYERS, FL | Truist Bank |
| $350,000–1 million | SURGICAL SPECIALISTS OF SW FLORIDA | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $1–2 million | SUTHERLIN NISSAN OF FT MYERS INC | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | SWEET LIFE 6 LLC | FORT MYERS, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | T-CLIPS, INC. | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | T3 COMMUNICATIONS, INC. | FORT MYERS, FL | Texas Partners Bank |
| $1–2 million | TARGET ROOFING AND SHEET METAL, INC. | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $350,000–1 million | TAYLOR CARPET ONE, INC | FORT MYERS, FL | JPMorgan Chase Bank, National Association |