| $350,000–1 million | SB LEASING LLC | JACKSONVILLE, FL | Heritage Bank, A Division of The First Bank |
| $350,000–1 million | SCHUMAN ELECTRIC INC | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | SCHUR & COMPANY LLC | JACKSONVILLE, FL | Synovus Bank |
| $350,000–1 million | SCOTT D. WARREN, M.D., P.A. | JACKSONVILLE, FL | Benchmark Bank |
| $350,000–1 million | SCOTT INDUSTRIAL SYSTEMS, LLC | JACKSONVILLE, FL | Fifth Third Bank |
| $150,000–350,000 | SCRIBE SOLUTIONS, INC. | JACKSONVILLE, FL | First Source Federal Credit Union |
| $350,000–1 million | SE FOODS, LLC | JACKSONVILLE, FL | TD Bank, National Association |
| $1–2 million | SEA BREEZE SERVICE INC | JACKSONVILLE, FL | First Source Federal Credit Union |
| $350,000–1 million | SEA SNAPPERS, INC. | JACKSONVILLE, FL | Bank of America, National Association |
| $350,000–1 million | SEACOAST CHARTER ACADEMY, INC. | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SEACOAST CHRISTIAN ACADEMY INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SEAMARK RANCH, INC. | JACKSONVILLE, FL | Truist Bank |
| $150,000–350,000 | SECUR-NET USA, INC. | JACKSONVILLE, FL | VyStar CU |
| $350,000–1 million | SECURE IDEAS, LLC | JACKSONVILLE, FL | 121 Financial CU, A Division of VyStar Credit Union |
| $150,000–350,000 | SECURITY DEVELOPMENT GROUP, LLC DBA S3 SECURITY | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | SECURITY ENGINEERING AND DESIGNS INC | JACKSONVILLE, FL | First Source Federal Credit Union |
| $350,000–1 million | SEDA CONSTRUCTION COMPANY | JACKSONVILLE, FL | Regions Bank |
| $150,000–350,000 | SERRANO PAINT & BODY SHOP CO., INC. | JACKSONVILLE, FL | SouthState Bank, National Association |
| $150,000–350,000 | SERVITOR, INC. | JACKSONVILLE, FL | First Bank of the Lake |
| $150,000–350,000 | SETZER, COCHRAN, SOARES | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SEVEN BRIDGES RADIO, LLC | JACKSONVILLE, FL | Cogent Bank |
| $150,000–350,000 | SFS HOLDINGS, LLC | JACKSONVILLE, FL | Hancock Whitney Bank |
| $1–2 million | SFTF, LLC DBA ASHLEY FURNITURE HOMESTORE | JACKSONVILLE, FL | Fifth Third Bank |
| $150,000–350,000 | SHAPELLS, INC. | JACKSONVILLE, FL | SouthState Bank, National Association |
| $150,000–350,000 | SHARENET LLC | JACKSONVILLE, FL | Orrstown Bank |
| $150,000–350,000 | SHARIAN INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SHAW'S LAND CLEARING, LLC | JACKSONVILLE, FL | SouthState Bank, National Association |
| $150,000–350,000 | SHAW'S TREE SERVICE, LLC | JACKSONVILLE, FL | SouthState Bank, National Association |
| $150,000–350,000 | SHAYCORE ENTERPRISES, INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SHAYCORE, L.L.C. | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SHEFFIELD & BOATRIGHT TITLE SERVICES LLC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SHELBY CRANE SERVICE, INC. | JACKSONVILLE, FL | First Source Federal Credit Union |
| $150,000–350,000 | SHEPPARD VENTURES, LLC | JACKSONVILLE, FL | Valley National Bank |
| $150,000–350,000 | SHEPPARD WHITE KACHERGUS AND DEMAGGIO | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | SHILOH METROPOLITAN BAPTIST CHURCH | JACKSONVILLE, FL | First-Citizens Bank & Trust Company |
| $2–5 million | SHIPPERS AUTOMOTIVE GROUP LLC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SHORELINE PLASTICS, LLC | JACKSONVILLE, FL | PNC Bank, National Association |
| $350,000–1 million | SHORSTEIN & SHORSTEIN PA | JACKSONVILLE, FL | Newtek Small Business Finance, Inc. |
| $350,000–1 million | SIGHT & SOUND PRODUCTIONS LLC | JACKSONVILLE, FL | TD Bank, National Association |
| $150,000–350,000 | SIMES & ROSCH LLC | JACKSONVILLE, FL | First Source Federal Credit Union |
| $150,000–350,000 | SIMONIC, SIMONIC, RATNECHT & ASSOCIATES, INC. | JACKSONVILLE, FL | First Source Federal Credit Union |
| $350,000–1 million | SISSINE'S BUSINESS SOLUTIONS OF ORLANDO, INC | JACKSONVILLE, FL | SouthState Bank, National Association |
| $350,000–1 million | SISSINE'S OFFICE SYSTEMS, INC. | JACKSONVILLE, FL | SouthState Bank, National Association |
| $350,000–1 million | SITEX LAND LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | SKINNER WASTE SOLUTIONS, LLC | JACKSONVILLE, FL | Cogent Bank |
| $150,000–350,000 | SKY ENTERTAINMENT JACKSONVILLE LLC | JACKSONVILLE, FL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | SLEEP CARE CENTERS OF AMERICA LLC | JACKSONVILLE, FL | Ameris Bank |
| $1–2 million | SLEIMAN HOLDINGS, INC. | JACKSONVILLE, FL | Valley National Bank |
| $1–2 million | SMART PHARMACY, INC. | JACKSONVILLE, FL | SouthState Bank, National Association |
| $350,000–1 million | SMARTSTAFF, INC. | JACKSONVILLE, FL | Bank of the Plains |
| $1–2 million | SMC SYSTEMS INC | JACKSONVILLE, FL | Truist Bank |
| $150,000–350,000 | SMITH & SURRENCY LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | SMITH BROS PLASTERING CO INC | JACKSONVILLE, FL | Bank of America, National Association |
| $1–2 million | SMITH HULSEY & BUSEY | JACKSONVILLE, FL | United Community Bank |
| $350,000–1 million | SMOAK, DAVIS & NIXON LLP | JACKSONVILLE, FL | TD Bank, National Association |
| $150,000–350,000 | SNOWBIRD TECHNOLOGIES, INC | JACKSONVILLE, FL | Hancock Whitney Bank |
| $1–2 million | SNYDER CO. | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | SOBU | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | SOFTWINK. INC | JACKSONVILLE, FL | Truist Bank |
| $350,000–1 million | SOUND PAYMENTS INC | JACKSONVILLE, FL | First Source Federal Credit Union |
| $2–5 million | SOUTHEAST MECHANICAL SYSTEMS, INC. | JACKSONVILLE, FL | Truist Bank |
| $150,000–350,000 | SOUTHEAST RIGGING, INC. | JACKSONVILLE, FL | Cogent Bank |
| $1–2 million | SOUTHEASTERN ALUMINUM PRODUCTS LLC | JACKSONVILLE, FL | Fifth Third Bank |
| $150,000–350,000 | SOUTHEASTERN ORNAMENTAL IRON CO | JACKSONVILLE, FL | VyStar CU |
| $350,000–1 million | SOUTHEASTERN RETINA SPECIALISTS, P.A. | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | SOUTHERN AIRE CONTRACTING, INC. | JACKSONVILLE, FL | Renasant Bank |
| $350,000–1 million | SOUTHERN ATLANTIC ELECTRIC COMPANY INC. | JACKSONVILLE, FL | Hancock Whitney Bank |
| $350,000–1 million | SOUTHERN BELLE FROZEN FOODS, INC. | JACKSONVILLE, FL | Truist Bank |
| $350,000–1 million | SOUTHERN BRAS LLC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SOUTHERN EQUIPMENT SALES CO. | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | SOUTHERN EXPRESS CARWASH INC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | SOUTHERN GROUNDS COFFEE SAN MARCO LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $350,000–1 million | SOUTHERN HILLS PLANTATION GOLF CLUB LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $350,000–1 million | SOUTHERN REFRIGERATION ENGINEERS OF NORTH FLORIDA, INC. | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | SOUTHERN TECHNOLOGIES OF JACKSONVILLE INC | JACKSONVILLE, FL | First Federal Bank |
| $150,000–350,000 | SOUTHPOINT COMMUNITY CHURCH | JACKSONVILLE, FL | Valley National Bank |
| $350,000–1 million | SOUTHPOINT SURGERY CENTER, L.L.C. | JACKSONVILLE, FL | Truist Bank |
| $350,000–1 million | SOUTHSIDE CLEANERS, INC. | JACKSONVILLE, FL | Cogent Bank |
| $350,000–1 million | SOUTHSIDE MELLOW JAX | JACKSONVILLE, FL | Synovus Bank |
| $150,000–350,000 | SOUTHSIDE UNITED METHODIST CHURCH | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SPANISH WELLS INVESTMENTS, INC. | JACKSONVILLE, FL | First Source Federal Credit Union |
| $350,000–1 million | SPECK PUMPS-POOL PRODUCTS, INC. | JACKSONVILLE, FL | TD Bank, National Association |
| $350,000–1 million | SPECTRUM INSTALLATIONS, INC. | JACKSONVILLE, FL | Truist Bank |
| $150,000–350,000 | SPHERE SOLUTIONS, INC. | JACKSONVILLE, FL | Fifth Third Bank |
| $150,000–350,000 | SPOHRER & DODD, P.L. | JACKSONVILLE, FL | Synovus Bank |
| $150,000–350,000 | SPORTS EDGE ATHLETICS, LLC | JACKSONVILLE, FL | First Source Federal Credit Union |
| $350,000–1 million | SSL NOC MANAGEMENT LLC | JACKSONVILLE, FL | United Community Bank |
| $150,000–350,000 | SSL PV MANAGEMENT LLC | JACKSONVILLE, FL | United Community Bank |
| $350,000–1 million | SSL SJ MANAGEMENT LLC | JACKSONVILLE, FL | United Community Bank |
| $150,000–350,000 | SSL TAL MANAGEMENT LLC | JACKSONVILLE, FL | United Community Bank |
| $350,000–1 million | ST DENIS & DAVEY PA | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | ST JOHNS BAR PILOTS | JACKSONVILLE, FL | Hancock Whitney Bank |
| $350,000–1 million | ST JOHNS CLASSICAL ACADEMY INC | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | ST JOHNS VEIN CENTER, INC | JACKSONVILLE, FL | Truist Bank |
| $150,000–350,000 | ST LUKE'S EMERGENCY CARE GROUP, LLC | JACKSONVILLE, FL | First Source Federal Credit Union |
| $350,000–1 million | ST MARTINS CHEMICAL INC | JACKSONVILLE, FL | Truist Bank |
| $150,000–350,000 | ST MARYS ENTERPRISES INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | ST MATTHEWS CATHOLIC CHURCH AND SCHOOL | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | ST VINCENTS PATHOLOGY ASSOC PA | JACKSONVILLE, FL | TD Bank, National Association |
| $350,000–1 million | ST. JOHN & PARTNERS ADVERTISING AND PUBLIC RELATIONS, INC. | JACKSONVILLE, FL | Valley National Bank |