| $350,000–1 million | 1ST CLASS PIZZA INC | PORT SAINT LUCIE, FL | TD Bank, National Association |
| $350,000–1 million | A & G CONCRETE POOLS INC | PORT SAINT LUCIE, FL | SouthState Bank, National Association |
| $150,000–350,000 | A GREAT FENCE LLC | PORT SAINT LUCIE, FL | Truist Bank |
| $350,000–1 million | AARON SCHAMBACK, D.M.D., P.A. | PORT SAINT LUCIE, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | AERO ENGINE SOLUTIONS INC | PORT SAINT LUCIE, FL | Synovus Bank |
| $350,000–1 million | AMETHYST RECOVERY CENTER, LLC | PORT SAINT LUCIE, FL | First Horizon Bank |
| $350,000–1 million | AQUA DIMENSIONS PLUMBING SERVICES, INC. | PORT SAINT LUCIE, FL | Seacoast National Bank |
| $150,000–350,000 | ATLANTIC COLLISION INC | PORT SAINT LUCIE, FL | BankUnited, National Association |
| $150,000–350,000 | BBL EQUINOX AT TRADITION, LLC | PORT SAINT LUCIE, FL | Chemung Canal Trust Company |
| $150,000–350,000 | BEACHES MRI OF PSL, LLC | PORT SAINT LUCIE, FL | Seacoast National Bank |
| $150,000–350,000 | BLEDSOE ENTERPRISES, LLC | PORT SAINT LUCIE, FL | Flagler Bank |
| $150,000–350,000 | CALVARY PORT ST. LUCIE, INC. | PORT SAINT LUCIE, FL | SouthState Bank, National Association |
| $350,000–1 million | CGI ST. LUCIE, LLC | PORT SAINT LUCIE, FL | TD Bank, National Association |
| $350,000–1 million | COASTAL ORTHOPAEDICS & SPORTS MEDICINE CENTER, INC. | PORT SAINT LUCIE, FL | Seacoast National Bank |
| $150,000–350,000 | COLLISION PROFESSIONALS ONC | PORT SAINT LUCIE, FL | Wells Fargo Bank, National Association |
| $1–2 million | COMMUNITIES CONNECTED FOR KIDS, INC. | PORT SAINT LUCIE, FL | KeyBank National Association |
| $150,000–350,000 | CUSTOM AIR SYSTEMS, INC. | PORT SAINT LUCIE, FL | Seacoast National Bank |
| $150,000–350,000 | D & D GARAGE DOORS OF PORT ST. LUCIE. INC. | PORT SAINT LUCIE, FL | SouthState Bank, National Association |
| $150,000–350,000 | DN ESCAPE NAILS AND SPA INC | PORT SAINT LUCIE, FL | Wells Fargo Bank, National Association |
| $350,000–1 million | E Z LOADER ADJUSTABLE BOAT TRAILER SALES CORP | PORT SAINT LUCIE, FL | First Interstate Bank |
| $150,000–350,000 | EMERGENCY MEDICAL CONSULTANTS INC | PORT SAINT LUCIE, FL | TD Bank, National Association |
| $150,000–350,000 | ENGINEERING DESIGN & CONSTRUCTION, INC. | PORT SAINT LUCIE, FL | BankUnited, National Association |
| $150,000–350,000 | ESS MANUFACTURING INC | PORT SAINT LUCIE, FL | Marine Bank & Trust Company |
| $350,000–1 million | FIRST CHOICE LOADING, INC. | PORT SAINT LUCIE, FL | Seacoast National Bank |
| $150,000–350,000 | FLORIDA METROLOGY, LLC | PORT SAINT LUCIE, FL | U.S. Bank, National Association |
| $150,000–350,000 | FOUNDATIONS WELLNESS CENTER, LLC | PORT SAINT LUCIE, FL | Truist Bank |
| $150,000–350,000 | FUSION SALON & SPA, LLC | PORT SAINT LUCIE, FL | Synovus Bank |
| $150,000–350,000 | G&S FAMILY HOSPITALITY SERVICES, INC | PORT SAINT LUCIE, FL | TD Bank, National Association |
| $350,000–1 million | GERELCO ELECTRICAL CONTRACTORS, INC | PORT SAINT LUCIE, FL | Truist Bank |
| $1–2 million | GERELCO TRAFFIC CONTROLS, INC | PORT SAINT LUCIE, FL | Truist Bank |
| $150,000–350,000 | GERELCOM, INC. | PORT SAINT LUCIE, FL | Truist Bank |
| $150,000–350,000 | GROZA BUILDERS, INC | PORT SAINT LUCIE, FL | SouthState Bank, National Association |
| $150,000–350,000 | H.O.A. PROPERTY MGMT INC | PORT SAINT LUCIE, FL | Kabbage, Inc. |
| $150,000–350,000 | HEALTHY HEART CENTER INC | PORT SAINT LUCIE, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | HIEPSL PS LP | PORT SAINT LUCIE, FL | First Foundation Bank |
| $150,000–350,000 | HOKKAIDO HIBACHI & SUSHI, LLC | PORT SAINT LUCIE, FL | LendingClub Bank, National Association |
| $150,000–350,000 | IDPRODUCTSOURCE LLC | PORT SAINT LUCIE, FL | Bank of America, National Association |
| $150,000–350,000 | INTERNATIONAL PLAZA, LLC | PORT SAINT LUCIE, FL | SouthState Bank, National Association |
| $350,000–1 million | ITA USA ENTERPRISE LLC | PORT SAINT LUCIE, FL | Bank of America, National Association |
| $2–5 million | IVOX SOLUTIONS, LLC | PORT SAINT LUCIE, FL | First Citizens Bank |
| $350,000–1 million | LINDA F. DELO, D.O., P.A | PORT SAINT LUCIE, FL | SouthState Bank, National Association |
| $150,000–350,000 | MARC A VASSOR DBA | PORT SAINT LUCIE, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | MARK A BARBER, DDS, PA | PORT SAINT LUCIE, FL | TD Bank, National Association |
| $350,000–1 million | MARK J POWERS MD PA | PORT SAINT LUCIE, FL | Flagler Bank |
| $150,000–350,000 | MCK VERANDA FALLS LLC | PORT SAINT LUCIE, FL | City National Bank of Florida |
| $150,000–350,000 | MIHOM HEALTHCARE INC | PORT SAINT LUCIE, FL | Bank of America, National Association |
| $150,000–350,000 | MIRANDA PLUMBING & AIR CONDITIONING, INC. | PORT SAINT LUCIE, FL | SouthState Bank, National Association |
| $350,000–1 million | MISE HOLDINGS LLC | PORT SAINT LUCIE, FL | LendingClub Bank, National Association |
| $350,000–1 million | MORNINGSIDE EVANGELICAL FRIENDS CHURCH, INC. | PORT SAINT LUCIE, FL | Seacoast National Bank |
| $150,000–350,000 | MR. GET IT DONE, LLC | PORT SAINT LUCIE, FL | Bank of America, National Association |
| $150,000–350,000 | NV OF PSL LLC | PORT SAINT LUCIE, FL | BSD Capital, LLC dba Lendistry |
| $150,000–350,000 | OC GLASS INC | PORT SAINT LUCIE, FL | TD Bank, National Association |
| $150,000–350,000 | PARADISE CAR WASH LLC | PORT SAINT LUCIE, FL | iTHINK Financial CU |
| $150,000–350,000 | PEBBLE CONCEPTS INC | PORT SAINT LUCIE, FL | PNC Bank, National Association |
| $1–2 million | PORT ST. LUCIE MGT,LLC | PORT SAINT LUCIE, FL | The Park National Bank |
| $150,000–350,000 | POST INSURANCE AND FINANCIAL INC | PORT SAINT LUCIE, FL | PNC Bank, National Association |
| $350,000–1 million | PREMIER FABRICATORS LLC | PORT SAINT LUCIE, FL | Machias Savings Bank |
| $350,000–1 million | PREMIER PHYSICAL THERAPY AND SPORTS MEDICINE INC | PORT SAINT LUCIE, FL | Seacoast National Bank |
| $150,000–350,000 | PREMIER WELLNESS CENTERS LLC | PORT SAINT LUCIE, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | QUESTCOMM INC | PORT SAINT LUCIE, FL | Midflorida CU |
| $150,000–350,000 | RECOVERY SPORTS GRILL AT TRADITION, LLC | PORT SAINT LUCIE, FL | Chemung Canal Trust Company |
| $2–5 million | REMETRONIX | PORT SAINT LUCIE, FL | Truist Bank |
| $150,000–350,000 | RITEWAY LINEN SERVICES, LLC | PORT SAINT LUCIE, FL | Bank Five Nine |
| $150,000–350,000 | RJM GOURMET SANDWICHES INC | PORT SAINT LUCIE, FL | PNC Bank, National Association |
| $350,000–1 million | ROSS MIXING, INC. | PORT SAINT LUCIE, FL | Citibank, N.A. |
| $350,000–1 million | SAMPSON TREE SERVICE | PORT SAINT LUCIE, FL | SouthState Bank, National Association |
| $150,000–350,000 | SIGNATURE PROPERTY MANAGEMENT, INC. | PORT SAINT LUCIE, FL | BayFirst National Bank |
| $150,000–350,000 | SINFONIA FAMILY SERVICES OF FLORIDA, INC | PORT SAINT LUCIE, FL | Bank of America, National Association |
| $150,000–350,000 | SPARKLE M&M, LLC | PORT SAINT LUCIE, FL | TD Bank, National Association |
| $150,000–350,000 | ST. LUCIE DRAFT HOUSE & SPORTS BAR INC. | PORT SAINT LUCIE, FL | Seacoast National Bank |
| $350,000–1 million | STEINGER ISCOE & GREENE, PA | PORT SAINT LUCIE, FL | IberiaBank, A Division of First Horizon Bank |
| $150,000–350,000 | STRANIGAN, ASKELAND & HARRIS DMD'S PA | PORT SAINT LUCIE, FL | PNC Bank, National Association |
| $350,000–1 million | SUNLIGHT COMMUNITY CHURCH OF PORT ST. LUCIE, INC. | PORT SAINT LUCIE, FL | iTHINK Financial CU |
| $150,000–350,000 | SUNNY COMMUNICATIONS, INC. | PORT SAINT LUCIE, FL | Bank of America, National Association |
| $150,000–350,000 | SURGCENTER OF ST. LUCIE, LLC | PORT SAINT LUCIE, FL | Midland States Bank |
| $150,000–350,000 | SYNERGY ANCILLARY SERVICES LLC | PORT SAINT LUCIE, FL | LendingClub Bank, National Association |
| $150,000–350,000 | THE TOLEDO CLINIC LLC | PORT SAINT LUCIE, FL | PNC Bank, National Association |
| $150,000–350,000 | TRADITION SURGERY CENTER, LLC | PORT SAINT LUCIE, FL | SouthState Bank, National Association |
| $350,000–1 million | USR HOLDINGS LLC | PORT SAINT LUCIE, FL | First Horizon Bank |
| $150,000–350,000 | VACATION SUPERSTORE NETWORK, INC. | PORT SAINT LUCIE, FL | Seacoast National Bank |
| $150,000–350,000 | VALANT ASSOCIATES LLC | PORT SAINT LUCIE, FL | Stearns Bank National Association |
| $150,000–350,000 | VALUE HEALTH CONSULTANTS, INC | PORT SAINT LUCIE, FL | SouthState Bank, National Association |
| $150,000–350,000 | VELCON ENGINEERING AND SURVEYING, LLC | PORT SAINT LUCIE, FL | SouthState Bank, National Association |