| $150,000–350,000 | 2010, INC. | FREDERICK, MD | John Marshall Bank |
| $150,000–350,000 | 270NET TECHNOLOGIES INC. | FREDERICK, MD | Itria Ventures LLC |
| $150,000–350,000 | A. MAY'S, INC | FREDERICK, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | ABEL CONSULTING ENGINEERS, PA | FREDERICK, MD | Sandy Spring Bank |
| $1–2 million | ABICOR BINZEL USA, INC. | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | ABOVEAIR TECHNOLOGIES LLC | FREDERICK, MD | Truist Bank |
| $150,000–350,000 | ADAMS INSURANCE AGENCY, INC. | FREDERICK, MD | Westfield Bank, FSB |
| $2–5 million | ADVANCED BEHAVIORAL HEALTH, INC. | FREDERICK, MD | First United Bank & Trust |
| $350,000–1 million | ADVANCED PAIN MANAGEMENT LLC | FREDERICK, MD | PNC Bank, National Association |
| $150,000–350,000 | AFFIRNX, LLC | FREDERICK, MD | Bank of Charles Town |
| $350,000–1 million | AKONNI BIOSYSTEMS, INC | FREDERICK, MD | City National Bank |
| $150,000–350,000 | ALBAUGH AND SONS FENCING | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | ALDEA SERVICES LLC | FREDERICK, MD | Bank of America, National Association |
| $150,000–350,000 | ALVAREZ CONTRACTORS, INC. | FREDERICK, MD | WesBanco Bank, Inc. |
| $150,000–350,000 | AMBER HILL PHYSICAL THERAPY INC | FREDERICK, MD | ACNB Bank |
| $1–2 million | AMERICAN COMPUTER DEVELOPMENT INC | FREDERICK, MD | Truist Bank |
| $150,000–350,000 | AMUSEOMATIC INC. | FREDERICK, MD | Atlantic Union Bank |
| $150,000–350,000 | ANDOCHICK SURGICAL CENTER, LLC | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | APPLE BLOSSOM OPTICS | FREDERICK, MD | First Bank of the Lake |
| $350,000–1 million | ASBURY COMMUNITIES, INC. | FREDERICK, MD | Signal Financial FCU |
| $150,000–350,000 | AUSHERMAN DEVELOPMENT CORPORATION II, INC. | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | AUTOBODY DIMENSIONS OF FREDERICK | FREDERICK, MD | Bank of America, National Association |
| $150,000–350,000 | AVIATION INSURANCE RESOURCES, LLC | FREDERICK, MD | ACNB Bank |
| $2–5 million | AXIOM SYSTEMS, INC. | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | BAY BROTHERS CO | FREDERICK, MD | Truist Bank |
| $150,000–350,000 | BBL, INC. | FREDERICK, MD | United Bank |
| $350,000–1 million | BDR EXPRESS, INC. | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | BELLEZA HAIR & NAIL STUDIO, LLC | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | BEST HEATING & AIR CONDITIONING COMPANY | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | BIO FACTURA INC | FREDERICK, MD | Forbright Bank |
| $150,000–350,000 | BLUE HORIZONS INC | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | BRETT WEEDON DDS PA | FREDERICK, MD | Bank of America, National Association |
| $150,000–350,000 | BRETT WEEDON DDS PA | FREDERICK, MD | Bank of America, National Association |
| $1–2 million | BRIGHT EYES, INC. | FREDERICK, MD | Fulton Bank, National Association |
| $150,000–350,000 | BRUCHEY BUILDERS INC | FREDERICK, MD | Bank of Charles Town |
| $350,000–1 million | BUESO & FORMAN INC. | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | BUILDING EVALUATION SERVICES & TECHNOLOGY, INC | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | BUSINESS MANAGEMENT COMPANY, INC. | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | BYRD DENTAL HEALTH CENTER LLC | FREDERICK, MD | Middletown Valley Bank |
| $150,000–350,000 | CAFE NOLA | FREDERICK, MD | Intuit Financing Inc. |
| $150,000–350,000 | CAPITOL GOLF CARS & UTILITY VEHICLES, LLC | FREDERICK, MD | MVB Bank, Inc. |
| $150,000–350,000 | CARDIOLOGY CENTER LLP | FREDERICK, MD | Truist Bank |
| $350,000–1 million | CARDIOVASCULAR SPECIALISTS OF FREDERICK, LLC | FREDERICK, MD | Sandy Spring Bank |
| $5–10 million | CAREY INTERNATIONAL, INC. | FREDERICK, MD | Simmons Bank |
| $150,000–350,000 | CENTRAL MARYLAND EYE ASSOCIATES PC | FREDERICK, MD | PNC Bank, National Association |
| $150,000–350,000 | CERESVILLE ASSOCIATES, INC | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | CHESAPEAKE MERCHANDISING INC | FREDERICK, MD | Truist Bank |
| $150,000–350,000 | CHILI PEPPERS COLLECTIBLES, LLC | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | CHS TRAFFIC CONTROL SERVICES INC | FREDERICK, MD | ACNB Bank |
| $350,000–1 million | CIRCUIT ELECTRIC INC. | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | CLAGETT ENTERPRISES, INC. | FREDERICK, MD | Western Alliance Bank |
| $150,000–350,000 | CLASSIC FORMS AND SYSTEMS, INC. | FREDERICK, MD | Sandy Spring Bank |
| $350,000–1 million | CLEARVIEW COMMUNITIES LLC | FREDERICK, MD | Legacy Bank |
| $350,000–1 million | CLOSUP I INC | FREDERICK, MD | PNC Bank, National Association |
| $150,000–350,000 | COGAN INSURANCE ADVISORS, INC. | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | COLLIVER DENTAL GROUP, PA | FREDERICK, MD | Affinity Bank, National Association |
| $350,000–1 million | COLONIAL SASH & DOOR, INC. | FREDERICK, MD | ACNB Bank |
| $350,000–1 million | COMMERCIAL ENERGY SYSTEMS INC | FREDERICK, MD | PNC Bank, National Association |
| $150,000–350,000 | COMPLETE CARE SOLUTIONS LLC | FREDERICK, MD | Wells Fargo Bank, National Association |
| $350,000–1 million | COMPLETE MECHANICAL AND ELECTRICAL SOLUT | FREDERICK, MD | Bank of America, National Association |
| $350,000–1 million | COMPREHENSIVE NEUROLOGY SERVICES P.A. | FREDERICK, MD | Capital One, National Association |
| $350,000–1 million | CONGRESSIONAL IRON WORKS, INC. | FREDERICK, MD | Capital Bank, National Association |
| $350,000–1 million | CONNELLY & ASSOCIATES, INC. | FREDERICK, MD | Sandy Spring Bank |
| $1–2 million | CONSTRUCTION TRADES SERVICES INC | FREDERICK, MD | Truist Bank |
| $350,000–1 million | COOPER BUILDING SERVICES, LLC | FREDERICK, MD | EagleBank |
| $150,000–350,000 | CORE PARTNERS INC | FREDERICK, MD | PNC Bank, National Association |
| $150,000–350,000 | COVENANT TITLE & ESCROW LLC | FREDERICK, MD | Capital Bank, National Association |
| $350,000–1 million | CREATIVE LANDSCAPES BY GREGORY INC | FREDERICK, MD | Bank of America, National Association |
| $350,000–1 million | CUSTOM GLASS SERVICES, INC. | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | CUTTING EDGE BUILDERS IN | FREDERICK, MD | Intuit Financing Inc. |
| $350,000–1 million | D & D DRILLING, INC. | FREDERICK, MD | ACNB Bank |
| $1–2 million | DARCARS OF FREDERICK INC | FREDERICK, MD | Truist Bank |
| $1–2 million | DATA MANAGEMENT SERVICES, INC. | FREDERICK, MD | MVB Bank, Inc. |
| $150,000–350,000 | DAYBREAK ADULT DAY SERVICES INC | FREDERICK, MD | Fulton Bank, National Association |
| $350,000–1 million | DECORATIVE FILMS LLC | FREDERICK, MD | Truist Bank |
| $1–2 million | DIW GROUP INC | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | DNA LAB, LLC | FREDERICK, MD | ACNB Bank |
| $2–5 million | DONALD B RICE TIRE CO, INC | FREDERICK, MD | Manufacturers and Traders Trust Company |
| $150,000–350,000 | DONELSON AND CARNELL MD PA | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | DR EJ STRINGER DMD PA | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | DRS. REID, AHMADIAN & THOMPSON | FREDERICK, MD | City National Bank of Florida |
| $350,000–1 million | DUTCH'S DAUGHTER, INC | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | DYNAMIC RUGS INC | FREDERICK, MD | Truist Bank |
| $350,000–1 million | EN NET SERVICES LLC | FREDERICK, MD | PNC Bank, National Association |
| $150,000–350,000 | ENCORE PROVISIONS | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | ENFORME INTERACTIVE INC | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | ERCOLE ELECTRIC INC | FREDERICK, MD | Sandy Spring Bank |
| $350,000–1 million | ESSENTIAL SYSTEMS SOLUTIONS LLC | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | EVANGELICAL LUTHERAN CHURCH OF FREDERICK COUNTY, INC. | FREDERICK, MD | ACNB Bank |
| $350,000–1 million | F. B. HARDING INC. | FREDERICK, MD | Truist Bank |
| $150,000–350,000 | FARAGALLA & ASSOCIATES, LLC | FREDERICK, MD | Manufacturers and Traders Trust Company |
| $2–5 million | FITZGERALD AUTO MALL, INC | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | FLYING DOG BREWERY LLC | FREDERICK, MD | Sandy Spring Bank |
| $1–2 million | FOODPRO CORPORATION | FREDERICK, MD | Truist Bank |
| $1–2 million | FOUNTAIN ROCK MANAGEMENT CORPORTAION | FREDERICK, MD | Truist Bank |
| $150,000–350,000 | FOUT CRANE AND RIGGING LLC | FREDERICK, MD | ACNB Bank |
| $350,000–1 million | FREDERICK DELIGHTS, INC. | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | FREDERICK ENDOSCOPY CENTER, LLC | FREDERICK, MD | Sandy Spring Bank |
| $350,000–1 million | FREDERICK FENCE COMPANY INC | FREDERICK, MD | Truist Bank |
| $350,000–1 million | FREDERICK FOOT AND ANKLE SPECIALISTS, P.C. | FREDERICK, MD | ACNB Bank |