| $150,000–350,000 | PRECISION AUTOMATION, LLC | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | PREMIER COMMERCIAL FLOORING | FREDERICK, MD | Truist Bank |
| $150,000–350,000 | PRINCIPLED CONTRACTING LLC | FREDERICK, MD | PNC Bank, National Association |
| $150,000–350,000 | PROGRESSIVE ONCOLOGY AND HEMATOLOGY CENTER LLC | FREDERICK, MD | Middletown Valley Bank |
| $350,000–1 million | PROLIST, INC | FREDERICK, MD | Sandy Spring Bank |
| $350,000–1 million | PROPERTYROOM.COM | FREDERICK, MD | Truist Bank |
| $150,000–350,000 | PROTEC GLASS, LLC | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | PVI BUSINESS PRODUCTS, INC. | FREDERICK, MD | United Bank |
| $150,000–350,000 | R G ALLEN ASSOCIATES INC. | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | R P M CONSTRUCTION CORP | FREDERICK, MD | PNC Bank, National Association |
| $2–5 million | R W WARNER INC | FREDERICK, MD | Sandy Spring Bank |
| $350,000–1 million | R. CHRISTOPHER GOODWIN & ASSOCIATES, INC | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | RADIOMETRIC SERVICES AND INSTRUMENTS LLC | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | RAMAR MOVING SYSTEMS INC. | FREDERICK, MD | Middletown Valley Bank |
| $150,000–350,000 | RED ENT INC | FREDERICK, MD | Burke and Herbert Bank and Trust Company |
| $350,000–1 million | REGENT EDUCATION, INC. | FREDERICK, MD | Banc of California |
| $1–2 million | RELIABLE INSTALLATION SERVICES LLC | FREDERICK, MD | PNC Bank, National Association |
| $150,000–350,000 | RENN KIRBY AUTOMOTIVE LLC | FREDERICK, MD | S & T Bank |
| $150,000–350,000 | REV DRILL SALES & RENTALS, INC. | FREDERICK, MD | ACNB Bank |
| $350,000–1 million | ROBERT W SHECKLES INC | FREDERICK, MD | ACNB Bank |
| $1–2 million | ROOSTERBIO, INC | FREDERICK, MD | Manufacturers and Traders Trust Company |
| $350,000–1 million | RYAN & WETMORE PC | FREDERICK, MD | Truist Bank |
| $150,000–350,000 | RYAN ELECTRIC LLC | FREDERICK, MD | ACNB Bank |
| $350,000–1 million | SABA DIRECT, LLC | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | SAINT JOHNS CATHOLIC CHURCH | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | SALEM HOSPITALITY LLC | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | SEISMIC SURVEYS INC | FREDERICK, MD | Sandy Spring Bank |
| $5–10 million | SERVICE COORDINATION, INC | FREDERICK, MD | ACNB Bank |
| $350,000–1 million | SERVICE GLASS INDUSTRIES, INC | FREDERICK, MD | ACNB Bank |
| $350,000–1 million | SHAFER, TROXELL & HOWE, INC. | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | SHEPHERDS STAFF IN HOME CARE | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | SHERMAN KAHAN MD PA | FREDERICK, MD | PNC Bank, National Association |
| $1–2 million | SHOCKLEY, INC. | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | SHOWCALL, INC. | FREDERICK, MD | First Bank of the Lake |
| $150,000–350,000 | SHOWTIME SOUND, LLC | FREDERICK, MD | Bank of America, National Association |
| $150,000–350,000 | SKATE FREDERICK LLC | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | SMI SIGN SYSTEMS, INC. | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | SMILE FREDERICK LLC | FREDERICK, MD | Fund-Ex Solutions Group, LLC |
| $150,000–350,000 | SOUTH SIDE TIRE AND AUTO INC | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | SOUTHERN STATES FREDERICK COOPERATIVE INC | FREDERICK, MD | Bank of Charles Town |
| $150,000–350,000 | SPECTRUM ENVIRONMENTAL SCIENCES, INC | FREDERICK, MD | ACNB Bank |
| $350,000–1 million | STADLER GARDEN CENTERS, INC. | FREDERICK, MD | Sandy Spring Bank |
| $350,000–1 million | STAUFFER FUNERAL HOMES, P.A. | FREDERICK, MD | ACNB Bank |
| $350,000–1 million | STEP3 INC | FREDERICK, MD | Truist Bank |
| $150,000–350,000 | SULMA CORPORATION | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | SUMMIT ANCHOR COMPANY, INC. | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | SUMMIT AUTO PARTS AND SERVICE, INC. | FREDERICK, MD | First National Bank of Pennsylvania |
| $350,000–1 million | SUMMIT CONSTRUCTION INC | FREDERICK, MD | Truist Bank |
| $150,000–350,000 | SUNSHINE MANAGEMENT CORPORATION | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | SUPERIOR AUTO SERVICE INC | FREDERICK, MD | PNC Bank, National Association |
| $150,000–350,000 | TELEGIA COMMUNICATIONS INC | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | TEXCELL-NORTH AMERICA, INC. | FREDERICK, MD | United Bank |
| $350,000–1 million | THE ASBURY GROUP INTEGRATED TECHNOLOGIES, LLC | FREDERICK, MD | City National Bank of Florida |
| $150,000–350,000 | THE COMMUNITY FOUNDATION OF FREDERICK COUNTY MARYLAND, INC. | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | THE FREDERICK SPORT AND SPINE | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | THE MONKEY LA LA, INC. | FREDERICK, MD | First Bank of the Lake |
| $1–2 million | THE PEDIATRIC CENTER OF FREDERICK | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | THE RANCH, INC. | FREDERICK, MD | ACNB Bank |
| $350,000–1 million | THE RISER ACADEMIES INC | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | THE STURGES FAMILY LLC | FREDERICK, MD | ACNB Bank |
| $350,000–1 million | TIRE WORLD WHOESALE, LLC | FREDERICK, MD | Atlantic Union Bank |
| $1–2 million | TISSA ENTERPRISE INC | FREDERICK, MD | Truist Bank |
| $1–2 million | TNT SERVICES GROUP, INC. | FREDERICK, MD | Sandy Spring Bank |
| $350,000–1 million | TOPPER CONSTRUCTION COMPANY INC | FREDERICK, MD | Truist Bank |
| $350,000–1 million | TRI-STATE HOME SERVICES LLC | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | TRIANGLE MOTORS INC | FREDERICK, MD | Manufacturers and Traders Trust Company |
| $350,000–1 million | TUCKERS AIR CONDITIONING & HEATING | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | TURNING POINT BENEFIT GROUP, INC. | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | UNCLE RALPH'S COOKIE COMPANY | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | US EVENT STRUCTURES, LLC | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | VINNY'S TOWING & RECOVERY, LLC | FREDERICK, MD | Middletown Valley Bank |
| $350,000–1 million | VINTAGE CLEANING CORP. INC | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | WARNER AND VANMETER MD PA | FREDERICK, MD | PNC Bank, National Association |
| $1–2 million | WESTERN SERVICES CORPORATION | FREDERICK, MD | Truist Bank |
| $350,000–1 million | WGS SYSTEMS, LLC | FREDERICK, MD | Truist Bank |
| $150,000–350,000 | WILLARD ADMINISTRATIVE SERVICES INC | FREDERICK, MD | PNC Bank, National Association |
| $150,000–350,000 | WILLARD AGRI SERVICE INC | FREDERICK, MD | PNC Bank, National Association |
| $150,000–350,000 | WILLARD AGRI SERVICE MT AIRY | FREDERICK, MD | PNC Bank, National Association |
| $150,000–350,000 | WILLARD AGRI SERVICE OF GREENWOOD LLC | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | WILLARD AGRI SERVICE OF LYNCH INC | FREDERICK, MD | PNC Bank, National Association |
| $150,000–350,000 | WILLIAM H. JOHNSON, MD, P.A. | FREDERICK, MD | ACNB Bank |
| $150,000–350,000 | WINE KITCHEN II, LLC | FREDERICK, MD | United Bank |
| $2–5 million | WLR PARENT COMPANY, INC. | FREDERICK, MD | First United Bank & Trust |
| $350,000–1 million | WONDER BOOK & VIDEO INC | FREDERICK, MD | PNC Bank, National Association |
| $350,000–1 million | WORD AMONG US INC, THE | FREDERICK, MD | Bank of America, National Association |
| $1–2 million | WORMALD CORPORATION | FREDERICK, MD | Sandy Spring Bank |
| $150,000–350,000 | WYANT HEATING & AIR INC | FREDERICK, MD | Truist Bank |
| $350,000–1 million | WYCLIFFE ENTERPRISES, INC. | FREDERICK, MD | Truist Bank |
| $150,000–350,000 | XECUNET, LLC. | FREDERICK, MD | Sandy Spring Bank |
| $350,000–1 million | YAKABOD FEDERAL SOLUTIONS INC | FREDERICK, MD | Bank of Charles Town |
| $150,000–350,000 | YELLOW SPRINGS VETERINARY CLINIC INC | FREDERICK, MD | PNC Bank, National Association |