| $150,000–350,000 | APPLIANCE PARTS SPECIALISTS, INC | POPLAR BLUFF, MO | Southern Bank |
| $350,000–1 million | BALDWIN CHEVROLET CADILLAC INC | POPLAR BLUFF, MO | Southern Bank |
| $350,000–1 million | BALDWIN FORD LINCOLN TOYOTA | POPLAR BLUFF, MO | Southern Bank |
| $150,000–350,000 | BOYCOM CABLEVISION, INC. | POPLAR BLUFF, MO | The Bank of Missouri |
| $350,000–1 million | BUFFINGTON BROS HEATING AND COOLING | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $350,000–1 million | BUTLER COUNTY EMS, LLC | POPLAR BLUFF, MO | Southern Bank |
| $150,000–350,000 | BUTLER COUNTY IN-HOME SERVICES, LLC | POPLAR BLUFF, MO | Peoples Community Bank |
| $150,000–350,000 | BUTLER COUNTY PUBLISHING, LLC | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $350,000–1 million | CEDARGATE HEALTHCARE GROUP, LLC | POPLAR BLUFF, MO | Pinnacle Bank |
| $350,000–1 million | COFFMAN AND COMPANY PC | POPLAR BLUFF, MO | Southern Bank |
| $150,000–350,000 | DAVIS HEATING, AIR CONDITIONING & REFRIGERATION, LLC | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $350,000–1 million | DENTAL ARTS GROUP, LLC | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $150,000–350,000 | DILLE TRAXEL LLC | POPLAR BLUFF, MO | Sterling Bank |
| $150,000–350,000 | FIRST BAPTIST CHURCH | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $150,000–350,000 | GAMBLIN LUMBER COMPANY, INC. | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $150,000–350,000 | GENERAL BAPTIST COUNCIL OF ASSOCIATIONS, INC. | POPLAR BLUFF, MO | Southern Bank |
| $350,000–1 million | GREGORY LOGISTICS INC. | POPLAR BLUFF, MO | Southern Bank |
| $150,000–350,000 | GRIFFIN MOTOR SPORTS | POPLAR BLUFF, MO | Southern Bank |
| $350,000–1 million | H. BLACKWELL OLDSMOBILE-CAD.,I | POPLAR BLUFF, MO | Southern Bank |
| $350,000–1 million | HAND CUT STEAKS OF POPLAR BLUFF, INC. | POPLAR BLUFF, MO | Southern Bank |
| $150,000–350,000 | HARWELL HOLDINGS, LLC. | POPLAR BLUFF, MO | Southern Bank |
| $350,000–1 million | HEALTH PARTNERS MANAGEMENT GROUP INC. | POPLAR BLUFF, MO | Access Bank |
| $150,000–350,000 | HEARTLAND GROUP INSURANCE AGENCY, INC. | POPLAR BLUFF, MO | Southern Bank |
| $350,000–1 million | HEFNER FURNITURE & APPLIANCE INC | POPLAR BLUFF, MO | Lamar Bank and Trust Company |
| $350,000–1 million | HILLIS AUTO SALES INC | POPLAR BLUFF, MO | First Missouri State Bank |
| $350,000–1 million | HOME CARE EQUIPMENT CO, INC. | POPLAR BLUFF, MO | Southern Bank |
| $350,000–1 million | HUFFMAN CONSTRUCTION, LLC | POPLAR BLUFF, MO | Montgomery Bank |
| $150,000–350,000 | HYDRO ADVENTURES, LLC | POPLAR BLUFF, MO | Centennial Bank |
| $350,000–1 million | INDEPENDENT LIVING CENTER OF SEMO | POPLAR BLUFF, MO | Commerce Bank |
| $150,000–350,000 | INTERNAL MEDICINE ASSOCIATES OF SOUTHEAST MISSOURI, LLC | POPLAR BLUFF, MO | Southern Bank |
| $150,000–350,000 | JOE'S BRIDGE & GRADING, INC. | POPLAR BLUFF, MO | Sterling Bank |
| $350,000–1 million | KAJACS CONTRACTORS, INC | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $150,000–350,000 | KRAFT, MILES, AND TATUM, LLC | POPLAR BLUFF, MO | First Missouri State Bank |
| $350,000–1 million | LAS MARGARITAS INC | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $150,000–350,000 | LEGACY FASTENERS, LLC | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $150,000–350,000 | LITTLE, SCHELHAMMER, RICHARDSON, & KNOWLAN LAW OFFICES PC | POPLAR BLUFF, MO | First Missouri State Bank |
| $1–2 million | M&A ELECTRIC POWER COOPERATIVE | POPLAR BLUFF, MO | Commerce Bank |
| $150,000–350,000 | MAVERICK GLASS INC | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $350,000–1 million | MCLANE LIVESTOCK TRANSPORT | POPLAR BLUFF, MO | Southern Bank |
| $150,000–350,000 | MIDWEST OB/GYN OF MISSOURI, LLC | POPLAR BLUFF, MO | Sterling Bank |
| $150,000–350,000 | MK SEAL TRUCKING, LLC | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $150,000–350,000 | MOZARK REAL ESTATE, LLC | POPLAR BLUFF, MO | Southern Bank |
| $150,000–350,000 | N AND R OF POPLAR BLUFF, INC | POPLAR BLUFF, MO | Southern Bank |
| $1–2 million | OZARK BORDER ELECTRIC COOPERATIVE | POPLAR BLUFF, MO | Southern Bank |
| $350,000–1 million | OZARK PHYSICAL MEDICINE CENTER FOR OPERATIONS, LLC | POPLAR BLUFF, MO | The Bank of Missouri |
| $150,000–350,000 | PACK BUILDING MATERIALS & CARPET, INC | POPLAR BLUFF, MO | Focus Bank |
| $350,000–1 million | PALLADIAN SENIOR CARE OF POPLAR BLUFF LLC | POPLAR BLUFF, MO | BOKF, National Association |
| $150,000–350,000 | PMB, INC. | POPLAR BLUFF, MO | First Missouri State Bank |
| $150,000–350,000 | POPLAR BLUFF REALTY, INC | POPLAR BLUFF, MO | Southern Bank |
| $350,000–1 million | R.L. PERSONS CONSTRUCTION INC. | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $150,000–350,000 | RIDGE MAUD DRUG CORPORATION | POPLAR BLUFF, MO | First Missouri State Bank |
| $350,000–1 million | ROBERTSON CONTRACTORS, INC. | POPLAR BLUFF, MO | First Missouri State Bank |
| $150,000–350,000 | ROBERTSON INC BRIDGE & GRADING DIVISION | POPLAR BLUFF, MO | First Missouri State Bank |
| $150,000–350,000 | S & S OF BLUFF | POPLAR BLUFF, MO | Southern Bank |
| $350,000–1 million | S. H. SMITH & COMPANY INC. | POPLAR BLUFF, MO | Southern Bank |
| $350,000–1 million | SCHALLER HARDWOOD LUMBER COMPANY | POPLAR BLUFF, MO | Southern Bank |
| $150,000–350,000 | SOUTHERN CARE AND COMFORT IN HOME AGENCY | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $350,000–1 million | STARTING USA CORPORATION | POPLAR BLUFF, MO | U.S. Bank, National Association |
| $350,000–1 million | THE DERMALOLOGY OFFICE, INC. | POPLAR BLUFF, MO | Southern Bank |
| $2–5 million | THREE RIVERS COLLEGE | POPLAR BLUFF, MO | Southern Bank |
| $150,000–350,000 | TURN-KEY CONTRACTORS LLC | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $150,000–350,000 | WESTWOOD BAPTIST CHURCH, INC | POPLAR BLUFF, MO | First Missouri State Bank |
| $150,000–350,000 | WILSON'S SUBS INC. | POPLAR BLUFF, MO | First Missouri State Bank |
| $150,000–350,000 | WORLEYS SERVICES INC. | POPLAR BLUFF, MO | First Midwest Bank of the Ozarks |
| $150,000–350,000 | XIN INC | POPLAR BLUFF, MO | Southern Bank |