| $150,000–350,000 | 3 AMIGOS ELIZABETH CITY II INC | ELIZABETH CITY, NC | Truist Bank |
| $150,000–350,000 | ALBEMARLE EDUCATIONAL FOUNDATION, INC. | ELIZABETH CITY, NC | First Bank |
| $350,000–1 million | ALBEMARLE EYE CENTER PLLC | ELIZABETH CITY, NC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | AMBROSE FURNITURE, INC. | ELIZABETH CITY, NC | Truist Bank |
| $350,000–1 million | ATLANTIC TAX GROUP, INC | ELIZABETH CITY, NC | Truist Bank |
| $350,000–1 million | B&M CONTRACTORS INC. | ELIZABETH CITY, NC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | BERGMAN ENTERPRISES, INC. DBA MOTION SENSORS, INC. | ELIZABETH CITY, NC | Southern Bank and Trust Company |
| $350,000–1 million | BIGGS CADILLAC, BUICK, GMC TRUCKS, INC | ELIZABETH CITY, NC | First-Citizens Bank & Trust Company |
| $350,000–1 million | CITY BEVERAGE CO., INC. | ELIZABETH CITY, NC | Atlantic Union Bank |
| $150,000–350,000 | COASTAL CAROLINA PROSTHOTICS | ELIZABETH CITY, NC | United Bank |
| $350,000–1 million | COASTAL REHABILITATION, INC | ELIZABETH CITY, NC | First-Citizens Bank & Trust Company |
| $350,000–1 million | EASTERN CAROLINA CARDIOVASCULAR, PA | ELIZABETH CITY, NC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | FIVE ''C'S', INC. | ELIZABETH CITY, NC | Southern Bank and Trust Company |
| $150,000–350,000 | FOOD BANK OF THE ALBEMARLE | ELIZABETH CITY, NC | First Bank |
| $150,000–350,000 | FROG ISLAND SEAFOOD INC | ELIZABETH CITY, NC | Atlantic Union Bank |
| $150,000–350,000 | G-MAX INC. | ELIZABETH CITY, NC | First Bank |
| $350,000–1 million | G. R. LITTLE AGENCY, INC. | ELIZABETH CITY, NC | Southern Bank and Trust Company |
| $350,000–1 million | HOFFER FLOW CONTROLS, INC. | ELIZABETH CITY, NC | Wells Fargo Bank, National Association |
| $350,000–1 million | HORNTHAL, RILEY, ELLIS & MALAND, L.L.P. | ELIZABETH CITY, NC | Southern Bank and Trust Company |
| $350,000–1 million | INTERSTATE RECOVERY SERVICE N.C., INC. | ELIZABETH CITY, NC | Southern Bank and Trust Company |
| $150,000–350,000 | JENNETTE BROTHERS, INC | ELIZABETH CITY, NC | TowneBank |
| $1–2 million | JW JONES LUMBER COMPANY, INC. | ELIZABETH CITY, NC | Truist Bank |
| $150,000–350,000 | KALEB C. THOMPSON, DMD, PA | ELIZABETH CITY, NC | Southern Bank and Trust Company |
| $350,000–1 million | MID-ATLANTIC CHRISTIAN UNIVERSITY, INC | ELIZABETH CITY, NC | Southern Bank and Trust Company |
| $350,000–1 million | MONEYSWORTH LINEN SERVICES, INC. | ELIZABETH CITY, NC | TowneBank |
| $150,000–350,000 | MONTERO'S INC | ELIZABETH CITY, NC | Truist Bank |
| $350,000–1 million | NISSAN OF ELIZABETH CITY LLC | ELIZABETH CITY, NC | BMO Bank National Association |
| $350,000–1 million | NORTHEAST ACADEMY FOR AEROSPACE & ADVANCED TECHNOLOGIES | ELIZABETH CITY, NC | TowneBank |
| $150,000–350,000 | NORTHEASTERN VETERINARY ASSOCIATES, PA | ELIZABETH CITY, NC | Atlantic Union Bank |
| $350,000–1 million | PERRY MOTORS, INC. | ELIZABETH CITY, NC | TowneBank |
| $150,000–350,000 | QUALITY FOODS FROM THE SEA, INC. | ELIZABETH CITY, NC | Southern Bank and Trust Company |
| $350,000–1 million | QUALITY SEAFOOD CO INC | ELIZABETH CITY, NC | Truist Bank |
| $150,000–350,000 | RICHARD'S ROFRIGERATION INC | ELIZABETH CITY, NC | United Bank |
| $150,000–350,000 | SCOTT C BLANCHARD DDS, PA | ELIZABETH CITY, NC | Southern Bank and Trust Company |
| $150,000–350,000 | SKILLS INC | ELIZABETH CITY, NC | PNC Bank, National Association |
| $150,000–350,000 | STEVENSON SAND, INC | ELIZABETH CITY, NC | Southern Bank and Trust Company |
| $150,000–350,000 | SUNSHINE CONTRACTING AND CONSTRUCTION L | ELIZABETH CITY, NC | First-Citizens Bank & Trust Company |
| $1–2 million | TANDEM INCORPORATED | ELIZABETH CITY, NC | Truist Bank |
| $150,000–350,000 | THE BENJAMIN HOUSE, INC. | ELIZABETH CITY, NC | TowneBank |
| $150,000–350,000 | THE BROOKS SENIOR LIVING LLC | ELIZABETH CITY, NC | First Bank |
| $150,000–350,000 | THE TWIFORD LAW FIRM, P.C. | ELIZABETH CITY, NC | Southern Bank and Trust Company |
| $150,000–350,000 | TWIFORD FUNERAL HOMES LLC | ELIZABETH CITY, NC | TowneBank |