| $350,000–1 million | HALFWAY ENVIRONMENT FOR ALCOHOLICS RECOVERING, INC | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | HAN-EM INC | LANCASTER, PA | First Commonwealth Bank |
| $350,000–1 million | HARBOR BUSINESS COMPLIANCE CORPORATION | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | HAVERSTICK BROS INC | LANCASTER, PA | PNC Bank, National Association |
| $350,000–1 million | HEARTFELT ENTERPRISES INC | LANCASTER, PA | PromiseOne Bank |
| $150,000–350,000 | HELLER CAPITAL GROUP | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | HIGHLAND PRESBYTERIAN CHURCH OF LANCASTER PA | LANCASTER, PA | S & T Bank |
| $350,000–1 million | HIGHWAY TRANSPORTATION EQUIPME | LANCASTER, PA | Orrstown Bank |
| $350,000–1 million | HODGE TOOL CO INC | LANCASTER, PA | Fulton Bank, National Association |
| $2–5 million | HOMESALE REALTY SERVICES GROUP INC | LANCASTER, PA | First National Bank of Pennsylvania |
| $1–2 million | HOPE INTERNATIONAL | LANCASTER, PA | LinkBank |
| $150,000–350,000 | HORST & SON INC | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | HOUSE OF PIZZA LANCASTER INC | LANCASTER, PA | PNC Bank, National Association |
| $1–2 million | HOUSING DEVELOPMENT CORPORATION MIDATLANTIC | LANCASTER, PA | Orrstown Bank |
| $350,000–1 million | HRI CONSTRUCTION, LLC | LANCASTER, PA | Truist Bank |
| $150,000–350,000 | INDOOR CITY GRANITE AND MARBLE INC | LANCASTER, PA | Truist Bank |
| $150,000–350,000 | INDOOR CITY OF LANCASTER INC | LANCASTER, PA | Truist Bank |
| $2–5 million | INTELLICOR LLC | LANCASTER, PA | Bryn Mawr Trust. A Division of |
| $350,000–1 million | INTERIORS INC. | LANCASTER, PA | Orrstown Bank |
| $1–2 million | JEROME H. RHOADS, INC. | LANCASTER, PA | Orrstown Bank |
| $350,000–1 million | JG ENVIRONMENTAL, LLC | LANCASTER, PA | Orrstown Bank |
| $1–2 million | JJLH OF MANHEIM PIKE, LLC | LANCASTER, PA | Ally Bank |
| $350,000–1 million | JJLH OF ROHRERSTOWN ROAD, LLC | LANCASTER, PA | Ally Bank |
| $150,000–350,000 | JOHN H. HYKES INC | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | JOHN J EICHENLAUB MD PC | LANCASTER, PA | PNC Bank, National Association |
| $150,000–350,000 | JOHN M. SCHMIDT, D.M.D., PC | LANCASTER, PA | Banc of California |
| $1–2 million | JONES DEALERSHIPS, INC. | LANCASTER, PA | Fulton Bank, National Association |
| $150,000–350,000 | JOYCAT VENTURES, LLC | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | JOYLAND ROOFING & EXTERIORS | LANCASTER, PA | Truist Bank |
| $350,000–1 million | K & A APPLIANCE INC | LANCASTER, PA | S & T Bank |
| $1–2 million | K & W TIRE COMPANY INC | LANCASTER, PA | Fulton Bank, National Association |
| $2–5 million | KALAS MFG, INC. | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | KEGEL KELIN ALMY & LORD LLP | LANCASTER, PA | PNC Bank, National Association |
| $1–2 million | KEGEL'S PRODUCE, INC. | LANCASTER, PA | S & T Bank |
| $350,000–1 million | KELLY CADILLAC INC | LANCASTER, PA | PNC Bank, National Association |
| $350,000–1 million | KEYSTONE GRANITE & TILE INC | LANCASTER, PA | TD Bank, National Association |
| $350,000–1 million | KEYSTONE WOOD SPECIALTIES INC | LANCASTER, PA | Mid Penn Bank |
| $350,000–1 million | L H BRUBAKER APPLIANCES INC. | LANCASTER, PA | First National Bank of Pennsylvania |
| $1–2 million | LANC CTY BR/PA ASSOC F/T BLIND | LANCASTER, PA | Fulton Bank, National Association |
| $150,000–350,000 | LANCASTER AREA HABITAT FOR HUMANITY | LANCASTER, PA | Orrstown Bank |
| $350,000–1 million | LANCASTER BREWING COMPANY | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | LANCASTER CANCER CENTER, LTD. | LANCASTER, PA | Orrstown Bank |
| $1–2 million | LANCASTER CATHOLIC HIGH SCHOOL | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | LANCASTER CLEFT PALATE CLINIC | LANCASTER, PA | Fulton Bank, National Association |
| $1–2 million | LANCASTER COUNTRY DAY SCHOOL | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | LANCASTER DAY CARE CENTER | LANCASTER, PA | PNC Bank, National Association |
| $150,000–350,000 | LANCASTER DODGE, INC. | LANCASTER, PA | Ally Bank |
| $1–2 million | LANCASTER EMERGENCY ASSOCIATES | LANCASTER, PA | Orrstown Bank |
| $350,000–1 million | LANCASTER FARM FRESH COOPERATIVE | LANCASTER, PA | Wilmington Savings Fund Society, FSB |
| $150,000–350,000 | LANCASTER FARM FRESH ORGANICS, LLC | LANCASTER, PA | Wilmington Savings Fund Society, FSB |
| $2–5 million | LANCASTER HEALTH CENTER | LANCASTER, PA | Truist Bank |
| $150,000–350,000 | LANCASTER MATERNAL FETAL MEDICINE LLC | LANCASTER, PA | First National Bank of Pennsylvania |
| $1–2 million | LANCASTER MENNONITE SCHOOL | LANCASTER, PA | Truist Bank |
| $150,000–350,000 | LANCASTER MORTGAGE COMPANY | LANCASTER, PA | Truist Bank |
| $150,000–350,000 | LANCASTER OTOLARYNGOLOGY, LLP | LANCASTER, PA | S & T Bank |
| $150,000–350,000 | LANCASTER RECREATION COMMISSION | LANCASTER, PA | PNC Bank, National Association |
| $150,000–350,000 | LANCASTER STONE & TILE COMPANY, LLC | LANCASTER, PA | First National Bank of Pennsylvania |
| $350,000–1 million | LANCOR LOGISTICS LLC | LANCASTER, PA | PNC Bank, National Association |
| $350,000–1 million | LAPP ELECTRICAL SERVICE, INC. | LANCASTER, PA | S & T Bank |
| $150,000–350,000 | LIBRARY SYSTEM OF LANCASTER COUNTY | LANCASTER, PA | Members 1st FCU |
| $150,000–350,000 | LONG COMMUNITY, INC. | LANCASTER, PA | Orrstown Bank |
| $350,000–1 million | LUCA ON JAMES, INC. | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | LYNDON CITY LINE DINER INC | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | MAC-IT CORPORATION | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | MACODO LLC | LANCASTER, PA | Wells Fargo Bank, National Association |
| $150,000–350,000 | MAJIC SERVICES INC | LANCASTER, PA | Truist Bank |
| $150,000–350,000 | MANBEL RESTAURANT LLC | LANCASTER, PA | Customers Bank |
| $150,000–350,000 | MANHEIM PIKE VETERINARY HOSPITAL, INC | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | MANHEIM TOWNSHIP AMBULANCE ASSOCIATION | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | MANOR BRETHREN IN CHRIST CHURCH | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | MASTER'S ADVISORS | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | MCCOMBS SUPPLY COMPANY, INC | LANCASTER, PA | The Ephrata National Bank |
| $150,000–350,000 | MCGGROUP, INC | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | MEADIA HEIGHTS GOLF CLUB, LLC | LANCASTER, PA | ACNB Bank |
| $150,000–350,000 | MENNONITE ECONOMIC DEVELOPMENT ASSOCIATES | LANCASTER, PA | Everence FCU |
| $350,000–1 million | MERGE INVESTIGATIONS INC | LANCASTER, PA | PNC Bank, National Association |
| $150,000–350,000 | METZLER HOME BUILDERS, INC. | LANCASTER, PA | Fulton Bank, National Association |
| $150,000–350,000 | MID ATLANTIC MUNICIPAL, LLC | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | MISSION CHURCH PENNSYLVANIA | LANCASTER, PA | Univest Bank and Trust Co |
| $150,000–350,000 | MJD SYSTEMS LLC | LANCASTER, PA | Orrstown Bank |
| $350,000–1 million | MJJM ENTERPRISES, INC. | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | MOBILTECH, LLC | LANCASTER, PA | Mid Penn Bank |
| $150,000–350,000 | MONTESSORI ACADEMY OF LANCASTER | LANCASTER, PA | First National Bank of Pennsylvania |
| $350,000–1 million | MOORE ENGINEERING CO | LANCASTER, PA | PNC Bank, National Association |
| $150,000–350,000 | MOSER ROOFING SOLUTIONS, LLC | LANCASTER, PA | Truist Bank |
| $150,000–350,000 | NADU CONSTRUCTION, INC. | LANCASTER, PA | Fulton Bank, National Association |
| $350,000–1 million | NEFFSVILLE VETERINARY CLINIC LTD | LANCASTER, PA | Northwest Bank |
| $350,000–1 million | NEPHROLOGY ASSOCIATES OF LANCASTER LIMITED | LANCASTER, PA | PNC Bank, National Association |
| $150,000–350,000 | NEW JERSEY DENTAL MANAGEMENT LLC | LANCASTER, PA | First Commonwealth Bank |
| $150,000–350,000 | NU-WAVE PAGING & CELLULAR INC | LANCASTER, PA | TD Bank, National Association |
| $150,000–350,000 | NUHAUS, INC. | LANCASTER, PA | Fulton Bank, National Association |
| $350,000–1 million | NURSING CARE IN HOME LLC. | LANCASTER, PA | Customers Bank |
| $150,000–350,000 | O'DONNELL AND PHILLIPS LLC | LANCASTER, PA | S & T Bank |
| $150,000–350,000 | ONE 2 ONE COMPUTER SERVICES INC. | LANCASTER, PA | The Ephrata National Bank |
| $2–5 million | ORTHOPEDIC ASSOCIATES OF LANCASTER LTD | LANCASTER, PA | Fulton Bank, National Association |
| $350,000–1 million | OTOLARYNGOLOGY PHYSICIANS OF LANCASTER LIMITED | LANCASTER, PA | PNC Bank, National Association |
| $150,000–350,000 | P L ROHRER & BRO INC | LANCASTER, PA | Univest Bank and Trust Co |
| $150,000–350,000 | PA FRANCHISE GROUP | LANCASTER, PA | First Commonwealth Bank |
| $1–2 million | PAP TECHNOLOGIES, INC. | LANCASTER, PA | Orrstown Bank |
| $1–2 million | PARAMOUNT CONTRACTING INC. | LANCASTER, PA | First National Bank of Pennsylvania |