| $350,000–1 million | 120 RIDER AVENUE OPERATING COMPANY LP | LANCASTER, PA | Valley National Bank |
| $150,000–350,000 | 120 RIDER AVENUE PCH OPERATING COMPANY LP | LANCASTER, PA | Valley National Bank |
| $150,000–350,000 | 1411 COLUMBIA AVENUE, INC | LANCASTER, PA | First Commonwealth Bank |
| $350,000–1 million | A.S.A.P STRATEGIES INC | LANCASTER, PA | The Ephrata National Bank |
| $150,000–350,000 | ABACUS SPORTS INSTALLATIONS LTD | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | ACCESS HOME MANAGERS, LLC | LANCASTER, PA | Hancock Whitney Bank |
| $350,000–1 million | ACUITY ADVISORS AND CPAS, LLP | LANCASTER, PA | Orrstown Bank |
| $350,000–1 million | ALBRIGHT & THIRY ORTHODONTICS, P.C. F/K/A RICHARD H ALBRIGHT | LANCASTER, PA | S & T Bank |
| $150,000–350,000 | ALLERGY AND ASTHMA CENTER PC | LANCASTER, PA | Fulton Bank, National Association |
| $350,000–1 million | AMERICAN MUSIC THEATRE, LLC | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | AMORETTE, LLC | LANCASTER, PA | S & T Bank |
| $1–2 million | ANESTHESIA ASSOCIATES OF LANCASTER, LTD | LANCASTER, PA | Mid Penn Bank |
| $150,000–350,000 | APPEL & YOST LLP | LANCASTER, PA | LinkBank |
| $350,000–1 million | APPLIED EDUCATIONAL SYSTEMS INC | LANCASTER, PA | Orrstown Bank |
| $350,000–1 million | ASPIRE VENTURES, LLC | LANCASTER, PA | Mid Penn Bank |
| $350,000–1 million | ATLEE HALL, LLP | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | AURORA FILMS, LLC | LANCASTER, PA | S & T Bank |
| $350,000–1 million | B & D MASONRY, INC. | LANCASTER, PA | The Ephrata National Bank |
| $2–5 million | BARLEY SNYDER, LLP | LANCASTER, PA | Orrstown Bank |
| $350,000–1 million | BCM INTERNATIONAL INC | LANCASTER, PA | Fulton Bank, National Association |
| $150,000–350,000 | BD HOSPITALITY LLC | LANCASTER, PA | S & T Bank |
| $150,000–350,000 | BECKER ENGINEERING, LLC | LANCASTER, PA | Fulton Bank, National Association |
| $150,000–350,000 | BEITTEL-BECKER PEDIATRIC ASSOCIATES | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | BELVEDERE INN INC | LANCASTER, PA | Northwest Bank |
| $350,000–1 million | BENJAMIN ROBERTS LTD | LANCASTER, PA | Fulton Bank, National Association |
| $150,000–350,000 | BLACKFORD DEVELOPMENT LTD. | LANCASTER, PA | First Commonwealth Bank |
| $350,000–1 million | BRANDYOURSELF.COM, INC | LANCASTER, PA | Kish Bank |
| $150,000–350,000 | BRENT L MILLER JEWELERS & GOLDSMITHS, INC. | LANCASTER, PA | S & T Bank |
| $150,000–350,000 | BRIMMERS LICENSE SERVICE, INC. | LANCASTER, PA | S & T Bank |
| $350,000–1 million | BRUBAKER CONNAUGHTON GOSS & LUCARELLI LLC | LANCASTER, PA | Fulton Bank, National Association |
| $150,000–350,000 | BRUBAKER MOTORS INC | LANCASTER, PA | Ally Bank |
| $1–2 million | BRUBAKER, INC | LANCASTER, PA | Truist Bank |
| $350,000–1 million | C-B TOOL CO. | LANCASTER, PA | First National Bank of Pennsylvania |
| $350,000–1 million | CALDWELL, HECKLES AND EGAN INC | LANCASTER, PA | Orrstown Bank |
| $1–2 million | CALVARY FELLOWSHIP HOMES, INC. | LANCASTER, PA | Orrstown Bank |
| $2–5 million | CARGAS SYSTEMS INC. | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | CARING HOSPICE SERVICES OF CENTRAL PENNSYLVANIA, LLC | LANCASTER, PA | Santander Bank, National Association |
| $150,000–350,000 | CARING HOSPICE SERVICES WESTERN PENNSYLVANIA, LLC | LANCASTER, PA | Santander Bank, National Association |
| $150,000–350,000 | CENTERVILLE FAMILY DENTAL | LANCASTER, PA | Truist Bank |
| $350,000–1 million | CENTRAL PENN NURSING CARE | LANCASTER, PA | Orrstown Bank |
| $1–2 million | CH&N SITE CONSTRUCTION, INC. | LANCASTER, PA | Orrstown Bank |
| $350,000–1 million | CHARLES BROTHERS INC | LANCASTER, PA | Fulton Bank, National Association |
| $1–2 million | CHARTER HOMES BUILDING COMPANY | LANCASTER, PA | Orrstown Bank |
| $5–10 million | CHARTWELL STAFFING SERVICES INC. | LANCASTER, PA | East West Bank |
| $150,000–350,000 | CHOICE SECURITY SERVICES LLC | LANCASTER, PA | CIBC Bank USA |
| $150,000–350,000 | CLASSICAL NUMISMATIC GROUP LLC | LANCASTER, PA | PNC Bank, National Association |
| $350,000–1 million | COLUMBIA DENTOFORM CORPORATION | LANCASTER, PA | Wilmington Savings Fund Society, FSB |
| $350,000–1 million | COMMONWEALTH CLINICAL GROUP, INC. | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | COMMUNITY INSURANCE SERVICES INC | LANCASTER, PA | PNC Bank, National Association |
| $150,000–350,000 | COMPANION CARE OF LANCASTER, INC | LANCASTER, PA | Fountainhead SBF LLC |
| $150,000–350,000 | CONESTOGA DATA SERVICES, INC. | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | CONESTOGA EYE PC | LANCASTER, PA | First National Bank of Pennsylvania |
| $1–2 million | CONESTOGA ORAL & MAXILLOFACIAL | LANCASTER, PA | PNC Bank, National Association |
| $350,000–1 million | CORK FACTORY HOTEL, LLC | LANCASTER, PA | The Ephrata National Bank |
| $150,000–350,000 | CORNERSTONE DRYWALL COMPANY LLC | LANCASTER, PA | Univest Bank and Trust Co |
| $150,000–350,000 | CP MANAGEMENT SERVICES, INC. | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | D. L. MYERS, INC. | LANCASTER, PA | Traditions Bank |
| $150,000–350,000 | DAVID MILLER/ASSOCIATES, INC. | LANCASTER, PA | S & T Bank |
| $350,000–1 million | DERMATOLOGY PHYSICIANS, INC | LANCASTER, PA | Truist Bank |
| $150,000–350,000 | DIVERSIFIED MACHINE, INC. | LANCASTER, PA | First National Bank of Pennsylvania |
| $350,000–1 million | DOMMEL'S HOTEL MANAGEMENT | LANCASTER, PA | Orrstown Bank |
| $350,000–1 million | DOODAD PRINTING, LLC | LANCASTER, PA | Wintrust Bank, National Association |
| $150,000–350,000 | DUTCH FAMILY SERVICES, LLC | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | DUTCH VALLEY AUTO WORKS, LLC | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | DYNATECH CONTROLS, INC. | LANCASTER, PA | Truist Bank |
| $150,000–350,000 | E.H. GOCHNAUER & SONS, INC. | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | ECKLIN DEVELOPMENT, LLC | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | ECOMM NETWORKS, LLC | LANCASTER, PA | First Commonwealth Bank |
| $150,000–350,000 | EDEN PARK PEDIATRIC ASSOCIATES, LLP | LANCASTER, PA | Mid Penn Bank |
| $350,000–1 million | EGSTOLTZFUS HOMES, LLC | LANCASTER, PA | Manufacturers and Traders Trust Company |
| $150,000–350,000 | EHC ASSOCIATES, INC. | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | ELITE DISTRIBUTORS | LANCASTER, PA | Univest Bank and Trust Co |
| $150,000–350,000 | ENERGYWORKS LANCASTER, LLC | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | EVE ENVIRONMENTAL SERVICES, INC | LANCASTER, PA | Mid Penn Bank |
| $150,000–350,000 | EVERYTHING BUT STROMBOLI LLC | LANCASTER, PA | Truist Bank |
| $350,000–1 million | EXECUTIVE COACH INC. | LANCASTER, PA | Truist Bank |
| $350,000–1 million | EYE ASSOCIATES OF LANCASTER, LTD | LANCASTER, PA | Truist Bank |
| $350,000–1 million | EZ SOLUTIONS INC | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | FAMILY EYE GROUP, P.C. | LANCASTER, PA | The Ephrata National Bank |
| $350,000–1 million | FESSENDEN HALL OF PA INC | LANCASTER, PA | PNC Bank, National Association |
| $150,000–350,000 | FIDELIS MORTGAGE CORPORATION | LANCASTER, PA | Customers Bank |
| $150,000–350,000 | FIG INDUSTRIES, LLC | LANCASTER, PA | Northwest Bank |
| $350,000–1 million | FIRST AMERICAN ABSTRACT OF PA LLC | LANCASTER, PA | Fulton Bank, National Association |
| $150,000–350,000 | FLURY FOUNDRY COMPANY | LANCASTER, PA | First National Bank of Pennsylvania |
| $150,000–350,000 | FPE DENTAL INC | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | FRANCIS J MANNING MD PC | LANCASTER, PA | Truist Bank |
| $150,000–350,000 | FTJOL, LLC DBA HOME INSTEAD SENIOR CARE | LANCASTER, PA | Tompkins VIST Bank, A Branch of |
| $150,000–350,000 | G.S. MADISON LLC | LANCASTER, PA | Orrstown Bank |
| $350,000–1 million | G.T.M. RESTAURANT CORPORATION | LANCASTER, PA | S & T Bank |
| $1–2 million | GARDEN SPOT FRAME & ALIGNMENT | LANCASTER, PA | Truist Bank |
| $150,000–350,000 | GERHART COFFEE COMPANY | LANCASTER, PA | Northwest Bank |
| $350,000–1 million | GLOBAL DISCIPLES | LANCASTER, PA | PNC Bank, National Association |
| $1–2 million | GODFREY ADVERTISING INC | LANCASTER, PA | PNC Bank, National Association |
| $150,000–350,000 | GREENAWALT ROOFING COMPANY | LANCASTER, PA | Truist Bank |
| $350,000–1 million | H & H GRAPHICS, INC. | LANCASTER, PA | Fulton Bank, National Association |
| $350,000–1 million | H L WIKER INC | LANCASTER, PA | Orrstown Bank |
| $150,000–350,000 | H2 VENTURES, LLC | LANCASTER, PA | Orrstown Bank |
| $1–2 million | H2, LLC | LANCASTER, PA | Mid Penn Bank |
| $350,000–1 million | HAIR DIRECT INC | LANCASTER, PA | PNC Bank, National Association |
| $150,000–350,000 | HALEY PAINT COMPANY | LANCASTER, PA | Meridian Bank |