| $150,000–350,000 | CAROLINA SERVICES INC | CHARLESTON, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | CATHEDRAL ACADEMY INC | CHARLESTON, SC | Wells Fargo Bank, National Association |
| $1–2 million | CENTURY RESTUARANTS INC | CHARLESTON, SC | Fifth Third Bank |
| $1–2 million | CETERUS, INC. | CHARLESTON, SC | Synovus Bank |
| $350,000–1 million | CHARLESTON ANIMAL SOCIETY | CHARLESTON, SC | Pinnacle Bank |
| $350,000–1 million | CHARLESTON AREA CONVENTION & VISITORS BUREAU | CHARLESTON, SC | First National Bank of Pennsylvania |
| $150,000–350,000 | CHARLESTON CATHOLIC SCHOOL | CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | CHARLESTON COTTON EXCHANGE, INC | CHARLESTON, SC | South Carolina FCU |
| $350,000–1 million | CHARLESTON DAY SCHOOL, INC. | CHARLESTON, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | CHARLESTON DEVELOPMENT ACADEMY | CHARLESTON, SC | Beacon Community Bank |
| $150,000–350,000 | CHARLESTON ELECTRICAL SERVICES, INC. | CHARLESTON, SC | United Bank |
| $150,000–350,000 | CHARLESTON EMERGENCY SERVICES, LLC | CHARLESTON, SC | Beacon Community Bank |
| $2–5 million | CHARLESTON ENT ASSOCIATES, LLC | CHARLESTON, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | CHARLESTON GREEN LLC | CHARLESTON, SC | The Bank of South Carolina |
| $150,000–350,000 | CHARLESTON MIYABI INC | CHARLESTON, SC | Truist Bank |
| $350,000–1 million | CHARLESTON NAVIGATION COMPANY | CHARLESTON, SC | First-Citizens Bank & Trust Company |
| $350,000–1 million | CHARLESTON NEUROSCIENCES INSTITUTE, LLC | CHARLESTON, SC | Ameris Bank |
| $350,000–1 million | CHARLESTON OB-GYN, LLC | CHARLESTON, SC | SouthState Bank, National Association |
| $2–5 million | CHARLESTON ONCOLOGY, P.A. | CHARLESTON, SC | Beacon Community Bank |
| $350,000–1 million | CHARLESTON ORAL AND FACIAL SURGERY, INC. | CHARLESTON, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | CHARLESTON ORTHODONTIC SPECIALISTS, LLC | CHARLESTON, SC | Pinnacle Bank |
| $150,000–350,000 | CHARLESTON PARKS CONSERVANCY | CHARLESTON, SC | Bank of America, National Association |
| $150,000–350,000 | CHARLESTON PEDIATRIC REHABILITATION, LLC | CHARLESTON, SC | Bank of America, National Association |
| $150,000–350,000 | CHARLESTON PERIODONTICS, PA | CHARLESTON, SC | Ameris Bank |
| $350,000–1 million | CHARLESTON PULMONARY ASSOCIATES, PA | CHARLESTON, SC | PNC Bank, National Association |
| $1–2 million | CHARLESTON SCHOOL OF LAW LLC | CHARLESTON, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | CHARLESTON SPORTS PUB 3 LLC | CHARLESTON, SC | United Community Bank |
| $150,000–350,000 | CHARLESTON SPORTS PUB LLC | CHARLESTON, SC | United Community Bank |
| $150,000–350,000 | CHARLESTON STAGE COMPANY | CHARLESTON, SC | SouthState Bank, National Association |
| $350,000–1 million | CHARLESTON SYMPHONY ORCHESTRA | CHARLESTON, SC | Truist Bank |
| $150,000–350,000 | CHARLESTON TURBINE MANAGEMENT, LLC | CHARLESTON, SC | TD Bank, National Association |
| $150,000–350,000 | CHASTAIN CONSTRUCTION INCORPORATED | CHARLESTON, SC | The Bank of South Carolina |
| $150,000–350,000 | CHATTOOGA CLUB INC. | CHARLESTON, SC | United Community Bank |
| $150,000–350,000 | CHESAPEAKE BAY SUBS, LLC | CHARLESTON, SC | First National Bank of Pennsylvania |
| $150,000–350,000 | CHILDRENS MUSEUM OF THE LOWCOUNTRY | CHARLESTON, SC | First Horizon Bank |
| $150,000–350,000 | CIRCA 1886 | CHARLESTON, SC | Synovus Bank |
| $150,000–350,000 | CITY PAPER PUBLISHING, LLC | CHARLESTON, SC | First Palmetto Bank |
| $150,000–350,000 | CLAENE GROUP LLC | CHARLESTON, SC | NBKC Bank |
| $350,000–1 million | COAST LLC | CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | COASTAL ANESTHESIA ASSOCIATES, LLC | CHARLESTON, SC | SouthState Bank, National Association |
| $350,000–1 million | COASTAL CARDIOLOGY ASSOCIATES, LLC | CHARLESTON, SC | BankVista |
| $350,000–1 million | COASTAL CARDIOLOGY PA | CHARLESTON, SC | PNC Bank, National Association |
| $150,000–350,000 | COASTAL HYDRAULICS, INC. | CHARLESTON, SC | Truist Bank |
| $2–5 million | COASTAL PEDIATRIC ASSOCIATES PA | CHARLESTON, SC | PNC Bank, National Association |
| $350,000–1 million | COASTAL VASCULAR AND VEIN CENTER | CHARLESTON, SC | Pinnacle Bank |
| $150,000–350,000 | CODE 1 TRAINING SOLUTIONS, LLC | CHARLESTON, SC | Berkshire Bank |
| $350,000–1 million | CONNOREX-LUCINDA, LLC | CHARLESTON, SC | Pinnacle Bank |
| $150,000–350,000 | CONSTRUCTION SERVICES GROUP, INC. THE | CHARLESTON, SC | Pinnacle Bank |
| $350,000–1 million | COTB, LLC | CHARLESTON, SC | Synovus Bank |
| $1–2 million | CRESCENT HOMES SC, LLC | CHARLESTON, SC | Ameris Bank |
| $150,000–350,000 | CROGHANS JEWEL BOX INC. | CHARLESTON, SC | The Bank of South Carolina |
| $150,000–350,000 | CROSSTOWN TAVERN, INC. | CHARLESTON, SC | Pinnacle Bank |
| $150,000–350,000 | CUMBERLAND & EAST BAY LP | CHARLESTON, SC | Synovus Bank |
| $150,000–350,000 | DANIEL ISLAND MARINA OPERATIONS LLC | CHARLESTON, SC | Bank of America, National Association |
| $150,000–350,000 | DANIEL POINTE RETIREMENT COMMUNITY, LLC | CHARLESTON, SC | Union Bank and Trust Company |
| $150,000–350,000 | DARKNESS TO LIGHT, INC. | CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | DAVID AYLOR LAW OFFICES LLC | CHARLESTON, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | DAVID M GILSTON INSURANCE AGENCY INC | CHARLESTON, SC | The Bank of South Carolina |
| $350,000–1 million | DEFENSE ENGINEERING SERVICES | CHARLESTON, SC | Truist Bank |
| $150,000–350,000 | DESIGN WORKS, L.C. | CHARLESTON, SC | SouthState Bank, National Association |
| $1–2 million | DEWBERRY 334 MEETING STREET LLC | CHARLESTON, SC | Synovus Bank |
| $150,000–350,000 | DIGITAL PRISM ADVISORS, INC. | CHARLESTON, SC | Bank of America, National Association |
| $350,000–1 million | DOCUGRAPHICS, LLC | CHARLESTON, SC | Synovus Bank |
| $150,000–350,000 | DOG & DUCK CLEMENTS FERRY LLC | CHARLESTON, SC | Pinnacle Bank |
| $350,000–1 million | DOOR SYTEMS OF CHARLESTON, LLC | CHARLESTON, SC | First Bank |
| $350,000–1 million | DOSCHERS DORCHESTER ROAD INC | CHARLESTON, SC | Ameris Bank |
| $150,000–350,000 | DOTTIES PHARMACY LLC | CHARLESTON, SC | LifeStore Bank |
| $150,000–350,000 | DOUG SHORTER PROPERTY MANAGEMENT, INC. | CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | DRAYTON HALL PRESERVATION TRUST | CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | DUFFY & YOUNG LLC | CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | DUMAS AT 294, LLC | CHARLESTON, SC | Beacon Community Bank |
| $350,000–1 million | ECIGCHARLESTON LLC | CHARLESTON, SC | Pinnacle Bank |
| $1–2 million | EDD, LLC | CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | ELECTRIC RED, INC | CHARLESTON, SC | Synovus Bank |
| $2–5 million | ENERGY ONE AMERICA LLC | CHARLESTON, SC | United Community Bank |
| $150,000–350,000 | ENVIROMIX, INC. | CHARLESTON, SC | United Community Bank |
| $350,000–1 million | EOAKIS, LLC | CHARLESTON, SC | United Community Bank |
| $150,000–350,000 | EOBC LLC | CHARLESTON, SC | Truist Bank |
| $150,000–350,000 | EVANS, CARTER, KUNES & BENNETT, P.A. | CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | EYE CENTER OF CHARLESTON | CHARLESTON, SC | The Bank of South Carolina |
| $1–2 million | FAMILY VENTURES 1, LLC | CHARLESTON, SC | Signature Bank |
| $350,000–1 million | FATHOM4,LLC | CHARLESTON, SC | The Citizens Bank |
| $350,000–1 million | FENDER MENDER OF WEST ASHLEY, INC | CHARLESTON, SC | United Community Bank |
| $1–2 million | FETTER HEALTH CARE NETWORK, INC. | CHARLESTON, SC | Synovus Bank |
| $150,000–350,000 | FIDDLERS ROOST SERVICES, LLC | CHARLESTON, SC | Pinnacle Bank |
| $350,000–1 million | FIRST BAPTIST SCHOOL | CHARLESTON, SC | Synovus Bank |
| $150,000–350,000 | FIVE LOAVES CAFE INC | CHARLESTON, SC | Synovus Bank |
| $350,000–1 million | FLOORING SERVICES, LLC | CHARLESTON, SC | Synovus Bank |
| $150,000–350,000 | FLORENCE CRITTENTON PROGRAMS OF SOUTH CAROLINA | CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | FLOYD BRACE COMPANY, INC | CHARLESTON, SC | Synovus Bank |
| $150,000–350,000 | FLOYD LEE LOCUMS INC | CHARLESTON, SC | PNC Bank, National Association |
| $350,000–1 million | FLYING FISH MARKET & GRILL, LLC | CHARLESTON, SC | United Community Bank |
| $1–2 million | FMH, L.P. | CHARLESTON, SC | First National Bank of Pennsylvania |
| $150,000–350,000 | FORSBERG ENGINEERING AND SURVEYING INC. | CHARLESTON, SC | South Atlantic Bank |
| $150,000–350,000 | FORT SUMTER TOURS, INC. | CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | FRANKIE'S FUN PARK OF CHARLESTON,LLC | CHARLESTON, SC | Truist Bank |
| $350,000–1 million | FRANKIE'S FUN PARK OF CHARLOTTE, LLC | CHARLESTON, SC | Truist Bank |
| $350,000–1 million | FRANKIE'S FUN PARK OF RALEIGH, LLC | CHARLESTON, SC | Truist Bank |
| $350,000–1 million | FRANKIES FUN PARK OF COLUMBIA, LLC | CHARLESTON, SC | Truist Bank |
| $150,000–350,000 | FRANKIES FUN PARK OF GREENVILLE LLC | CHARLESTON, SC | Truist Bank |