| $350,000–1 million | RESORT SALES BY SPINNAKER INC. | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $150,000–350,000 | RESORT SALES FLORIDA INC. | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $350,000–1 million | RESORT SALES MISSOURI INC. | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $350,000–1 million | RMC PROPERTY MANAGEMENT & CONSULTING, INC. | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $350,000–1 million | ROLLING DOUGH LLC | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $150,000–350,000 | S & R, LLC | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $150,000–350,000 | S. M. BRADFORD CO. | HILTON HEAD ISLAND, SC | SouthState Bank, National Association |
| $150,000–350,000 | SANDCASTLE CONSTRUCTORS, INC | HILTON HEAD ISLAND, SC | TD Bank, National Association |
| $150,000–350,000 | SANTA FE CAFE RESTAURANTS, INC. | HILTON HEAD ISLAND, SC | South Atlantic Bank |
| $350,000–1 million | SCOTT GOCHNAUER, INC. | HILTON HEAD ISLAND, SC | Cross River Bank |
| $2–5 million | SDC PROPERTIES | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $150,000–350,000 | SEA PINES CIRCLE IMMEDIATE CARE, LLC | HILTON HEAD ISLAND, SC | Truist Bank |
| $150,000–350,000 | SEA PINES MONTESSORI SCHOOL INC. | HILTON HEAD ISLAND, SC | TD Bank, National Association |
| $1–2 million | SERG RESTAURANT GROUP, LLC | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $350,000–1 million | SHOOGIE SHACK, LLC | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $150,000–350,000 | SIGNATURE SALES GROUP, LLC | HILTON HEAD ISLAND, SC | Western Alliance Bank |
| $350,000–1 million | SKULL CREEK DOCKSIDE, LLC | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $350,000–1 million | SKULL CREEK PARTNERS, LLC | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $150,000–350,000 | SNELL & ASSOCIATES LANDSCAPE CONTRACTOR INC | HILTON HEAD ISLAND, SC | Ameris Bank |
| $150,000–350,000 | SOUTH CAROLINA CANCER SPECIALISTS PA | HILTON HEAD ISLAND, SC | Bank of America, National Association |
| $150,000–350,000 | SOUTH CAROLINA YACHT CLUB LLC | HILTON HEAD ISLAND, SC | Truist Bank |
| $150,000–350,000 | SOUTHERN MAGNOLIAS | HILTON HEAD ISLAND, SC | Bank of America, National Association |
| $150,000–350,000 | SOUTHERN WINGS LLC | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $150,000–350,000 | ST FRANCIS BY THE SEA CATHOLIC CHURCH | HILTON HEAD ISLAND, SC | SouthState Bank, National Association |
| $150,000–350,000 | ST. ANDREWBY THE SEA UNITED METHODIST CHURCH | HILTON HEAD ISLAND, SC | Truist Bank |
| $150,000–350,000 | ST. FRANCIS CATHOLIC SCHOOL | HILTON HEAD ISLAND, SC | SouthState Bank, National Association |
| $150,000–350,000 | STACKS PANCAKES OF HH, INC. | HILTON HEAD ISLAND, SC | SouthState Bank, National Association |
| $350,000–1 million | STONEWORKS, INC. | HILTON HEAD ISLAND, SC | Truist Bank |
| $150,000–350,000 | SUNSET RENTALS, INC. | HILTON HEAD ISLAND, SC | Pinnacle Bank |
| $150,000–350,000 | SUSTAINED CARE SERVICES, INC. | HILTON HEAD ISLAND, SC | First Bank of the Lake |
| $150,000–350,000 | THE CHILDREN'S CENTER, INC. | HILTON HEAD ISLAND, SC | Synovus Bank |
| $350,000–1 million | THE CLUB GROUP, LTD. | HILTON HEAD ISLAND, SC | Synovus Bank |
| $2–5 million | THE GREENERY, INC. | HILTON HEAD ISLAND, SC | SouthState Bank, National Association |
| $1–2 million | THE SEABROOK OF HILTON HEAD, INC | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $150,000–350,000 | THE WALSTON GROUP INC | HILTON HEAD ISLAND, SC | TD Bank, National Association |
| $150,000–350,000 | TRANSPORTATION SAFETY APPAREL | HILTON HEAD ISLAND, SC | PNC Bank, National Association |
| $150,000–350,000 | TRUFFLES BELFAIR, LLC | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $150,000–350,000 | VAN DER MEER TENNIS UNIVERSITY, INC. | HILTON HEAD ISLAND, SC | SouthState Bank, National Association |
| $150,000–350,000 | VOLUNTEERS IN MEDICINE CLINIC | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $150,000–350,000 | WALKER WELLS VENTURES, LLC | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $1–2 million | WEXFORD PLANTATION HOME OWNERS ASSOCIATION, INC. | HILTON HEAD ISLAND, SC | SouthState Bank, National Association |
| $350,000–1 million | WINDSURFING HILTON HEAD INC | HILTON HEAD ISLAND, SC | Synovus Bank |
| $150,000–350,000 | WISE GUYS LOUNGE LLC | HILTON HEAD ISLAND, SC | Coastal States Bank |
| $150,000–350,000 | WOOD AND PARTNERS, INCORPORATED | HILTON HEAD ISLAND, SC | SouthState Bank, National Association |