| $150,000–350,000 | QUALITY HEALTHCARE DEVELOPMENT LLC | NORTH CHARLESTON, SC | ServisFirst Bank |
| $350,000–1 million | QUALITY TOUCH JANITORIAL SERVICE, INC. | NORTH CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | RAE MANAGEMENT SERVICES, LLC | NORTH CHARLESTON, SC | United Community Bank |
| $150,000–350,000 | RED BAY CONSTRUCTORS CORP. | NORTH CHARLESTON, SC | ServisFirst Bank |
| $150,000–350,000 | RESCLEAN, INC. DBA THE CLEANING AUTHORITY | NORTH CHARLESTON, SC | Beacon Community Bank |
| $150,000–350,000 | REWINED LLC | NORTH CHARLESTON, SC | Pinnacle Bank |
| $150,000–350,000 | ROSS SALES ASSOCIATES INC | NORTH CHARLESTON, SC | United Community Bank |
| $150,000–350,000 | ROYAL MISSIONARY BAPTIST CHURCH | NORTH CHARLESTON, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | ROYAL UNITED LC | NORTH CHARLESTON, SC | ServisFirst Bank |
| $150,000–350,000 | RU THEATRE LLC | NORTH CHARLESTON, SC | Bank of America, National Association |
| $350,000–1 million | SALON 813 LLC | NORTH CHARLESTON, SC | BankVista |
| $2–5 million | SANDERS BROTHERS CONSTRUCTION COMPANY, INC. | NORTH CHARLESTON, SC | SouthState Bank, National Association |
| $350,000–1 million | SAULISBURY BUSINESS MACHINES INC. | NORTH CHARLESTON, SC | First-Citizens Bank & Trust Company |
| $1–2 million | SCHOONOVER HOLDING INC. | NORTH CHARLESTON, SC | Synovus Bank |
| $150,000–350,000 | SEACOAST SUPPLY, LLC | NORTH CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | SELDEN MAST, INC. | NORTH CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | SEVEN FARMS SERVICES, LLC | NORTH CHARLESTON, SC | CIBC Bank USA |
| $350,000–1 million | SHELLY LEEKE LAW FIRM LLC | NORTH CHARLESTON, SC | Truist Bank |
| $150,000–350,000 | SITEWORKS, INC | NORTH CHARLESTON, SC | ServisFirst Bank |
| $150,000–350,000 | SJ HAMILL CONSTRUCTION COMPANY, LLC | NORTH CHARLESTON, SC | United Community Bank |
| $150,000–350,000 | SMITH'S HEATING & AIR CONDITIONING CO., INC. | NORTH CHARLESTON, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | SNYDER EVENT SERVICES, INC. | NORTH CHARLESTON, SC | First-Citizens Bank & Trust Company |
| $350,000–1 million | SOC, LLC | NORTH CHARLESTON, SC | Truist Bank |
| $350,000–1 million | SOIL CONSULTANTS INC | NORTH CHARLESTON, SC | Truist Bank |
| $350,000–1 million | SONITROL SECURITY SYSTEMS OF CHARLESTON, INC. | NORTH CHARLESTON, SC | Beacon Community Bank |
| $150,000–350,000 | SOTERIA LLC | NORTH CHARLESTON, SC | Bank of America, National Association |
| $150,000–350,000 | SOUTH CAROLINA STINGRAYS INC | NORTH CHARLESTON, SC | Truist Bank |
| $150,000–350,000 | SOUTHEASTERN GARAGEDOORS OF CHARLESTON, INC. | NORTH CHARLESTON, SC | SouthState Bank, National Association |
| $1–2 million | SOUTHERN CURRENT LLC | NORTH CHARLESTON, SC | ServisFirst Bank |
| $2–5 million | SOUTHERN DIVERSIFIED DISTRIBUTORS, INC | NORTH CHARLESTON, SC | Regions Bank |
| $150,000–350,000 | SOUTHLAND LANDSCAPE CORPORATION | NORTH CHARLESTON, SC | First Federal Bank |
| $350,000–1 million | STAFFORD RESTAURANT MANAGEMENT LLC | NORTH CHARLESTON, SC | ServisFirst Bank |
| $150,000–350,000 | STASH STORAGE HOLDINGS, INC. | NORTH CHARLESTON, SC | Beacon Community Bank |
| $350,000–1 million | STASMAYER, INCORPORATED | NORTH CHARLESTON, SC | Pinnacle Bank |
| $350,000–1 million | STEADY MODDIN MOTORSPORTS LLC | NORTH CHARLESTON, SC | BankVista |
| $350,000–1 million | STOKES AND STOKES ENTERPRISES INC | NORTH CHARLESTON, SC | TD Bank, National Association |
| $350,000–1 million | STOKES AUTOMOTIVE II INC | NORTH CHARLESTON, SC | TD Bank, National Association |
| $350,000–1 million | STOKES ENTERPRISES INC | NORTH CHARLESTON, SC | TD Bank, National Association |
| $150,000–350,000 | STREIT USA ARMORING, LLC | NORTH CHARLESTON, SC | Beacon Community Bank |
| $150,000–350,000 | SUKKAR & SONS OF SOUTH CAROLINA, INC | NORTH CHARLESTON, SC | SouthPoint Bank |
| $1–2 million | SUPERIOR TRANSPORTATION, INC. | NORTH CHARLESTON, SC | Southern First Bank |
| $150,000–350,000 | SUSTAINABLE LIGHTING SOLUTIONS, LLC | NORTH CHARLESTON, SC | Bank of America, National Association |
| $350,000–1 million | TD NORTH CHARLESTON HOTEL LLC | NORTH CHARLESTON, SC | Commercial Bank of California |
| $150,000–350,000 | TECHNICAL EVENT COMPANY LLC | NORTH CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | TECHNOLOGY SOLUTIONS OF CHARLESTON, INC. | NORTH CHARLESTON, SC | Pinnacle Bank |
| $150,000–350,000 | TECHVENTURES, LLC | NORTH CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | TEKNA CORPORATION | NORTH CHARLESTON, SC | United Bank |
| $1–2 million | TERRESSENTIA CORP | NORTH CHARLESTON, SC | Truist Bank |
| $150,000–350,000 | THE 4 ELLIOTTS | NORTH CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | THE BAY COMPANY, LLC | NORTH CHARLESTON, SC | Beacon Community Bank |
| $150,000–350,000 | THE REVEER GROUP, LLC | NORTH CHARLESTON, SC | Beacon Community Bank |
| $2–5 million | THE URBAN ELECTRIC COMPANY | NORTH CHARLESTON, SC | Truist Bank |
| $150,000–350,000 | THESIGNCHEF.COM, INC. | NORTH CHARLESTON, SC | Beacon Community Bank |
| $150,000–350,000 | THREAT MANAGEMENT GROUP LLC | NORTH CHARLESTON, SC | Truist Bank |
| $150,000–350,000 | THUNDERSTAR SEAFOOD, INC. DBA CROSBY'S SEAFOOD CO. | NORTH CHARLESTON, SC | First National Bank of Pennsylvania |
| $150,000–350,000 | TIDEWATER INTERIORS INC | NORTH CHARLESTON, SC | ServisFirst Bank |
| $150,000–350,000 | TRANSFER SOLUTIONS CORPORATION | NORTH CHARLESTON, SC | SouthState Bank, National Association |
| $350,000–1 million | TRANSWORLD, INC. | NORTH CHARLESTON, SC | SouthState Bank, National Association |
| $350,000–1 million | TRIDENT DENTAL MANAGEMENT, LLC | NORTH CHARLESTON, SC | Pinnacle Bank |
| $350,000–1 million | TRIDENT SECURITY SERVICES INC | NORTH CHARLESTON, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | TRUAUTO - RIVERS, LLC | NORTH CHARLESTON, SC | Pinnacle Bank |
| $350,000–1 million | TWELVE SOUTH LLC | NORTH CHARLESTON, SC | Truist Bank |
| $1–2 million | URBAN NIRVANA, LLC | NORTH CHARLESTON, SC | ServisFirst Bank |
| $150,000–350,000 | WARREN FASTENINGS SOUTH, INC. | NORTH CHARLESTON, SC | Synovus Bank |
| $150,000–350,000 | WASTE SERVICES LLC | NORTH CHARLESTON, SC | ServisFirst Bank |
| $1–2 million | WE ARE SHARING HOPE SC | NORTH CHARLESTON, SC | Synovus Bank |
| $1–2 million | WEEKS & IRVINE LLC | NORTH CHARLESTON, SC | ServisFirst Bank |
| $150,000–350,000 | WEIL'S MATTRESS CO, INC | NORTH CHARLESTON, SC | The Bank of South Carolina |
| $350,000–1 million | WHOLESALE INDUSTRIAL ELECTRONICS, INC. | NORTH CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | WIGGER LAW FIRM, INC. | NORTH CHARLESTON, SC | SouthState Bank, National Association |
| $150,000–350,000 | WIREGRASS INSURANCE SERVICES, INC. | NORTH CHARLESTON, SC | United Bank |
| $150,000–350,000 | WOOD ON, LLC | NORTH CHARLESTON, SC | Truist Bank |
| $150,000–350,000 | ZELTWANGER CNC MANUFACTURING LP | NORTH CHARLESTON, SC | Bank of America, National Association |
| $350,000–1 million | ZOCALO, LLC | NORTH CHARLESTON, SC | Truist Bank |
| $150,000–350,000 | ZUUK INTERNATIONAL, INC. | NORTH CHARLESTON, SC | Pinnacle Bank |