| $150,000–350,000 | SPARTAN TANK AND TRAILER, LLC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | SPARTANBURG & PELHAM OB-GYN PA | SPARTANBURG, SC | The Park National Bank |
| $350,000–1 million | SPARTANBURG AUTO ACQUISTIONS, INC | SPARTANBURG, SC | Truist Bank |
| $1–2 million | SPARTANBURG DAY SCHOOL | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | SPARTANBURG DERMATOLOGY AND SKIN SURGERY CLINIC PC | SPARTANBURG, SC | The Park National Bank |
| $1–2 million | SPARTANBURG DODGE, INC. | SPARTANBURG, SC | First Horizon Bank |
| $350,000–1 million | SPARTANBURG EAR NOSE & THROAT HEAD & NECK SURGERY CLINIC PA | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $350,000–1 million | SPARTANBURG HEALTH CARE, LLC | SPARTANBURG, SC | BOKF, National Association |
| $150,000–350,000 | SPARTANBURG MEAT PROCESSING CO., INC. | SPARTANBURG, SC | TD Bank, National Association |
| $150,000–350,000 | SPARTANBURG MEDICAL RESEARCH, L.L.C. | SPARTANBURG, SC | SouthState Bank, National Association |
| $1–2 million | SPARTANBURG METHODIST COLLEGE | SPARTANBURG, SC | Truist Bank |
| $350,000–1 million | SPARTANBURG PREPARATORY SCHOOL | SPARTANBURG, SC | SouthState Bank, National Association |
| $5–10 million | SPARTANBURG STEEL PRODUCTS, INC. | SPARTANBURG, SC | Comerica Bank |
| $150,000–350,000 | SQUARE ONE CONSTRUCTION, LLC | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | ST PETE BEACH HOTELS, LLC | SPARTANBURG, SC | United Community Bank |
| $1–2 million | STAFFING ASSOCIATES EXECUTIVE RECRUITING | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | SUNNYVALE HOTELS, LLC | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | SYMTECH INC | SPARTANBURG, SC | Truist Bank |
| $1–2 million | TAYLOR ENTERPRISES INC | SPARTANBURG, SC | Truist Bank |
| $350,000–1 million | TECHNICO INC. | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | TEECEES INC | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | THE CATE LAW FIRM | SPARTANBURG, SC | Wells Fargo Bank, National Association |
| $350,000–1 million | THE FORRESTER CENTER FOR BEHAVIORAL HEALTH | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $350,000–1 million | THE NATIONAL HONORARY BETA CLUB | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | THE SOUTHERN CONFERENCE | SPARTANBURG, SC | Fifth Third Bank |
| $150,000–350,000 | THE SPARTANBURG HUMANE SOCIETY | SPARTANBURG, SC | Synovus Bank |
| $350,000–1 million | THE UROLOGY CENTER OF SPARTANBURG PC | SPARTANBURG, SC | The Park National Bank |
| $350,000–1 million | THE WARD LAW FIRM, P.A. | SPARTANBURG, SC | First Horizon Bank |
| $1–2 million | THI OF SOUTH CAROLINA AT MAGNOLIA PLACE AT SPARTANBURG, LLC | SPARTANBURG, SC | BOKF, National Association |
| $2–5 million | TIETEX INTERNATIONAL, LTD. | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | TONEY FAMILY FLOUNDER FISH CAMP | SPARTANBURG, SC | The Park National Bank |
| $350,000–1 million | TRICOR CONSTRUCTION, INC. | SPARTANBURG, SC | SouthState Bank, National Association |
| $350,000–1 million | UNITED FOREST PRODUCTS, INC. | SPARTANBURG, SC | United Bank |
| $150,000–350,000 | UNITED WAY OF THE PIEDMONT | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | UPSTATE HOME HEALTH CARE SOLUTION LLC | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | UPSTATE LUNG AND CRITICAL CARE SPECIALISTS, PC | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | VAUGHN BELTING COMPANY | SPARTANBURG, SC | UMB Bank, National Association |
| $350,000–1 million | W N KIRKLAND INC. | SPARTANBURG, SC | The Park National Bank |
| $350,000–1 million | W R FLOYD CORPORATION | SPARTANBURG, SC | Truist Bank |
| $350,000–1 million | W. R. FLOYD SERVICES, INC. | SPARTANBURG, SC | Truist Bank |
| $350,000–1 million | WADE'S RESTAURANT, INC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | WAKEFIELD AUTOMOTIVE INC | SPARTANBURG, SC | Truist Bank |
| $350,000–1 million | WESTGATE FAMILY PHYSICIANS PA | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | WHITAKER TRANSPORTATION COMPANY | SPARTANBURG, SC | 1st Source Bank |
| $150,000–350,000 | WILKES LAW FIRM, P.A. | SPARTANBURG, SC | United Community Bank |
| $2–5 million | WILLIAM BARNET & SON, LLC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | WING AND A PRAYER ENTERPRISES INC | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | WJ STRUTCO INC | SPARTANBURG, SC | First Horizon Bank |
| $150,000–350,000 | WOLFF INDUSTRIES, INC. | SPARTANBURG, SC | Arthur State Bank |
| $350,000–1 million | YMCA OF GREATER SPARTANBURG | SPARTANBURG, SC | TD Bank, National Association |