| $150,000–350,000 | 3 HEARTS LLC | SPARTANBURG, SC | Truist Bank |
| $350,000–1 million | A BERGER INC | SPARTANBURG, SC | Bank of America, National Association |
| $150,000–350,000 | A PLUS PALLET CO. LLC | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | ADO CORPORATION | SPARTANBURG, SC | Sauk Valley Bank & Trust Company |
| $150,000–350,000 | ADVANCED ENVIRONMENTAL OPTIONS, INC | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | ADVANCED PROFESSIONAL SERVICES LLC | SPARTANBURG, SC | TransPecos Banks, SSB. |
| $350,000–1 million | ADVANCED THERAPY SOLUTIONS INC | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | AMERICAN YUNCHENG GRAVURE CYLINDER INC | SPARTANBURG, SC | Bank of America, National Association |
| $350,000–1 million | APEXICAL INC. | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | ASSOCIATED PETROLEUM CARRIERS, INC. | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | ASSURE ALLIANCE, INC | SPARTANBURG, SC | The Park National Bank |
| $350,000–1 million | AURORA TECHNOLOGIES, INCORPARATED-SOUTH | SPARTANBURG, SC | Carrollton Bank |
| $350,000–1 million | AWL AUTOMATION, LLC | SPARTANBURG, SC | Mechanics Bank |
| $350,000–1 million | BAGWELL FENCE COMPANY, INC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | BELL LAUNDRY AND CLEANERS, INC. | SPARTANBURG, SC | Wells Fargo Bank, National Association |
| $350,000–1 million | BELMONT HOTELS, LLC | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | BELUE TRUCKING COMPANY, INC. | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | BENSON AUTOMOTIVE OF SPARTANBURG, LLC | SPARTANBURG, SC | Truist Bank |
| $350,000–1 million | BENSON HYUNDAI, LLC | SPARTANBURG, SC | Truist Bank |
| $350,000–1 million | BENSON NISSAN, INC. | SPARTANBURG, SC | TD Bank, National Association |
| $150,000–350,000 | BETTER BEGINNINGS, INC | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | BILL KIRKLAND HEATING & AIR | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | BILL KIRKLAND HEATING AND AIR CONDITIONING, INC. | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | BIRDZ OF A FEATHER, INC. | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | BLUE EAGLE RENTALS, INC. | SPARTANBURG, SC | SouthState Bank, National Association |
| $1–2 million | BMC MANUFACTURING LLC | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | BRICE HOLDINGS LLC | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $350,000–1 million | BUDWEISER OF SPARTANBURG, INC. | SPARTANBURG, SC | SouthState Bank, National Association |
| $150,000–350,000 | C L CANNON & SONS INC. | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | CAFE VIENNA, INC. | SPARTANBURG, SC | SouthState Bank, National Association |
| $150,000–350,000 | CAMCO MACHINING INC | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | CAMPBELL'S BODY SHOP AND WRECKER SERVICE | SPARTANBURG, SC | Bank of America, National Association |
| $350,000–1 million | CANNON ROOFING, LLC | SPARTANBURG, SC | Southern Bank and Trust Company |
| $150,000–350,000 | CAPITAL CONSTRUCTION OF THE CAROLINAS LLC | SPARTANBURG, SC | United Community Bank |
| $1–2 million | CARDIOLOGY CONSULTANTS, INC. | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | CAREY MOVING & STORAGE, INC | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | CAROLINA DENTAL STUDIO PA | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | CAROLINA NEUROLOGY OF SPARTANBURG LLC | SPARTANBURG, SC | Truist Bank |
| $1–2 million | CAROLINA ORTHOPAEDIC AND NEUROSURGICAL ASSOCIATES | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | CAROLINA SMILES LLC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | CAROLINA STAFFING SOLUTIONS INC | SPARTANBURG, SC | Bank of America, National Association |
| $350,000–1 million | CAROLINA VISION ASSOCIATES, LLC. | SPARTANBURG, SC | The Park National Bank |
| $350,000–1 million | CAROLINAS CENTER FOR ADVANCED MANAGEMENT OF PAIN, P.A. | SPARTANBURG, SC | SouthState Bank, National Association |
| $150,000–350,000 | CEDAR SPRING FAMILY DENTISTRY LLC | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | CHAPEL HILL HOTELS, LLC | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | CHAPMAN CULTURAL CENTER INC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | CHAPMAN CULTURAL CENTER INC. | SPARTANBURG, SC | The Park National Bank |
| $1–2 million | CLARKSON INDUSTRIAL CONTRACTORS INC | SPARTANBURG, SC | HSBC Bank USA, National Association |
| $2–5 million | CLARY HOOD & ASSOCIATES, INC. | SPARTANBURG, SC | Pinnacle Bank |
| $150,000–350,000 | CLAY-KING.COM, INC | SPARTANBURG, SC | Arthur State Bank |
| $350,000–1 million | CLAYTON CONSTRUCTION COMPANY, INC. | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | CLEMENTS AUTOMOTIVE INC | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $350,000–1 million | CLY INC | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | COMMON THREADS EMBROIDERY & APPAREL | SPARTANBURG, SC | The Park National Bank |
| $1–2 million | CONCEPT MANAGEMENT CORPORATION | SPARTANBURG, SC | Bank of America, National Association |
| $2–5 million | CONVERSE COLLEGE | SPARTANBURG, SC | First Horizon Bank |
| $350,000–1 million | CONVERSE LOGISTICS GROUP, LLC | SPARTANBURG, SC | Synovus Bank |
| $350,000–1 million | COVINGTON FABRIC & DESIGN, LLC | SPARTANBURG, SC | First Source Federal Credit Union |
| $150,000–350,000 | CP ANDERSON TRUCKING, LLC | SPARTANBURG, SC | Regions Bank |
| $150,000–350,000 | CR WOODBRIDGE LLC | SPARTANBURG, SC | Truist Bank |
| $350,000–1 million | CRIBBS HOSPITALITY GROUP, LLC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | CROSS COUNTRY TOURS, INC | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | CUSTOM FOREST PRODUCTS INC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | CWS INSURANCE AGENCY, INC. | SPARTANBURG, SC | Arthur State Bank |
| $350,000–1 million | DAF INC | SPARTANBURG, SC | Truist Bank |
| $350,000–1 million | DANTHERM COOLING, INC | SPARTANBURG, SC | Lincoln Savings Bank |
| $1–2 million | DAVE EDWARDS INC | SPARTANBURG, SC | TD Bank, National Association |
| $150,000–350,000 | DELL CORNING CORPORATION | SPARTANBURG, SC | Wells Fargo Bank, National Association |
| $150,000–350,000 | DSJ AL HOLDINGS, LLC | SPARTANBURG, SC | CIBC Bank USA |
| $150,000–350,000 | DUNBAR CONSTRUCTION COMPANY, INC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | EAST COAST GRANITE & TILE INC. | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | EAST COAST UNDERWRITERS, LLC | SPARTANBURG, SC | First Horizon Bank |
| $150,000–350,000 | EASTSIDE ANIMAL HOSPITAL LLC | SPARTANBURG, SC | The Park National Bank |
| $350,000–1 million | EDGEWATER AUTOMATION SC, LLC | SPARTANBURG, SC | The Huntington National Bank |
| $350,000–1 million | EL SEGUNDO HOTELS, LLC | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | ELLIOTT & PAINTER, LLP | SPARTANBURG, SC | Bank of Travelers Rest |
| $150,000–350,000 | EMORY GROUP LLC | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | EPISCOPAL CHURCH OF THE ADVENT | SPARTANBURG, SC | SouthState Bank, National Association |
| $350,000–1 million | EUG HOLDCO, LLC | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | EVENT RENTALS, INC. | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $1–2 million | FAMILY PHYSICIANS OF SPARTANBURG, PC | SPARTANBURG, SC | Arthur State Bank |
| $350,000–1 million | FIRST BAPTIST CHURCH SPARTANBURG | SPARTANBURG, SC | Truist Bank |
| $350,000–1 million | FOOTHILLS ANESTHESIA CONSULTANTS | SPARTANBURG, SC | Arthur State Bank |
| $150,000–350,000 | FOOTHILLS NEPHROLOGY, P. C. | SPARTANBURG, SC | SouthState Bank, National Association |
| $150,000–350,000 | FOOTHILLS PEDIATRIC DENTISTRY PA | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $350,000–1 million | GIBBS INTERNATIONAL, INC. | SPARTANBURG, SC | Pinnacle Bank |
| $150,000–350,000 | GOMEZ IBARRA LLC | SPARTANBURG, SC | Wells Fargo Bank, National Association |
| $1–2 million | GRACE MANAGEMENT GROUP, LLC | SPARTANBURG, SC | Truist Bank |
| $150,000–350,000 | GREEN RIVER CABINS, LLC | SPARTANBURG, SC | Synovus Bank |
| $350,000–1 million | GUARDIAN RESEARCH NETWORK, INC. | SPARTANBURG, SC | The Park National Bank |
| $1–2 million | GUY ROOFING, INC. | SPARTANBURG, SC | Ameris Bank |
| $150,000–350,000 | HABITAT FOR HUMANITY OF SPARTANBURG INC | SPARTANBURG, SC | Truist Bank |
| $350,000–1 million | HALLIDAY SCHWARTZ & CO | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $350,000–1 million | HARRISON WHITE, PC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | HENDERSON, BRANDT & VIETH, P.A. | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $1–2 million | HIGH POINT ACADEMY INC | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | HODGE & LANGLEY LAW FIRM, P.C. | SPARTANBURG, SC | The Park National Bank |
| $350,000–1 million | HOLCOMBE BOMAR PA | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | HOLCOMBE, HOLTZCLAW & RAVAN, LLC | SPARTANBURG, SC | SouthState Bank, National Association |
| $350,000–1 million | HOPE CENTER FOR CHILDREN | SPARTANBURG, SC | Truist Bank |