| $150,000–350,000 | CREEK HOUSE SEAFOOD & GRILL, LLC) | KNOXVILLE, TN | SmartBank |
| $150,000–350,000 | CRU, LLC | KNOXVILLE, TN | Citizens Bank |
| $150,000–350,000 | CRUZE-BHATTI, LLC | KNOXVILLE, TN | Citizens National Bank |
| $150,000–350,000 | CSI FIRE EQUIPMENT, LLC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | CUSTOM FABRICATION SERVICES LLC | KNOXVILLE, TN | Pinnacle Bank |
| $2–5 million | CUSTOM FOODS OF AMERICA, INC | KNOXVILLE, TN | Truist Bank |
| $150,000–350,000 | CUSTOMER SERVICE ELECTRIC SUPPLY, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | D JIMMY BRINIAS | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | DALEN PRODUCTS INC | KNOXVILLE, TN | Truist Bank |
| $350,000–1 million | DALTON COLLISION, INCORPORATED | KNOXVILLE, TN | Bank of Tennessee |
| $350,000–1 million | DAVID'S CARPET SALES, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | DB SUBS, LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | DE MAXIMIS DATA MANAGEMENT SOLUTIONS, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $1–2 million | DE MAXIMIS, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | DEAD END BBQ, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | DEBORAH L. CURLEE COMMUNICATION CONSULTANTS, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | DEGA CATERING INC | KNOXVILLE, TN | Truist Bank |
| $1–2 million | DEL-AIR MECHANICAL CONTRACTORS, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | DEMPSTER POURED FOUNDATIONS, LLC | KNOXVILLE, TN | Bank of Tennessee |
| $350,000–1 million | DENARK CONSTRUCTION, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | DENCO HOLDINGS, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $1–2 million | DENTAL ASSOCIATES OF EAST TENNESSEE, PLLC | KNOXVILLE, TN | KeyBank National Association |
| $350,000–1 million | DERMATOPATHOLOGY PARTNERS PC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | DESIGN AND CONSTRUCTION SERVICES INC | KNOXVILLE, TN | Citizens Bank |
| $150,000–350,000 | DESIGN INNOVATION ARCHITECTS INC | KNOXVILLE, TN | Bank of Tennessee |
| $350,000–1 million | DESIGNSENSORY, INC. | KNOXVILLE, TN | First-Citizens Bank & Trust Company |
| $1–2 million | DICK BROADCASTING COMPANY, INC. OF TENNESSEE | KNOXVILLE, TN | Pinnacle Bank |
| $5–10 million | DIOCESE OF KNOXVILLE | KNOXVILLE, TN | Regions Bank |
| $150,000–350,000 | DISABILITY ADVANTAGE GROUP | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | DIVERSE CONCEPTS LLC | KNOXVILLE, TN | SmartBank |
| $150,000–350,000 | DIXIE KITCHEN DISTRIBUTORS, INC. | KNOXVILLE, TN | Truist Bank |
| $150,000–350,000 | DMGX, LLC | KNOXVILLE, TN | First Peoples Bank of Tennessee |
| $350,000–1 million | DML SUBS LLC | KNOXVILLE, TN | Citizens National Bank |
| $350,000–1 million | DOCTORSMANAGEMENT, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | DON TACO, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | DOVER SIGNATURE PROPERTIES, INCORPORATED | KNOXVILLE, TN | Citizens Bank |
| $150,000–350,000 | DRS. BLACK & BENTON, P. S. C. | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | DUACARRIER ELECTRONICS TECHNOLOGY, INC | KNOXVILLE, TN | Regions Bank |
| $350,000–1 million | DUNCAN & SONS BUILDING MAINTENANCE, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | DUO-FAST OF KNOXVILLE, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | DYNAMIC SOLUTIONS, LLC | KNOXVILLE, TN | FirstBank |
| $2–5 million | EAGLE DISTRIBUTING COMPANY, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $1–2 million | EAR, NOSE & THROAT CONSULTANTS OF EAST TN, PC | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | EARNEST ENTERPRISES, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | EARTHADELIC ENTERPRISES LLC | KNOXVILLE, TN | SmartBank |
| $350,000–1 million | EAST GARDEN, INC. | KNOXVILLE, TN | Truist Bank |
| $150,000–350,000 | EAST TENNESSEE FOUNDATION | KNOXVILLE, TN | Truist Bank |
| $150,000–350,000 | EAST TENNESSEE PEDIATRIC DENTISTRY PLLC | KNOXVILLE, TN | First-Citizens Bank & Trust Company |
| $150,000–350,000 | EAST TENNESSEE RADIATION ONCOLOGY, P.C. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | EAST TENNESSEE SPINE & SPORT, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | EAST TENNESSEE SUBWAY LLC | KNOXVILLE, TN | Truist Bank |
| $150,000–350,000 | EASTERN TENNESSEE SUBWAY DEVELOPMENT | KNOXVILLE, TN | Truist Bank |
| $150,000–350,000 | EASTERN TENNESSEE TANNING LLC | KNOXVILLE, TN | Truist Bank |
| $2–5 million | EDFINANCIAL SERVICES, LLC | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | EDGERTON MCAFEE ARMISTEAD & DAVIS PC | KNOXVILLE, TN | CapStar Bank, A Division of Old National Bank |
| $150,000–350,000 | EDISON ELECTRIC, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | EFRC ENTERPRISES, INC. | KNOXVILLE, TN | Regions Bank |
| $350,000–1 million | ELEATION FOODS, LLC | KNOXVILLE, TN | BancFirst |
| $350,000–1 million | ELECTRIC SERVICE COMPANY | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | ELKMONT EXCHANGE, LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | ELLIOTT'S TENNESSEE BOOT CO., LLC | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | EMERALD CHARTER SCHOOLS | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | EMERALD YOUTH FOUNDATION | KNOXVILLE, TN | Pinnacle Bank |
| $1–2 million | EMPIRE CORPORATION OF TENNESSEE INC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | EMR ASSOCIATES INC | KNOXVILLE, TN | First Horizon Bank |
| $1–2 million | ENDOCRINOLOGY CONSULTANTS OF EAST TENNESSEE, PLLC | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | ENERGY ELECTRIC, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | ENERNEX LLC | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | ENGINEERING SERVICES GROUP, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | ENROLLMENT FIRST, INC. | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | ENTERPRISE WASTE OIL INC | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | ERECTION SPECIALISTS, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | ERISA SERVICES, INC. | KNOXVILLE, TN | First-Citizens Bank & Trust Company |
| $150,000–350,000 | ESC AGILAIRE LLC | KNOXVILLE, TN | First Peoples Bank of Tennessee |
| $1–2 million | EVANS, RHEA & ASSOCIATES, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | EVENTBOOKING.COM, LLC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | F E TRAINER CONSTRUCTION, INC | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | FACULTY INTERNAL MEDICINE, PLLC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | FAITH PROMISE CHURCH | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | FAMILY FIRST HANDYMAN SERVICES LLC | KNOXVILLE, TN | UBank |
| $150,000–350,000 | FAMILY MEDICINE WEST PLLC | KNOXVILLE, TN | Truist Bank |
| $150,000–350,000 | FARMERS MUTUAL OF TENNESSEE | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | FARRAGUT HEALTH CARE CENTER LP | KNOXVILLE, TN | Truist Bank |
| $1–2 million | FELLOWSHIP EVANGELICAL FREE CHURCH | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | FENCO SUPPLY COMPANY, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | FINISH POINT TRIM AND MILLWORK | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | FINKLESTEIN, KERN, STEINBERG & CUNNINGHAM, PC | KNOXVILLE, TN | Pinnacle Bank |
| $2–5 million | FIRST BAPTIST CHURCH CONCORD | KNOXVILLE, TN | Truist Bank |
| $350,000–1 million | FIRST CHOICE LENDING SERVICES, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | FIRST SOUTHERN MORTGAGE CORP. OF TENNESSEE | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | FISHER TIRE COMPANY WEST INC | KNOXVILLE, TN | Truist Bank |
| $150,000–350,000 | FISHER TIRE COMPANY, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | FLEET TIRE, INC. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | FLORLINE SOUTH, INC. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | FLOWERS DIRECT, INC | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | FLYING HORSE LLC | KNOXVILLE, TN | SmartBank |
| $150,000–350,000 | FOCUS HEALTH GROUP, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | FORESTER BENEFITS MANAGEMENT, LLC | KNOXVILLE, TN | SmartBank |
| $350,000–1 million | FORT SANDERS OBSTETRICAL AND GYNECOLOGICAL GROUP PC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | FOUNDATION MORTGAGE COMPANY LLC | KNOXVILLE, TN | Mountain Commerce Bank |