| $150,000–350,000 | ROUSE CONSTRUCTION COMPANY | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | ROWE TRANSFER, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $2–5 million | ROYAL BRASS, INC. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | RUSSELL COACH COMPANY, LLC. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | RUSSELL PRINTING OPTIONS CORP | KNOXVILLE, TN | Regions Bank |
| $350,000–1 million | RUSTY WALLACE NISSAN LLC | KNOXVILLE, TN | Truist Bank |
| $150,000–350,000 | S & H CROWN & BRIDGE, INC. | KNOXVILLE, TN | First-Citizens Bank & Trust Company |
| $150,000–350,000 | S&S WHOLESALE TIRE OF KNOXVILLE, INC | KNOXVILLE, TN | Bank of Tennessee |
| $150,000–350,000 | SACHCHIDANAND G PAPERMILL, LLC | KNOXVILLE, TN | Citizens National Bank |
| $150,000–350,000 | SACHCHIDANAND HOTEL CEDAR BLUFF LLC | KNOXVILLE, TN | Citizens National Bank |
| $150,000–350,000 | SACHCHIDANAND HOTEL PAPERMILL INC | KNOXVILLE, TN | Citizens National Bank |
| $150,000–350,000 | SAFE HARBOR DEVELOPMENT LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | SAFET SYSTEMS, INC. | KNOXVILLE, TN | Truist Bank |
| $350,000–1 million | SAGEVIEW RETIREMENT PLAN CONSULTANTS, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | SALON VISAGE INC. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | SANDBERG FOOT HEALTH CENTER, PC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | SANDERS PACE ARCHITECTURE LLC | KNOXVILLE, TN | Peoples Bank of the South |
| $150,000–350,000 | SCHAADSOURCE, LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | SCHMID & RHODES CONSTRUCTION | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | SCOTT LABORATORY SOLUTIONS, LLC | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | SCOTTS PLUMBING COMPANY INC | KNOXVILLE, TN | First Horizon Bank |
| $2–5 million | SECURITY WALLS LLC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | SENIOR CITIZENS HOME ASSISTANCE SERVICE INC | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | SEQUOYAH HILLS PRESBYTERIAN CHURCH (THE) | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | SEQUOYAH SWIMMING POOLS, INC. | KNOXVILLE, TN | First Horizon Bank |
| $1–2 million | SERTOMA CENTER, INCORPORATED | KNOXVILLE, TN | First Horizon Bank |
| $1–2 million | SERVICE ONE, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | SHADES OF DEVELOPMENT | KNOXVILLE, TN | Itria Ventures LLC |
| $350,000–1 million | SHADES UNLIMITED, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | SHAFER INSURANCE AGENCY, INC. | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | SHELTON COMMUNICATIONS GROUP INC | KNOXVILLE, TN | SmartBank |
| $150,000–350,000 | SHERRILL HILLS RETIREMENT COMMUNITY LLC | KNOXVILLE, TN | Union Bank and Trust Company |
| $150,000–350,000 | SHIELD AND BUCKLER SECURITY, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | SHIELDS ELECTRONICS SUPPLY INC | KNOXVILLE, TN | Truist Bank |
| $2–5 million | SHONEY'S OF KNOXVILLE, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | SIBYL WRAY, M.D. NEUROLOGY, P.C. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | SIGN CO, INC. | KNOXVILLE, TN | SouthEast Bank |
| $150,000–350,000 | SILVER PHOENIX LLC | KNOXVILLE, TN | Wilmington Savings Fund Society, FSB |
| $150,000–350,000 | SILVERS PLUMBING & MECHANICAL, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | SKILLED SERVICES QUALITY CONSTRUCTION, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $2–5 million | SKYLINE TRANSPORTATION, INC. | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | SMALLEY MANUFACTURING COMPANY, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | SMART AUTO, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | SMITH2OGLE, LLC | KNOXVILLE, TN | SmartBank |
| $1–2 million | SMOKEY MOUNTAIN TOPS, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | SMOKY MOUNTAIN BLUE MOOSE LLC | KNOXVILLE, TN | SmartBank |
| $350,000–1 million | SMOKY MOUNTAIN LOGISTICS | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | SMOKY MOUNTAIN OBSERVATION WHEEL INVESTORS, LLC | KNOXVILLE, TN | SmartBank |
| $350,000–1 million | SOCCER SENORITAS LLC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | SOFTING, INC | KNOXVILLE, TN | Truist Bank |
| $150,000–350,000 | SONIC EAST, INC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | SONIC EAST, L.P. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | SONIRAC IS BACK LLC | KNOXVILLE, TN | SmartBank |
| $150,000–350,000 | SOUTHEAST EXTERMINATING CO LLC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | SOUTHEAST SERVICE GROUP LLC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | SOUTHEAST TITLE & ESCROW LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | SOUTHEASTERN DERMATOLGY CONSULTANTS PC | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | SOUTHERN ALLIANCE FOR CLEAN ENERGY | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | SOUTHERN CRAFT BAR-B-QUE, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | SOUTHERN NATURAL FOODS, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | SOUTHERN REBAR & SUPPLIES, INC. | KNOXVILLE, TN | ServisFirst Bank |
| $150,000–350,000 | SOUTHLAND LANDSCAPES, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | SPA VISAGE LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | SPECIALTY SERVICE GROUP LLC | KNOXVILLE, TN | FirstBank |
| $150,000–350,000 | SPECIALTY TRANSPORT, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | SR MEDICAL SERVICES LLC | KNOXVILLE, TN | Truist Bank |
| $150,000–350,000 | ST. JOHN'S EPISCOPAL OF KNOXVILLE | KNOXVILLE, TN | SmartBank |
| $150,000–350,000 | STANDARD KITCHEN & BATH, INC | KNOXVILLE, TN | SmartBank |
| $150,000–350,000 | STANLEYS PLANT FARM DBA NONE | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | STARR EQUIPMENT CO., INC. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | STC FRANCHISEE MANAGEMENT GROUP LLC | KNOXVILLE, TN | Truist Bank |
| $150,000–350,000 | STEEL BUILDING ATTITUDES, INC. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | STEINER & ELLIS, PLLC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | STERLING & BIAGI, PLLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | STERLING WINDOW SYSTEMS, INC. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | STOKELY HOSPITALITY PROPERTIES, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | STOKES ELECTRIC COMPANY | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | STOKES WILLIAMS SHARP COPE & MANN PC | KNOXVILLE, TN | Bank of Tennessee |
| $150,000–350,000 | STONEHOUSE SOLUTIONS, INC. | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | STRATA ENVIRONMENTAL SERVICES, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | STRATEGIC CONSULTING SOLUTIONS, INC | KNOXVILLE, TN | TNBANK |
| $150,000–350,000 | STREAMLINE PRODUCTIONS, LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | STUDIO FOUR DESIGN, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $1–2 million | SUB SOUTH, LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | SUB TENN LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | SUBWAY SANDWICHES & SALADS LLC | KNOXVILLE, TN | Truist Bank |
| $150,000–350,000 | SULLIVANS AT ROCKY HILL, INC. | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | SUMMIT GENERAL CONTRACTORS, INC. | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | SUMMIT VIEW OF FARRAGUT LLC | KNOXVILLE, TN | Truist Bank |
| $350,000–1 million | SUN ELECTRIC COMPANY OF TENNESSEE INC | KNOXVILLE, TN | SmartBank |
| $1–2 million | SUPER BEE HOLDINGS, LLC | KNOXVILLE, TN | CapStar Bank, A Division of Old National Bank |
| $350,000–1 million | SUPERIOR PAVEMENT MARKING, INC. | KNOXVILLE, TN | CapStar Bank, A Division of Old National Bank |
| $2–5 million | SUPERIOR STEEL, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | SWEET P'S BARBEQUE AND SOUL HOUSE LLC | KNOXVILLE, TN | Pinnacle Bank |
| $1–2 million | SWIFT INDUSTRIAL POWER INC | KNOXVILLE, TN | Regions Bank |
| $350,000–1 million | SWISS TECHNOLOGIES, INC | KNOXVILLE, TN | Bank of Tennessee |
| $150,000–350,000 | SYNERGY AUTO WASH LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | SYNERGY GOLF GROUP, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | SYSTEM IMPROVEMENTS INC | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | SYSTEMATIC POWER SOLUTIONS, LLC | KNOXVILLE, TN | Pinnacle Bank |