| $350,000–1 million | DU-MOR ENTERPRISES INC. | SAN ANTONIO, TX | American Momentum Bank |
| $350,000–1 million | DUGGER GRAFE SWANSON INC. | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | DUMAS HARDWARE COMPANY | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | DURA SOFTWARE, INC | SAN ANTONIO, TX | Texas Partners Bank |
| $350,000–1 million | DURRSET AMIGOS LTD. | SAN ANTONIO, TX | Jefferson Bank |
| $150,000–350,000 | DURY'S GUN SHOP, INC. | SAN ANTONIO, TX | Jefferson Bank |
| $150,000–350,000 | DUTCH BOY CLEANERS, INC. | SAN ANTONIO, TX | Sage Capital Bank |
| $1–2 million | DYNAMIC DOWNHOLE SERVICES, LLC | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | DYNAMIC MANAGEMENT MECHANICAL CONTRACTING, LLC | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | E I B CONTRACTORS, INC. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | E&D ENTERPRISE LLC | SAN ANTONIO, TX | Credit Human Federal Credit Union |
| $150,000–350,000 | E-LEGAL, INC. | SAN ANTONIO, TX | Bank of America, National Association |
| $1–2 million | E-Z BEL CONSTRUCTION COMPANY | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | E. L. SMITH PLUMBING & HEATING, INC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | E.F. MARKETING GROUP LLC | SAN ANTONIO, TX | Texas Heritage Bank |
| $350,000–1 million | E.J. WARD, INC. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | E.Z. MECHANICAL, INC. | SAN ANTONIO, TX | Jefferson Bank |
| $350,000–1 million | EAR INSTITUTE OF TEXAS, PA | SAN ANTONIO, TX | Texas Partners Bank |
| $350,000–1 million | EAR MEDICAL GROUP | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | EARTH CLASS MAIL INC | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | EAST & WEST TRUE LOVE ENTERPRISES, LLC | SAN ANTONIO, TX | Jefferson Bank |
| $2–5 million | EASTER SEALS REHABILITATION CENTER INC. | SAN ANTONIO, TX | Broadway National Bank |
| $1–2 million | ECHO HOSPICE, LLC | SAN ANTONIO, TX | Arvest Bank |
| $350,000–1 million | ECONOMY LUMBER YARD, INC | SAN ANTONIO, TX | First Source Federal Credit Union |
| $150,000–350,000 | EDI TRANSPORT | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | EDP CONCRETE CONTRACTOR LLC | SAN ANTONIO, TX | American Momentum Bank |
| $150,000–350,000 | EDUCARE CHILD CARE, INC | SAN ANTONIO, TX | Bank of America, National Association |
| $150,000–350,000 | EDUCATION INSPIRATION ONE, INC | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | EDUCATION MANAGEMENT SERVICES, LLC | SAN ANTONIO, TX | Jefferson Bank |
| $5–10 million | EDUCATION SERVICE CENTER REGION 20 | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | EEMPLOYERS SOLUTIONS II, INC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | EL CHAPARRAL REDLAND LLC. | SAN ANTONIO, TX | PlainsCapital Bank |
| $150,000–350,000 | EL JARRO DE ARTURO | SAN ANTONIO, TX | Zions Bank, A Division of |
| $1–2 million | EL PRADO STONE, LP | SAN ANTONIO, TX | TransPecos Banks, SSB. |
| $150,000–350,000 | EL TIPICO ENTERPRISES, INC. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | EL TROPICANO HOTEL, LLC | SAN ANTONIO, TX | Vantage Bank Texas |
| $150,000–350,000 | ELECTROCHEMICAL OXYGEN CONCEPTS, INC. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | ELEVATED ENTERTAINMENT, LLC | SAN ANTONIO, TX | Bank OZK |
| $150,000–350,000 | ELEVATED RESTAURANT GROUP, L.P. | SAN ANTONIO, TX | Bank OZK |
| $150,000–350,000 | ELITE CASTLE RESOURCES LLC | SAN ANTONIO, TX | Truist Bank |
| $150,000–350,000 | ELITE LAWN & LANDSCAPING LLC | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | ELLA S.A. CONTRACTING, LP | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | ELLEN W. LIN MDPA | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | ELLIS INSURANCE AGENCY, INC | SAN ANTONIO, TX | Prosperity Bank |
| $150,000–350,000 | ELLISON DRIVE ANIMAL HOSPITAL INC | SAN ANTONIO, TX | Wells Fargo Bank, National Association |
| $350,000–1 million | ELM LOGISTICS, LLC | SAN ANTONIO, TX | Broadway National Bank |
| $2–5 million | EMBREY MANAGEMENT SERVICES, LTD | SAN ANTONIO, TX | Texas Capital Bank |
| $150,000–350,000 | EMERALD OAKS RETIREMENT COMMUNITY, LLC | SAN ANTONIO, TX | Union Bank and Trust Company |
| $150,000–350,000 | EMILY R. PINEDA, M.D., P.A. | SAN ANTONIO, TX | Frost Bank |
| $2–5 million | EN SU CASA PRIMARY HOME CARE SERVICE, INC. | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | ENCINO AUTOMATION, LLC | SAN ANTONIO, TX | Security State Bank & Trust |
| $350,000–1 million | ENCORE SUPPORT SYSTEMS, LLC | SAN ANTONIO, TX | Fifth Third Bank |
| $150,000–350,000 | ENDEAVORS UNLIMITED, INC. | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | ENDOCRINOLOGY-NUCLEAR MEDICINE ASSOCIATES, P. A. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | ENDURA ADVISORY GROUP, LTD | SAN ANTONIO, TX | Jefferson Bank |
| $350,000–1 million | ENGINEERING DYNAMICS, INCORPORATED | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | ENROLLMENT RESEARCH ASSOCIATES LLC | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $350,000–1 million | ENTCASA MANAGEMENT SERVICES, LLC | SAN ANTONIO, TX | Zions Bank, A Division of |
| $150,000–350,000 | EPILEPSY FOUNDATION CENTRAL & SOUTH TEXAS | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | EQUIMAX MANAGEMENT, LC | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | EQUIP ENTERPRISES INC | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | ERICSTAD INC. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | ERT LIGHTING & SALES INC | SAN ANTONIO, TX | Independent Bank d/b/a Independent Financial |
| $350,000–1 million | ESC CONSULTANTS, INC. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | ESCAMILLA & PONECK, LLP | SAN ANTONIO, TX | Vantage Bank Texas |
| $150,000–350,000 | ESPADA PERSONNEL MANAGEMENT, LLC | SAN ANTONIO, TX | Zions Bank, A Division of |
| $350,000–1 million | ESPEY & ASSOCIATES, PC | SAN ANTONIO, TX | Third Coast Bank |
| $350,000–1 million | ESQUIRE TAVERN MANAGEMENT LLC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | ESSY QUALITY HEALTHCARE INC | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | ESTIA, INC. | SAN ANTONIO, TX | American Bank, National Association |
| $150,000–350,000 | EURASIAN IMPORTS INC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | EVANS, ROWE & HOLBROOK, P.C. | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | EVAPOCORE, INC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | EVERGREEN EXHIBITION LTD LLP | SAN ANTONIO, TX | Cadence Bank |
| $350,000–1 million | EVO PARTNERS, LP | SAN ANTONIO, TX | Lone Star Capital Bank, National Association |
| $350,000–1 million | EVOQUE GROUP LLC | SAN ANTONIO, TX | Texas Partners Bank |
| $350,000–1 million | EVT INC | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | EXECUPAY, INC. | SAN ANTONIO, TX | Zions Bank, A Division of |
| $150,000–350,000 | EXPRESS INFORMATION SYSTEMS INC. | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | EXPRESS INFORMATION SYSTEMS, INC. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | F. A. MCCOMAS, INC | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | F. A. NUNNELLY COMPANY | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | F. GUERRA DEBERRY, L.L.C. | SAN ANTONIO, TX | Sunflower Bank National Association |
| $150,000–350,000 | FAB STAFFING, LLC | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | FACIAL & OCULOPLASTIC SURGERY CENTER OF TEXAS, PLLC | SAN ANTONIO, TX | Vantage Bank Texas |
| $150,000–350,000 | FACILITY PROGRAMMING LTD | SAN ANTONIO, TX | Texas Capital Bank |
| $150,000–350,000 | FACILITY RX LLC | SAN ANTONIO, TX | Jefferson Bank |
| $150,000–350,000 | FAD-TX LLC | SAN ANTONIO, TX | Texas Partners Bank |
| $150,000–350,000 | FAK COMMERCIAL PAINTING INC | SAN ANTONIO, TX | Wells Fargo Bank, National Association |
| $150,000–350,000 | FALCONA MANAGEMENT & TECHNOLOGY, LLC | SAN ANTONIO, TX | Bank Independent |
| $5–10 million | FAMILY ENDEAVORS, INC. | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | FAMILY HEALTH OF SOUTH TEXAS PA | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | FAMILY HEALTH OF SOUTH TEXAS, PA | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | FAMILY MEDICAL HOME, PLLC | SAN ANTONIO, TX | First Source Federal Credit Union |
| $350,000–1 million | FAMILY SERVICE ASSOCIATION OF SAN ANTONIO, INC. | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | FAMILY VIOLENCE PREVENTION SERVICES INC. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | FAR SOUTH MINING, LLC | SAN ANTONIO, TX | Vantage Bank Texas |
| $150,000–350,000 | FAZZONE DEVELOPMENT CO FOR FAZ | SAN ANTONIO, TX | First United Bank and Trust Company |
| $2–5 million | FBD PARTNERSHIP, LP | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | FD CONCRETE LLC | SAN ANTONIO, TX | American Momentum Bank |