| $150,000–350,000 | EXPRESS FAMILY CARE LLC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | EXTREME DESIGN GROUP, INC. | ROANOKE, VA | Bank of Botetourt |
| $350,000–1 million | EYE CARE AND SURGERY PC | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | EZ RAMPZ, INC. | ROANOKE, VA | Atlantic Union Bank |
| $350,000–1 million | F & S BUILDING INNOVATIONS, INC. | ROANOKE, VA | Freedom First FCU |
| $150,000–350,000 | F.A.C.T. CONSTRUCTION LLC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | FAH LLC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | FALLETTA ENTERPRISES, INC. | ROANOKE, VA | Greater Nevada CU |
| $1–2 million | FINK'S JEWELERS INC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | FIREFLI MEDIA LLC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | FIRST BAPTIST CHURCH OF ROANOKE INC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | FIRST CHOICE TITLE SERVICES, LLC | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | FIRST FOUR PETROLEUM GROUP LLC | ROANOKE, VA | Atlantic Union Bank |
| $2–5 million | FLEETMASTER EXPRESS, INC. | ROANOKE, VA | Pinnacle Bank |
| $1–2 million | FOOT LEVELERS INC. | ROANOKE, VA | Bank of Botetourt |
| $150,000–350,000 | FORTUNATO HOLDINGS LLC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | FORTUNATO HOLDINGS LLC | ROANOKE, VA | Atlantic Union Bank |
| $350,000–1 million | FOTI, FLYNN, LOWEN & COMPANY, A PROFESSIONAL CORPORATION | ROANOKE, VA | Freedom First FCU |
| $1–2 million | FRANK CHERVAN, INC. | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | FRANKL MILLER WEBB & MOYERS | ROANOKE, VA | Truist Bank |
| $350,000–1 million | FRITH ANDERSON & PEAKE PC | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $350,000–1 million | GASTROENTEROLOGY CONSULTANTS OF SOUTHWEST VIRGINIA, INC. | ROANOKE, VA | First Bank |
| $150,000–350,000 | GBSR ATTORNEYS, LLP | ROANOKE, VA | Freedom First FCU |
| $150,000–350,000 | GENERAL SALES OF VIRGINIA, INC. | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | GENERATION SOLUTIONS PERSONAL CARE OF ROANOKE LLC | ROANOKE, VA | Bank of the James |
| $2–5 million | GENTRY LOCKE RAKES & MOORE LLP | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | GEORG NORTH AMERICA INC | ROANOKE, VA | Wells Fargo Bank, National Association |
| $150,000–350,000 | GIRL SCOUTS OF VIRGINIA SKYLINE COUNCIL, INC. | ROANOKE, VA | The First Bank and Trust Company |
| $150,000–350,000 | GLENN ROBINSON CATHEY MEMMER & SKAFF PLC | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | GLENN, FELDMANN, DARBY & GOODLATTE, APROFESSIONAL CORPORATIO | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $350,000–1 million | GOOD SAMARITAN HOSPICE INC. | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $350,000–1 million | GREENVILLE OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | GREGORY PALLET AND LUMBER LLC | ROANOKE, VA | Skyline National Bank |
| $150,000–350,000 | GREYSTAR CONSTRUCTION GROUP LLC | ROANOKE, VA | Bank of Botetourt |
| $350,000–1 million | H.L. LAWSON & SONS, INC. | ROANOKE, VA | Bank of Botetourt |
| $150,000–350,000 | HABITAT FOR HUMANITY IN THE ROANOKE VALLEY, INC. | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | HALL COMMUNITY SERVICES, INC. | ROANOKE, VA | Freedom First FCU |
| $350,000–1 million | HAMPDEN OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | HAMPTON IL OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | HANGING ROCK ANIMAL HOSPITAL, INC. | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | HANNABASS & ROWE, INC. | ROANOKE, VA | First Bank |
| $350,000–1 million | HANOVER OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | HARBOUR VIEW HARMONY MANAGEMENT, LLC | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | HARMONY SENIOR SERVICES, LLC | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | HARRIS OFFICE FURNITURE CO. INC. | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | HAWK ADVISERS INC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | HB REHAB SUPPLIES, INC. | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | HEAD 2 HEAD INC. | ROANOKE, VA | Atlantic Union Bank |
| $1–2 million | HIGHWAY MOTORS, INCORPORATED | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | HONEYTREE EARLY LEARNING CENTERS, INC. | ROANOKE, VA | Select Bank |
| $150,000–350,000 | HUFFMAN & KREGER FAMILY DENTISTRY PLLC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | HUGHES ASSOCIATES ARCHITECTS & ENGINEERS | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | HUNTING HILLS COUNTRY CLUB INC. | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | HYPERGEN, INC. | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | IB OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | INPHASE | ROANOKE, VA | Village Bank |
| $150,000–350,000 | INTERACTIVE DESIGN INC. | ROANOKE, VA | Freedom First FCU |
| $150,000–350,000 | INTOPRINT TECHNOLOGIES, INC. | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | IT'S ABOUT TIME, INC. | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | JACK ST. CLAIR INC. | ROANOKE, VA | Freedom First FCU |
| $150,000–350,000 | JANITORIAL & MAINTENANCE SOLUTIONS INC. | ROANOKE, VA | Intuit Financing Inc. |
| $150,000–350,000 | JEFFERSON CENTER FOUNDATION LTD | ROANOKE, VA | Atlantic Union Bank |
| $1–2 million | JEFFERSON SURGICAL CLINIC INC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | JOE BANDY AND SON INC. | ROANOKE, VA | Truist Bank |
| $350,000–1 million | JOHNSON CURRAN OPTOMETRY CENTERS PC | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | JOHNSON ORTHODONTICS, LTD | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | JOHNSON, AYERS & MATTHEWS, P.L.C. | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | JUSTICE ENERGY COMPANY INC | ROANOKE, VA | Pendleton Community Bank, Inc. |
| $150,000–350,000 | KBS ANALYTICS, LLC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | KEGLEY ELECTRIC COMPANY LLC | ROANOKE, VA | First Bank |
| $350,000–1 million | KELTECH, INC | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | KELTRON OF VIRGINIA, INC. | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $350,000–1 million | KENNEDY BUSINESS SERVICES LTD | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | KING, SHORES & PRESTON CPAS, LLC | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $350,000–1 million | KREIDER MECHANICAL INC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | L-M-C SAFETY BARRICADE CORPORATION | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | LAND & SEA RESTAURANT CO. LLC | ROANOKE, VA | Atlantic Union Bank |
| $1–2 million | LANFORD BROTHERS CO INC | ROANOKE, VA | Truist Bank |
| $350,000–1 million | LAW OFFICES OF DANIEL L. CRANDALL AND ASSOCIATES, P.C. | ROANOKE, VA | Pinnacle Bank |
| $2–5 million | LAWRENCE COMPANIES INC. | ROANOKE, VA | Select Bank |
| $350,000–1 million | LEE HARTMAN AND SONS INC | ROANOKE, VA | Truist Bank |
| $150,000–350,000 | LEE KESLER CONSTRUCTION, INC. | ROANOKE, VA | Bank of Botetourt |
| $150,000–350,000 | LEISURE MEDIA360 INC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | LEISUREMEDIA360 INC. | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | LIFE ACADEMY OF THE ROANOKE VALLEY | ROANOKE, VA | Bank of Botetourt |
| $150,000–350,000 | LITTLE BIZ, INC. | ROANOKE, VA | The National Bank of Blacksburg |
| $150,000–350,000 | LOCAL OFFICE ON AGING, INC. | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | LOCAL ROOTS CAFE, LLC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | LONGVIEW MANAGEMENT, LLC | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | LORTON OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | LUCAS & KITE, PLC | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | LUCAS PHYSICAL THERAPY INC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | LUMSDEN ASSOCIATES, P.C. | ROANOKE, VA | Truist Bank |
| $2–5 million | LUTHERINE FAMILY SERVICES OF VIRGINIA, INC. | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | LYNCH DICKEY & SINGLETON DENTISTS INC. | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $2–5 million | MACADO'S INC. | ROANOKE, VA | Atlantic Union Bank |
| $2–5 million | MACADOS INC | ROANOKE, VA | Atlantic Union Bank |
| $1–2 million | MAGIC CITY MOTOR CORPORATION | ROANOKE, VA | Atlantic Union Bank |
| $350,000–1 million | MAINSTREAM MENTAL HEALTH SERVICES, INC. | ROANOKE, VA | Bank of Botetourt |
| $150,000–350,000 | MARIO INDUSTRIES OF VIRGINIA, INC. | ROANOKE, VA | Pinnacle Bank |