| $150,000–350,000 | 1912 GRILL INC. | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | 202 SOCIAL HOUSE INC. | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | 419 WEST RESTAURANT CO. LLC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | 611 LLC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | AAA AUTO REPAIR, INC | ROANOKE, VA | Atlantic Union Bank |
| $350,000–1 million | ABBOTT BUS LINES INC | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | ACCELERATION POINT, LLC | ROANOKE, VA | First Bank |
| $150,000–350,000 | ACCESS, INC. | ROANOKE, VA | Freedom First FCU |
| $350,000–1 million | ACTION INSTALLERS INC | ROANOKE, VA | Truist Bank |
| $1–2 million | ACV INC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | AIR MECHANICAL SOLUTIONS, INC. | ROANOKE, VA | Pinnacle Bank |
| $2–5 million | ALCOVA MORTGAGE LLC | ROANOKE, VA | Truist Bank |
| $350,000–1 million | ALLEGHENY CONSTRUCTION COMPANY INC. | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | AMERICAN NATIONAL UNIVERSITY OF TENNESSEE INC. | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | ANDERSON & REED LLP | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $350,000–1 million | ANDREW HENRITZE DDS PLLC | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | ANSTEY HODGE ADVERTISING GROUP INC | ROANOKE, VA | Truist Bank |
| $150,000–350,000 | ARCH ROANOKE | ROANOKE, VA | Freedom First FCU |
| $150,000–350,000 | ARELLANO VALLEY VIEW INC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | ASSISI ANIMAL CLINICS OF VIRGINIA | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | ASSOCIATES IN BRIEF THERAPY, INC. | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | AUDIOTRONICS INC | ROANOKE, VA | Atlantic Union Bank |
| $350,000–1 million | AUTOMOTIVE VENTURES INC | ROANOKE, VA | Bank of America, National Association |
| $350,000–1 million | AVIS CONSTRUCTION COMPANY, INC. | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | B&B MACHINE & TOOL INC. | ROANOKE, VA | Freedom First FCU |
| $2–5 million | BALZER AND ASSOCIATES, INC. | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $350,000–1 million | BB&C ENTERPRISES, LLC | ROANOKE, VA | Atlantic Union Bank |
| $350,000–1 million | BENEFIT PLAN ADMINISTRATORS INC | ROANOKE, VA | Atlantic Union Bank |
| $2–5 million | BERGLUND CHEVROLET | ROANOKE, VA | Atlantic Union Bank |
| $350,000–1 million | BERGLUND LUXURY ROA INC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | BERGLUND MANAGEMENT GROUP INC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | BLACK DOG SALVAGE, LLC | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $2–5 million | BLACKSTONE ENERGY LTD | ROANOKE, VA | MVB Bank, Inc. |
| $150,000–350,000 | BLUE MOUNTAIN SALES, INC. | ROANOKE, VA | Bank of Botetourt |
| $150,000–350,000 | BLUE RIDGE CATERING, INC. | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | BLUE RIDGE HEARING GROUP LLC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | BLUE RIDGE MOUNTAINS COUNCIL, BOY SCOUTS OF AMERICA, INC. | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | BLUE RIDGE PUBLIC TELEVISION, INC. | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | BLUE RIDGE SIGN & STAMP COMPANY INC. | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $2–5 million | BLUESTONE COKE, LLC | ROANOKE, VA | Pendleton Community Bank, Inc. |
| $150,000–350,000 | BONDOUGH, INC. | ROANOKE, VA | Bank of Botetourt |
| $150,000–350,000 | BONSACK BAPTIST CHURCH | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | BOWER HEATING AND AIR CONDITIONING INC | ROANOKE, VA | Truist Bank |
| $150,000–350,000 | BOYS & GIRLS CLUBS OF SOUTHWEST VIRGINIA INC. | ROANOKE, VA | Freedom First FCU |
| $150,000–350,000 | BRADLEY FREE CLINIC OF ROANOKE VALLEY | ROANOKE, VA | First Bank |
| $150,000–350,000 | BRAMBLETON IMPORTS INC. | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | BRENTWOOD OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | BRIDGEPORT OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | BRIGHT PERSONNEL & BUSINESS CONSULTANTS, INC | ROANOKE, VA | Atlantic Union Bank |
| $5–10 million | BROWN, EDWARDS & COMPANY, L.L.P. | ROANOKE, VA | Truist Bank |
| $150,000–350,000 | BUG MAN EXTERMINATING, INC. | ROANOKE, VA | Atlantic Union Bank |
| $350,000–1 million | BUNCOMBE OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | BUTLER PARACHUTE SYSTEMS, INC. | ROANOKE, VA | Pinnacle Bank |
| $1–2 million | C. M. C. SUPPLY, INC. | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $350,000–1 million | CARDINAL RUBBER &SEAL, INC. | ROANOKE, VA | Bank of Botetourt |
| $150,000–350,000 | CAVE SPRING AUTO BODY, INC. | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | CAVE SPRING VETERINARY CLINIC INC. | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | CERTIFIED MEDICAL REPRESENTATIVES INSTITUTE INC | ROANOKE, VA | Truist Bank |
| $350,000–1 million | CHANTILLY OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | CHAPTER 13 TRUSTEESHIP OF CHRISTOPHER MICALE | ROANOKE, VA | Virginia National Bank |
| $350,000–1 million | CHARLESTON OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | CHESAPEAKE OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | CHILD HEALTH INVESTMENT PARTNERSHIP INC. | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | CHILDREN'S TRUST FOUNDATION ROANOKE VALLEY, INC. | ROANOKE, VA | Freedom First FCU |
| $150,000–350,000 | CHURCH OF THE HOLY SPIRIT, INC. | ROANOKE, VA | Atlantic Union Bank |
| $350,000–1 million | CLARKE INVESTMENTS, LLC | ROANOKE, VA | Buckeye State Bank |
| $350,000–1 million | COLUMBIA AL OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | COMER ENTERPRISES INC | ROANOKE, VA | Highlands Community Bank |
| $150,000–350,000 | COMMUNITY HIGH SCHOOL OF THE ROANOKE VALLEY | ROANOKE, VA | Bank of Botetourt |
| $150,000–350,000 | COMMUNITY SCHOOL | ROANOKE, VA | First Bank |
| $150,000–350,000 | CONSOLIDATED CONSTRUCTION SERVICES INC. | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | COOK OUT ROANOKE INC | ROANOKE, VA | Truist Bank |
| $150,000–350,000 | CRAWFORD ENVIRONMENTAL SERVICES, LLC | ROANOKE, VA | United Community Bank |
| $350,000–1 million | CREDITOR'S COLLECTION SERVICE, INC. | ROANOKE, VA | Atlantic Union Bank |
| $350,000–1 million | CROSS, LAVINDER, QUINN & PARK DENTISTRY, P.L.L.C. | ROANOKE, VA | Bank of Botetourt |
| $350,000–1 million | CULLEN MANAGEMENT, LLC | ROANOKE, VA | The First Bank and Trust Company |
| $350,000–1 million | CUMBERLAND OPERATIONS, LLC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | CUSTOM TOOL AND MACHINE, INC. | ROANOKE, VA | Truist Bank |
| $150,000–350,000 | DEHAVEN TRANSPORTATION COMPANY, INC | ROANOKE, VA | Bank of Botetourt |
| $1–2 million | DEPAUL COMMUNITY RESOURCES | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | DESIGN RESOURCE SERVICES 360, INC | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $350,000–1 million | DESIGN RESOURCE SERVICES INCORPORATED | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $350,000–1 million | DOMINION AIR & MACHINERY CO | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | DOMINION DOOR AND HARDWARE INC. | ROANOKE, VA | Select Bank |
| $2–5 million | DOMINION HOLDINGS, INC. | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | DOMINION PATHOLOGY ASSOCIATES PC | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | DOUG & EVIE ENTERPRISES INC | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | DR.S HARRISON, BURCHETT AND RYAN DDS | ROANOKE, VA | Truist Bank |
| $350,000–1 million | DUNLOP HOUSE, LLC | ROANOKE, VA | Truist Bank |
| $350,000–1 million | E. C. PACE COMPANY, INC. | ROANOKE, VA | Pinnacle Bank |
| $150,000–350,000 | EDEN CUSTOM PROCESSING LLC | ROANOKE, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | EDWIN C. HALL ASSOCIATES, INC. | ROANOKE, VA | Freedom First FCU |
| $350,000–1 million | EGGLESTON & EGGLESTON, P.C. | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | EL RODEO ELECTRIC, INC. | ROANOKE, VA | Atlantic Union Bank |
| $150,000–350,000 | ELKNIRT ENTERPRISES LLC | ROANOKE, VA | Truist Bank |
| $150,000–350,000 | EMTECH LABORATORIES INC | ROANOKE, VA | Truist Bank |
| $350,000–1 million | ENDOCRINOLOGY ASSOCIATES, INC. | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | ENGLANDER TRANSPORTATION, INC. | ROANOKE, VA | Pinnacle Bank |
| $350,000–1 million | ESH SUPPORT SERVICES LLC | ROANOKE, VA | Cornerstone Bank |
| $350,000–1 million | EXCEL PROSTHETICS AND ORTHOTICS | ROANOKE, VA | First-Citizens Bank & Trust Company |