| $1–2 million | ROSIES RESTAURANTS INC. | HUNTSVILLE, AL | Regions Bank |
| $350,000–1 million | ROY SLEEP MEDICINE, INC | HUNTSVILLE, AL | South State Bank, National Association |
| $150,000–350,000 | ROYAL FUNERAL HOME, INC. | HUNTSVILLE, AL | Live Oak Banking Company |
| $350,000–1 million | SAINT JOHN PAUL II CATHOLIC HIGH SCHOOL | HUNTSVILLE, AL | Oakworth Capital Bank |
| $150,000–350,000 | SALON ALLURE INC. | HUNTSVILLE, AL | Synovus Bank |
| $150,000–350,000 | SALON GRAY, INC. | HUNTSVILLE, AL | BBVA USA |
| $150,000–350,000 | SAMMY T'S MUSIC HALL, L.L.C. | HUNTSVILLE, AL | Bank Independent |
| $150,000–350,000 | SAMOVAR GARDENS, LLC | HUNTSVILLE, AL | South State Bank, National Association |
| $150,000–350,000 | SAMPLES COMMERCIAL REAL ESTATE LLC | HUNTSVILLE, AL | IBERIABANK |
| $150,000–350,000 | SC HUNTSVILLE, INC. | HUNTSVILLE, AL | BBVA USA |
| $350,000–1 million | SCIENTIC, INC. | HUNTSVILLE, AL | Synovus Bank |
| $150,000–350,000 | SEAMAN, SHINKUNAS, & LINDGREN, PC | HUNTSVILLE, AL | ServisFirst Bank |
| $350,000–1 million | SEI GROUP, INC. | HUNTSVILLE, AL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | SERINA THERAPEUTICS, INC. | HUNTSVILLE, AL | BBVA USA |
| $150,000–350,000 | SERVICE STEEL, INC | HUNTSVILLE, AL | Synovus Bank |
| $150,000–350,000 | SEXTON WELDING SUPPLY CO INC | HUNTSVILLE, AL | BBVA USA |
| $150,000–350,000 | SHAGGY'S RESTAURANTS LLC | HUNTSVILLE, AL | Trustmark National Bank |
| $150,000–350,000 | SHANNON BROTHERS TILE INC | HUNTSVILLE, AL | First National Bank of Pulaski |
| $350,000–1 million | SHAPEFIDELITY INC | HUNTSVILLE, AL | ServisFirst Bank |
| $350,000–1 million | SHEARER & ASSOCIATES INC | HUNTSVILLE, AL | Regions Bank |
| $150,000–350,000 | SIMPLE HELIX, LLC | HUNTSVILLE, AL | Renasant Bank |
| $350,000–1 million | SINIARD TIMBERLAKE & LEAGUE PC | HUNTSVILLE, AL | Bryant Bank |
| $1–2 million | SJ&L CONTRACTOR LLC | HUNTSVILLE, AL | Bank of Lincoln County |
| $150,000–350,000 | SLATON CUSTOM HOMES | HUNTSVILLE, AL | ServisFirst Bank |
| $150,000–350,000 | SMITH ENTERPRISES, INC | HUNTSVILLE, AL | South State Bank, National Association |
| $150,000–350,000 | SMITH INFINITI OF HUNTSVILLE, L.L.C. | HUNTSVILLE, AL | Bank Independent |
| $150,000–350,000 | SONYA L WINTZELL DMD PC | HUNTSVILLE, AL | Renasant Bank |
| $150,000–350,000 | SOUTHBRIDGE LLC | HUNTSVILLE, AL | ServisFirst Bank |
| $150,000–350,000 | SOUTHEASTERN BUSINESS MACHINES, INC. | HUNTSVILLE, AL | Bryant Bank |
| $150,000–350,000 | SOUTHERN ATHLETIC CLUB LLC | HUNTSVILLE, AL | IBERIABANK |
| $150,000–350,000 | SOUTHERN COMFORT HVAC, LLC | HUNTSVILLE, AL | Premier Bank of the South |
| $150,000–350,000 | SOUTHERN FIDELITY MORTGAGE GROUP OF HUNTSVILLE, LLC | HUNTSVILLE, AL | Premier Bank of the South |
| $150,000–350,000 | SOUTHERN STATES FACILITIES SERVICES, LLC | HUNTSVILLE, AL | Merit Bank |
| $150,000–350,000 | SOUTHERN URBAN VINO, LLC | HUNTSVILLE, AL | Progress Bank and Trust |
| $350,000–1 million | SPA CONCEPTS INCORPORATED | HUNTSVILLE, AL | ServisFirst Bank |
| $350,000–1 million | SPACE CENTER HOTELS, LLC | HUNTSVILLE, AL | The Citizens National Bank of Meridian |
| $150,000–350,000 | SPECON SYSTEMS, INC | HUNTSVILLE, AL | Regions Bank |
| $2–5 million | SPORTSMED ORTHOPAEDIC SPECIALISTS, PC | HUNTSVILLE, AL | Regions Bank |
| $1–2 million | SPUR JOBS, INC. | HUNTSVILLE, AL | IBERIABANK |
| $150,000–350,000 | STANLEY GRAHAM CONSTRUCTION, LLC | HUNTSVILLE, AL | Premier Bank of the South |
| $350,000–1 million | STANLEY LANDSCAPING & CONSTRUCTION CO INC | HUNTSVILLE, AL | Progress Bank and Trust |
| $350,000–1 million | STAR DISCOUNT PHARMACY, INC | HUNTSVILLE, AL | Progress Bank and Trust |
| $350,000–1 million | STAR MARKET, INC. | HUNTSVILLE, AL | Progress Bank and Trust |
| $350,000–1 million | STARS HUNTSVILLE, LLC | HUNTSVILLE, AL | IBERIABANK |
| $150,000–350,000 | STEPHENS MILLIRONS, PC | HUNTSVILLE, AL | Progress Bank and Trust |
| $350,000–1 million | STEWART ELECTRIC CO INC | HUNTSVILLE, AL | ServisFirst Bank |
| $150,000–350,000 | STILL SERVING VETERANS | HUNTSVILLE, AL | FirstBank |
| $150,000–350,000 | STL CORPORATION | HUNTSVILLE, AL | ServisFirst Bank |
| $350,000–1 million | STONERIDGE HOMES INC | HUNTSVILLE, AL | Centennial Bank |
| $150,000–350,000 | STOVEHOUSE INC | HUNTSVILLE, AL | Bank Independent |
| $2–5 million | STRATA-G SOLUTIONS LLC | HUNTSVILLE, AL | ServisFirst Bank |
| $350,000–1 million | STRATAGEM SOLUTIONS INC | HUNTSVILLE, AL | Progress Bank and Trust |
| $1–2 million | STRATEGIC DEFENSE SOLUTIONS, LLC | HUNTSVILLE, AL | ServisFirst Bank |
| $150,000–350,000 | STREAMLINE AUTOMATION, LLC | HUNTSVILLE, AL | ServisFirst Bank |
| $150,000–350,000 | STREET SERVICES, INC. | HUNTSVILLE, AL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | STRONG ARM LLC | HUNTSVILLE, AL | IBERIABANK |
| $150,000–350,000 | STUTTS CORPORATION, INC. | HUNTSVILLE, AL | Progress Bank and Trust |
| $150,000–350,000 | SUCCESSUS LLC | HUNTSVILLE, AL | Progress Bank and Trust |
| $1–2 million | SULLIVAN STREET, LLC | HUNTSVILLE, AL | STAR Financial Bank |
| $350,000–1 million | SUMMIT 7 SYSTEMS, INC | HUNTSVILLE, AL | Synovus Bank |
| $2–5 million | SURGERY CENTER, JV | HUNTSVILLE, AL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | SYNTERVISION | HUNTSVILLE, AL | Cross River Bank |
| $2–5 million | SYSTEM DYNAMICS INTERNATIONAL INC. | HUNTSVILLE, AL | Synovus Bank |
| $5–10 million | SYSTEM STUDIES & SIMULATION, INC. | HUNTSVILLE, AL | Bank of America, National Association |
| $2–5 million | SYSTEMS PRODUCTS AND SOLUTIONS, INC | HUNTSVILLE, AL | Synovus Bank |
| $350,000–1 million | T&W OPERATIONS, INC. | HUNTSVILLE, AL | Byline Bank |
| $350,000–1 million | T-H MARINE SUPPLIES, LLC | HUNTSVILLE, AL | Cadence Bank, National Association |
| $150,000–350,000 | TACO MAMA | HUNTSVILLE, AL | ServisFirst Bank |
| $150,000–350,000 | TACO MAMA HUNTSVILLE, LLC | HUNTSVILLE, AL | ServisFirst Bank |
| $350,000–1 million | TATE SERVICES, INC. | HUNTSVILLE, AL | ServisFirst Bank |
| $2–5 million | TEC-MASTERS, INC. | HUNTSVILLE, AL | Synovus Bank |
| $350,000–1 million | TECHNICAL CONSULTING SERVICES, INC. | HUNTSVILLE, AL | ServisFirst Bank |
| $150,000–350,000 | TECHNICAL MICRONICS CONTROL,I | HUNTSVILLE, AL | Wilson Bank & Trust |
| $150,000–350,000 | TECHNOLOGY MANAGEMENT TRAINING GROUP, INC. | HUNTSVILLE, AL | Bryant Bank |
| $150,000–350,000 | TEKFIVE, INC | HUNTSVILLE, AL | South State Bank, National Association |
| $150,000–350,000 | TENDERS, INC. | HUNTSVILLE, AL | Merit Bank |
| $350,000–1 million | TENNESSEE VALLEY FENCE INC | HUNTSVILLE, AL | Bryant Bank |
| $350,000–1 million | TENNESSEE VALLEY OB/GYN CLINIC, P.C. | HUNTSVILLE, AL | Trustmark National Bank |
| $350,000–1 million | TENNESSEE VALLEY PAIN CONSULTANTS, PC | HUNTSVILLE, AL | Progress Bank and Trust |
| $350,000–1 million | THE ATLANTIC GROUP, LLC | HUNTSVILLE, AL | Progress Bank and Trust |
| $350,000–1 million | THE CANCER CENTER OF HUNTSVILLE PC | HUNTSVILLE, AL | ServisFirst Bank |
| $350,000–1 million | THE CENTER FOR COLON AND DIGESTIVE DISEASE, PC | HUNTSVILLE, AL | BBVA USA |
| $350,000–1 million | THE COMFORT GROUP OF ALABAMA | HUNTSVILLE, AL | Truxton Trust Company |
| $350,000–1 million | THE EYE CENTER SURGEONS AND ASSOCIATES, LLC | HUNTSVILLE, AL | ServisFirst Bank |
| $150,000–350,000 | THE HOUSE OF STAUNTON | HUNTSVILLE, AL | Synovus Bank |
| $150,000–350,000 | THE HUNTSVILLE ENDOSCOPY CENTER | HUNTSVILLE, AL | BBVA USA |
| $150,000–350,000 | THE HUTCHENS CO. INC | HUNTSVILLE, AL | ServisFirst Bank |
| $150,000–350,000 | THE LASER EYE CENTER, PC | HUNTSVILLE, AL | ServisFirst Bank |
| $350,000–1 million | THE LEDGES OF HUNTSVILLE, LTD | HUNTSVILLE, AL | Regions Bank |
| $350,000–1 million | THE LIOCE GROUP | HUNTSVILLE, AL | IBERIABANK |
| $150,000–350,000 | THE NATIONAL CHILDRENS ADVOCACY CENTER | HUNTSVILLE, AL | ServisFirst Bank |
| $5–10 million | THE ORTHOPAEDIC CENTER, PC | HUNTSVILLE, AL | Regions Bank |
| $1–2 million | THE REDSTONE MILITARY RETIREMENT RESIDENCE ASSOC | HUNTSVILLE, AL | Synovus Bank |
| $150,000–350,000 | THE RILEY BEHAVIORAL AND EDUCATION CENTER | HUNTSVILLE, AL | CB&S Bank |
| $150,000–350,000 | THE ROBERTS GROUP, INC. | HUNTSVILLE, AL | ServisFirst Bank |
| $350,000–1 million | THE ROCK FAMILY WORSHIP CENTER OF HUNTSVILLE, INC. | HUNTSVILLE, AL | Cadence Bank, National Association |
| $150,000–350,000 | THE SPA, LLC | HUNTSVILLE, AL | Cadence Bank, National Association |
| $1–2 million | THE SPENCER COMPANIES INCORPORATED | HUNTSVILLE, AL | Synovus Bank |
| $150,000–350,000 | THE STONECUTTER'S GUILD, INC. | HUNTSVILLE, AL | Bryant Bank |
| $150,000–350,000 | THE TRIDENT GROUP INC | HUNTSVILLE, AL | Progress Bank and Trust |