| $150,000–350,000 | SPIRES AND ASSOCIATES PA | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | SRA STRUCTURAL CONSULTANTS LLC | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | SS GREY II LLC DBA 10 TWENTY FIVE | FORT MYERS, FL | Wells Fargo Bank, National Association |
| $350,000–1 million | ST MARKS SURGICAL CENTER LLC | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | ST. FRANCIS XAVIER PARISH IN FORT MYERS, INC. | FORT MYERS, FL | The Northern Trust Company |
| $350,000–1 million | STANCEL CONCRETE INCORPORATED | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | STANLEY STEEMER OF LEE COUNTY INC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | STARLITE ELECTRIC LLC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | STARZ ACQUISITION LLC | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | STATEWIDE SECURITY ENFORCEMENT & INVESTIGATIONS INC. | FORT MYERS, FL | Regions Bank |
| $150,000–350,000 | STEPHEN E SMITH MD PA | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | STEVENS & LAYTON INC | FORT MYERS, FL | First Bank |
| $350,000–1 million | STEVENS CONSTRUCTION, INC | FORT MYERS, FL | Lake Michigan CU |
| $150,000–350,000 | STEWART & SONS INSURANCE, INC. | FORT MYERS, FL | Regions Bank |
| $350,000–1 million | STOKES MARINE, INC. | FORT MYERS, FL | Lake Michigan CU |
| $150,000–350,000 | STRATEGY MARKETING GROUP INC. | FORT MYERS, FL | BankUnited, National Association |
| $150,000–350,000 | STRICKLER BROS UNDERGROUND INC | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | STROEMER AND COMPANY LLC | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | STUDIO R.K., INC. | FORT MYERS, FL | Busey Bank |
| $350,000–1 million | STUDIOPLUS, LLC | FORT MYERS, FL | ServisFirst Bank |
| $150,000–350,000 | STULTZ INC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | SUMMERLIN BEND SURGERY CENTER LLP | FORT MYERS, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | SUMMERLIN IMAGING CENTER, LLC | FORT MYERS, FL | First Home Bank |
| $150,000–350,000 | SUMMIT CHRISTIAN SCHOOL INC | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | SUN BROADCASTING, INC. | FORT MYERS, FL | Bank of America, National Association |
| $350,000–1 million | SUN SPORTS CYCLE AND WATERCRAFT, INC. | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | SUNCOAST ALUMINUM FURNITURE, INC. | FORT MYERS, FL | First Florida Integrity Bank |
| $1–2 million | SUNCOAST CONTRACTORS SUPPLY, INC. | FORT MYERS, FL | Busey Bank |
| $150,000–350,000 | SUNIL MALKANI, M.D., P.A. | FORT MYERS, FL | Busey Bank |
| $350,000–1 million | SUNMAC STONE SPECIALISTS INC | FORT MYERS, FL | First-Citizens Bank & Trust Company |
| $1–2 million | SUNNYGROVE LANDSCAPE IRRIGATION & MAINTENANCE LLC | FORT MYERS, FL | Valley National Bank |
| $1–2 million | SUNNYGROVE LANDSCAPING & NURSERY, INC. | FORT MYERS, FL | Valley National Bank |
| $350,000–1 million | SUNSET AIR, INC. | FORT MYERS, FL | First Bank |
| $350,000–1 million | SUNSHINE RECYCLING SERVICES OF SWFL, LLC | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | SURGICAL SPECIALISTS OF SW FLORIDA | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $350,000–1 million | SURVIVAL ARMOUR, INC. | FORT MYERS, FL | Fifth Third Bank |
| $1–2 million | SUTHERLIN NISSAN OF FT MYERS INC | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | SWEET LIFE 6 LLC | FORT MYERS, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | SWFL DIGNOSTIC EMC SERVICE LLC | FORT MYERS, FL | Celtic Bank Corporation |
| $150,000–350,000 | T-CLIPS, INC. | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | T3 COMMUNICATIONS, INC. | FORT MYERS, FL | The Bank of San Antonio |
| $150,000–350,000 | TAG MEDIA GROUP LLC | FORT MYERS, FL | Live Oak Banking Company |
| $1–2 million | TARGET ROOFING AND SHEET METAL, INC. | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $350,000–1 million | TAYLOR CARPET ONE, INC | FORT MYERS, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | TEAM MANAGEMENT SYSTEMS, INC. | FORT MYERS, FL | Fifth Third Bank |
| $350,000–1 million | TEKRAM SERVICES LLC | FORT MYERS, FL | Bank of America, National Association |
| $350,000–1 million | TELESPECIALISTS LLC | FORT MYERS, FL | FineMark National Bank & Trust |
| $150,000–350,000 | TEMPCO PEST CONTROL, INC | FORT MYERS, FL | Charlotte State Bank & Trust |
| $150,000–350,000 | TEMPLE BETH EL OF FT. MYERS, INC | FORT MYERS, FL | Lake Michigan CU |
| $150,000–350,000 | TEVE INCORPORATED | FORT MYERS, FL | Valley National Bank |
| $350,000–1 million | THE ALESCO GROUP | FORT MYERS, FL | Synovus Bank |
| $150,000–350,000 | THE BEACHED WHALE INC. | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | THE BEST L.D.S OF COAST INC | FORT MYERS, FL | Regions Bank |
| $150,000–350,000 | THE BOAT PLACE OF NAPLES INC | FORT MYERS, FL | Wells Fargo Bank, National Association |
| $350,000–1 million | THE BOATHOUSE FORT MYERS LLC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | THE CLAM BAKE INC | FORT MYERS, FL | Kabbage, Inc. |
| $350,000–1 million | THE CLUB AT GATEWAY, LLC | FORT MYERS, FL | Synovus Bank |
| $350,000–1 million | THE CLUB AT RENAISSANCE LLC | FORT MYERS, FL | Kabbage, Inc. |
| $150,000–350,000 | THE DELLUTRI LAW GROUP, PA | FORT MYERS, FL | Bank OZK |
| $150,000–350,000 | THE DORCEY LAW FIRM, PLC | FORT MYERS, FL | First Florida Integrity Bank |
| $150,000–350,000 | THE HEIGHTS CENTER, INC. | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | THE HODGES GROUP INC. | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | THE MCLEROY GISME DEVELOPMENT GROUP LLC | FORT MYERS, FL | Celtic Bank Corporation |
| $350,000–1 million | THE MOTORCYCLE COMPANY LLC | FORT MYERS, FL | Comerica Bank |
| $150,000–350,000 | THE OLSON GROUP, INC. | FORT MYERS, FL | Fifth Third Bank |
| $150,000–350,000 | THE PHONESTORE USA INC | FORT MYERS, FL | Fifth Third Bank |
| $150,000–350,000 | THE SOUTHWEST FLORIDA SYMPHONY ORCHESTRA AND CHORUS ASSOCIATION, INC. | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | THE SPIRO GROUP, INC. | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | THE SUMMIT CHURCH, INC. | FORT MYERS, FL | First Florida Integrity Bank |
| $350,000–1 million | THE SYPERT INSTITUTE, PA | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | THERMAL DYNAMICS INTERNATIONAL, INC. | FORT MYERS, FL | Lake Michigan CU |
| $350,000–1 million | THOMAS EDISON & HENRY FORD WINTER ESTATES, INC. | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | THREAD SOURCE INC. | FORT MYERS, FL | BankUnited, National Association |
| $150,000–350,000 | TIBURON GROUP, LLC | FORT MYERS, FL | Suncoast CU |
| $150,000–350,000 | TIM M VERWEST DMD PA | FORT MYERS, FL | Synovus Bank |
| $1–2 million | TINCHER CONCRETE CONSTRUCTION INC | FORT MYERS, FL | First Horizon Bank |
| $350,000–1 million | TJF LLC | FORT MYERS, FL | Community National Bank & Trust of Texas |
| $350,000–1 million | TMCFM, INC. | FORT MYERS, FL | Comerica Bank |
| $350,000–1 million | TMT NAPLES LLC | FORT MYERS, FL | SmartBank |
| $150,000–350,000 | TMT SERVICES LLC | FORT MYERS, FL | Celtic Bank Corporation |
| $1–2 million | TOMAHAWK CONSTRUCTION LLC | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | TOP NOTCH CARPET CARE | FORT MYERS, FL | Suncoast CU |
| $350,000–1 million | TOTAL ELECTRIC CONTRACTING LLC | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | TOUCHING HEARTS HOME CARE SERVICES LLC | FORT MYERS, FL | Fundbox, Inc. |
| $150,000–350,000 | TRADE ADVANTAGE, CORP. | FORT MYERS, FL | Lake Michigan CU |
| $150,000–350,000 | TRAININGWHEEL, INC. | FORT MYERS, FL | Bank of America, National Association |
| $350,000–1 million | TRANQUILITY PLUMBING, INC. | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | TRI-CITY POOLS LLC | FORT MYERS, FL | First Federal Bank |
| $350,000–1 million | TRI-TOWN CONSTRUCTION, L.L.C. | FORT MYERS, FL | MidWestOne Bank |
| $1–2 million | TRICIRCLE PAVERS, INC. | FORT MYERS, FL | Bank OZK |
| $150,000–350,000 | TRIPLE J GRASSING, LLC | FORT MYERS, FL | Busey Bank |
| $150,000–350,000 | TROPIC ENTERPRISES LLC | FORT MYERS, FL | First Bank |
| $150,000–350,000 | TROPICAL ISLES MANAGEMENT SERVICE INC | FORT MYERS, FL | IBERIABANK |
| $1–2 million | TROYER BROTHERS FLORIDA INC | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | TRUSCAPES SW FLA INC | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | TUSCAN & COMPANY, PA | FORT MYERS, FL | First Bank |
| $350,000–1 million | U.S. SIGN AND MILL, INC. | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | UNDERGROUND UTILITIES GROUP INC | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | UNITED WAY OF LEE COUNTY | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | URBAN DELI | FORT MYERS, FL | Bank of America, National Association |