| $350,000–1 million | UNITED BROTHERS DEVELOPMENT CORPORATION | JACKSONVILLE, FL | Valley National Bank |
| $150,000–350,000 | UNITED RIGGING, INC. | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | UNITED SERVICE CONNECTION INC. | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | UNITED WAY OF NORTHEAST FLORIDA | JACKSONVILLE, FL | City National Bank of Florida |
| $350,000–1 million | UNIVERSITY BAPTIST CHURCH OF JACKSONVILLE, FLORIDA INC. | JACKSONVILLE, FL | TD Bank, National Association |
| $150,000–350,000 | UP-SIDE MANAGEMENT CO | JACKSONVILLE, FL | Navy FCU |
| $150,000–350,000 | URBAN AIR JACKSONVILLE LLC | JACKSONVILLE, FL | Byline Bank |
| $150,000–350,000 | URBAN MINING P.B.C. INC. | JACKSONVILLE, FL | First-Citizens Bank & Trust Company |
| $1–2 million | US ASSURE INSURANCE SERVICES OF FLORIDA INC | JACKSONVILLE, FL | City National Bank of Florida |
| $350,000–1 million | US PREVENTIVE MEDICINE INC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | USA TURNKEY MANAGEMENT INC | JACKSONVILLE, FL | Kabbage, Inc. |
| $150,000–350,000 | V PIZZA MANDARIN LLC | JACKSONVILLE, FL | South State Bank, National Association |
| $350,000–1 million | VAK-PAK, INC. | JACKSONVILLE, FL | South State Bank, National Association |
| $350,000–1 million | VALLENCOURT, INC. | JACKSONVILLE, FL | Synovus Bank |
| $150,000–350,000 | VANGUARD ELECTRICAL CONTRACTORS, INC. | JACKSONVILLE, FL | VyStar CU |
| $150,000–350,000 | VAPORNINE LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | VERNIS & BOWLING OF NORTH FLORIDA PA | JACKSONVILLE, FL | Centennial Bank |
| $5–10 million | VESTA PROPERTY SERVICES, INC | JACKSONVILLE, FL | Bank of America, National Association |
| $350,000–1 million | VETERANS HEALTHCARE SUPPLY SOLUTIONS, INC. | JACKSONVILLE, FL | Fifth Third Bank |
| $150,000–350,000 | VIGNEAUX CORPORATION | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | VISION MANUFACTURING TECHNOLOGIES INC | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $350,000–1 million | VISIONWORX, LLC | JACKSONVILLE, FL | Synovus Bank |
| $350,000–1 million | VIVERETTES PAINT & BODY SHOP INC | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | VOSS INCORPORATED | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | W C O ENTERPRISES | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $350,000–1 million | W GARDNER LLC | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | W.J. SAPP & SON, INC. | JACKSONVILLE, FL | Regions Bank |
| $150,000–350,000 | WACKOS TOO, INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | WADDINGTON AND SON ELECTRIC, CO | JACKSONVILLE, FL | PowerNet CU |
| $150,000–350,000 | WALKER BLOCK INC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | WALL TO WALL WINDOWS AND DOORS, LLC | JACKSONVILLE, FL | Regions Bank |
| $350,000–1 million | WARJON INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | WASABI-JACKSONVILLE, LLC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | WATERPROOFING SPECIALISTS INC. | JACKSONVILLE, FL | Heritage Bank, A Division of |
| $350,000–1 million | WATSON CONSTRUCTION GROUP, INC | JACKSONVILLE, FL | Regions Bank |
| $350,000–1 million | WATSON MORTGAGE CORP. | JACKSONVILLE, FL | First Federal Bank |
| $150,000–350,000 | WATSON TITLE SERVICES OF N FL INC | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | WAVE6, LLC | JACKSONVILLE, FL | Trustmark National Bank |
| $350,000–1 million | WAYCHOFF'S HEATING & AIR CONDITIONING INC. | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | WAYMAN ACADEMY OF THE ARTS INC. | JACKSONVILLE, FL | South State Bank, National Association |
| $150,000–350,000 | WAYMAN COMMUNITY DEVELOPMENT CORPORATION | JACKSONVILLE, FL | South State Bank, National Association |
| $350,000–1 million | WE INSURE GROUP INC | JACKSONVILLE, FL | South State Bank, National Association |
| $350,000–1 million | WE LOVE AVONDALE MELLOW, LLC | JACKSONVILLE, FL | Synovus Bank |
| $350,000–1 million | WEATHER ENGINEERS, INC. | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | WEAVER REALTY GROUP, LLC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | WEINZIERL ENTERPRISES INC. | JACKSONVILLE, FL | Flagship Bank |
| $150,000–350,000 | WELL-DONE HOME CARE, INC | JACKSONVILLE, FL | First Federal Bank |
| $350,000–1 million | WELLBOX INC. | JACKSONVILLE, FL | Western Alliance Bank |
| $150,000–350,000 | WESNIC SERVICES INC | JACKSONVILLE, FL | VyStar CU |
| $150,000–350,000 | WESTSIDE BAPTIST CHURCH OF JACKSONVILLE | JACKSONVILLE, FL | South State Bank, National Association |
| $350,000–1 million | WESTSIDE ELECTRIC, INC. | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | WG PITTS GROUP, INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | WHITE PUBLISHING COMPANY | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | WHITEHALL ORTEGA LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $350,000–1 million | WHITLEY STEEL CO. INC. | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | WICKED BARLEY BREWING COMPANY, LLC | JACKSONVILLE, FL | South State Bank, National Association |
| $1–2 million | WILLIAMS & ROWE COMPANY INC. | JACKSONVILLE, FL | South State Bank, National Association |
| $150,000–350,000 | WILLIAMS' PLANT NURSERY, INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | WILSON 17890, INC | JACKSONVILLE, FL | TD Bank, National Association |
| $150,000–350,000 | WING SLINGERS INC | JACKSONVILLE, FL | 121 Financial CU |
| $150,000–350,000 | WINGARD, LLC | JACKSONVILLE, FL | Cogent Bank |
| $150,000–350,000 | WINTAKE EMPLOYMENT SERVICES LLC | JACKSONVILLE, FL | VyStar CU |
| $150,000–350,000 | WIRED PEOPLE, INC. | JACKSONVILLE, FL | TD Bank, National Association |
| $150,000–350,000 | WJC INVESTMENTS, INC. | JACKSONVILLE, FL | BBVA USA |
| $350,000–1 million | WJCT, INC | JACKSONVILLE, FL | Regions Bank |
| $350,000–1 million | WOMEN'S CENTER OF JACKSONVILLE | JACKSONVILLE, FL | Valley National Bank |
| $150,000–350,000 | WOODCHUCKS COUNTRY STORE INC | JACKSONVILLE, FL | South State Bank, National Association |
| $2–5 million | WOODSMAN KITCHENS & FLOORS INC | JACKSONVILLE, FL | PNC Bank, National Association |
| $350,000–1 million | WORKPLACE SOLUTIONS INC | JACKSONVILLE, FL | IBERIABANK |
| $150,000–350,000 | WORKS OF B&L LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | WORLD IMPORTS U.S.A., INC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | WORLDWIDE DIESEL POWER, INC. | JACKSONVILLE, FL | American Express National Bank |
| $150,000–350,000 | WORLDWIDE PRODUCTION COMPANY, LLC | JACKSONVILLE, FL | Regions Bank |
| $150,000–350,000 | YANI A LLC | JACKSONVILLE, FL | VyStar CU |
| $150,000–350,000 | YASH CREATIONS INC | JACKSONVILLE, FL | Northeast Bank |
| $2–5 million | ZABATT ENGINE SERVICE, INC. | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | ZAREPHATH ACADEMY | JACKSONVILLE, FL | Regions Bank |
| $150,000–350,000 | ZIEG HOSPITALITY OF JACKSONVILLE, INC. | JACKSONVILLE, FL | Valley National Bank |
| $150,000–350,000 | ZISSER FAMILY LAW PLLC | JACKSONVILLE, FL | Ameris Bank |