| $2–5 million | DUVAL ASPHALT PRODUCTS, INC. | JACKSONVILLE, FL | Valley National Bank |
| $2–5 million | DUVAL FORD, LLC. | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | DUVAL GLASS & MIRROR INC | JACKSONVILLE, FL | BBVA USA |
| $1–2 million | DUVAL LANDSCAPE MAINTENANCE LLC | JACKSONVILLE, FL | Synovus Bank |
| $350,000–1 million | DUVAL MOTOR COMPANY, INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | DUVAL PAINT AND DECORATING, INC. | JACKSONVILLE, FL | Primesouth Bank |
| $350,000–1 million | DYNAMIC DENTAL SOLUTIONS, INC. | JACKSONVILLE, FL | First Federal Bank |
| $150,000–350,000 | E&A HEAVY HAULING INC | JACKSONVILLE, FL | VyStar CU |
| $350,000–1 million | E.F. LEA ELECTRICAL CONTRACTOR INC. | JACKSONVILLE, FL | South State Bank, National Association |
| $150,000–350,000 | E.G. PUMP CONTROLLS, INC. | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | E3 ELECTRIC OF NE FL INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | EAGERTON PLUMBING CO., INC | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | EAGLE CREST INC | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | EAGLE ELECTRIC INC | JACKSONVILLE, FL | Synovus Bank |
| $150,000–350,000 | EAGLE EYE ANESTHESIA INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | EAGLE'S VIEW ACADEMY INC | JACKSONVILLE, FL | South State Bank, National Association |
| $350,000–1 million | EARTH WORKS UNLIMITED OF FLORIDA, LLC | JACKSONVILLE, FL | First-Citizens Bank & Trust Company |
| $1–2 million | EARTHCORE INDUSTRIES, LLC | JACKSONVILLE, FL | Fifth Third Bank |
| $150,000–350,000 | EAST ARLINGTON GRACE LUTHERAN CHURCH INC | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | EAST COAST INSTITUTE FOR RESEARCH LLC | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | EASTERN WIRE PRODUCTS, INC. | JACKSONVILLE, FL | WebBank |
| $150,000–350,000 | EASY RENT INC | JACKSONVILLE, FL | Bank of America, National Association |
| $350,000–1 million | EBEL INC. | JACKSONVILLE, FL | Regions Bank |
| $150,000–350,000 | ECIR MEDICAL COMMUNICATIONS LLC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | ECONOMY CONTROL SYSTEMS, INC. | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $350,000–1 million | ECONOMY DENTURES MANAGEMENT SERVICES, LLC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | EDGEWOOD NURSING CENTER INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | EDMA SCHOOL LLC | JACKSONVILLE, FL | Regions Bank |
| $1–2 million | EDWARD WATERS COLLEGE INC | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | EDWARDS & RAGATZ P.A. | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | EDWARDS, COHEN, DAWSON, NOBLE & DAWES, P.A. | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | EFRON RESTAURANT GROUP LLC | JACKSONVILLE, FL | Regions Bank |
| $2–5 million | EISMAN & RUSSO INC | JACKSONVILLE, FL | South State Bank, National Association |
| $150,000–350,000 | EJEMMCO INC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | EK BIRKEN MASONRY INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | EL JEFE JAX LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | ELEVATE LIFE CHURCH INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | ELITE AC LLC | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $350,000–1 million | ELITE HOME HEALTH, LLC | JACKSONVILLE, FL | Cross River Bank |
| $350,000–1 million | ELITE PARKING SERVICES OF AMERICA INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | ELKINS CONSTRUCTION LLC | JACKSONVILLE, FL | Hancock Whitney Bank |
| $150,000–350,000 | ELLIS-MOORE CORPORATION | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | ELM INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | ELO RESTORATION INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | ELTONALAN, INCORPORATED | JACKSONVILLE, FL | First-Citizens Bank & Trust Company |
| $350,000–1 million | EMED URGENT AND PRIMARY CARE P.A. | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | EMERALD C'S DEVELOPMENT, INC. | JACKSONVILLE, FL | Community Bank of Mississippi |
| $350,000–1 million | EMERGENCY PHYSICIAN'S INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | EMERGENCY SYSTEMS, INC | JACKSONVILLE, FL | South State Bank, National Association |
| $150,000–350,000 | EMPIRE ELECTRIC, INC | JACKSONVILLE, FL | Navy FCU |
| $150,000–350,000 | EMPOWERMENT PROGRAMS, INC | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | EMTEC APPLICATION SERVICES, INC. | JACKSONVILLE, FL | Trustmark National Bank |
| $1–2 million | EMTEC CONSULTING SERVICES, LLC | JACKSONVILLE, FL | Trustmark National Bank |
| $1–2 million | EMTEC, INC. | JACKSONVILLE, FL | Trustmark National Bank |
| $150,000–350,000 | ENGINEERED LINING SYSTEMS, INC | JACKSONVILLE, FL | Hancock Whitney Bank |
| $150,000–350,000 | ENGINEERING RECRUITING EXPERTS LLC | JACKSONVILLE, FL | Regions Bank |
| $350,000–1 million | ENGLAND TRADING COMPANY, LLC | JACKSONVILLE, FL | Synovus Bank |
| $2–5 million | ENGLAND, THIMS & MILLER, INC. | JACKSONVILLE, FL | First-Citizens Bank & Trust Company |
| $1–2 million | ENGLISH-EL ENTERPRISES LLC | JACKSONVILLE, FL | American Momentum Bank |
| $5–10 million | ENHANCED RECOVERY COMPANY LLC | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $350,000–1 million | ENNIS, PELLUM & ASSOCIATES, P.A. | JACKSONVILLE, FL | Hancock Whitney Bank |
| $1–2 million | ENTERPRISE INTEGRATION, INC. | JACKSONVILLE, FL | BankUnited, National Association |
| $150,000–350,000 | ENVIRONMENT CONTROL OF JACKSONVILLE EAST | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | ENVISION WORX LLC | JACKSONVILLE, FL | Celtic Bank Corporation |
| $2–5 million | EPISCOPAL SCHOOL OF JACKSONVILLE INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | EQUIPMENT SERVICES OF JACKSONVILLE, INC. | JACKSONVILLE, FL | Cogent Bank |
| $150,000–350,000 | ERKAN ENTERPRISES LLC | JACKSONVILLE, FL | VyStar CU |
| $1–2 million | ERNIE PALMER INC | JACKSONVILLE, FL | PNC Bank, National Association |
| $350,000–1 million | ERNST NICOLITZ, M.D., P.A. | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | ERS CORP | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | ETCHASOFT, INC. | JACKSONVILLE, FL | Synovus Bank |
| $350,000–1 million | ETM SURVEYING & MAPPING, INC. | JACKSONVILLE, FL | First-Citizens Bank & Trust Company |
| $350,000–1 million | EVANGEL TEMPLE ASSEMBLY OF GOD, INC. | JACKSONVILLE, FL | South State Bank, National Association |
| $150,000–350,000 | EVERLOGIC INC | JACKSONVILLE, FL | Bank of America, National Association |
| $350,000–1 million | EXACT, INC. | JACKSONVILLE, FL | South State Bank, National Association |
| $150,000–350,000 | EXCEL PROPERTY SERVICES, INC | JACKSONVILLE, FL | South State Bank, National Association |
| $150,000–350,000 | EXCEPTIONAL CASE SERVICES INC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | EXLOG GLOBAL | JACKSONVILLE, FL | Navy FCU |
| $150,000–350,000 | EXOTIC BIRD HOSPITAL-SBA SMALL 7A TERM | JACKSONVILLE, FL | TD Bank, National Association |
| $150,000–350,000 | EZ AUTOMATION SYSTEMS LLC | JACKSONVILLE, FL | Synovus Bank |
| $2–5 million | F M X, INC | JACKSONVILLE, FL | Regions Bank |
| $150,000–350,000 | F&G CONSTRUCTION GENERAL CONTRACTORS, INC. | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | FA RESTAURANT HOLDINGS LLC | JACKSONVILLE, FL | BBVA USA |
| $1–2 million | FACILITY AUTOMATION SOLUTIONS, INC. | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | FACTORY AUTO GLASS | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | FALCON'S FIRE GOLF MANAGEMENT LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | FAMILY ALLERGY & ASTHMA CONSULTANTS PA | JACKSONVILLE, FL | Synovus Bank |
| $2–5 million | FAMILY CARE PARTNERS OF NORTHEAST FL, LLC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | FAMILY ENTERTAINMENT LLC | JACKSONVILLE, FL | Celtic Bank Corporation |
| $150,000–350,000 | FAMILY FOUNDATIONS OF NORTHEAST FLORIDA INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | FAMILY HARVEST MINISTRIES INC. | JACKSONVILLE, FL | Regions Bank |
| $1–2 million | FAMILY SUPPORT SERVICES OF NORTH FLORIDA | JACKSONVILLE, FL | Regions Bank |
| $350,000–1 million | FAR EAST BROKERS AND CONSULTANTS, INC. | JACKSONVILLE, FL | South State Bank, National Association |
| $2–5 million | FARAH AND FARAH, PA | JACKSONVILLE, FL | Seaside National Bank & Trust |
| $150,000–350,000 | FARMAND, FARMAND & FARMAND, LLP | JACKSONVILLE, FL | First Federal Bank |
| $150,000–350,000 | FARRELL BROTHERS MARINE CONSTRUCTION IN | JACKSONVILLE, FL | Bank of America, National Association |
| $350,000–1 million | FENFIT, INC. | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $350,000–1 million | FERNANDEZ TRIAL LAWYERS P.A. | JACKSONVILLE, FL | South State Bank, National Association |
| $350,000–1 million | FERNANDINA MULCH & STONE, LLC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | FETNER & HARTIGAN PERIODONTICS & IMPLANTS PA | JACKSONVILLE, FL | Ameris Bank |