| $2–5 million | S.S.WHITE TECHNOLOGIES INC | SAINT PETERSBURG, FL | First Home Bank |
| $150,000–350,000 | SACINO & SONS INC | SAINT PETERSBURG, FL | Freedom Bank |
| $350,000–1 million | SALVADOR DALI MUSEUM, INC. | SAINT PETERSBURG, FL | Pilot Bank |
| $150,000–350,000 | SAVVYPHONE, LLC | SAINT PETERSBURG, FL | The Bank of Tampa |
| $350,000–1 million | SBF, LLC | SAINT PETERSBURG, FL | Synovus Bank |
| $150,000–350,000 | SCHERER CONSTRUCTION LLC | SAINT PETERSBURG, FL | Republic Bank & Trust Company |
| $150,000–350,000 | SCUBS N STUFF INC | SAINT PETERSBURG, FL | Bank of America, National Association |
| $350,000–1 million | SCULLEY'S MANAGEMENT, LLC | SAINT PETERSBURG, FL | First Home Bank |
| $150,000–350,000 | SEATING INSTALLATION GROUP, LLC | SAINT PETERSBURG, FL | Centennial Bank |
| $150,000–350,000 | SECURITY POINT HOLDINGS, INC. | SAINT PETERSBURG, FL | IBERIABANK |
| $150,000–350,000 | SEMINOLE, FL 1015 LLC | SAINT PETERSBURG, FL | Peoples National Bank, National Association |
| $150,000–350,000 | SENIOR CARE OF CLEARWATER, LLC | SAINT PETERSBURG, FL | The Bank of Tampa |
| $350,000–1 million | SENSOR SYSTEMS, LLC | SAINT PETERSBURG, FL | The Bank of Tampa |
| $2–5 million | SENTAGE CORPORATION | SAINT PETERSBURG, FL | CIBC Bank USA |
| $150,000–350,000 | SHARON'S BISTRO INC | SAINT PETERSBURG, FL | Republic Bank & Trust Company |
| $150,000–350,000 | SHEAR ENTERPRISES LLC | SAINT PETERSBURG, FL | Bank of America, National Association |
| $2–5 million | SHORECREST PREPATORY SCHOOL INC | SAINT PETERSBURG, FL | Pilot Bank |
| $150,000–350,000 | SINUS AND NASAL INSTITUTE OF FLORIDA, P.A. | SAINT PETERSBURG, FL | First Home Bank |
| $150,000–350,000 | SLC FRANCHISE HOLDINGS LLC | SAINT PETERSBURG, FL | Valley National Bank |
| $2–5 million | SMILE DESIGN DENTISTRY ST PETE LLC | SAINT PETERSBURG, FL | Valley National Bank |
| $150,000–350,000 | SMS MANAGERS OF PINELLAS INC | SAINT PETERSBURG, FL | Freedom Bank |
| $1–2 million | SOCIETY OF ST. VINCENT DE PAUL SOUTH PINELLAS SOUTH PINELLAS, INC | SAINT PETERSBURG, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | SOLAR SUN LLC | SAINT PETERSBURG, FL | Valley National Bank |
| $150,000–350,000 | SOUTHEASTERN MARINE POWER, LLC | SAINT PETERSBURG, FL | Regions Bank |
| $150,000–350,000 | SOUTHERN STRUCTURAL STEEL OF FLORIDA, INC. | SAINT PETERSBURG, FL | BankUnited, National Association |
| $1–2 million | SPATIAL NETWORKS INC | SAINT PETERSBURG, FL | CIBC Bank USA |
| $150,000–350,000 | ST PAUL CATHOLIC SCHOOL | SAINT PETERSBURG, FL | Pilot Bank |
| $150,000–350,000 | ST PETE AVIATION SERVICES, LLC | SAINT PETERSBURG, FL | Freedom Bank |
| $150,000–350,000 | ST PETERSBURG ENDOSCOPY CENTER LLC | SAINT PETERSBURG, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | ST RAPHAELS CATHOLIC SCHOOL | SAINT PETERSBURG, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | ST. JOHN VIANNEY CATHOLIC CHURCH AND SCHOOL | SAINT PETERSBURG, FL | Republic Bank & Trust Company |
| $150,000–350,000 | ST. PAUL CATHOLIC CHURCH | SAINT PETERSBURG, FL | Pilot Bank |
| $350,000–1 million | ST. PETE DELIVERY INC | SAINT PETERSBURG, FL | Bank of America, National Association |
| $350,000–1 million | ST. PETERSBURG CATHOLIC HIGH SCHOOL, INC. | SAINT PETERSBURG, FL | First Citrus Bank |
| $150,000–350,000 | ST. PETERSBURG DISTILLERY COMPANY, LLC | SAINT PETERSBURG, FL | Bank OZK |
| $350,000–1 million | ST. PETERSBURG FREE CLINIC INC. | SAINT PETERSBURG, FL | Synovus Bank |
| $350,000–1 million | ST. PETERSBURG NURSING & REHABILITATION LLC | SAINT PETERSBURG, FL | CIBC Bank USA |
| $1–2 million | STABIL CONCRETE PRODUCTS, LLC | SAINT PETERSBURG, FL | Hancock Whitney Bank |
| $350,000–1 million | STAHL & ASSOCIATES INSURANCE, INC. | SAINT PETERSBURG, FL | Westfield Bank, FSB |
| $150,000–350,000 | STANDARDS SOLUTION HOLDING LLC | SAINT PETERSBURG, FL | First Home Bank |
| $150,000–350,000 | STEPHEN G NELSON MD PA | SAINT PETERSBURG, FL | The Bank of Tampa |
| $350,000–1 million | STILLWATERS TAVERN LLC | SAINT PETERSBURG, FL | Synovus Bank |
| $150,000–350,000 | STORMFITTERS CORPORATION | SAINT PETERSBURG, FL | Pilot Bank |
| $350,000–1 million | STRATEGIC ENTERPRISE SUPPORT SERVICES, LLC | SAINT PETERSBURG, FL | ServisFirst Bank |
| $350,000–1 million | SUMMIT EXERCISES AND TRAINING LLC | SAINT PETERSBURG, FL | Hancock Whitney Bank |
| $350,000–1 million | SUN DENTAL LABORATORIES, LLC | SAINT PETERSBURG, FL | Hancock Whitney Bank |
| $150,000–350,000 | SUNBILITY LLC | SAINT PETERSBURG, FL | JPMorgan Chase Bank, National Association |
| $350,000–1 million | SUNCOAST CATHEDRAL FIRST ASSEMBLY OF GOD, INC. | SAINT PETERSBURG, FL | Republic Bank & Trust Company |
| $2–5 million | SUNCOAST CENTER INC | SAINT PETERSBURG, FL | Synovus Bank |
| $150,000–350,000 | SUNCOAST ELECTRIC, INC. | SAINT PETERSBURG, FL | Cogent Bank |
| $150,000–350,000 | SUNFLORA, INC | SAINT PETERSBURG, FL | Pilot Bank |
| $1–2 million | SURFACE ENGINEERING & ALLOY COMPANY, INC | SAINT PETERSBURG, FL | Synovus Bank |
| $150,000–350,000 | SURFACE ENGINEERING AND ALLOY POWDERS, INC. | SAINT PETERSBURG, FL | Synovus Bank |
| $150,000–350,000 | SURGCENTER NORTHEAST LLC | SAINT PETERSBURG, FL | Valley National Bank |
| $350,000–1 million | SUTTON INSPECTION BUREAU INC OF FLORIDA | SAINT PETERSBURG, FL | Bank of America, National Association |
| $150,000–350,000 | SYNCSITE INC | SAINT PETERSBURG, FL | First Citrus Bank |
| $150,000–350,000 | T2THES, INC. | SAINT PETERSBURG, FL | Hancock Whitney Bank |
| $150,000–350,000 | TAG AGENCY OF PINELLAS, INC. | SAINT PETERSBURG, FL | Valley National Bank |
| $150,000–350,000 | TAHITIAN TREASURE ISLAND LLC | SAINT PETERSBURG, FL | Republic Bank & Trust Company |
| $150,000–350,000 | TAMPA BAY TEMPS INC | SAINT PETERSBURG, FL | Republic Bank & Trust Company |
| $150,000–350,000 | TAMPA BAY TURNERS GYMNASTICS & SWIMMING ACADEMY, INC. | SAINT PETERSBURG, FL | Valley National Bank |
| $150,000–350,000 | TAP ROOM AT THE HOLLANDER LLC | SAINT PETERSBURG, FL | Valley National Bank |
| $350,000–1 million | TARHEEL ROOFING, INC. | SAINT PETERSBURG, FL | Synovus Bank |
| $1–2 million | TAYLOR MEDIA CORP | SAINT PETERSBURG, FL | Hancock Whitney Bank |
| $150,000–350,000 | TEMPLE BETH EL OF ST PETERSBURG FLORIDA INCORPORATED | SAINT PETERSBURG, FL | Freedom Bank |
| $150,000–350,000 | THE AMERICAN STAGE COMPANY INC | SAINT PETERSBURG, FL | Freedom Bank |
| $350,000–1 million | THE CANTERBURY SCHOOL OF FLORIDA | SAINT PETERSBURG, FL | Hancock Whitney Bank |
| $150,000–350,000 | THE CARPET STORE, INC. | SAINT PETERSBURG, FL | First Citrus Bank |
| $350,000–1 million | THE CINNAMON GROUP LLC | SAINT PETERSBURG, FL | Capital City Bank |
| $150,000–350,000 | THE ELECTRIC CONNECTION INC | SAINT PETERSBURG, FL | Valley National Bank |
| $150,000–350,000 | THE FLORIDA HOLOCAUST MUSEUM, INC | SAINT PETERSBURG, FL | The Bank of Tampa |
| $1–2 million | THE FLORIDA ORCHESTRA, INC | SAINT PETERSBURG, FL | PNC Bank, National Association |
| $1–2 million | THE GETAWAY TAMPA BAY LLC | SAINT PETERSBURG, FL | Hancock Whitney Bank |
| $150,000–350,000 | THE MILL RESTAURANT LLC | SAINT PETERSBURG, FL | Synovus Bank |
| $350,000–1 million | THE POYNTER INSTITUTE FOR MEDIA STUDIES, INC. | SAINT PETERSBURG, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | THE PRINCESS MARTHA, LLC | SAINT PETERSBURG, FL | Valley National Bank |
| $350,000–1 million | THE SEMBLER COMPANY | SAINT PETERSBURG, FL | City National Bank of Florida |
| $150,000–350,000 | THE SYMPHONI GROUP, LLC | SAINT PETERSBURG, FL | ServisFirst Bank |
| $150,000–350,000 | THE TODD GROUP INC | SAINT PETERSBURG, FL | Synovus Bank |
| $150,000–350,000 | THERAPY AND SPORTS CENTER INC | SAINT PETERSBURG, FL | Republic Bank & Trust Company |
| $150,000–350,000 | THERMOPLY, INC. | SAINT PETERSBURG, FL | The Bank of Tampa |
| $350,000–1 million | THOMAS J BOLAND DMD MD PA | SAINT PETERSBURG, FL | Republic Bank & Trust Company |
| $350,000–1 million | THOMPSON MILLER PA | SAINT PETERSBURG, FL | Freedom Bank |
| $150,000–350,000 | THREE BIRDS TAVERN, LLC | SAINT PETERSBURG, FL | Pilot Bank |
| $5–10 million | TIMES HOLDING COMPANY | SAINT PETERSBURG, FL | Hancock Whitney Bank |
| $350,000–1 million | TLR OF BONITA INC | SAINT PETERSBURG, FL | Bank of America, National Association |
| $150,000–350,000 | TMS MANAGERS OF PINELLAS INC | SAINT PETERSBURG, FL | Freedom Bank |
| $150,000–350,000 | TOTAL AIR, INC. | SAINT PETERSBURG, FL | TD Bank, National Association |
| $150,000–350,000 | TRANSCONTINENTAL FINANCIAL CORP. | SAINT PETERSBURG, FL | Bank OZK |
| $150,000–350,000 | TRI KING INC | SAINT PETERSBURG, FL | Republic Bank & Trust Company |
| $350,000–1 million | TROWBRIDGE AG LLC | SAINT PETERSBURG, FL | Bank of America, National Association |
| $1–2 million | TSP INSTITUTE, INC. | SAINT PETERSBURG, FL | Hancock Whitney Bank |
| $150,000–350,000 | TSUNAMI IN ST. PETERSBURG INC. | SAINT PETERSBURG, FL | Fifth Third Bank |
| $150,000–350,000 | TUCKER LAW GROUP, P.A. | SAINT PETERSBURG, FL | South State Bank, National Association |
| $350,000–1 million | TV MARINA RESTAURANT, LLC | SAINT PETERSBURG, FL | Centennial Bank |
| $1–2 million | UNITED FIRE PROTECTION INC | SAINT PETERSBURG, FL | Bank of America, National Association |
| $350,000–1 million | UNITED PARK SERVICES, INC. | SAINT PETERSBURG, FL | Valley National Bank |
| $350,000–1 million | UNIVERSAL LABELING SYSTEMS, INC. | SAINT PETERSBURG, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | US FEDERAL CONTRACTOR REGISTRATION INC | SAINT PETERSBURG, FL | Hancock Whitney Bank |
| $150,000–350,000 | VELOCITY IQ LLC | SAINT PETERSBURG, FL | Regions Bank |