| $150,000–350,000 | SCHAUMAN CONSTRUCTION COMPANY | SAGINAW, MI | Isabella Bank |
| $350,000–1 million | SCIENTIFIC BRAKE & EQUIPMENT CO. | SAGINAW, MI | Fifth Third Bank |
| $150,000–350,000 | SELECTIVE CASE MANAGEMENT, INC. | SAGINAW, MI | Dort Financial CU |
| $150,000–350,000 | SERENITY SPRINGS LLC | SAGINAW, MI | Fifth Third Bank |
| $1–2 million | SERRA SAGINAW AUTOMOTIVE LLC | SAGINAW, MI | The Huntington National Bank |
| $150,000–350,000 | SEVERANCE TOOL INDUSTRIES INC. | SAGINAW, MI | The Huntington National Bank |
| $150,000–350,000 | SHAY WATER CO., INC. | SAGINAW, MI | United Financial CU |
| $150,000–350,000 | SHIELDS COMFORT CARE, LLC | SAGINAW, MI | 1st State Bank |
| $150,000–350,000 | SHINNERS & COOK, P.C. | SAGINAW, MI | 1st State Bank |
| $150,000–350,000 | SKORIC HEARING AID CENTER LLC | SAGINAW, MI | Independent Bank |
| $150,000–350,000 | SMB PROBATION CENTER, INC | SAGINAW, MI | The Huntington National Bank |
| $350,000–1 million | SMITH BOVILL PC | SAGINAW, MI | The State Bank |
| $150,000–350,000 | SPARKLE PRO CLEAN INC. | SAGINAW, MI | 1st State Bank |
| $150,000–350,000 | SPAULDING MFG, INC. | SAGINAW, MI | 1st State Bank |
| $350,000–1 million | SPECIALTY MANUFACTURING, INC. | SAGINAW, MI | JPMorgan Chase Bank, National Association |
| $2–5 million | SPENCE BROTHER | SAGINAW, MI | The Huntington National Bank |
| $2–5 million | SPICER GROUP, INC. | SAGINAW, MI | 1st State Bank |
| $350,000–1 million | SQUARE JACK, LLC | SAGINAW, MI | TCF National Bank |
| $350,000–1 million | SSP ASSOCIATES, INC. | SAGINAW, MI | The Huntington National Bank |
| $1–2 million | ST. FRANCIS HOME OF SAGINAW | SAGINAW, MI | Notre Dame FCU |
| $2–5 million | STANDARD ELECTRIC COMPANY | SAGINAW, MI | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | STANDARD TILE INC | SAGINAW, MI | The Huntington National Bank |
| $150,000–350,000 | STARDUST LANES, INC. | SAGINAW, MI | Live Oak Banking Company |
| $150,000–350,000 | STATE CORNER BAR AND GRILL INC. | SAGINAW, MI | The Huntington National Bank |
| $350,000–1 million | STATE STREET GRILL, LTD | SAGINAW, MI | TCF National Bank |
| $150,000–350,000 | STEVENS FORWARDERS, INC. | SAGINAW, MI | 1st State Bank |
| $350,000–1 million | STEVENS MOVING & STORAGE, INC. | SAGINAW, MI | 1st State Bank |
| $2–5 million | STONE TRANSPORT LIMITED PARTNERSHIP | SAGINAW, MI | TCF National Bank |
| $1–2 million | STONE WELL SERVICE, LLC | SAGINAW, MI | TCF National Bank |
| $350,000–1 million | SUPER-FLITE OIL CO., INC. | SAGINAW, MI | 1st State Bank |
| $1–2 million | SVRC INDUSTRIES, INC. | SAGINAW, MI | TCF National Bank |
| $150,000–350,000 | SWEENEY METALWORKING, LLC | SAGINAW, MI | Isabella Bank |
| $350,000–1 million | SWS-TRIMAC, INC. | SAGINAW, MI | 1st State Bank |
| $150,000–350,000 | THE AVENUE HAIR DESIGNERS | SAGINAW, MI | The Huntington National Bank |
| $150,000–350,000 | THE GERMAN EVANGELICAL-LUTHERAN BETHLEHEM CONGREGATION, UNALTERED AUGSBURG CONFE | SAGINAW, MI | 1st State Bank |
| $150,000–350,000 | THE JADED SHAMROCK, LLC | SAGINAW, MI | TCF National Bank |
| $350,000–1 million | THE MACDONALD BROADCASTING COMPANY | SAGINAW, MI | Independent Bank |
| $150,000–350,000 | THE SCOTT & MILLER DESIGN ASSOCIATES, INC. | SAGINAW, MI | TCF National Bank |
| $150,000–350,000 | THERESA'S BAR & GRILL, INC. | SAGINAW, MI | Wildfire CU |
| $150,000–350,000 | TMS USA, INC. | SAGINAW, MI | 1st State Bank |
| $350,000–1 million | TRI CITY UROLOGY ASSOCIATES PC | SAGINAW, MI | The Huntington National Bank |
| $150,000–350,000 | TRI-CITY ACOUSTICAL CO. | SAGINAW, MI | 1st State Bank |
| $150,000–350,000 | TRI-STEEL, INC. | SAGINAW, MI | 1st State Bank |
| $350,000–1 million | TRIPLE R TRUCKING INC | SAGINAW, MI | PNC Bank, National Association |
| $350,000–1 million | U.S. GRAPHITE, INC | SAGINAW, MI | MetaBank, National Association |
| $350,000–1 million | U.S. SHEET METAL, INC. | SAGINAW, MI | 1st State Bank |
| $150,000–350,000 | UNIVERSAL AIR, INC. | SAGINAW, MI | 1st State Bank |
| $2–5 million | V.O.I.C.E. INC. OF MICHIGAN, DBA VALLEY ORGANIZATION FOR IMRPOVED COMMUNICATIONS | SAGINAW, MI | Fifth Third Bank |
| $350,000–1 million | VALLEY OB-GYN CLINIC, P.C. | SAGINAW, MI | 1st State Bank |
| $150,000–350,000 | VALLEY STEEL COMPANY | SAGINAW, MI | 1st State Bank |
| $150,000–350,000 | VAN HERWEG ELECTRIC INC | SAGINAW, MI | PNC Bank, National Association |
| $150,000–350,000 | VICTORY CLINICAL SERVICES IV LLC | SAGINAW, MI | Mercantile Bank of Michigan |
| $150,000–350,000 | W.L. CASE AND COMPANY FUNERAL DIRECTORS INC | SAGINAW, MI | The Huntington National Bank |
| $350,000–1 million | WENDLING SHEET METAL, INC. | SAGINAW, MI | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | WIGEN, TINCKNELL, MEYER & ASSOCIATES, INC. | SAGINAW, MI | Team One CU |
| $350,000–1 million | WILLIAM A KIBBE & ASSOCIATES, INC. | SAGINAW, MI | Capitol National Bank |
| $150,000–350,000 | WILLIAM E MASON DDS MS P C | SAGINAW, MI | PNC Bank, National Association |
| $350,000–1 million | WILSON FORD LINCOLN LLC | SAGINAW, MI | TCF National Bank |
| $350,000–1 million | WINEMAN TECHNOLOGY, LLC | SAGINAW, MI | Country Club Bank |
| $350,000–1 million | WOBIG CONSTRUCTION CO., INC | SAGINAW, MI | 1st State Bank |
| $150,000–350,000 | WOHLFEIL HARDWARE & TOOLS INC | SAGINAW, MI | The Huntington National Bank |
| $2–5 million | WOLGAST CORPORATION | SAGINAW, MI | 1st State Bank |
| $350,000–1 million | WOMENS OB-GYN PC | SAGINAW, MI | The Huntington National Bank |
| $350,000–1 million | WOODRUFF CONTRACTING INC | SAGINAW, MI | The State Bank |
| $350,000–1 million | WRIGHT-K TECHNOLOGY, INC. | SAGINAW, MI | 1st State Bank |
| $2–5 million | YEO & YEO | SAGINAW, MI | The Huntington National Bank |
| $150,000–350,000 | YOUNG MEN'S CHRISTIAN ASSOCIATION OF SAGINAW | SAGINAW, MI | The Huntington National Bank |