| $350,000–1 million | SPARTACUS LOMBARD LP | SAINT LOUIS, MO | Axos Bank |
| $5–10 million | SPARTAN LIGHT METAL PRODUCTS, INC | SAINT LOUIS, MO | First Bank |
| $150,000–350,000 | SPEARTIP, LLC | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $350,000–1 million | SPECIALISTS IN GASTROENTEROLOGY, L.L.C. | SAINT LOUIS, MO | Midland States Bank |
| $350,000–1 million | SPECIALTY CARTS, LLC | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | SPECIALTY MAILING, INC. | SAINT LOUIS, MO | Regions Bank |
| $350,000–1 million | SPECIALTY PAPERS & SUPPLIES LLC | SAINT LOUIS, MO | PNC Bank, National Association |
| $150,000–350,000 | SPECTOR, WOLFE, MCLAUGHLIN & O'MARA LLC | SAINT LOUIS, MO | St. Louis Bank |
| $350,000–1 million | SPELLMAN BRADY AND COMPANY | SAINT LOUIS, MO | Carrollton Bank |
| $1–2 million | SPIRTAS COMPANY | SAINT LOUIS, MO | Busey Bank |
| $350,000–1 million | SPOGEN BIOTECH INC. | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $150,000–350,000 | SPOKE, LLC | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $150,000–350,000 | SPORTSPLAY EQUIPMENT, INC. | SAINT LOUIS, MO | Triad Bank |
| $150,000–350,000 | SPORTSTIME 1 LP | SAINT LOUIS, MO | Montgomery Bank |
| $150,000–350,000 | SPOT CONTENT STUDIO, INC. | SAINT LOUIS, MO | Busey Bank |
| $350,000–1 million | SPOTLESS, INC | SAINT LOUIS, MO | Midwest BankCentre |
| $150,000–350,000 | SPRY DIGITAL, LLC | SAINT LOUIS, MO | Triad Bank |
| $2–5 million | SQUARE UP BUILDERS, LLC | SAINT LOUIS, MO | First Bank |
| $150,000–350,000 | SQWIRES INC. | SAINT LOUIS, MO | Midwest BankCentre |
| $350,000–1 million | ST ELIZABETH ADULT DAY CARE CENT | SAINT LOUIS, MO | Midland States Bank |
| $350,000–1 million | ST GERARD MAJELLA CATHOLIC CHURCH | SAINT LOUIS, MO | Central Bank of St. Louis |
| $150,000–350,000 | ST JOHNS PLACE INC | SAINT LOUIS, MO | Royal Banks of Missouri |
| $2–5 million | ST LOUIS ARC INC | SAINT LOUIS, MO | Carrollton Bank |
| $350,000–1 million | ST LOUIS CANCER CARE LLP | SAINT LOUIS, MO | Bank of America, National Association |
| $350,000–1 million | ST LOUIS CARDIOLOGY CONSULTANTS LTD | SAINT LOUIS, MO | Bank of America, National Association |
| $150,000–350,000 | ST LOUIS CENTER FOR FAMILY DEVELOPMENT | SAINT LOUIS, MO | Cass Commercial Bank |
| $150,000–350,000 | ST LOUIS CHURCH OF GOD, INC. | SAINT LOUIS, MO | Cass Commercial Bank |
| $150,000–350,000 | ST LOUIS CONTRACT EMBROIDERY, LLC | SAINT LOUIS, MO | U.S. Bank, National Association |
| $150,000–350,000 | ST LOUIS COUNTY DENTAL PARTNERSHIP, TIMOTHY M GRAYEN DDS AND ASSOCIATES, LLC | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | ST LOUIS GENERAL HOSPITAL | SAINT LOUIS, MO | Midland States Bank |
| $150,000–350,000 | ST LOUIS GYMNASTIC CENTRE | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | ST LOUIS LAWN CARE INC | SAINT LOUIS, MO | Celtic Bank Corporation |
| $350,000–1 million | ST LOUIS PATHOLOGY ASSOCIATES INC | SAINT LOUIS, MO | PNC Bank, National Association |
| $350,000–1 million | ST LOUIS PEDIATRIC DENTISTRY LLC | SAINT LOUIS, MO | PNC Bank, National Association |
| $350,000–1 million | ST LOUIS PRE SORT INC | SAINT LOUIS, MO | Regions Bank |
| $2–5 million | ST LOUIS UNIVERSITY HIGH SCHOOL | SAINT LOUIS, MO | PNC Bank, National Association |
| $150,000–350,000 | ST LOUIS WHOLESALE FOODS INC | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | ST MONICA CATHOLIC CHURCH | SAINT LOUIS, MO | First Bank |
| $150,000–350,000 | ST PETER'S PROTESTANT EPISCOPAL CHURCH OF ST. LOUIS COUNTY, MISSOURI | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | ST STEPHEN PROTOMARTYR CATHOLIC CHURCH | SAINT LOUIS, MO | Lindell Bank & Trust Company |
| $5–10 million | ST. ALEXIUS HOSPITAL CORPORATION 1 | SAINT LOUIS, MO | U.S. Bank, National Association |
| $150,000–350,000 | ST. AMBROSE CATHOLIC CHURCH | SAINT LOUIS, MO | Peoples National Bank, National Association |
| $150,000–350,000 | ST. ANDREW'S AT HOME SERVICES, LLC | SAINT LOUIS, MO | Commerce Bank |
| $350,000–1 million | ST. ANDREW'S RESOURCES FOR SENIORS SYSTEM | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | ST. ANN CATHOLIC CHURCH, NORMANDY | SAINT LOUIS, MO | Peoples National Bank, National Association |
| $350,000–1 million | ST. CATHERINE LABOURE CATHOLIC CHURCH | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $350,000–1 million | ST. CLEMENT OF ROME CATHOLIC CHURCH | SAINT LOUIS, MO | Central Bank of St. Louis |
| $150,000–350,000 | ST. FRANCIS COMMUNITY SERVICES | SAINT LOUIS, MO | FortuneBank |
| $150,000–350,000 | ST. FRANCIS OF ASSISI CATHOLIC CHURCH, OAKVILLE | SAINT LOUIS, MO | Midwest BankCentre |
| $1–2 million | ST. JOHN VIANNEY HIGH SCHOOL, INC. | SAINT LOUIS, MO | Commerce Bank |
| $350,000–1 million | ST. JOSEPH'S ACADEMY, FRONTENAC, MISSOURI | SAINT LOUIS, MO | U.S. Bank, National Association |
| $350,000–1 million | ST. LOUIS ALTENHEIM | SAINT LOUIS, MO | Midwest BankCentre |
| $150,000–350,000 | ST. LOUIS ANTIQUE LIGHTING COMPANY, INC. | SAINT LOUIS, MO | Home State Bank |
| $350,000–1 million | ST. LOUIS BOILER SUPPLY COMPANY | SAINT LOUIS, MO | PNC Bank, National Association |
| $1–2 million | ST. LOUIS CHARTER SCHOOL | SAINT LOUIS, MO | Community Banks of Colorado, A Division of |
| $350,000–1 million | ST. LOUIS CHILDCARE HOLDINGS LLC | SAINT LOUIS, MO | Carrollton Bank |
| $350,000–1 million | ST. LOUIS COLLEGE OF HEALTH CAREERS | SAINT LOUIS, MO | Lindell Bank & Trust Company |
| $150,000–350,000 | ST. LOUIS COUNTY CAB COMPANY, INC. | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $150,000–350,000 | ST. LOUIS CREMATION SERVICE INC. | SAINT LOUIS, MO | Carrollton Bank |
| $350,000–1 million | ST. LOUIS CRISIS NURSERY | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | ST. LOUIS DESIGN ALLIANCE, INC | SAINT LOUIS, MO | Triad Bank |
| $150,000–350,000 | ST. LOUIS ELECTRIC INC | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | ST. LOUIS EQUITY FUND, INC. | SAINT LOUIS, MO | Midland States Bank |
| $150,000–350,000 | ST. LOUIS EYE CLINIC | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | ST. LOUIS FORMALWEAR, INC. | SAINT LOUIS, MO | Central Bank of St. Louis |
| $350,000–1 million | ST. LOUIS HOME HEALTH INC. | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | ST. LOUIS HOMECARE LLC | SAINT LOUIS, MO | Independent Bank |
| $350,000–1 million | ST. LOUIS LANGUAGE IMMERSION SCHOOL | SAINT LOUIS, MO | St. Louis Bank |
| $150,000–350,000 | ST. LOUIS MAGAZINE, LLC | SAINT LOUIS, MO | FortuneBank |
| $350,000–1 million | ST. LOUIS MEDICAL CLINIC, P.C. | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $350,000–1 million | ST. LOUIS MEDICAL SUPPLY, INC. | SAINT LOUIS, MO | Carrollton Bank |
| $1–2 million | ST. LOUIS METRO ELECTRIC SUPPLY, INC | SAINT LOUIS, MO | First Bank |
| $150,000–350,000 | ST. LOUIS MOTORCYCLE COMPANY, LLC | SAINT LOUIS, MO | CIBC Bank USA |
| $350,000–1 million | ST. LOUIS PAVING LLC | SAINT LOUIS, MO | Busey Bank |
| $150,000–350,000 | ST. LOUIS PRECISION CASTING COMPANY | SAINT LOUIS, MO | Central Bank of St. Louis |
| $1–2 million | ST. LOUIS REGIONAL PUBLIC MEDIA, INC. | SAINT LOUIS, MO | UMB Bank, National Association |
| $150,000–350,000 | ST. LOUIS RESTAURANT CONSULTING & WHOLSALE | SAINT LOUIS, MO | Midwest Regional Bank |
| $1–2 million | ST. LOUIS SCIENCE CENTER FOUNDATION | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | ST. LOUIS SOCIETY FOR THE BLIND AND VISUALLY IMPAIRED | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $150,000–350,000 | ST. LOUIS SURFACE | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $150,000–350,000 | ST. LOUIS TAG CO.,INC. | SAINT LOUIS, MO | Commerce Bank |
| $1–2 million | ST. LOUIS TESTING LABORATORIES, INC. | SAINT LOUIS, MO | Busey Bank |
| $150,000–350,000 | ST. LOUIS TITLE, LLC | SAINT LOUIS, MO | Midwest BankCentre |
| $350,000–1 million | ST. MARGARET OF SCOTLAND CATHOLIC CHURCH | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | ST. MARK CATHOLIC CHURCH-AFFTON | SAINT LOUIS, MO | Midwest BankCentre |
| $150,000–350,000 | ST. MARY MAGDALEN CATHOLIC CHURCHM BRENTWOOD | SAINT LOUIS, MO | Peoples National Bank, National Association |
| $1–2 million | ST. PATRICK CENTER | SAINT LOUIS, MO | Busey Bank |
| $150,000–350,000 | ST. PAUL UNITED CHURCH OF CHRIST | SAINT LOUIS, MO | Midwest BankCentre |
| $150,000–350,000 | ST. PIUS V CATHOLIC CHURCH | SAINT LOUIS, MO | Peoples National Bank, National Association |
| $150,000–350,000 | ST. RAPHAEL THE ARCHANGEL CATHOLIC CHURCH | SAINT LOUIS, MO | Triad Bank |
| $150,000–350,000 | ST. ROCH CATHOLIC CHURCH | SAINT LOUIS, MO | Peoples National Bank, National Association |
| $150,000–350,000 | ST. SIMON THE APOSTLE CHURCH | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $1–2 million | STAAT INC | SAINT LOUIS, MO | Lindell Bank & Trust Company |
| $350,000–1 million | STAENBERG GROUP, INC. | SAINT LOUIS, MO | First Bank |
| $350,000–1 million | STAFFING RESOURCES, DBA FAST | SAINT LOUIS, MO | Busey Bank |
| $150,000–350,000 | STANTON BARTON LLC | SAINT LOUIS, MO | Bank Star |
| $150,000–350,000 | STARBEAM LIGHTING LLC | SAINT LOUIS, MO | Bank of America, National Association |
| $350,000–1 million | STATE MECHANICAL SERVICES INC | SAINT LOUIS, MO | U.S. Bank, National Association |
| $150,000–350,000 | STATEWIDE INVESTMENTS, LLC | SAINT LOUIS, MO | Triad Bank |
| $150,000–350,000 | STE GENEVIEVE DU BOIS CHURCH | SAINT LOUIS, MO | Central Bank of St. Louis |