| $150,000–350,000 | GREEN RIVER CABINS, LLC | SPARTANBURG, SC | Synovus Bank |
| $350,000–1 million | GUARDIAN RESEARCH NETWORK, INC. | SPARTANBURG, SC | The Park National Bank |
| $1–2 million | GUY ROOFING, INC. | SPARTANBURG, SC | Ameris Bank |
| $150,000–350,000 | HABITAT FOR HUMANITY OF SPARTANBURG INC | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | HALLIDAY SCHWARTZ & CO | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $350,000–1 million | HARRISON WHITE, PC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | HENDERSON, BRANDT & VIETH, P.A. | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $1–2 million | HIGH POINT ACADEMY INC | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | HODGE & LANGLEY LAW FIRM, P.C. | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | HODGE CONTRACT CARPETS, INC | SPARTANBURG, SC | The Park National Bank |
| $350,000–1 million | HOLCOMBE BOMAR PA | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | HOLCOMBE, HOLTZCLAW & RAVAN, LLC | SPARTANBURG, SC | South State Bank, National Association |
| $350,000–1 million | HOPE CENTER FOR CHILDREN | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | HOPE CHURCH OF SC, INC. | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | IN HIS MOST HOLY SERVICE, LLC | SPARTANBURG, SC | Live Oak Banking Company |
| $350,000–1 million | INNOVAK OF FLORIDA INC | SPARTANBURG, SC | Wells Fargo Bank, National Association |
| $1–2 million | INSULFAB PLASTICS INC | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | INTEGRATED BIOMETRICS, LLC | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | INTERSTATE MECHANICAL & MILLWRIGHT, INC | SPARTANBURG, SC | Arthur State Bank |
| $350,000–1 million | ITEMA AMERICA INC | SPARTANBURG, SC | Wells Fargo Bank, National Association |
| $350,000–1 million | J FRANK BLAKELY COMPANY | SPARTANBURG, SC | Synovus Bank |
| $350,000–1 million | JB RUSSELL AND SON CONSTRUCTION CO INC | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $1–2 million | JIM NASIM DMD, PA | SPARTANBURG, SC | Regions Bank |
| $1–2 million | JOC, INC. | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | JOHN FLOYD DUNBAR, JR., D.M.D., P.A. | SPARTANBURG, SC | First Horizon Bank |
| $350,000–1 million | JOHNSON SMITH HIBBARD & WILDMAN LAW FIR | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | JORDAN OIL COMPANY, INC. | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | JORDAN OIL TRANSPORTATION, LLC | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | KEY WEST HOTELS, LLC | SPARTANBURG, SC | United Community Bank |
| $1–2 million | KIKI'S KARE LLC | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | KSA KELLER AND SON INC | SPARTANBURG, SC | TD Bank, National Association |
| $150,000–350,000 | LIGHTHOUSE ENTERPRISES LLC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | LITTLEJOHN, INC. | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | LUNG & CHEST MEDICAL ASSOCIATION PA | SPARTANBURG, SC | Bank of America, National Association |
| $150,000–350,000 | MACHINE SOLUTIONS | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | MAHLO AMERICA, INC. | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | MARATHON HOTELS, LLC | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | MARCHEL INDUSTRIES INC. | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | MARLOW TRUCKING COMPANY LLC | SPARTANBURG, SC | Anderson Brothers Bank |
| $350,000–1 million | MASTER MACHINE WORKS, INC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | MCCARTER MECHANICAL, INC | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | MCCHESNEY & MCCHESNEY PC | SPARTANBURG, SC | Countybank |
| $150,000–350,000 | MCCORMACK GROUP, INC. | SPARTANBURG, SC | Arthur State Bank |
| $350,000–1 million | MENZEL LP | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | MG HOLDINGS, LLC | SPARTANBURG, SC | Regions Bank |
| $150,000–350,000 | ML WOODLAND PLACE LLC | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | MOBILE MEAL SERVICE OF SPARTANBURG COUNTY, INC. | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | NEASE & HIGGINBOTHAM ORTHODONTICS PA | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $350,000–1 million | OAKBROOK PREPARATORY SCHOOL | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $150,000–350,000 | OEC FLUID HANDLING INC | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | OEC PETROLEUM SYSTEMS INC | SPARTANBURG, SC | Synovus Bank |
| $350,000–1 million | OILMEN'S TRUCK TANKS INC | SPARTANBURG, SC | Synovus Bank |
| $350,000–1 million | OPSOURCE STAFFING, INC. | SPARTANBURG, SC | First Horizon Bank |
| $150,000–350,000 | ORAL & MAXILLOFACIAL SURGERY ASSOCIATES | SPARTANBURG, SC | TD Bank, National Association |
| $350,000–1 million | ORTHOPEDIC SPECIALTIES OF SPARTANBURG, LLC | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $350,000–1 million | OYSTER POINT HOTELS, LLC | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | PALMETTO DENTURE CARE P.A. | SPARTANBURG, SC | Bank of Travelers Rest |
| $350,000–1 million | PALMETTO GRADING AND DRAINAGE, INC | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | PALMETTO HOSPITALITY OF ANNAPOLIS, LLC | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | PALMETTO HOSPITALITY OF BELLEVUE, LLC | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | PALMETTO HOSPITALITY OF BURBANK, LLC | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | PALMETTO HOSPITALITY OF MANHATTAN II, LLC | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | PALMETTO HOSPITALITY OF MANHATTAN III | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | PALMETTO HOSPITALITY OF MOUNT PLEASANT, LLC | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | PALMETTO HOSPITALITY OF MOUNTAIN VIEW, LLC | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | PALMETTO HOSPITALITY OF NAPA, LLC | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | PALMETTO HOSPITALITY OF PALO ALTO, LLC | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | PALMETTO HOSPITALITY OF SAN DIEGO, LLC | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | PALMETTO HOSPITALITY OF SANTA MONICA I, LLC | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | PALMETTO HOSPITALITY OF SANTA MONICA II, LLC | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | PALMETTO HOSPITALITY OF SPARTANBURG, LLC | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | PALMETTO HOSPITALITY OF WASHINGTON DC II, LLC | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | PALMETTO HOSPITALITY OF WASHINGTON DC IV, LLC | SPARTANBURG, SC | United Community Bank |
| $150,000–350,000 | PALMETTO POSTING INC. | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | PALMETTO PROACTIVE HEALTHCARE, LLC | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | PALMETTO SOUND WORKS, LLC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | PALMETTO SUBHOUSE LLC | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | PAR GRADING & HAULING, INC. | SPARTANBURG, SC | The Park National Bank |
| $350,000–1 million | PARRIS LAWN MANAGEMENT, LLC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | PEDIATRICS UNLIMITED INC. | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | PIEDMONT EYE ASSOCIATES | SPARTANBURG, SC | The Park National Bank |
| $1–2 million | PIEDMONT MECHANICAL INC | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | PINNACLE COATING & CONVERTING, INC | SPARTANBURG, SC | Newtek Small Business Finance, Inc. |
| $2–5 million | POLYDECK SCREEN CORPORATION | SPARTANBURG, SC | South State Bank, National Association |
| $150,000–350,000 | PORK RINDS & SNACKS, LLC | SPARTANBURG, SC | Renasant Bank |
| $350,000–1 million | PRECISION CONVERTERS, INC. | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | PREFERRED PERSONNEL INCORPRATED | SPARTANBURG, SC | Wells Fargo Bank, National Association |
| $150,000–350,000 | PRIDE MASONRY OF GAFFNEY, INC. | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | PRO MARKETING INCORPORATED | SPARTANBURG, SC | Live Oak Banking Company |
| $350,000–1 million | PROJECT INTEGRATION INC. | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $1–2 million | PRYM CONSUMER USA INC. | SPARTANBURG, SC | HSBC Bank USA, National Association |
| $2–5 million | R. L. JORDAN OIL COMPANY OF NORTH CAROLINA, INC | SPARTANBURG, SC | Synovus Bank |
| $150,000–350,000 | R.J. ROCKERS, INC. | SPARTANBURG, SC | The Park National Bank |
| $350,000–1 million | RANK DISTRIBUTORS, INC. | SPARTANBURG, SC | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | REDWOOD CITY HOTELS, LLC | SPARTANBURG, SC | United Community Bank |
| $1–2 million | REGENESIS HEALTH CARE | SPARTANBURG, SC | United Community Bank |
| $350,000–1 million | REGIONAL UTILITY SERVICES INC | SPARTANBURG, SC | First-Citizens Bank & Trust Company |
| $2–5 million | RENFROW BROTHERS, INC. | SPARTANBURG, SC | South State Bank, National Association |
| $1–2 million | RIMS USA, LLC | SPARTANBURG, SC | The Park National Bank |
| $150,000–350,000 | ROCHESTER INSURANCE INC | SPARTANBURG, SC | First Piedmont Federal Savings & Loan Association |