| $350,000–1 million | HUMANE SOCIETY OF SAN ANTONIO | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | HUPECOL OPERATING, LLC | SAN ANTONIO, TX | Texas Capital Bank, National Association |
| $1–2 million | HVH HOMES, LLC | SAN ANTONIO, TX | WestStar Bank |
| $150,000–350,000 | HWI CAPITAL, LLC | SAN ANTONIO, TX | First National Bank Texas |
| $350,000–1 million | HYPERION BIOTECHNOLOGY, INC. | SAN ANTONIO, TX | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | I AM TRUCKING, LLC | SAN ANTONIO, TX | BMO Harris Bank National Association |
| $1–2 million | IAS SERVICES GROUP LLC | SAN ANTONIO, TX | Texas Capital Bank, National Association |
| $150,000–350,000 | ICWW MARINE COMPANIES LLC | SAN ANTONIO, TX | The First State Bank |
| $150,000–350,000 | IDEAL LIFE DEVELOPMENT GROUP LLC | SAN ANTONIO, TX | Wells Fargo Bank, National Association |
| $350,000–1 million | IGEM COMMUNICATIONS HOLDING INC | SAN ANTONIO, TX | American Bank, National Association |
| $350,000–1 million | IKARE HOLDINGS LLC | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | IKARE MOOD TRAUMA RECOVERY CLINIC, PLLC | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | IMAGE HOMES, LTD | SAN ANTONIO, TX | International Bank of Commerce |
| $150,000–350,000 | IMAGE IMPLANTS INTERNATIONAL LLC | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | IMAGEBLOOM, INC. | SAN ANTONIO, TX | Customers Bank |
| $350,000–1 million | IMAGINE BUILT HOMES LTD | SAN ANTONIO, TX | Vantage Bank Texas |
| $150,000–350,000 | IMAGINE EDUCATION FOUNDATION | SAN ANTONIO, TX | Wells Fargo Bank, National Association |
| $350,000–1 million | IMATOWED ENTERPRISES, INC. | SAN ANTONIO, TX | Newtek Small Business Finance, Inc. |
| $350,000–1 million | IMCMV SAN ANTONIO, LLC | SAN ANTONIO, TX | Seacoast National Bank |
| $150,000–350,000 | IMMERSION LEARNING CENTERS LLC | SAN ANTONIO, TX | Plains State Bank |
| $350,000–1 million | IMPACT RECOVERY SYSTEMS, INC. | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | IMPERIAL FLEET SERVICES, INC. | SAN ANTONIO, TX | BBVA USA |
| $350,000–1 million | IMPLICITY MANAGEMENT COMPANY LLC | SAN ANTONIO, TX | IncredibleBank |
| $350,000–1 million | IN HOME SERVICES, INC. | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | INCARNATE WORD HIGH SCHOOL | SAN ANTONIO, TX | Jefferson Bank |
| $1–2 million | INCARNATE WORD RETIREMENT COMMUNITY, INC. | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | INDEPENDENT CONTRACTORS, INC | SAN ANTONIO, TX | International Bank of Commerce |
| $150,000–350,000 | INDEPENDENT INSURANCE CENTER INC | SAN ANTONIO, TX | Texas Capital Bank, National Association |
| $350,000–1 million | INDUSTRIAL DISPOSAL SUPPLY COMPANY, LLC | SAN ANTONIO, TX | TexStar National Bank |
| $150,000–350,000 | INDUSTRIAL GROUP SOUTHWEST LLC | SAN ANTONIO, TX | Keystone Bank, National Association |
| $150,000–350,000 | INET SECURITY AND SURVEILLANCE, LLC | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | INFLOWLOGISTICS, LLC | SAN ANTONIO, TX | Spirit of Texas Bank, SSB |
| $150,000–350,000 | INFORMATION MANAGEMENT SOLUTIONS, LLC | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | INFOTOUCH CORPORATION | SAN ANTONIO, TX | The Bank of San Antonio |
| $1–2 million | INGRAM PARK CHRYSLER JEEP, INC. | SAN ANTONIO, TX | BBVA USA |
| $350,000–1 million | INNOVATIVE COMMUNICATION SYSTEMS,INC | SAN ANTONIO, TX | The Bank of San Antonio |
| $350,000–1 million | INPATIENT PROGRESSIVE HEALTH OF AMERICA | SAN ANTONIO, TX | BBVA USA |
| $2–5 million | INSCO DISTRIBUTING, INC. | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | INSITE ARCHITECTS INC | SAN ANTONIO, TX | Frost Bank |
| $1–2 million | INSPIRED ELEARNING LLC | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | INSTANT DATA TECHNOLOGIES, INC. | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | INSTITUTE OF THE DAUGHTERS OF MARY HELP OF CHRISTIANS - ST. JOHN BOSCO SCHOOL | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | INTEGRATED BUSINESS TECHNOLOGIES INC | SAN ANTONIO, TX | Wells Fargo Bank, National Association |
| $150,000–350,000 | INTEGRATED SHREDDER TECHNOLOGY, LLC | SAN ANTONIO, TX | Comerica Bank |
| $350,000–1 million | INTEGRATED TESTING AND ENGINEERING COMPANY OF SAN ANTONIO | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | INTEGRITY MANUFACTURING, LLC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | INTEGRITY PAIN MANAGEMENT, PLLC | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | INTELLIGENT ENGINEERING SERVICES, LLP | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | INTERCEPT PRODUCTION SERVICES, LLC | SAN ANTONIO, TX | Prosperity Bank |
| $350,000–1 million | INTERCONTINENTAL WEALTH ADVISORS LLC | SAN ANTONIO, TX | Bank of America, National Association |
| $150,000–350,000 | INTERNATIONAL MECHANICAL SERVICES, INC. | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | INTERSTATE BARRICADES & MARKINGS, INC | SAN ANTONIO, TX | International Bank of Commerce |
| $150,000–350,000 | INTERVENTIONAL MANAGEMENT LLC | SAN ANTONIO, TX | BBVA USA |
| $350,000–1 million | INTERVENTIONAL PAIN MANAGEMENT PHYSICIANS PA | SAN ANTONIO, TX | BBVA USA |
| $350,000–1 million | INTREPID STAFFING SERVICES | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | INTREPID STAFFING SERVICES | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | INTRINSIC IMAGING LLC | SAN ANTONIO, TX | Zions Bank, A Division of |
| $150,000–350,000 | INTRUDER ALERT SYSTEMS, INC. | SAN ANTONIO, TX | Vantage Bank Texas |
| $150,000–350,000 | IPAC BODY SHOP, LLC | SAN ANTONIO, TX | BBVA USA |
| $150,000–350,000 | IPAC PRE-OWNED AUTO, LLC | SAN ANTONIO, TX | BBVA USA |
| $350,000–1 million | IPP-IMPROVED PIPING PRODUCTS, INC. | SAN ANTONIO, TX | East West Bank |
| $2–5 million | IR PAYROLL SERVICES, INC. | SAN ANTONIO, TX | Texas Capital Bank, National Association |
| $350,000–1 million | IRISH IDEAS, LTD | SAN ANTONIO, TX | Jefferson Bank |
| $150,000–350,000 | IRON HORSE RV INC | SAN ANTONIO, TX | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | ISI AGENCY, LLC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | ISSA FOODS INC | SAN ANTONIO, TX | First Home Bank |
| $350,000–1 million | ITHACA INVESTMENTS, LTD | SAN ANTONIO, TX | PlainsCapital Bank |
| $150,000–350,000 | ITI SOLUTIONS INC | SAN ANTONIO, TX | Credit Human FCU |
| $150,000–350,000 | J & J REBAR AND POST TENSION | SAN ANTONIO, TX | Security Service FCU |
| $150,000–350,000 | J & L ELECTRIC, INC. | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | J & T CORPUS HOLDINGS, INC. | SAN ANTONIO, TX | Frost Bank |
| $1–2 million | J AND R SALES INC. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | J R (JOE) RAMON & SONS, INC. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | J&P PAVING CO INC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | J. A. DAVIS & ASSOCIATES, LLP | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | J. SANCHEZ CONTRACTING, INC. | SAN ANTONIO, TX | Live Oak Banking Company |
| $350,000–1 million | J. STEWART CONSTRUCTION, LLC | SAN ANTONIO, TX | The Bank of San Antonio |
| $150,000–350,000 | J. W. DIELMANN, INC. | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | J.E. TRAVIS PAINTING, INC. | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | J.H. DESIGN, LP | SAN ANTONIO, TX | Vantage Bank Texas |
| $350,000–1 million | JAC BAKERY LLC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | JAG PUBLIC SAFETY LLC | SAN ANTONIO, TX | River City FCU |
| $150,000–350,000 | JAIRALA CORP | SAN ANTONIO, TX | Jefferson Bank |
| $350,000–1 million | JAMES R. VAN WINKLE | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | JAMIE GRAHAM & ASSOCIATES PLLC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | JANE ENVY, LLC | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | JANICEK LAW FIRM P.C. | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | JAPHET ENTERPRISES LLC | SAN ANTONIO, TX | The Bank of San Antonio |
| $150,000–350,000 | JAS DEVELOPMENT CORP | SAN ANTONIO, TX | PlainsCapital Bank |
| $150,000–350,000 | JAT PARTNERS, LLC | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | JAWANDA NEWSOME ABA AND BEHAVIORAL SERICES | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | JAYASREE RAO, MD PA | SAN ANTONIO, TX | The Bank of San Antonio |
| $150,000–350,000 | JAZZ IN THE BASEMENT, L.P. | SAN ANTONIO, TX | The Bank of San Antonio |
| $150,000–350,000 | JCD PROPERTIES, LP | SAN ANTONIO, TX | Frost Bank |
| $1–2 million | JDSA I, LTD. | SAN ANTONIO, TX | Jefferson Bank |
| $350,000–1 million | JEFF BONNER R&D, INC. | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | JEFFERSON FAMILY PRACTICE ASSOCIATES | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | JEREMY C. JONES MD, PLLC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | JET CLIPS LLC | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | JET MECHANICAL, INC | SAN ANTONIO, TX | Broadway National Bank |