| $150,000–350,000 | ST PATRICK CHURCH & SCHOOL | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | STAFFORD STONE WORKS, LLC | FREDERICKSBURG, VA | Towne Bank |
| $350,000–1 million | STH3 OPERATING COMPANY LLC | FREDERICKSBURG, VA | South State Bank, National Association |
| $150,000–350,000 | STONE CENTER FREDERICKSBURG, INC. | FREDERICKSBURG, VA | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | STUDENTS FOR LIFE OF AMERICA | FREDERICKSBURG, VA | Atlantic Union Bank |
| $350,000–1 million | SULLIVAN, DONAHOE, AND INGALLS, A PROFESSIONAL CORPORATION | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | SUMMIT ENVIRONMENTAL SOLUTIONS | FREDERICKSBURG, VA | The Fauquier Bank |
| $150,000–350,000 | SUMMIT RECYCLING LLC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | SUMPTER ELECTRIC LLC | FREDERICKSBURG, VA | First-Citizens Bank & Trust Company |
| $150,000–350,000 | SUPERIOR SECURITY ASSOCIATES, LLC | FREDERICKSBURG, VA | Radius Bank |
| $350,000–1 million | SUPERSUDS MANAGEMENT LLC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $350,000–1 million | SYLVAIN ANALYTICS, INC. | FREDERICKSBURG, VA | Readycap Lending, LLC |
| $5–10 million | SYSTEMS TECHNOLOGY FORUM, LTD. | FREDERICKSBURG, VA | Manufacturers and Traders Trust Company |
| $350,000–1 million | T & T DISTRIBUTION LLC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $2–5 million | TEKLA RESEARCH, INC. | FREDERICKSBURG, VA | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | TELEMEDIA BROADCASTING, INC. | FREDERICKSBURG, VA | Atlantic Union Bank |
| $350,000–1 million | TEMACC, LLC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | THANK YOU VERY MUCH LLC | FREDERICKSBURG, VA | Community Bank of the Chesapeake |
| $150,000–350,000 | THE DERMATOLOGY CENTER PC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $350,000–1 million | THE GEMROI COMPANY | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | THE GEORGE WASHINGTON FOUNDATION | FREDERICKSBURG, VA | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | THE MCCORMICK GROUP, INC | FREDERICKSBURG, VA | Virginia Partners Bank |
| $2–5 million | THE NEW HAVEN COMPANIES INC. | FREDERICKSBURG, VA | Bankwell Bank |
| $350,000–1 million | THE THOS. J. WACK CO. INC. | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | THURMAN BRISBEN HOMELESS SHELTER, INC. | FREDERICKSBURG, VA | Virginia Partners Bank |
| $150,000–350,000 | TIRE TREAD SERVICE, INC. | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | TNT SURVEILLANCE LLC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $350,000–1 million | TOMMY WALLACE ELECTRICAL, INC. | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | TOTAL COMFORT LLC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | TOTAL MECHANICAL SOLUTIONS, LLC | FREDERICKSBURG, VA | John Marshall Bank |
| $150,000–350,000 | TOTAL POWER SWEEPING SERVICES, INC. | FREDERICKSBURG, VA | Community Bank of the Chesapeake |
| $150,000–350,000 | TRICORD HOMES INCORPORATED | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | TRICORD INCORPORATED | FREDERICKSBURG, VA | Atlantic Union Bank |
| $2–5 million | TT & C ONE LLC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | TULIPS SALON LLC | FREDERICKSBURG, VA | Blue Ridge Bank, National Association |
| $150,000–350,000 | TURBINE ASSET HOLDINGS GROUP LLC | FREDERICKSBURG, VA | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | ULTIMATE BUICK GMC, INC. | FREDERICKSBURG, VA | Ally Bank |
| $150,000–350,000 | ULTIMATE SUBARU, INC. | FREDERICKSBURG, VA | Ally Bank |
| $1–2 million | UNITED GLOBAL GROUP INC | FREDERICKSBURG, VA | Wells Fargo Bank, National Association |
| $350,000–1 million | UNITED SPRINKLER CO., INC. | FREDERICKSBURG, VA | United Bank |
| $1–2 million | UNIVERSAL DYNAMICS, INC | FREDERICKSBURG, VA | Trustar Bank |
| $150,000–350,000 | UNIVERSITY OF MARY WASHINGTON FOUNDATION | FREDERICKSBURG, VA | Atlantic Union Bank |
| $350,000–1 million | UROLOGY ASSOCIATES OF FREDERICKSBURG PC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $350,000–1 million | VETERANS RANGE SOLUTIONS, LLC | FREDERICKSBURG, VA | Watertown Savings Bank |
| $350,000–1 million | VIRGINIA CARDIOVASCULAR CONSULTANTS PC | FREDERICKSBURG, VA | PNC Bank, National Association |
| $1–2 million | VIRGINIA CONSTRUCTION COMPANY, INC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | VIRGINIA DENTAL & ANESTHESIA ASSOCIATES, PLLC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | VIRGINIA HOME CARE PARTNERS | FREDERICKSBURG, VA | Blue Ridge Bank, National Association |
| $350,000–1 million | VIRGINIA ONCOLOGY CARE, P.C. | FREDERICKSBURG, VA | Bank of America, National Association |
| $150,000–350,000 | VIRGINIA SNOW AND ICE INC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | VIRGINIA YOUTH SOCCER ASSOCIATION | FREDERICKSBURG, VA | The Fauquier Bank |
| $150,000–350,000 | VISTA EYE SPECIALISTS, PC | FREDERICKSBURG, VA | Community Bank of the Chesapeake |
| $150,000–350,000 | VITATECH ELECTROMAGNETICS, LLC | FREDERICKSBURG, VA | Virginia Partners Bank |
| $150,000–350,000 | W W WEBB AND ASSOCIATES PLLC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $150,000–350,000 | W&W RESTORATION SERVICES INC | FREDERICKSBURG, VA | Kabbage, Inc. |
| $350,000–1 million | W. J. VAKOS MANAGEMENT COMPANY | FREDERICKSBURG, VA | Atlantic Union Bank |
| $1–2 million | W.C. SPRATT, INC | FREDERICKSBURG, VA | Atlantic Union Bank |
| $350,000–1 million | WCC CABLE, INC | FREDERICKSBURG, VA | Virginia Partners Bank |
| $350,000–1 million | WEB BUSINESS SOLUTIONS INC | FREDERICKSBURG, VA | Customers Bank |
| $150,000–350,000 | WHITE OAK ANIMAL HOSPITAL PC | FREDERICKSBURG, VA | PNC Bank, National Association |
| $350,000–1 million | WORLDWIDE COUNTER THREAT SOLUTIONS LLC | FREDERICKSBURG, VA | The Freedom Bank of Virginia |
| $350,000–1 million | XCEPTIONAL WILDLIFE REMOVAL | FREDERICKSBURG, VA | Oak View National Bank |
| $350,000–1 million | ZENITH AVIATION INC | FREDERICKSBURG, VA | Atlantic Union Bank |