| $150,000–350,000 | ROBERT A. CROWE P.C. | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $350,000–1 million | ROBERT LEE | SAINT LOUIS, MO | PNC Bank, National Association |
| $150,000–350,000 | ROBERT PISKULICH & ASSOCIATES INC. | SAINT LOUIS, MO | Great Southern Bank |
| $350,000–1 million | ROBERTS PERRYMAN PC | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | ROCKWOOD MANAGEMENT CORPORATION | SAINT LOUIS, MO | Live Oak Banking Company |
| $150,000–350,000 | ROD'S SERVICES, INC. | SAINT LOUIS, MO | Busey Bank |
| $150,000–350,000 | ROESER CONSTRUCTION COMPANY | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | ROGER KEPNER, INC. | SAINT LOUIS, MO | Montgomery Bank |
| $350,000–1 million | ROHA USA LLC | SAINT LOUIS, MO | CIBC Bank USA |
| $150,000–350,000 | ROHAN WOODS SCHOOL | SAINT LOUIS, MO | Midland States Bank |
| $350,000–1 million | ROI SEARCH PARTNERS, LLC | SAINT LOUIS, MO | Triad Bank |
| $1–2 million | ROMA GROCERY CO. | SAINT LOUIS, MO | Peoples National Bank, National Association |
| $150,000–350,000 | RONALD MCDONALD HOUSE CHARITIES OF ST. LOUIS | SAINT LOUIS, MO | Triad Bank |
| $350,000–1 million | RONZIO-LEMAY CORP | SAINT LOUIS, MO | Triad Bank |
| $1–2 million | ROOFERS MART, INC. | SAINT LOUIS, MO | First Bank |
| $350,000–1 million | ROOSTER AND THE HEN LLC | SAINT LOUIS, MO | Commerce Bank |
| $350,000–1 million | ROSALITA'S CANTINA DES PERES, LLC | SAINT LOUIS, MO | American Bank of Freedom |
| $150,000–350,000 | ROSALITAS CANTINA MANAGEMENT GROUP, LLC | SAINT LOUIS, MO | American Bank of Freedom |
| $350,000–1 million | ROSENBLUM GOLDENHERSH, P.C. | SAINT LOUIS, MO | The Central Trust Bank |
| $350,000–1 million | ROTHMAN FURNITURE STORES INC | SAINT LOUIS, MO | West Community CU |
| $150,000–350,000 | ROTHSCHILD MANAGEMENT LLC | SAINT LOUIS, MO | Midwest Regional Bank |
| $150,000–350,000 | ROTOLITE OF ST LOUIS INC | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | ROTON PRODUCTS, INC | SAINT LOUIS, MO | Busey Bank |
| $2–5 million | ROTTLER PEST CONTROL COMPANY | SAINT LOUIS, MO | Alliance CU |
| $350,000–1 million | ROUTE 66 HOSPITALITY LLC | SAINT LOUIS, MO | The Bank of Houston |
| $150,000–350,000 | ROY E. SCHMIDT, INC. | SAINT LOUIS, MO | Busey Bank |
| $150,000–350,000 | ROY WILLIAMS ENTERPRISE | SAINT LOUIS, MO | Midwest BankCentre |
| $1–2 million | ROYAL PAPERS, INC. | SAINT LOUIS, MO | The Central Trust Bank |
| $350,000–1 million | ROYAL VENDORS, INC. | SAINT LOUIS, MO | Citizens Bank |
| $150,000–350,000 | RP GROUP, INC. | SAINT LOUIS, MO | First Bank of the Lake |
| $150,000–350,000 | RRAH VETS I, LLC | SAINT LOUIS, MO | The Central Trust Bank |
| $150,000–350,000 | RT JONES FS LADNER & ASSOCIATES INC | SAINT LOUIS, MO | First Bank |
| $150,000–350,000 | RTBMO: LLC | SAINT LOUIS, MO | Bank of Washington |
| $150,000–350,000 | RUMPLEMAN, LLC | SAINT LOUIS, MO | American Bank of Freedom |
| $350,000–1 million | RUNGE PAINTING COMPANY, INC. | SAINT LOUIS, MO | Southern Bank |
| $150,000–350,000 | RUSSO STONE AND TILE DESIGN, LLC | SAINT LOUIS, MO | Peoples National Bank, National Association |
| $350,000–1 million | RYNEARSON, SUESS, SCHNURBUSCH & CHAMPION, L.L.C. | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $150,000–350,000 | S & M BAR & GRILL LLC | SAINT LOUIS, MO | Bank of America, National Association |
| $2–5 million | S.M. WILSON & CO. | SAINT LOUIS, MO | Newtek Small Business Finance, Inc. |
| $150,000–350,000 | SACRED HEART VILLA | SAINT LOUIS, MO | BMO Bank National Association |
| $350,000–1 million | SAINT LOUIS COUNSELING, INC. | SAINT LOUIS, MO | Southern Bank |
| $2–5 million | SAINT LOUIS SYMPHONY ORCHESTRA | SAINT LOUIS, MO | Commerce Bank |
| $350,000–1 million | SAINT PETER CATHOLIC CHURCH | SAINT LOUIS, MO | St. Louis Bank |
| $150,000–350,000 | SALEM IN LADUE UNITED METHODIST CHURCH | SAINT LOUIS, MO | Cass Commercial Bank |
| $150,000–350,000 | SALEM LUTHERAN CHURCH | SAINT LOUIS, MO | Midwest BankCentre |
| $150,000–350,000 | SALES RESOURCE INC. | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $150,000–350,000 | SALUTARE FOODS, LLC | SAINT LOUIS, MO | The First National Bank of Waterloo |
| $5–10 million | SANDBERG PHOENIX & VON GONTARD, P.C. | SAINT LOUIS, MO | St. Louis Bank |
| $2–5 million | SANSONE GROUP LLC | SAINT LOUIS, MO | Royal Banks of Missouri |
| $1–2 million | SAPPER CONSULTING, LLC | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $350,000–1 million | SAUL MIROWITZ JEWISH COMMUNITY SCHOOL | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $350,000–1 million | SAVANNAH, LLC | SAINT LOUIS, MO | Simmons Bank |
| $350,000–1 million | SBC CONTRACTING INC | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $150,000–350,000 | SBM HOLDING LLC | SAINT LOUIS, MO | U.S. Bank, National Association |
| $1–2 million | SBS CREATIX, LLC | SAINT LOUIS, MO | Busey Bank |
| $2–5 million | SCHAEFER AUTOBODY CENTERS, INC. | SAINT LOUIS, MO | Carrollton Bank |
| $2–5 million | SCHAEFFER MANUFACTURING COMPANY | SAINT LOUIS, MO | Cass Commercial Bank |
| $150,000–350,000 | SCHAEFFER MARKETING GROUP INC | SAINT LOUIS, MO | Midwest BankCentre |
| $150,000–350,000 | SCHAUB & SROTE LLC | SAINT LOUIS, MO | The Central Trust Bank |
| $350,000–1 million | SCHLICHTER, BOGARD & DENTON, LLP | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | SCHLUETER PERIODONTICS AND IMPLANTS | SAINT LOUIS, MO | PNC Bank, National Association |
| $350,000–1 million | SCHMERSAHL TRELOAR & CO., PC | SAINT LOUIS, MO | Busey Bank |
| $350,000–1 million | SCHMIDT RESTAURANT GROUP LLC | SAINT LOUIS, MO | Triad Bank |
| $1–2 million | SCHNEIDER ELECTRIC OF ST. LOUIS LLC | SAINT LOUIS, MO | The Central Trust Bank |
| $150,000–350,000 | SCHNEIDER INDUSTRIES INC. | SAINT LOUIS, MO | Regions Bank |
| $150,000–350,000 | SCHNELL EXPRESS LLC | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $350,000–1 million | SCHOELLHORN-ALBRECHT MACHINE CO., INC. | SAINT LOUIS, MO | Cass Commercial Bank |
| $150,000–350,000 | SCHOEN & SCHMITZ, LLC | SAINT LOUIS, MO | First Community CU |
| $350,000–1 million | SCHROEDER & TREMAYNE INC. | SAINT LOUIS, MO | CIBC Bank USA |
| $150,000–350,000 | SCHROEDER TRUCK REPAIR | SAINT LOUIS, MO | Bank of America, National Association |
| $150,000–350,000 | SCHUCHAT COOK & WERNER | SAINT LOUIS, MO | UMB Bank, National Association |
| $150,000–350,000 | SCI GROUP LLC | SAINT LOUIS, MO | Carrollton Bank |
| $350,000–1 million | SCORCH AGENCY LLC | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $150,000–350,000 | SCOTSMAN COIN & JEWELRY, INC. | SAINT LOUIS, MO | Busey Bank |
| $150,000–350,000 | SCOTT BROTHERS INVESTMENT CORP | SAINT LOUIS, MO | Sterling Bank |
| $350,000–1 million | SCOTT LEE GUTTERING CO INC | SAINT LOUIS, MO | Commerce Bank |
| $1–2 million | SCOTT LEE HEATING COMPANY | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | SEAFOOD CITY INC | SAINT LOUIS, MO | Bank of America, National Association |
| $150,000–350,000 | SEAL TITE CORPORATION | SAINT LOUIS, MO | Midwest BankCentre |
| $350,000–1 million | SEALING SPECIALISTS, INC. | SAINT LOUIS, MO | Bloomsdale Bank |
| $1–2 million | SECOND STREET MEDIA, INC | SAINT LOUIS, MO | Midwest BankCentre |
| $350,000–1 million | SECOND STREET SANDWICHES, INC. | SAINT LOUIS, MO | Midwest Regional Bank |
| $2–5 million | SEILER INSTRUMENT MANUFACTURING CO INC. | SAINT LOUIS, MO | UMB Bank, National Association |
| $150,000–350,000 | SEILER PLASTICS CORPORATION | SAINT LOUIS, MO | Carrollton Bank |
| $350,000–1 million | SELECT ORTHOPEDICS INC. | SAINT LOUIS, MO | St. Louis Bank |
| $2–5 million | SEMCO PLASTIC COMPANY | SAINT LOUIS, MO | Associated Bank, National Association |
| $150,000–350,000 | SEMMELMEYER - CORBY CO | SAINT LOUIS, MO | Busey Bank |
| $350,000–1 million | SENIORS HOME CARE LLC | SAINT LOUIS, MO | PNC Bank, National Association |
| $150,000–350,000 | SENSORY SOLUTIONS, LLC | SAINT LOUIS, MO | CNB Bank and Trust, National Association |
| $1–2 million | SERVICES BY DESIGN | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | SESSION FIXTURE CO., INC. | SAINT LOUIS, MO | Midwest BankCentre |
| $350,000–1 million | SFP LANDSCAPING INC | SAINT LOUIS, MO | Lindell Bank & Trust Company |
| $350,000–1 million | SFW PARTNERS, LLC | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | SHA TIN, LLC | SAINT LOUIS, MO | Montgomery Bank |
| $350,000–1 million | SHAARE EMETH CONGREGATION | SAINT LOUIS, MO | Triad Bank |
| $150,000–350,000 | SHACK FRONTENAC | SAINT LOUIS, MO | American Bank of Freedom |
| $150,000–350,000 | SHANDS, ELBERT, GIANOULAKIS & GILJUM, LLP | SAINT LOUIS, MO | Commerce Bank |
| $350,000–1 million | SHANNAHAN CRANE & HOIST, INC. | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $150,000–350,000 | SHAPIRO METAL SUPPLY | SAINT LOUIS, MO | U.S. Bank, National Association |
| $2–5 million | SHAPIRO METALS COMPANY | SAINT LOUIS, MO | CIBC Bank USA |