| $350,000–1 million | SHERPA, LLC | SAINT LOUIS, MO | CIBC Bank USA |
| $150,000–350,000 | SHERWOOD FOREST CAMP INC. | SAINT LOUIS, MO | Midwest Regional Bank |
| $150,000–350,000 | SHOW ME INDUSTRIAL SERVICES INC | SAINT LOUIS, MO | Commerce Bank |
| $350,000–1 million | SHRINK TECH SYSTEMS, INC. | SAINT LOUIS, MO | UMB Bank, National Association |
| $150,000–350,000 | SHS HANLEY LODGING LLC | SAINT LOUIS, MO | Simmons Bank |
| $150,000–350,000 | SIBIC TRUCKING, LLC | SAINT LOUIS, MO | Midwest BankCentre |
| $150,000–350,000 | SIDNEY INSULATION INC | SAINT LOUIS, MO | St. Louis Bank |
| $150,000–350,000 | SIDNEY STREET CAFE, LLC | SAINT LOUIS, MO | First Mid Bank & Trust, National Association |
| $150,000–350,000 | SIGNATURE CRAFT | SAINT LOUIS, MO | Bank Star |
| $150,000–350,000 | SILVER MAPLE PET CENTER, INC | SAINT LOUIS, MO | St. Louis Bank |
| $350,000–1 million | SILVERWEST-I CLAYTON HOLDINGS LLC | SAINT LOUIS, MO | Equity Bank |
| $150,000–350,000 | SIMON KATZ, INC | SAINT LOUIS, MO | The Central Trust Bank |
| $150,000–350,000 | SIMON KOHN ENTERPRISES | SAINT LOUIS, MO | The Central Trust Bank |
| $150,000–350,000 | SIMPTRONICS, LLC | SAINT LOUIS, MO | American Bank of Freedom |
| $2–5 million | SINCLAIR BUICK GMC TRUCK INC | SAINT LOUIS, MO | Midwest BankCentre |
| $150,000–350,000 | SISTER SERVANTS OF THE HOLY GHOST OF PERPETUAL ADORATION | SAINT LOUIS, MO | UMB Bank, National Association |
| $350,000–1 million | SISTERS OF ST. JOSEPH OF CARONDELET, ST. LOUIS PROVINCE | SAINT LOUIS, MO | U.S. Bank, National Association |
| $350,000–1 million | SITEX ENVIRONMENTAL INC | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | SKINNER & KENNEDY CO., INC. | SAINT LOUIS, MO | Cass Commercial Bank |
| $1–2 million | SLAH LLC | SAINT LOUIS, MO | Bank of Washington |
| $1–2 million | SLAM LLC | SAINT LOUIS, MO | Bank of Washington |
| $350,000–1 million | SLEEP DENTISTRY-ST LOUIS LLC | SAINT LOUIS, MO | The Central Trust Bank |
| $150,000–350,000 | SMARTHOUSE HEATING & COOLING LLC | SAINT LOUIS, MO | Peoples National Bank, National Association |
| $350,000–1 million | SMG-II, LLC | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | SMITH PATRICK PC | SAINT LOUIS, MO | Carrollton Bank |
| $350,000–1 million | SMJM, LLC | SAINT LOUIS, MO | Busey Bank |
| $350,000–1 million | SO HOSPITALITY GROUP LLC | SAINT LOUIS, MO | Bank Star |
| $150,000–350,000 | SOAR MEDICAL, LLC | SAINT LOUIS, MO | UMB Bank, National Association |
| $1–2 million | SOCIETY OF ST. VINCENT DE PAUL ARCHDIOCESAN COUNCIL OF ST. L | SAINT LOUIS, MO | Commerce Bank |
| $350,000–1 million | SOCIETY OF THE SACRED HEART, UNITED STATES-CANADA PROVINCE, | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $350,000–1 million | SOLON GERSHMAN, INC. | SAINT LOUIS, MO | The Central Trust Bank |
| $350,000–1 million | SOLUTIONS AEC, LLC | SAINT LOUIS, MO | Carrollton Bank |
| $2–5 million | SOUND HEALTH SERVICES, PC | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $150,000–350,000 | SOUTH CITY CATHOLIC ACADAMY | SAINT LOUIS, MO | Peoples National Bank, National Association |
| $150,000–350,000 | SOUTH CITY COMMUNITY SCHOOL | SAINT LOUIS, MO | Cass Commercial Bank |
| $350,000–1 million | SOUTH COUNTY CHRISTIAN CENTER | SAINT LOUIS, MO | Cass Commercial Bank |
| $150,000–350,000 | SOUTH COUNTY PEDIATRIC ASSOCIATIES INC | SAINT LOUIS, MO | PNC Bank, National Association |
| $150,000–350,000 | SOUTH COUNTY UROLOGICAL,INC | SAINT LOUIS, MO | Newtek Small Business Finance, Inc. |
| $2–5 million | SOUTH SIDE MACHINE WORKS, INC. | SAINT LOUIS, MO | Busey Bank |
| $150,000–350,000 | SOUTH ST. LOUIS MEDICAL ASSOCIATES, LLC | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $1–2 million | SOUTHLAND VOLKSWAGEN, INC | SAINT LOUIS, MO | St. Louis Bank |
| $350,000–1 million | SOUTHSIDE EARLY CHILDHOOD CENTER | SAINT LOUIS, MO | Commerce Bank |
| $1–2 million | SOUTHTOWN DODGE INC | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | SOUTHWEST PEDIATRICS, INC | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | SOUTHWESTERN ELECTRIC CO | SAINT LOUIS, MO | Regions Bank |
| $350,000–1 million | SOUTHWESTERN HEARING AID COMPANY INC | SAINT LOUIS, MO | Bank of America, National Association |
| $350,000–1 million | SOVEREIGN TECHNOLOGIES LLC | SAINT LOUIS, MO | Montgomery Bank |
| $150,000–350,000 | SPANISH SERVICE CENTER LLC | SAINT LOUIS, MO | Bank of America, National Association |
| $350,000–1 million | SPARTACUS LOMBARD LP | SAINT LOUIS, MO | Axos Bank |
| $5–10 million | SPARTAN LIGHT METAL PRODUCTS, INC | SAINT LOUIS, MO | First Bank |
| $150,000–350,000 | SPEARTIP, LLC | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $350,000–1 million | SPECIALISTS IN GASTROENTEROLOGY, L.L.C. | SAINT LOUIS, MO | Midland States Bank |
| $350,000–1 million | SPECIALTY CARTS, LLC | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | SPECIALTY MAILING, INC. | SAINT LOUIS, MO | Regions Bank |
| $350,000–1 million | SPECIALTY PAPERS & SUPPLIES LLC | SAINT LOUIS, MO | PNC Bank, National Association |
| $150,000–350,000 | SPECTOR, WOLFE, MCLAUGHLIN & O'MARA LLC | SAINT LOUIS, MO | St. Louis Bank |
| $350,000–1 million | SPELLMAN BRADY AND COMPANY | SAINT LOUIS, MO | Carrollton Bank |
| $1–2 million | SPIRTAS COMPANY | SAINT LOUIS, MO | Busey Bank |
| $350,000–1 million | SPOGEN BIOTECH INC. | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $150,000–350,000 | SPOKE, LLC | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $150,000–350,000 | SPORTSPLAY EQUIPMENT, INC. | SAINT LOUIS, MO | Triad Bank |
| $150,000–350,000 | SPORTSTIME 1 LP | SAINT LOUIS, MO | Montgomery Bank |
| $150,000–350,000 | SPOT CONTENT STUDIO, INC. | SAINT LOUIS, MO | Busey Bank |
| $350,000–1 million | SPOTLESS, INC | SAINT LOUIS, MO | Midwest BankCentre |
| $150,000–350,000 | SPRY DIGITAL, LLC | SAINT LOUIS, MO | Triad Bank |
| $2–5 million | SQUARE UP BUILDERS, LLC | SAINT LOUIS, MO | First Bank |
| $150,000–350,000 | SQWIRES INC. | SAINT LOUIS, MO | Midwest BankCentre |
| $350,000–1 million | ST ELIZABETH ADULT DAY CARE CENT | SAINT LOUIS, MO | Midland States Bank |
| $350,000–1 million | ST GERARD MAJELLA CATHOLIC CHURCH | SAINT LOUIS, MO | The Central Trust Bank |
| $150,000–350,000 | ST JOHNS PLACE INC | SAINT LOUIS, MO | Royal Banks of Missouri |
| $2–5 million | ST LOUIS ARC INC | SAINT LOUIS, MO | Carrollton Bank |
| $350,000–1 million | ST LOUIS CANCER CARE LLP | SAINT LOUIS, MO | Bank of America, National Association |
| $350,000–1 million | ST LOUIS CARDIOLOGY CONSULTANTS LTD | SAINT LOUIS, MO | Bank of America, National Association |
| $150,000–350,000 | ST LOUIS CENTER FOR FAMILY DEVELOPMENT | SAINT LOUIS, MO | Cass Commercial Bank |
| $150,000–350,000 | ST LOUIS CHURCH OF GOD, INC. | SAINT LOUIS, MO | Cass Commercial Bank |
| $150,000–350,000 | ST LOUIS COUNTY DENTAL PARTNERSHIP, TIMOTHY M GRAYEM DDS AND | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | ST LOUIS GENERAL HOSPITAL | SAINT LOUIS, MO | Midland States Bank |
| $150,000–350,000 | ST LOUIS GYMNASTIC CENTRE | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | ST LOUIS LAWN CARE INC | SAINT LOUIS, MO | Celtic Bank Corporation |
| $350,000–1 million | ST LOUIS PATHOLOGY ASSOCIATES INC | SAINT LOUIS, MO | PNC Bank, National Association |
| $350,000–1 million | ST LOUIS PEDIATRIC DENTISTRY LLC | SAINT LOUIS, MO | PNC Bank, National Association |
| $350,000–1 million | ST LOUIS PRE SORT INC | SAINT LOUIS, MO | Regions Bank |
| $2–5 million | ST LOUIS UNIVERSITY HIGH SCHOOL | SAINT LOUIS, MO | PNC Bank, National Association |
| $150,000–350,000 | ST LOUIS WHOLESALE FOODS INC | SAINT LOUIS, MO | Carrollton Bank |
| $150,000–350,000 | ST MONICA CATHOLIC CHURCH | SAINT LOUIS, MO | First Bank |
| $150,000–350,000 | ST PETER'S PROTESTANT EPISCOPAL CHURCH OF ST. LOUIS COUNTY, | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | ST STEPHEN PROTOMARTYR CATHOLIC CHURCH | SAINT LOUIS, MO | Lindell Bank & Trust Company |
| $5–10 million | ST. ALEXIUS HOSPITAL CORPORATION 1 | SAINT LOUIS, MO | U.S. Bank, National Association |
| $150,000–350,000 | ST. AMBROSE CATHOLIC CHURCH | SAINT LOUIS, MO | Peoples National Bank, National Association |
| $150,000–350,000 | ST. ANDREW'S AT HOME SERVICES, LLC | SAINT LOUIS, MO | Commerce Bank |
| $350,000–1 million | ST. ANDREW'S RESOURCES FOR SENIORS SYSTEM | SAINT LOUIS, MO | Commerce Bank |
| $150,000–350,000 | ST. ANN CATHOLIC CHURCH, NORMANDY | SAINT LOUIS, MO | Peoples National Bank, National Association |
| $350,000–1 million | ST. CATHERINE LABOURE CATHOLIC CHURCH | SAINT LOUIS, MO | Enterprise Bank & Trust |
| $350,000–1 million | ST. CLEMENT OF ROME CATHOLIC CHURCH | SAINT LOUIS, MO | The Central Trust Bank |
| $150,000–350,000 | ST. FRANCIS COMMUNITY SERVICES | SAINT LOUIS, MO | Southern Bank |
| $150,000–350,000 | ST. FRANCIS OF ASSISI CATHOLIC CHURCH, OAKVILLE | SAINT LOUIS, MO | Midwest BankCentre |
| $1–2 million | ST. JOHN VIANNEY HIGH SCHOOL, INC. | SAINT LOUIS, MO | Commerce Bank |
| $350,000–1 million | ST. JOSEPH'S ACADEMY, FRONTENAC, MISSOURI | SAINT LOUIS, MO | U.S. Bank, National Association |
| $350,000–1 million | ST. LOUIS ALTENHEIM | SAINT LOUIS, MO | Midwest BankCentre |
| $150,000–350,000 | ST. LOUIS ANTIQUE LIGHTING COMPANY, INC. | SAINT LOUIS, MO | Home State Bank |