| $350,000–1 million | PRECISION GRAPHICS INC | BIRMINGHAM, AL | Cadence Bank, National Association |
| $1–2 million | PRESBYTERIAN RETIREMENT HOMES OF BIRMINGHAM, INC. | BIRMINGHAM, AL | BancorpSouth Bank |
| $150,000–350,000 | PRESCRIPTION SPECIALTIES, INC. | BIRMINGHAM, AL | Peoples Bank of Alabama |
| $350,000–1 million | PRIME, INC. | BIRMINGHAM, AL | The Commercial Bank |
| $150,000–350,000 | PRINTSMART, INC. | BIRMINGHAM, AL | Renasant Bank |
| $1–2 million | PRIVATE INDUSTRIAL HOLDINGS INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | PROACT DENTAL, INC. | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | PROFESSIONAL BUILDING SERVICES LLC | BIRMINGHAM, AL | IBERIABANK |
| $350,000–1 million | PROGRESS INDUSTRIES INC | BIRMINGHAM, AL | Regions Bank |
| $150,000–350,000 | PROHEALTH GROUP INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | PROMETHEUS GROUP, LLC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $150,000–350,000 | PROMINENCE HOMES, LLC | BIRMINGHAM, AL | Cross River Bank |
| $350,000–1 million | PROTEUS MOLECULAR AND CLINICAL LAB, LLC | BIRMINGHAM, AL | Trustmark National Bank |
| $1–2 million | PROXSYS RX, LLC | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | PT ORTHODONTICS PC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | PUBLIC HOUSE LLC | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | PULMONARY ASSOCIATES OF THE SOUTHEAST PC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | PUMP & PROCESS EQUIPMENT COMPANY, INC | BIRMINGHAM, AL | Renasant Bank |
| $150,000–350,000 | PURE DERMATOLOGY & AESTHETICS, PC | BIRMINGHAM, AL | South State Bank, National Association |
| $2–5 million | QCHC MANAGEMENT SERVICES COMPANY INC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | QUALITY ARCHITECTURAL METAL & ROOFING, INC. | BIRMINGHAM, AL | Oakworth Capital Bank |
| $150,000–350,000 | QUALITY CREATIVE CUTTING LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | QUALITY CREATIVE LANDSCAPING, LLC | BIRMINGHAM, AL | CB&S Bank |
| $150,000–350,000 | QUINLAN PARTNERS, LLC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | R&M EQUIPMENT RENTALS, INC | BIRMINGHAM, AL | SouthPoint Bank |
| $150,000–350,000 | R&R ELECTRICAL SERVICES, INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | R.E.M. CLEANERS, INC. | BIRMINGHAM, AL | BancorpSouth Bank |
| $350,000–1 million | RADIOLOGY ASSOCIATES OF BIRMINGHAM | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | RARE TRANSPORTATION | BIRMINGHAM, AL | Bryant Bank |
| $1–2 million | RARESTEP, INC. | BIRMINGHAM, AL | CommerceOne Bank |
| $350,000–1 million | RASMUSSEN LAW FIRM, LLC | BIRMINGHAM, AL | Greater Nevada CU |
| $350,000–1 million | RAST CONSTRUCTION INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | REAL ESTATE MATRIX, L.L.C. | BIRMINGHAM, AL | BancorpSouth Bank |
| $150,000–350,000 | RED MOUNTAIN MEDICAL LLC | BIRMINGHAM, AL | BBVA USA |
| $150,000–350,000 | RED MOUNTAIN RESTAURANT GROUP LLC | BIRMINGHAM, AL | Renasant Bank |
| $150,000–350,000 | RED MOUNTAIN TECHNOLOGIES, LLC | BIRMINGHAM, AL | IBERIABANK |
| $150,000–350,000 | RED MOUNTAIN THEATRE COMPANY, INC. | BIRMINGHAM, AL | Regions Bank |
| $150,000–350,000 | RED ROCK REALTY GROUP, INC. | BIRMINGHAM, AL | Oakworth Capital Bank |
| $150,000–350,000 | REDMONT DISTILLING COMPANY, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | REDMONT PEDIATRIC ASSOCIATES, P. C. | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | REEMO WIRELESS | BIRMINGHAM, AL | SouthPoint Bank |
| $350,000–1 million | REEVE ELECTRIC COMPANY INC | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | REFLEX BLUE MEDIA INC. | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | REGIONAL PRODUCE DISTRIBUTORS, LIMITED LIABILITY COMPANY | BIRMINGHAM, AL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | REGULATORY SOLUTIONS LLC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | RELI SETTLEMENT SOLUTIONS LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $1–2 million | RESIDENTIAL WASTE SERVICES, LLC | BIRMINGHAM, AL | SouthPoint Bank |
| $150,000–350,000 | RETAIL SPECIALISTS LLC | BIRMINGHAM, AL | IBERIABANK |
| $350,000–1 million | RETAIL STRATEGIES, LLC | BIRMINGHAM, AL | SouthPoint Bank |
| $350,000–1 million | RETINA CONSULTANTS OF ALABAMA PC | BIRMINGHAM, AL | BancorpSouth Bank |
| $150,000–350,000 | RETINA SPECIALISTS OF ALABAMA IN MONTGOMERY, LLC | BIRMINGHAM, AL | BBVA USA |
| $350,000–1 million | RETINA SPECIALISTS OF ALABAMA, LLC. | BIRMINGHAM, AL | BBVA USA |
| $150,000–350,000 | REV BIRMINGHAM, INC. | BIRMINGHAM, AL | Synovus Bank |
| $350,000–1 million | RHEUMATOLOGY ASSOCIATES, P. C. | BIRMINGHAM, AL | Regions Bank |
| $150,000–350,000 | RICHTER LANDSCAPE COMPANY, LLC | BIRMINGHAM, AL | Progress Bank and Trust |
| $150,000–350,000 | RILEY & JACKSON, P. C. | BIRMINGHAM, AL | NobleBank & Trust |
| $350,000–1 million | RIVERVIEW ANIMAL CLINIC | BIRMINGHAM, AL | Regions Bank |
| $1–2 million | RIVES CONSTRUCTION COMPANY INC | BIRMINGHAM, AL | IBERIABANK |
| $350,000–1 million | RLS DESIGN GROUP INC. | BIRMINGHAM, AL | Regions Bank |
| $150,000–350,000 | RM LOGISTICS, INC. | BIRMINGHAM, AL | BBVA USA |
| $150,000–350,000 | RM MANAGEMENT, LLC | BIRMINGHAM, AL | Renasant Bank |
| $350,000–1 million | ROBERTSON AND ASSOCIATES INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | ROCKY HEIGHTS PRINT & BINDING LLC | BIRMINGHAM, AL | Bryant Bank |
| $150,000–350,000 | RODNEY SCOTT'S BBQ BIRMINGHAM LLC | BIRMINGHAM, AL | SouthPoint Bank |
| $150,000–350,000 | RODNEY SCOTTS BBQ CHARLESTON LC | BIRMINGHAM, AL | SouthPoint Bank |
| $350,000–1 million | ROEBUCK IMPORTED CARS, LLC | BIRMINGHAM, AL | Community Bank of Mississippi |
| $150,000–350,000 | ROHRER AESTHETICS LLC | BIRMINGHAM, AL | Regions Bank |
| $150,000–350,000 | RONALD MCDONALD HOUSE CHARITIES OF ALABAMA INC | BIRMINGHAM, AL | Renasant Bank |
| $350,000–1 million | ROOFERS MART SOUTHEAST INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | ROSS NEELY SYSTEMS, INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | ROUSSO FACIAL PLASTIC SURGERY CLINIC, PC | BIRMINGHAM, AL | South State Bank, National Association |
| $150,000–350,000 | ROXBERRY SERVICES, INC | BIRMINGHAM, AL | ServisFirst Bank |
| $1–2 million | ROYAL AUTOMOTIVE, INC | BIRMINGHAM, AL | CB&S Bank |
| $150,000–350,000 | ROYAL RESTORATION, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | ROYAL STREET, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | ROZAR'S AUTO PAINT SUPPLY INC. | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | RTO I, LLC | BIRMINGHAM, AL | CommerceOne Bank |
| $1–2 million | RURAL URGENT CARE LLC | BIRMINGHAM, AL | Peoples Bank of Alabama |
| $2–5 million | RUSSO CORPORATION | BIRMINGHAM, AL | Bryant Bank |
| $150,000–350,000 | S & W ELECTRIC COMPANY INC | BIRMINGHAM, AL | Alabama Central CU |
| $350,000–1 million | S E MEATS INC. | BIRMINGHAM, AL | IBERIABANK |
| $150,000–350,000 | SAI JUNG INC | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | SAIN ASSOCIATES, INC. | BIRMINGHAM, AL | ServisFirst Bank |
| $1–2 million | SAIN ENGINEERING ASSOCIATES, I | BIRMINGHAM, AL | PNC Bank, National Association |
| $150,000–350,000 | SAINT ROSE OF LIMA SCHOOL | BIRMINGHAM, AL | IBERIABANK |
| $150,000–350,000 | SAINT STEPHEN'S EPISCOPAL CHURCH | BIRMINGHAM, AL | South State Bank, National Association |
| $150,000–350,000 | SALON 43 ONE, LLC | BIRMINGHAM, AL | Pinnacle Bank |
| $150,000–350,000 | SAM-TAY ENTERPRISES | BIRMINGHAM, AL | NobleBank & Trust |
| $150,000–350,000 | SANDI GORNATI, INC. | BIRMINGHAM, AL | South State Bank, National Association |
| $350,000–1 million | SANDNER COMMERCIAL REAL ESTATE, INC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SANSOM EQUIPMENT COMPANY INC. | BIRMINGHAM, AL | Regions Bank |
| $150,000–350,000 | SATTERFIELD'S RESTAURANT AND CATERING, LLC | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | SAULS SEISMIC LLC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $1–2 million | SAVELA & ASSOCIATES INC. | BIRMINGHAM, AL | BBVA USA |
| $2–5 million | SB HOLDING CORPORATION | BIRMINGHAM, AL | SouthPoint Bank |
| $150,000–350,000 | SCHAFFER PLASTIC SURGERY PC | BIRMINGHAM, AL | ServisFirst Bank |
| $1–2 million | SCHOEL ENGINEERING COMPANY INC | BIRMINGHAM, AL | Truist Bank d/b/a Branch Banking & Trust Co |
| $2–5 million | SCHOLAR CRAFT PRODUCTS, INC. | BIRMINGHAM, AL | Valley National Bank |
| $150,000–350,000 | SCOTT DUKES & GEISLER P.C. | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | SCOTT ELECTRIC SIGN COMPANY INC | BIRMINGHAM, AL | IBERIABANK |