| $350,000–1 million | SCOTT ENERGY SERVICES LLC | BIRMINGHAM, AL | IBERIABANK |
| $150,000–350,000 | SCOTT, SULLIVAN, STREETMAN & FOX PC | BIRMINGHAM, AL | BBVA USA |
| $350,000–1 million | SCP COLDWORKS LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SDH PIZZA, INC. | BIRMINGHAM, AL | Millennial Bank |
| $1–2 million | SDS RESOURCES LLC | BIRMINGHAM, AL | SouthPoint Bank |
| $350,000–1 million | SEALE HARRIS CLINIC, PC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SECOND WIND PROGRAMS, INC | BIRMINGHAM, AL | South State Bank, National Association |
| $150,000–350,000 | SECURIT360, LLC | BIRMINGHAM, AL | IBERIABANK |
| $5–10 million | SECURITY ENGINEERS INC | BIRMINGHAM, AL | BBVA USA |
| $150,000–350,000 | SENIORSELECT PARTNERS INC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SERRA CHEVROLET, INC | BIRMINGHAM, AL | BancorpSouth Bank |
| $350,000–1 million | SERRA NISSAN-OLDSMOBILE, INC. | BIRMINGHAM, AL | BancorpSouth Bank |
| $350,000–1 million | SERVICE CONSTRUCTION SUPPLY, INC. | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SHADES CREST BAPTIST CHURCH | BIRMINGHAM, AL | South State Bank, National Association |
| $150,000–350,000 | SHAIA'S OF HOMEWOOD INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SHARP AND STONE OB/GYN PC | BIRMINGHAM, AL | Synovus Bank |
| $1–2 million | SHEBANIAH LLC | BIRMINGHAM, AL | MBE Capital Partners |
| $150,000–350,000 | SHEFFIELD ELECTRICAL CONTRACTORS, LLC | BIRMINGHAM, AL | Progress Bank and Trust |
| $150,000–350,000 | SHEFFIELD RISK MANAGEMENT SERVICES, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SHELBY COMPANY LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SHOEMAKER POOL SERVICE, INC. | BIRMINGHAM, AL | Synovus Bank |
| $1–2 million | SHOOK AND FLETCHER MECHANICAL CONTRACTORS INC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SHUNNARAH INJURY LAWYERS, P.C. | BIRMINGHAM, AL | Community Bank of Mississippi |
| $150,000–350,000 | SIG ALABAMA LLC | BIRMINGHAM, AL | Regions Bank |
| $150,000–350,000 | SIGAO STUDIOS, LLC. | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | SIGN BUILDERS, INC. | BIRMINGHAM, AL | Truist Bank d/b/a Branch Banking & Trust Co |
| $1–2 million | SIMON-WILLIAMSON CLINIC PC | BIRMINGHAM, AL | BBVA USA |
| $150,000–350,000 | SIMPLESHIP HOLDINGS, LLC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | SIMPSON PLASTERING LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $5–10 million | SIROTE & PERMUTT, PC | BIRMINGHAM, AL | Cadence Bank, National Association |
| $150,000–350,000 | SIXTH AVENUE BAPTIST CHURCH | BIRMINGHAM, AL | Sixth Avenue Baptist FCU |
| $350,000–1 million | SKIN DIAGNOSTICS GROUP PC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SKIPPER CONSULTING, INC | BIRMINGHAM, AL | Progress Bank and Trust |
| $150,000–350,000 | SLEEP DISORDER CENTER OF ALABAMA INC | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | SLICE, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SLOSS REAL ESTATE COMPANY, INC. | BIRMINGHAM, AL | First US Bank |
| $350,000–1 million | SLS WEST INC | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | SMAO, LLC | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | SMART DIGITAL, LLC | BIRMINGHAM, AL | Renasant Bank |
| $1–2 million | SMW ENGINEERING GROUP, INC | BIRMINGHAM, AL | Regions Bank |
| $150,000–350,000 | SNIDER THERAPY CENTERS INC | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | SOCIALLYIN. LLC | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | SOURCEPOINTE OF AL, LLC | BIRMINGHAM, AL | South State Bank, National Association |
| $150,000–350,000 | SOUTH CYPRESS, INC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $150,000–350,000 | SOUTH HIGHLAND CHILD DEVELOPMENT CENTER | BIRMINGHAM, AL | IBERIABANK |
| $350,000–1 million | SOUTH OAK TITLE, LLC | BIRMINGHAM, AL | Progress Bank and Trust |
| $150,000–350,000 | SOUTHEAST BUSINESS FURNITURE SERVICES, INC. | BIRMINGHAM, AL | First US Bank |
| $350,000–1 million | SOUTHEAST CLINICAL LABORATORIES, LLC | BIRMINGHAM, AL | BancorpSouth Bank |
| $150,000–350,000 | SOUTHEASTERN COMMERCIAL FINANCE, L.L.C. | BIRMINGHAM, AL | Pinnacle Bank |
| $150,000–350,000 | SOUTHEASTERN CONVEYOR SERVICES,INC. | BIRMINGHAM, AL | Traditions Bank |
| $350,000–1 million | SOUTHEASTERN REFRIGERATION, INC. | BIRMINGHAM, AL | Renasant Bank |
| $350,000–1 million | SOUTHEASTERN SEALCOATING INC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SOUTHERN BIOTECHNOLOGY ASSOCIATES INC | BIRMINGHAM, AL | Synovus Bank |
| $350,000–1 million | SOUTHERN COFFEE COMPANY | BIRMINGHAM, AL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | SOUTHERN CONSOLIDATED ELECTRICAL SALES, INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SOUTHERN ENT & SINUS CENTER P. C. | BIRMINGHAM, AL | Synovus Bank |
| $350,000–1 million | SOUTHERN EQUIPMENT & CREW LLC | BIRMINGHAM, AL | Cadence Bank, National Association |
| $150,000–350,000 | SOUTHERN HEMATOLOGY & ONCOLOGY, P.C. | BIRMINGHAM, AL | South State Bank, National Association |
| $350,000–1 million | SOUTHERN LAB PARTNERS, LLC | BIRMINGHAM, AL | Community Bank of Mississippi |
| $150,000–350,000 | SOUTHERN LABEL CO. | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SOUTHERN OVERHEAD DOOR INC | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | SOUTHERN PATIENT CARE, INC. | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | SOUTHERN PRECISION STAFFING | BIRMINGHAM, AL | Bryant Bank |
| $5–10 million | SOUTHERN RESEARCH INSTITUTE | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | SOUTHERN SKY AVIATION, LLC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | SOUTHERN SWEEPERS & SCRUBBERS INC | BIRMINGHAM, AL | Renasant Bank |
| $150,000–350,000 | SOUTHERN TRUCK CENTER, INC. | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | SOUTHLAKE PEDIATRICS, INC. | BIRMINGHAM, AL | Regions Bank |
| $350,000–1 million | SOUTHLAND ELECTRIC COMPANY INC | BIRMINGHAM, AL | ServisFirst Bank |
| $2–5 million | SOUTHLAND INTERNATIONAL TRUCKS INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SOUTHPACE, INC. | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | SOUTHSIDE APARTMENT COMPANY LLC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | SOUTHSIDE PAIN SPECIALISTS PC | BIRMINGHAM, AL | ServisFirst Bank |
| $2–5 million | SOUTHVIEW MEDICAL GROUP PC | BIRMINGHAM, AL | Regions Bank |
| $150,000–350,000 | SOUTHWESTERN ATHLETIC CONFERENCE | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SPAIN & GILLON LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SPARKS & FAVOR PC | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | SPARTAN VALUE INVESTORS LLC | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | SPLAWN & WARD ASSOC | BIRMINGHAM, AL | BBVA USA |
| $1–2 million | SPM, LLC | BIRMINGHAM, AL | First US Bank |
| $150,000–350,000 | SPOT COLOR LLC | BIRMINGHAM, AL | Bryant Bank |
| $350,000–1 million | SPOTSWOOD, SANSOM & SANSBURY, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SPREADRITE, LLC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | SPRING VALLEY SCHOOL FOUNDATION | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | SPRINGER EQUIPMENT CO. INC. | BIRMINGHAM, AL | South State Bank, National Association |
| $150,000–350,000 | SPROUTHOUSE, LLC | BIRMINGHAM, AL | IBERIABANK |
| $350,000–1 million | ST FRANCIS XAVIER CATHOLIC CHURCH | BIRMINGHAM, AL | Oakworth Capital Bank |
| $150,000–350,000 | ST MARYS ON THE HIGHLANDS | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | ST PETER THE APOSTLE CATHOLIC CHURCH | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | ST. LUKE'S EPISCOPAL CHURCH, MOUNTAIN BROOK, ALABAMA, INC. | BIRMINGHAM, AL | South State Bank, National Association |
| $350,000–1 million | ST. VINCENT'S ORTHOPEDICS, PC | BIRMINGHAM, AL | Oakworth Capital Bank |
| $350,000–1 million | STANDARD FURNITURE COMPANY OF ALABAMA, INC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | STANDARD HEATING & AIR CONDITIONING COMPANY INC | BIRMINGHAM, AL | ServisFirst Bank |
| $150,000–350,000 | STANDRIDGE LOGISTICS AND CONSULTING, LLC | BIRMINGHAM, AL | Truist Bank d/b/a Branch Banking & Trust Co |
| $1–2 million | STAR INSULATION INC | BIRMINGHAM, AL | ServisFirst Bank |
| $350,000–1 million | STARBOARD MANAGEMENT, LLC | BIRMINGHAM, AL | BBVA USA |
| $2–5 million | STARNES DAVIS FLORIE LLP | BIRMINGHAM, AL | South State Bank, National Association |
| $150,000–350,000 | STARNES HOLDINGS, INC. | BIRMINGHAM, AL | Synovus Bank |
| $150,000–350,000 | START TRUCK PARTS | BIRMINGHAM, AL | IBERIABANK |
| $150,000–350,000 | STATE OF ALABAMA BALLET, INC | BIRMINGHAM, AL | Regions Bank |