| $350,000–1 million | BOB DEAN SUPPLY INC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | BOW ECHO CONSTRUCTION, LLC | FORT MYERS, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | BOWLING MANAGEMENT ASSOCIATES, INC. | FORT MYERS, FL | Lake Michigan CU |
| $350,000–1 million | BOYLE LEONARD ANDERSON PA | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | BRITTANIA ELECTRIC II, LLC | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | BROOKS & FREUND LLC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | BRYANT ROOFING LLC | FORT MYERS, FL | First Bank |
| $150,000–350,000 | BSSW ARCHITECTS INC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | BUSHWOOD TREE COMPANY LLC | FORT MYERS, FL | FineMark National Bank & Trust |
| $150,000–350,000 | BUSINESS VIEW PUBLISHING INC. | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | C-T FIRE PROTECTION, INC | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | C.L. NOONAN DISPOSAL, INC. | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | CABO CANTINA | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | CALOOSA SITE DEVELOPMENT INC | FORT MYERS, FL | Achieva CU |
| $350,000–1 million | CAMPO FELICE PHASE 1 LLC | FORT MYERS, FL | Newtek Small Business Finance, Inc. |
| $350,000–1 million | CAPE CORAL PLUMBING INC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | CAPONE'S COAL FIRED PIZZA LLC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | CAPSTONE HOLDINGS INC | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | CARDIOLOGY CONSULTANTS OF SW FLORIDA INC | FORT MYERS, FL | Synovus Bank |
| $150,000–350,000 | CARING MEDICAL AND REHABILITATION | FORT MYERS, FL | FineMark National Bank & Trust |
| $150,000–350,000 | CARING MEDICAL FLORIDA PLLC | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | CARRIGAN BROTHERS LLC | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | CATLIN DENTAL PA | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | CCNL, LLC | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | CEMENT INDUSTRIES INC | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | CERTIFIED HEATING AND COOLING, INC. | FORT MYERS, FL | Live Oak Banking Company |
| $150,000–350,000 | CERTIFIED POOL MECHANICS 1 INC | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | CGC SOLUTIONS INC | FORT MYERS, FL | Synovus Bank |
| $1–2 million | CHATT TRANSPORT SERVICES, LLC | FORT MYERS, FL | First Community National Bank |
| $350,000–1 million | CHILD CARE OF SOUTHWEST FLORID | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | CHILDREN'S ADVOCACY CENTER OF SOUTHWEST FLORIDA, INC. | FORT MYERS, FL | Edison National Bank |
| $350,000–1 million | CHRIS-TEL COMPANY OF SOUTHWEST FL INC. | FORT MYERS, FL | FineMark National Bank & Trust |
| $150,000–350,000 | CHUCK A. TAYLOR, LLC | FORT MYERS, FL | Fifth Third Bank |
| $150,000–350,000 | CICCIO BELLO FM LLC | FORT MYERS, FL | Centennial Bank |
| $350,000–1 million | CIGENT TECHNOLOGY INC. | FORT MYERS, FL | First Bank |
| $350,000–1 million | CITY OF PALMS CHARTER HIGH SCHOOL, INC | FORT MYERS, FL | Synovus Bank |
| $350,000–1 million | CKC DELIVERY SERVICE | FORT MYERS, FL | Cross River Bank |
| $350,000–1 million | CKCTB INC. | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | CLA LANDSCAPING, INC. | FORT MYERS, FL | WebBank |
| $150,000–350,000 | CLAIM JUMPER, INC. | FORT MYERS, FL | The Huntington National Bank |
| $350,000–1 million | CLARKE CONSTRUCTION GROUP, INC. | FORT MYERS, FL | Fifth Third Bank |
| $2–5 million | CLIVE DANIEL HOME HOLDINGS LLC | FORT MYERS, FL | City National Bank of Florida |
| $1–2 million | CLOUD HUB IT SOLUTIONS INC | FORT MYERS, FL | First United Bank and Trust Company |
| $150,000–350,000 | CLUB CARE INC | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | COASTAL CONCRETE PRODUCTS, LLC | FORT MYERS, FL | First-Citizens Bank & Trust Company |
| $350,000–1 million | COASTAL COOLING, INC | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | COASTAL PRECAST OF FLORIDA INC | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | COLLIER ELECTRIC COMPANY OF FORT MYERS | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | COLONIAL COUNTRY CLUB OF LEE COUNTY MASTER ASSOCIATION INC. | FORT MYERS, FL | Lake Michigan CU |
| $150,000–350,000 | COLONIAL FUNDING GROUP LLC | FORT MYERS, FL | Fifth Third Bank |
| $150,000–350,000 | COLONIAL POOL & SPA, INC. | FORT MYERS, FL | First Horizon Bank |
| $150,000–350,000 | COMMERCIAL PLUMBING SOLUTIONS | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | COMMERCIAL PROPERTY OF SW FL | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | COMMERCIAL REAL ESTATE CONSULTANTS L.L.C. | FORT MYERS, FL | Busey Bank |
| $150,000–350,000 | COMMUNITY COOPERATIVE INC. | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | COMMUNITY DENTAL PRACTICES, LLC | FORT MYERS, FL | First Bank |
| $350,000–1 million | COMPUTERS AT WORK!, INC. | FORT MYERS, FL | Radius Bank |
| $150,000–350,000 | CONSEL, INC. OF FLORIDA | FORT MYERS, FL | First Horizon Bank |
| $350,000–1 million | COOLAIR CONDITIONING | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | COPY CONCEPTS, INC. | FORT MYERS, FL | Busey Bank |
| $2–5 million | CORNERSTONE BUILDERS OF SW FLORIDA, INC. | FORT MYERS, FL | First Florida Integrity Bank |
| $1–2 million | COSAS BUENAS BARATAS INC. | FORT MYERS, FL | Regions Bank |
| $1–2 million | COUGAR CUTTING, INC. | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | COUNTRY BUMPKINS INC | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | COUNTY WASTE, LLC | FORT MYERS, FL | First Horizon Bank |
| $150,000–350,000 | CPR TOOLS INC | FORT MYERS, FL | First Bank |
| $150,000–350,000 | CRAZY HORSE ENTERPRISES, INC. | FORT MYERS, FL | Busey Bank |
| $150,000–350,000 | CREEL TRACTOR COMPANY | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | CREW CONCEPTS LLC | FORT MYERS, FL | Cogent Bank |
| $150,000–350,000 | CRISTOF'S ON MCGREGOR INC. | FORT MYERS, FL | Busey Bank |
| $350,000–1 million | CROWN COLONY GOLF & COUNTRY CLUB INC | FORT MYERS, FL | IBERIABANK |
| $2–5 million | CROWTHER HOLDINGS, INC. | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | CRYSTAL CLEAN S LLC | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | CRYSTEK CRYSTALS CORPORATION | FORT MYERS, FL | Busey Bank |
| $150,000–350,000 | CULBERTSON AGENCY | FORT MYERS, FL | WebBank |
| $350,000–1 million | CYPRESS LAKE COUNTRY CLUB INC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | CYPRESS LAKE UNITED METHODIST CHURCH INC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | CYPRESS PHARMACY, INC. | FORT MYERS, FL | Live Oak Banking Company |
| $2–5 million | D PECK ROOFING INC | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | D T WATER LLC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | D&D MACHINE & HYDRAULICS INC | FORT MYERS, FL | South State Bank, National Association |
| $150,000–350,000 | D.S.I. GENERAL CONTRACTORS INC. | FORT MYERS, FL | Busey Bank |
| $150,000–350,000 | D3 GLASS, LLC | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | DALTON COMMUNITIES LLC | FORT MYERS, FL | Bank OZK |
| $150,000–350,000 | DARUMA BELL TOWER | FORT MYERS, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | DATA PARTNERS INC | FORT MYERS, FL | Regions Bank |
| $150,000–350,000 | DAVE'S QUALITY SERVICES INC. | FORT MYERS, FL | Radius Bank |
| $350,000–1 million | DE LASALLE ACADEMY OF FORT MYERS INC | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | DEAN STEEL BUILDINGS, INC. | FORT MYERS, FL | Regions Bank |
| $150,000–350,000 | DEBORAH S RUDDELL DDS PA | FORT MYERS, FL | Regions Bank |
| $350,000–1 million | DEEP LAGOON FORT MYERS LLC | FORT MYERS, FL | Synovus Bank |
| $150,000–350,000 | DENCO CONSTRUCTION INC | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | DENTAL DESIGNS OF FORT MYERS LLC | FORT MYERS, FL | Newtek Small Business Finance, Inc. |
| $150,000–350,000 | DERMATOLOGY SOULTIONS, A PROFESSIONAL LIMITED LIABILITY COMPANY | FORT MYERS, FL | First-Citizens Bank & Trust Company |
| $150,000–350,000 | DEVLIN SHUTTERS LLC | FORT MYERS, FL | Lake Michigan CU |
| $150,000–350,000 | DEVOTED RESTORATION LLC | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | DF CAPTIVA ISLAND LLC | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $350,000–1 million | DF FORT MYERS BEACH LLC | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $1–2 million | DIAMOND ARCHITECTURAL BUILDING PRODUCTS, LLC | FORT MYERS, FL | BMO Harris Bank National Association |
| $150,000–350,000 | DIAMOND GLASS AND ALUMINUM LLC | FORT MYERS, FL | Bank of America, National Association |