| $150,000–350,000 | DIAMOND SECURITY SYSTEMS, INC | FORT MYERS, FL | First-Citizens Bank & Trust Company |
| $150,000–350,000 | DISCOVER MARBLE & GRANITE II INC | FORT MYERS, FL | Bank of America, National Association |
| $1–2 million | DIVISION 16 LLC | FORT MYERS, FL | First Home Bank |
| $350,000–1 million | DIXIE BUICK GMC TRUCK, INC. | FORT MYERS, FL | Ally Bank |
| $150,000–350,000 | DIXIE WHARF LLC | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | DJ GOULD ELECTRIC CO, INC. | FORT MYERS, FL | Regions Bank |
| $150,000–350,000 | DLS CONSTRUCTION, INC. | FORT MYERS, FL | Busey Bank |
| $1–2 million | DNA COMPREHENSIVE THERAPY SERVICES, LLC | FORT MYERS, FL | Busey Bank |
| $350,000–1 million | DOC FORDS SANIBEL, LLC | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | DOWNTOWN HOUSE OF PIZZA | FORT MYERS, FL | MidWestOne Bank |
| $350,000–1 million | DOWNTOWN PUBLIC HOUSE LLC | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | DRAKE READY MIX INC | FORT MYERS, FL | Synovus Bank |
| $350,000–1 million | DSK RETAIL INC. | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | DTC DISTRIBUTORS LLC | FORT MYERS, FL | First-Citizens Bank & Trust Company |
| $150,000–350,000 | DUKE FARMS, LLC | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | DWAYNE BERGMANN LLC | FORT MYERS, FL | Busey Bank |
| $350,000–1 million | E Z METALS INC | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | E. TREVOR ELMQUIST, D.O. P.A. | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | EAR, NOSE & THROAT ASSOCIATES, M.D, P.A. | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | EARTH TECH ENTERPRISES INC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | EAST & GREENWELL INSURANCE INC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | EASTSIDE ANIMAL HOSPITAL INC | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | EBA BOWLING, LLC | FORT MYERS, FL | First Hope Bank, A National Banking Association |
| $150,000–350,000 | ECOSYSTEM TECHNOLOGIES INC | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | EDISON OIL COMPANY | FORT MYERS, FL | First Florida Integrity Bank |
| $150,000–350,000 | EDSALL GROVES, INC. | FORT MYERS, FL | Synovus Bank |
| $150,000–350,000 | EISELE PIE LLC | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | ELECTRONIC SYSTEM SERVICES INC | FORT MYERS, FL | IBERIABANK |
| $1–2 million | ELEVEN ASH INC | FORT MYERS, FL | Bank of America, National Association |
| $1–2 million | ELITE ELECTRICAL CONTRACTORS, LLC | FORT MYERS, FL | Busey Bank |
| $350,000–1 million | EMCYTE CORP. | FORT MYERS, FL | South State Bank, National Association |
| $150,000–350,000 | EMERGENCY & MOLD SPECIALIST, INC | FORT MYERS, FL | BankUnited, National Association |
| $150,000–350,000 | EMT, INC. | FORT MYERS, FL | Synovus Bank |
| $150,000–350,000 | ENCLOSURE RESCUE, INC. | FORT MYERS, FL | Regions Bank |
| $350,000–1 million | ENTECH COMPUTER SERVICES, INC. | FORT MYERS, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | ENTERTAINMENT METALS, LLC | FORT MYERS, FL | MidWestOne Bank |
| $350,000–1 million | ENVIRONMENTAL CONCRETE AND MATERIALS LLC | FORT MYERS, FL | Synovus Bank |
| $150,000–350,000 | ENVIRONMENTAL RISK MANAGEMENT, INC. | FORT MYERS, FL | Synovus Bank |
| $150,000–350,000 | ENVISION GLASS & ALUMINUM, LLC | FORT MYERS, FL | Benworth Capital |
| $350,000–1 million | ESTATE LANDSCAPING & LAWN MANAGEMENT, LLC | FORT MYERS, FL | Busey Bank |
| $1–2 million | EVANGELICAL CHRISTIAN SCHOOL, INC. | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | EVANGELISTIC WORKS, INC. | FORT MYERS, FL | Lake Michigan CU |
| $150,000–350,000 | EVERGLADES AIRBOAT RESORTS LLC | FORT MYERS, FL | First Bank |
| $150,000–350,000 | EVERGLADES JACKS, LLC | FORT MYERS, FL | First Bank |
| $350,000–1 million | EVERGLADES PINESTRAW, INC | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | EVERYDAY MAINTENANCE INC | FORT MYERS, FL | First Florida Integrity Bank |
| $150,000–350,000 | EXCEL SERVICES INC | FORT MYERS, FL | Regions Bank |
| $150,000–350,000 | EXCELSIOR HOLDINGS I, LLC | FORT MYERS, FL | Newtek Small Business Finance, Inc. |
| $150,000–350,000 | EXTREME DISPOSAL, LLC | FORT MYERS, FL | First Federal Bank |
| $150,000–350,000 | EXTREME PAINTING & CONTRACTING, INC. | FORT MYERS, FL | First Federal Bank |
| $2–5 million | EYE CENTERS OF FLORIDA PA | FORT MYERS, FL | Synovus Bank |
| $350,000–1 million | FABRI-TECH SCREEN ENCLOSURES, LLC | FORT MYERS, FL | First-Citizens Bank & Trust Company |
| $5–10 million | FALLSAFE SOLUTIONS, LLC | FORT MYERS, FL | Regions Bank |
| $150,000–350,000 | FANCY'S SOUTHERN CAFE LLC | FORT MYERS, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | FEIL, INC. | FORT MYERS, FL | Regions Bank |
| $150,000–350,000 | FF FT MYERS I LLC | FORT MYERS, FL | Citizens Bank of Florida |
| $1–2 million | FIDDLESTICKS COUNTRY CLUB, INC | FORT MYERS, FL | First Horizon Bank |
| $150,000–350,000 | FIESTA FIVE SUPERMARKET, INC | FORT MYERS, FL | BankUnited, National Association |
| $350,000–1 million | FIFER & HELIGMAN MD PA | FORT MYERS, FL | FineMark National Bank & Trust |
| $150,000–350,000 | FILTCO INC | FORT MYERS, FL | Regions Bank |
| $350,000–1 million | FIRESERVICE INC | FORT MYERS, FL | First Florida Integrity Bank |
| $350,000–1 million | FIRESTONES RESTAURANT | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | FIRST ASSEMBLY OF GOD OF FORT MYERS, FL INC. | FORT MYERS, FL | Valley National Bank |
| $150,000–350,000 | FIRST CLASS PAVERS AND TILE, LLC | FORT MYERS, FL | Fifth Third Bank |
| $350,000–1 million | FIRST FAMILY INSURANCE INC | FORT MYERS, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | FIRST FLORIDA FINANCIAL GROUP, LLC | FORT MYERS, FL | Bank OZK |
| $150,000–350,000 | FIVE COUNTY INSURANCE AGENCY, INC. | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | FLOOD PROS OF SWFL, CORP. | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | FLORIDA EMPLOYMENT SPECIALISTS | FORT MYERS, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | FLORIDA GLASS & ALUMINUM, INC. | FORT MYERS, FL | BankUnited, National Association |
| $1–2 million | FLORIDA HEART ASSOCIATES PL | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | FLORIDA HEAT & AIR INC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | FLORIDA INSTALL LLC | FORT MYERS, FL | Busey Bank |
| $150,000–350,000 | FLORIDA LIFESTYLE HOMES | FORT MYERS, FL | American Momentum Bank |
| $150,000–350,000 | FLORIDA MAIL & PRINT SOLUTIONS INC | FORT MYERS, FL | Bank OZK |
| $350,000–1 million | FLORIDA MEDIA GROUP LLC DBA FLORIDA WEEKLY | FORT MYERS, FL | Synovus Bank |
| $350,000–1 million | FLORIDA NEUROLOGY GROUP, P.L. | FORT MYERS, FL | FineMark National Bank & Trust |
| $350,000–1 million | FLORIDA RADIOLOGY CONSULTANT PA | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $350,000–1 million | FLORIDA REPERTORY COMPANY, INC | FORT MYERS, FL | Sanibel Captiva Community Bank |
| $150,000–350,000 | FLORIDA SALES & MARKETING INC | FORT MYERS, FL | First-Citizens Bank & Trust Company |
| $1–2 million | FLORIDA SERVICE PAINTING INC | FORT MYERS, FL | Cogent Bank |
| $350,000–1 million | FLORIDA SKIN CENTER, INC. | FORT MYERS, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | FLORIDA STAIRWORKS AND CARPENTRY LLC | FORT MYERS, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | FLORIDA STRUCTURAL GROUP, INC. | FORT MYERS, FL | Synovus Bank |
| $1–2 million | FLORIDA WEST COAST INC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | FLORIDA WOOD WINDOW & DOOR, INC. | FORT MYERS, FL | Lake Michigan CU |
| $150,000–350,000 | FLUHARTY-MONROE CONSTRUCTION INC | FORT MYERS, FL | IBERIABANK |
| $350,000–1 million | FM RNC, LLC | FORT MYERS, FL | Customers Bank |
| $150,000–350,000 | FM VEREANDA LLC | FORT MYERS, FL | IBERIABANK |
| $150,000–350,000 | FOOD AND DRINK, INC | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | FOOT & ANKLE GROUP OF SOUTHWEST FLORIDA P.A. | FORT MYERS, FL | Blue Ridge Bank, National Association |
| $150,000–350,000 | FOR GOD & COUNTY INC | FORT MYERS, FL | The Huntington National Bank |
| $350,000–1 million | FORD'S GARAGE LLC | FORT MYERS, FL | First Home Bank |
| $350,000–1 million | FORKLIFT EXCHANGE, INC. | FORT MYERS, FL | The First National Bank of Ottawa |
| $150,000–350,000 | FORRESTER HART BELISLE AND WHITAKER PL | FORT MYERS, FL | Regions Bank |
| $350,000–1 million | FORT MYERS ACQUISITIONS, LLC | FORT MYERS, FL | Lake Michigan CU |
| $150,000–350,000 | FORT MYERS BREWING COMPANY LLC | FORT MYERS, FL | FineMark National Bank & Trust |
| $2–5 million | FORT MYERS BROADCASTING COMPANY | FORT MYERS, FL | Bank of America, National Association |
| $150,000–350,000 | FORT MYERS CHRISTIAN SCHOOL INC | FORT MYERS, FL | Edison National Bank |
| $150,000–350,000 | FORT MYERS DERMATOPATHOLOGY, P.A. | FORT MYERS, FL | Busey Bank |