| $150,000–350,000 | SAFE TOUCH OF CENTRAL FLORIDA INC | JACKSONVILLE, FL | Valley National Bank |
| $150,000–350,000 | SAFE TOUCH OF TALLAHASSEE INC | JACKSONVILLE, FL | Valley National Bank |
| $150,000–350,000 | SAFETOUCH OF TAMPA INC | JACKSONVILLE, FL | Valley National Bank |
| $150,000–350,000 | SAFETY CONTRACTORS, INC. | JACKSONVILLE, FL | Valley National Bank |
| $350,000–1 million | SAIL NURSING AND REHABILITATION CENTER, LLC | JACKSONVILLE, FL | BOKF, National Association |
| $150,000–350,000 | SAKE HOUSE SUSHI INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | SALAZAR FINANCIAL GROUP LLC | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $350,000–1 million | SALLY INDUSTRIES INC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | SAM'S HEAVY HAUL, INC. DBA JIMMIES WRECKER SERVICE | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $350,000–1 million | SAN JOSE CATHOLIC GRADE SCHOOL | JACKSONVILLE, FL | South State Bank, National Association |
| $150,000–350,000 | SAN JOSE COLLISION, INC. | JACKSONVILLE, FL | First Federal Bank |
| $350,000–1 million | SAN JOSE EPISCOPAL DAY | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | SAN PABLO ANIMAL HOSPITAL, P.A. | JACKSONVILLE, FL | United National Bank |
| $350,000–1 million | SANIGLAZE INTERNATIONAL, LLC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SARAJAX EDU ENTERPRISES, INC. | JACKSONVILLE, FL | First Chatham Bank |
| $150,000–350,000 | SAUNDERS & COMPANY INC | JACKSONVILLE, FL | Florida Capital Bank, National Association |
| $150,000–350,000 | SAW MANAGEMENT GROUP, INC. | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | SAWCROSS, INC. | JACKSONVILLE, FL | TD Bank, National Association |
| $350,000–1 million | SB LEASING LLC | JACKSONVILLE, FL | Heritage Bank, A Division of |
| $150,000–350,000 | SBME, LLC | JACKSONVILLE, FL | TD Bank, National Association |
| $350,000–1 million | SCHUMAN ELECTRIC INC | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | SCHUR & COMPANY LLC | JACKSONVILLE, FL | Synovus Bank |
| $350,000–1 million | SCOTT D. WARREN, M.D., P.A. | JACKSONVILLE, FL | Benchmark Bank |
| $350,000–1 million | SCOTT INDUSTRIAL SYSTEMS, LLC | JACKSONVILLE, FL | Fifth Third Bank |
| $150,000–350,000 | SCRIBE SOLUTIONS, INC. | JACKSONVILLE, FL | BBVA USA |
| $350,000–1 million | SE FOODS, LLC | JACKSONVILLE, FL | TD Bank, National Association |
| $1–2 million | SEA BREEZE SERVICE INC | JACKSONVILLE, FL | BBVA USA |
| $350,000–1 million | SEA SNAPPERS, INC. | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | SEA-EST INCORPORATED | JACKSONVILLE, FL | Newtek Small Business Finance, Inc. |
| $350,000–1 million | SEACOAST CHARTER ACADEMY, INC. | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SEACOAST CHRISTIAN ACADEMY INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SEAMARK RANCH, INC. | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | SECUR-NET USA, INC. | JACKSONVILLE, FL | VyStar CU |
| $350,000–1 million | SECURE IDEAS, LLC | JACKSONVILLE, FL | 121 Financial CU |
| $150,000–350,000 | SECURITY DEVELOPMENT GROUP, LLC DBA S3 SECURITY | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | SECURITY ENGINEERING AND DESIGNS INC | JACKSONVILLE, FL | BBVA USA |
| $350,000–1 million | SEDA CONSTRUCTION COMPANY | JACKSONVILLE, FL | Regions Bank |
| $150,000–350,000 | SERRANO PAINT & BODY SHOP CO., INC. | JACKSONVILLE, FL | South State Bank, National Association |
| $1–2 million | SERVICE FIRST INSURANCE GROUP, LLC | JACKSONVILLE, FL | Citizens Bank, National Association |
| $150,000–350,000 | SERVITOR, INC. | JACKSONVILLE, FL | First Bank of the Lake |
| $150,000–350,000 | SETZER, COCHRAN, SOARES | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SEVEN BRIDGES RADIO, LLC | JACKSONVILLE, FL | Cogent Bank |
| $150,000–350,000 | SFS HOLDINGS, LLC | JACKSONVILLE, FL | Hancock Whitney Bank |
| $1–2 million | SFTF, LLC DBA ASHLEY FURNITURE HOMESTORE | JACKSONVILLE, FL | Fifth Third Bank |
| $1–2 million | SGS TECHNOLOGIE LLC | JACKSONVILLE, FL | Synovus Bank |
| $150,000–350,000 | SHARENET LLC | JACKSONVILLE, FL | Orrstown Bank |
| $150,000–350,000 | SHARIAN INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SHAW'S LAND CLEARING, LLC | JACKSONVILLE, FL | South State Bank, National Association |
| $150,000–350,000 | SHAW'S TREE SERVICE, LLC | JACKSONVILLE, FL | South State Bank, National Association |
| $150,000–350,000 | SHAYCORE ENTERPRISES, INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SHAYCORE, L.L.C. | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SHEFFIELD & BOATRIGHT TITLE SERVICES LLC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SHELBY CRANE SERVICE, INC. | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | SHELDRICK, MCGEHEE & KOHLER, LLC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | SHEPHERD'S FINANCE LLC | JACKSONVILLE, FL | LCA Bank Corporation |
| $150,000–350,000 | SHEPPARD VENTURES, LLC | JACKSONVILLE, FL | Valley National Bank |
| $150,000–350,000 | SHEPPARD WHITE KACHERGUS AND DEMAGGIO | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | SHILOH METROPOLITAN BAPTIST CHURCH | JACKSONVILLE, FL | First-Citizens Bank & Trust Company |
| $2–5 million | SHIPPERS AUTOMOTIVE GROUP LLC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SHORELINE PLASTICS LLC | JACKSONVILLE, FL | PNC Bank, National Association |
| $350,000–1 million | SHORSTEIN & SHORSTEIN PA | JACKSONVILLE, FL | Newtek Small Business Finance, Inc. |
| $350,000–1 million | SIGHT & SOUND PRODUCTIONS LLC | JACKSONVILLE, FL | TD Bank, National Association |
| $150,000–350,000 | SIM’S AFRICAN MARKET | JACKSONVILLE, FL | Celtic Bank Corporation |
| $150,000–350,000 | SIMES & ROSCH LLC | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | SIMONIC, SIMONIC, RATNECHT & ASSOCIATES, INC. | JACKSONVILLE, FL | BBVA USA |
| $350,000–1 million | SISSINE'S BUSINESS SOLUTIONS OF ORLANDO, INC | JACKSONVILLE, FL | South State Bank, National Association |
| $350,000–1 million | SISSINE'S OFFICE SYSTEMS, INC. | JACKSONVILLE, FL | South State Bank, National Association |
| $350,000–1 million | SITEX LAND LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | SKINNER WASTE SOLUTIONS, LLC | JACKSONVILLE, FL | Cogent Bank |
| $150,000–350,000 | SKY ENTERTAINMENT JACKSONVILLE LLC | JACKSONVILLE, FL | IBERIABANK |
| $150,000–350,000 | SKY-PAXXX INTERIOR REPAIRS, LLC | JACKSONVILLE, FL | Readycap Lending, LLC |
| $150,000–350,000 | SKYCAP VENTURES, LLC | JACKSONVILLE, FL | Fountainhead SBF LLC |
| $150,000–350,000 | SLEEP CARE CENTERS OF AMERICA LLC | JACKSONVILLE, FL | Ameris Bank |
| $1–2 million | SLEIMAN HOLDINGS, INC. | JACKSONVILLE, FL | Valley National Bank |
| $1–2 million | SMART PHARMACY, INC. | JACKSONVILLE, FL | South State Bank, National Association |
| $350,000–1 million | SMARTSTAFF, INC. | JACKSONVILLE, FL | The Plains State Bank |
| $1–2 million | SMC SYSTEMS INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | SMILEY'S MARKETS AND MALLS INC | JACKSONVILLE, FL | WebBank |
| $150,000–350,000 | SMITH & SURRENCY LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | SMITH BROS PLASTERING CO INC | JACKSONVILLE, FL | Bank of America, National Association |
| $1–2 million | SMITH HULSEY & BUSEY | JACKSONVILLE, FL | Seaside National Bank & Trust |
| $350,000–1 million | SMOAK, DAVIS & NIXON LLP | JACKSONVILLE, FL | TD Bank, National Association |
| $150,000–350,000 | SNOWBIRD TECHNOLOGIES, INC | JACKSONVILLE, FL | Hancock Whitney Bank |
| $1–2 million | SNYDER CO. | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | SOBU | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | SOFTWINK. INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | SOME PLACE LIKE HOME, INC | JACKSONVILLE, FL | Community First CU of Florida |
| $350,000–1 million | SOUND PAYMENTS INC | JACKSONVILLE, FL | BBVA USA |
| $2–5 million | SOUTHEAST MECHANICAL SYSTEMS, INC. | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | SOUTHEAST PAVING, INC. | JACKSONVILLE, FL | Valley National Bank |
| $150,000–350,000 | SOUTHEAST RIGGING, INC. | JACKSONVILLE, FL | Cogent Bank |
| $1–2 million | SOUTHEASTERN ALUMINUM PRODUCTS LLC | JACKSONVILLE, FL | Fifth Third Bank |
| $150,000–350,000 | SOUTHEASTERN ORNAMENTAL IRON CO | JACKSONVILLE, FL | VyStar CU |
| $350,000–1 million | SOUTHEASTERN RETINA SPECIALISTS, P.A. | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | SOUTHERN AIRE CONTRACTING, INC. | JACKSONVILLE, FL | Renasant Bank |
| $350,000–1 million | SOUTHERN ATLANTIC ELECTRIC COMPANY INC. | JACKSONVILLE, FL | Hancock Whitney Bank |
| $350,000–1 million | SOUTHERN BELLE FROZEN FOODS, INC. | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | SOUTHERN BRAS LLC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SOUTHERN EQUIPMENT SALES CO. | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | SOUTHERN EXPRESS CARWASH INC | JACKSONVILLE, FL | Bank of America, National Association |