| $150,000–350,000 | SOUTHERN GROUNDS COFFEE SAN MARCO LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $350,000–1 million | SOUTHERN HILLS PLANTATION GOLF CLUB LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $350,000–1 million | SOUTHERN REFRIGERATION ENGINEERS OF NORTH FLORIDA, INC. | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | SOUTHERN TECHNOLOGIES OF JACKSONVILLE INC | JACKSONVILLE, FL | First Federal Bank |
| $150,000–350,000 | SOUTHPOINT COMMUNITY CHURCH | JACKSONVILLE, FL | Valley National Bank |
| $350,000–1 million | SOUTHPOINT SURGERY CENTER, L.L.C. | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | SOUTHSIDE MELLOW JAX | JACKSONVILLE, FL | Synovus Bank |
| $150,000–350,000 | SOUTHSIDE UNITED METHODIST CHURCH | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | SPANISH WELLS INVESTMENTS, INC. | JACKSONVILLE, FL | BBVA USA |
| $350,000–1 million | SPECK PUMPS-POOL PRODUCTS, INC. | JACKSONVILLE, FL | TD Bank, National Association |
| $350,000–1 million | SPECTRUM INSTALLATIONS, INC. | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | SPHERE SOLUTIONS, INC. | JACKSONVILLE, FL | Fifth Third Bank |
| $150,000–350,000 | SPOHRER & DODD, P.L. | JACKSONVILLE, FL | Synovus Bank |
| $150,000–350,000 | SPOKEN WORD MINISTRIES INC | JACKSONVILLE, FL | Celtic Bank Corporation |
| $150,000–350,000 | SPORTS EDGE ATHLETICS, LLC | JACKSONVILLE, FL | BBVA USA |
| $350,000–1 million | SSL NOC MANAGEMENT LLC | JACKSONVILLE, FL | United Community Bank |
| $150,000–350,000 | SSL PV MANAGEMENT LLC | JACKSONVILLE, FL | United Community Bank |
| $350,000–1 million | SSL SJ MANAGEMENT LLC | JACKSONVILLE, FL | United Community Bank |
| $150,000–350,000 | SSL TAL MANAGEMENT LLC | JACKSONVILLE, FL | United Community Bank |
| $350,000–1 million | ST DENIS & DAVEY PA | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | ST JOHNS BAR PILOTS | JACKSONVILLE, FL | Hancock Whitney Bank |
| $350,000–1 million | ST JOHNS CLASSICAL ACADEMY INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | ST JOHNS PEDIATRICS PA | JACKSONVILLE, FL | First-Citizens Bank & Trust Company |
| $350,000–1 million | ST JOHNS VEIN CENTER, INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | ST LUKE'S EMERGENCY CARE GROUP, LLC | JACKSONVILLE, FL | BBVA USA |
| $350,000–1 million | ST MARTINS CHEMICAL INC | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | ST MARYS ENTERPRISES INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | ST MATTHEWS CATHOLIC CHURCH AND SCHOOL | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $350,000–1 million | ST PATRICK CATHOLIC CHURCH AND SCHOOL | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | ST PAUL UNITED METHODIST CHURCH OF JACKSONVILLE, INC. | JACKSONVILLE, FL | Regions Bank |
| $150,000–350,000 | ST VINCENTS PATHOLOGY ASSOC PA | JACKSONVILLE, FL | TD Bank, National Association |
| $350,000–1 million | ST. JOHN & PARTNERS ADVERTISING AND PUBLIC RELATIONS, INC. | JACKSONVILLE, FL | Valley National Bank |
| $150,000–350,000 | ST. JOHNS ENDODONTICS, P.A. | JACKSONVILLE, FL | TD Bank, National Association |
| $150,000–350,000 | ST. JOHNS GROUP, INC. | JACKSONVILLE, FL | TD Bank, National Association |
| $350,000–1 million | ST. JOHNS MARINE GROUP, LLC | JACKSONVILLE, FL | Synovus Bank |
| $350,000–1 million | ST. JOSEPH CATHOLIC SCHOOL | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | ST. MARK'S EPISCOPAL DAY SCHOOL OF JACKSONVILLE, INC | JACKSONVILLE, FL | South State Bank, National Association |
| $150,000–350,000 | ST. PAULS CATHOLIC SCHOOL | JACKSONVILLE, FL | Readycap Lending, LLC |
| $150,000–350,000 | STAR BRITE LAUNDRIES LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | STAR V CORPORATE TRAINING, LLC | JACKSONVILLE, FL | Cogent Bank |
| $350,000–1 million | STARFLEETX LLC | JACKSONVILLE, FL | Fountainhead SBF LLC |
| $150,000–350,000 | STATION FOUR INC | JACKSONVILLE, FL | Regions Bank |
| $150,000–350,000 | STEALTH FUELS AND TRUCKING, LLC | JACKSONVILLE, FL | Primesouth Bank |
| $150,000–350,000 | STEELBRIDGE LOGISTICS, INC. | JACKSONVILLE, FL | Bank of America, National Association |
| $5–10 million | STEIN MART, INC. | JACKSONVILLE, FL | Harvest Small Business Finance, LLC |
| $1–2 million | STELLAR ENERGY AMERICAS INC | JACKSONVILLE, FL | Synovus Bank |
| $150,000–350,000 | STONE PLUS, INC. | JACKSONVILLE, FL | Intracoastal Bank |
| $150,000–350,000 | STONE WORLD IMPORTS AND MANUFACTURING CORP | JACKSONVILLE, FL | First Federal Bank |
| $150,000–350,000 | STONEWOOD BAY MEADOWS/SAN JOSE LLC | JACKSONVILLE, FL | South State Bank, National Association |
| $350,000–1 million | STORMFORCE OF JACKSONVILLE, LLC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | STOVER SALES, INC. | JACKSONVILLE, FL | 121 Financial CU |
| $350,000–1 million | STREAMLINE IMAGING | JACKSONVILLE, FL | Hancock Whitney Bank |
| $350,000–1 million | SUBARU OF JACKSONVILLE INC. | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | SUBWAY MANAGEMENT GROUP OF JACKSONVILLE INC | JACKSONVILLE, FL | Renasant Bank |
| $350,000–1 million | SUDDATH RELOCATION SYSTEMS OF JACKSONVILLE, INC. | JACKSONVILLE, FL | BBVA USA |
| $350,000–1 million | SUMMER BROOK FL SNF MANAGEMENT LLC D/B/A HEALTHCARE CENTER OF JACKSONVILLE | JACKSONVILLE, FL | Popular Bank |
| $350,000–1 million | SUMMIT ELECTRICAL CONTRACTORS, INC | JACKSONVILLE, FL | Synovus Bank |
| $150,000–350,000 | SUMMIT JACKSONVILLE, LLC | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $350,000–1 million | SUMMIT TECHNOLOGY, INC. | JACKSONVILLE, FL | Trustmark National Bank |
| $350,000–1 million | SUN COAST PROPERTY MANAGEMENT LLC | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | SUN STATE NURSERY & LANDSCAPING, INC. | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | SUN-IT SOLUTIONS, INC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | SUNBEAM AUTOBODY - ATLANTIC, INC | JACKSONVILLE, FL | BBVA USA |
| $350,000–1 million | SUNBEAM AUTOBODY INC. | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | SUNBELT HEALTH SOLUTIONS, LLC | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | SUNBELT TRANSPORT LLC | JACKSONVILLE, FL | TD Bank, National Association |
| $150,000–350,000 | SUNLIGHT MEDICAL INC | JACKSONVILLE, FL | Bank of America, National Association |
| $1–2 million | SUNOPTIC TECHNOLOGIES LLC | JACKSONVILLE, FL | TD Bank, National Association |
| $350,000–1 million | SUNRISE FOODS, LLC | JACKSONVILLE, FL | Florida Capital Bank, National Association |
| $150,000–350,000 | SUNSHINE PEANUT COMPANY | JACKSONVILLE, FL | Florida Capital Bank, National Association |
| $350,000–1 million | SUPERIOR FENCE & RAIL OF NORTH FLORIDA | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | SURGCENTER OF GREATER JACKSONVILLE, LLC | JACKSONVILLE, FL | Valley National Bank |
| $350,000–1 million | SWAMP FAMILY MUSIC, LLC | JACKSONVILLE, FL | Renasant Bank |
| $350,000–1 million | SWEETWATER RESTORATION | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | SWIMMING SAFARI SWIM SCHOOL, INC. | JACKSONVILLE, FL | Community First CU of Florida |
| $150,000–350,000 | SYNAPTIC RESOURCES OF FLORIDA, LLC | JACKSONVILLE, FL | BancFirst |
| $150,000–350,000 | SZH HOCKEY LLC | JACKSONVILLE, FL | PNC Bank, National Association |
| $150,000–350,000 | T & S RESTORATION AND PAINTING | JACKSONVILLE, FL | Wells Fargo Bank, National Association |
| $150,000–350,000 | T G UTILITY COMPANY INC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | T MAK'S INTERNATIONAL INC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | TALLAHASSEE CRANES LLC | JACKSONVILLE, FL | Bank of America, National Association |
| $150,000–350,000 | TALON HOLDINGS LLC | JACKSONVILLE, FL | IBERIABANK |
| $150,000–350,000 | TAMBOLINA SERVICES, INC | JACKSONVILLE, FL | VyStar CU |
| $150,000–350,000 | TANK REPAIR AND MAINTENANCE, INC. | JACKSONVILLE, FL | Bank of America, National Association |
| $2–5 million | TAX DEFENSE NETWORK, LLC | JACKSONVILLE, FL | Newtek Small Business Finance, Inc. |
| $350,000–1 million | TAYLOR DAY P.A. | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | TAYLOR ENGINEERING, INC | JACKSONVILLE, FL | Synovus Bank |
| $150,000–350,000 | TAYLOR SIGN & DESIGN, INC. | JACKSONVILLE, FL | First Federal Bank |
| $1–2 million | TB LANDMARK CONSTRUCTION, INC. | JACKSONVILLE, FL | Primesouth Bank |
| $350,000–1 million | TC MOTORCYCLES LLC | JACKSONVILLE, FL | JPMorgan Chase Bank, National Association |
| $2–5 million | TECH PACKAGING INC | JACKSONVILLE, FL | Ameris Bank |
| $350,000–1 million | TECH X SERVICES, LLC | JACKSONVILLE, FL | Ameris Bank |
| $150,000–350,000 | TECTRON ENGINEERING COMPANY | JACKSONVILLE, FL | South State Bank, National Association |
| $150,000–350,000 | TEMPLE CHRISTIAN ACADEMY INC | JACKSONVILLE, FL | VyStar CU |
| $350,000–1 million | TEMPOOL INC | JACKSONVILLE, FL | BBVA USA |
| $150,000–350,000 | TENANT CONTRACTORS, INC. | JACKSONVILLE, FL | South State Bank, National Association |
| $1–2 million | TERRACE OF JACKSONVILLE LLC | JACKSONVILLE, FL | CIBC Bank USA |
| $150,000–350,000 | THAMES MARKEY & HEEKIN, P.A. | JACKSONVILLE, FL | City National Bank of Florida |
| $150,000–350,000 | THE AMELIA CONCOURS DELEGANCE FOUNDATION | JACKSONVILLE, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | THE AMERICAN FALLEN VETERAN SERVICE PROJECT | JACKSONVILLE, FL | VyStar CU |