| $350,000–1 million | COASTAL SUPPLY CO, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | COKESBURY UNITED METHODIST CHURCH, INC. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | COLLABORATIVE COMPOSITE SOLUTIONS CORPORATION | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | COLLEGE AND UNIVERSITY PROFESSIONAL ASSOCIATION FOR HUMAN RESOURCES | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | COLONIAL FREIGHT SYSTEMS, INC. | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | COMMERCIAL FURNITURE SERVICES, LLC | KNOXVILLE, TN | SouthEast Bank |
| $150,000–350,000 | COMPETITIVE EDGE REFURBISHING LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | COMPONENT FABRICATORS INC. | KNOXVILLE, TN | Regions Bank |
| $150,000–350,000 | CONCORD ENTERPRISES LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | CONCORD PROFESSIONAL SERVICES, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | CONCORD UNITED METHODIST CHURCH | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | CONCRETE HOLDINGS, LLC | KNOXVILLE, TN | First Horizon Bank |
| $5–10 million | CONNER CONCEPTS, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | CONRY-TAYLOR AND MORROW CPAS PC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | CONTEMPORARY WOMEN'S HEALTH PLLC | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | CONTINUUM COURTYARDS, LLC | KNOXVILLE, TN | FirstBank |
| $150,000–350,000 | CONTRACT FURNITURE ALLIANCE INC | KNOXVILLE, TN | ServisFirst Bank |
| $150,000–350,000 | CONTRACT HEALTH SERVICES, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | CONTROL TECHNOLOGY INC | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | CONVOY SOLUTIONS LLC | KNOXVILLE, TN | Citizens Bank |
| $350,000–1 million | COOPER DRYWALL & PAINTING INC | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | COPE ASSOCIATES, INC. | KNOXVILLE, TN | Regions Bank |
| $5–10 million | COPPER CELLER CORPORATION | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | CORECHEM, INC | KNOXVILLE, TN | SmartBank |
| $150,000–350,000 | CORNERSTONE CHURCH OF KNOXVILLE, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | CORNERSTONE DENTAL ASSOCIATES, PLLC | KNOXVILLE, TN | First-Citizens Bank & Trust Company |
| $150,000–350,000 | CORPORATE QUARTERS, INC. | KNOXVILLE, TN | Regions Bank |
| $350,000–1 million | COSTUME GALLERY HOLDINGS, LLC | KNOXVILLE, TN | Touchmark National Bank |
| $350,000–1 million | COULTER & JUSTUS, PC | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | COURTHOUSE RETRIEVAL SYSTEM, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | CPJ LLC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | CRAIG BELITZ CONSTRUCTION, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | CRAIG'S FIREARM SUPPLY INC | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | CRANMORE RIDGE HOLDINGS, INC. | KNOXVILLE, TN | CBBC Bank |
| $150,000–350,000 | CREATIVE STRUCTURES, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | CREEK HOUSE SEAFOOD & GRILL, LLC) | KNOXVILLE, TN | SmartBank |
| $150,000–350,000 | CRU, LLC | KNOXVILLE, TN | Citizens Bank |
| $150,000–350,000 | CRUZE-BHATTI, LLC | KNOXVILLE, TN | Citizens National Bank |
| $150,000–350,000 | CSI FIRE EQUIPMENT, LLC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | CTR UTILITY REHAB LLC | KNOXVILLE, TN | Regions Bank |
| $150,000–350,000 | CUSTOM FABRICATION SERVICES LLC | KNOXVILLE, TN | Pinnacle Bank |
| $2–5 million | CUSTOM FOODS OF AMERICA, INC | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | CUSTOMER SERVICE ELECTRIC SUPPLY, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | D JIMMY BRINIAS | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | DALEN PRODUCTS INC | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | DALTON COLLISION, INCORPORATED | KNOXVILLE, TN | Bank of Tennessee |
| $350,000–1 million | DAVID'S CARPET SALES, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | DAVID'S COMMERCIAL TIRE, INC. | KNOXVILLE, TN | Northeast Bank |
| $150,000–350,000 | DB SUBS, LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | DE MAXIMIS DATA MANAGEMENT SOLUTIONS, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $1–2 million | DE MAXIMIS, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | DEAD END BBQ, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | DEBORAH L. CURLEE COMMUNICATION CONSULTANTS, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | DEGA CATERING INC | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $1–2 million | DEL-AIR MECHANICAL CONTRACTORS, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | DEMPSTER POURED FOUNDATIONS, LLC | KNOXVILLE, TN | Bank of Tennessee |
| $350,000–1 million | DENARK CONSTRUCTION, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | DENCO HOLDINGS, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | DENNIS HALL'S AUTO SERVICE | KNOXVILLE, TN | Regions Bank |
| $1–2 million | DENTAL ASSOCIATES OF EAST TENNESSEE, PLLC | KNOXVILLE, TN | KeyBank National Association |
| $350,000–1 million | DERMATOPATHOLOGY PARTNERS PC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | DESIGN AND CONSTRUCTION SERVICES INC | KNOXVILLE, TN | Citizens Bank |
| $150,000–350,000 | DESIGN INNOVATION ARCHITECTS INC | KNOXVILLE, TN | Bank of Tennessee |
| $350,000–1 million | DESIGNSENSORY, INC. | KNOXVILLE, TN | First-Citizens Bank & Trust Company |
| $1–2 million | DICK BROADCASTING CORPORATION INC. OF TENNESSEE | KNOXVILLE, TN | Pinnacle Bank |
| $5–10 million | DIOCESE OF KNOXVILLE | KNOXVILLE, TN | Regions Bank |
| $150,000–350,000 | DISABILITY ADVANTAGE GROUP, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | DIVERSE CONCEPTS LLC | KNOXVILLE, TN | SmartBank |
| $150,000–350,000 | DIXIE KITCHEN DISTRIBUTORS, INC. | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | DMGX, LLC | KNOXVILLE, TN | First Peoples Bank of Tennessee |
| $350,000–1 million | DML SUBS, LLC | KNOXVILLE, TN | Citizens National Bank |
| $350,000–1 million | DOCTORSMANAGEMENT, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | DON GALLO MEXICAN GRILL | KNOXVILLE, TN | Readycap Lending, LLC |
| $350,000–1 million | DON TACO, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | DOVER SIGNATURE PROPERTIES, INCORPORATED | KNOXVILLE, TN | Citizens Bank |
| $150,000–350,000 | DRS. BLACK & BENTON, P. S. C. | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | DUACARRIER ELECTRONICS TECHNOLOGY, INC | KNOXVILLE, TN | Regions Bank |
| $350,000–1 million | DUNCAN & SONS BUILDING MAINTENANCE, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | DUO-FAST OF KNOXVILLE, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | DYNAMIC SOLUTIONS, LLC | KNOXVILLE, TN | FirstBank |
| $2–5 million | EAGLE DISTRIBUTING COMPANY, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $1–2 million | EAR, NOSE & THROAT CONSULTANTS OF EAST TN, PC | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | EARNEST ENTERPRISES, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | EARTH TECH EROSION CONTROL LLC | KNOXVILLE, TN | Readycap Lending, LLC |
| $350,000–1 million | EARTHADELIC ENTERPRISES LLC | KNOXVILLE, TN | SmartBank |
| $350,000–1 million | EAST GARDEN, INC. | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | EAST TENNESSEE FOUNDATION | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | EAST TENNESSEE MECHANICAL CONTRACTORS | KNOXVILLE, TN | Regions Bank |
| $150,000–350,000 | EAST TENNESSEE PEDIATRIC DENTISTRY PLLC | KNOXVILLE, TN | First-Citizens Bank & Trust Company |
| $150,000–350,000 | EAST TENNESSEE PUBLIC COMMUNICATION CORPORATION | KNOXVILLE, TN | Regions Bank |
| $150,000–350,000 | EAST TENNESSEE RADIATION ONCOLOGY, P.C. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | EAST TENNESSEE SPINE & SPORT, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | EAST TENNESSEE SUBWAY LLC | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | EAST TENNESSEE SURGICAL GROUP P.C., | KNOXVILLE, TN | Regions Bank |
| $150,000–350,000 | EASTERN TENNESSEE SUBWAY DEVELOPMENT | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | EASTERN TENNESSEE TANNING LLC | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | EASTWOOD LANDSCAPING, LLC | KNOXVILLE, TN | Cross River Bank |
| $2–5 million | EDFINANCIAL SERVICES, LLC | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | EDGERTON MCAFEE ARMISTEAD & DAVIS PC | KNOXVILLE, TN | CapStar Bank |
| $150,000–350,000 | EDISON ELECTRIC, LLC | KNOXVILLE, TN | Pinnacle Bank |