| $150,000–350,000 | EFRC ENTERPRISES, INC. | KNOXVILLE, TN | Regions Bank |
| $350,000–1 million | ELEATION FOODS, LLC | KNOXVILLE, TN | BancFirst |
| $350,000–1 million | ELECTRIC SERVICE COMPANY | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | ELKMONT EXCHANGE, LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | ELLIOTT'S TENNESSEE BOOT CO., LLC | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | EMERALD CHARTER SCHOOLS | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | EMERALD HOUSING MANAGEMENT LLC | KNOXVILLE, TN | Regions Bank |
| $350,000–1 million | EMERALD YOUTH FOUNDATION | KNOXVILLE, TN | Pinnacle Bank |
| $1–2 million | EMPIRE CORPORATION OF TENNESSEE INC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | EMR ASSOCIATES INC | KNOXVILLE, TN | First Horizon Bank |
| $1–2 million | ENDOCRINOLOGY CONSULTANTS OF EAST TENNESSEE, PLLC | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | ENERGY ELECTRIC, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | ENERNEX LLC | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | ENGINEERING SERVICES GROUP, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | ENROLLMENT FIRST, INC. | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | ENTERPRISE WASTE OIL INC | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | EPISCOPAL SCHOOL OF KNOXVILLE | KNOXVILLE, TN | FirstBank |
| $150,000–350,000 | ERECTION SPECIALISTS, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | ERISA SERVICES, INC. | KNOXVILLE, TN | First-Citizens Bank & Trust Company |
| $150,000–350,000 | ESC AGILAIRE LLC | KNOXVILLE, TN | First Peoples Bank of Tennessee |
| $1–2 million | EVANS, RHEA & ASSOCIATES, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | EVENTBOOKING.COM, LLC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | EYEXCEL, PLLC | KNOXVILLE, TN | First Volunteer Bank |
| $150,000–350,000 | F E TRAINER CONSTRUCTION, INC | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | FACULTY INTERNAL MEDICINE, PLLC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | FAITH PROMISE CHURCH | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | FAMILY FIRST HANDYMAN SERVICES LLC | KNOXVILLE, TN | UBank |
| $150,000–350,000 | FARMERS MUTUAL OF TENNESSEE | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | FARRAGUT HEALTH CARE CENTER LP | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $1–2 million | FELLOWSHIP EVANGELICAL FREE CHURCH | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | FENCO SUPPLY COMPANY, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | FINISH POINT TRIM AND MILLWORK INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | FINKLESTEIN, KERN, STEINBERG & CUNNINGHAM, PC | KNOXVILLE, TN | Pinnacle Bank |
| $2–5 million | FIRST BAPTIST CHURCH CONCORD | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | FIRST CHOICE LENDING SERVICES, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | FIRST SOUTHERN MORTGAGE CORP. OF TENNESSEE | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | FISHER TIRE COMPANY WEST INC | KNOXVILLE, TN | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | FISHER TIRE COMPANY, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | FLEET TIRE, INC. | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | FLEXIBLE STAFFING SOLUTIONS OF TENNESSEE INC. | KNOXVILLE, TN | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | FLORLINE SOUTH, INC. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | FLOWERS DIRECT, INC | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | FLYING HORSE LLC | KNOXVILLE, TN | SmartBank |
| $150,000–350,000 | FOCUS HEALTH GROUP, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | FOOD DONATION CONNECTION LLC | KNOXVILLE, TN | Regions Bank |
| $150,000–350,000 | FORESTER BENEFITS MANAGEMENT, LLC | KNOXVILLE, TN | SmartBank |
| $350,000–1 million | FORT SANDERS OBSTETRICAL AND GYNECOLOGICAL GROUP PC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | FOUNDATION MORTGAGE COMPANY LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | FOUNDATION SYSTEMS ENGINEERING, P.C. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | FOUNTAIN CITY FUNDING, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | FOUNTAIN CITY UNITED METHODIST CHURCH | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | FOUR SEASONS INCORPORATED | KNOXVILLE, TN | FirstBank |
| $150,000–350,000 | FRAME ENTERPRISES, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | FRANK'S BARBER SHOP LLC | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | FRANTZ, MCCONNELL & SEYMOUR, LLP | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | FRAZIER'S FLOORING, INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | FULGHUM MACINDOE & ASSOCIATES INC | KNOXVILLE, TN | FirstBank |
| $1–2 million | FUNDERBURK ELECTRICAL SERVICES LLC | KNOXVILLE, TN | SmartBank |
| $350,000–1 million | FURNITURE WORLD, INC. | KNOXVILLE, TN | Pinnacle Bank |
| $1–2 million | FW OF KNOXVILLE 1, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | GALATEN FOODS, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | GALBRAITH LABORATORIES, INC. | KNOXVILLE, TN | Regions Bank |
| $150,000–350,000 | GARDEN MONTESSORI SCHOOL, INC. | KNOXVILLE, TN | Regions Bank |
| $150,000–350,000 | GARY VILES MOTORS, LLC | KNOXVILLE, TN | Community Trust Bank, Inc. |
| $1–2 million | GASTROINTESTINAL ASSOCIATES, P.C. | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | GATORSTEP LLC | KNOXVILLE, TN | Renasant Bank |
| $150,000–350,000 | GDP PROPERTIES, LLC | KNOXVILLE, TN | Readycap Lending, LLC |
| $1–2 million | GEM CARE, INC | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | GEM CONSTRUCTION GROUP CORP | KNOXVILLE, TN | Pinnacle Bank |
| $2–5 million | GEM TECHNOLOGIES, INC | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | GENERAL GRAPHENE CORPORATION | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | GENERATIONS OBGYN, PC | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | GENTRY, TIPTON & MCLEMORE, P.C. | KNOXVILLE, TN | Tennessee State Bank |
| $350,000–1 million | GEOCONEX CORPORATION | KNOXVILLE, TN | First Horizon Bank |
| $350,000–1 million | GEORGE W. REAGAN CO., INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $1–2 million | GEOSERVICES, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | GI FOR KIDS PLLC | KNOXVILLE, TN | First-Citizens Bank & Trust Company |
| $150,000–350,000 | GIBSON HOTEL MANAGEMENT, INC | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | GIRL SCOUT COUNCIL OF THE SOUTHERN APPALACHIANS, INC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | GODDARD GUTTERING, INC | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $150,000–350,000 | GODDARD INDUSTRIAL, INC | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | GOUFFON MOVING & STORAGE COMPANY, INC | KNOXVILLE, TN | Regions Bank |
| $150,000–350,000 | GRANDE AVIATION LLC | KNOXVILLE, TN | First Horizon Bank |
| $150,000–350,000 | GRAPHIC CREATIONS, INC. | KNOXVILLE, TN | Regions Bank |
| $150,000–350,000 | GRAVADI LLC | KNOXVILLE, TN | Mountain Commerce Bank |
| $350,000–1 million | GRAY HODGES CORPORATION | KNOXVILLE, TN | SmartBank |
| $1–2 million | GRAYSON HYUNDAI LLC | KNOXVILLE, TN | Bank of America, National Association |
| $1–2 million | GRAYSON PONTIAC INC | KNOXVILLE, TN | Bank of America, National Association |
| $150,000–350,000 | GRAYSONS CONCRETE WORK LLC | KNOXVILLE, TN | Cross River Bank |
| $350,000–1 million | GRAYSTONE CONSTRUCTION, INC. | KNOXVILLE, TN | First Horizon Bank |
| $1–2 million | GREAT SALONS OF KNOXVILLE INC | KNOXVILLE, TN | Pinnacle Bank |
| $350,000–1 million | GREAT SMOKY MOUNTAIN COUNCIL OF BOY SCOUTS OF AMERICA INC | KNOXVILLE, TN | FirstBank |
| $350,000–1 million | GREEN VALLEY TRANSPORTATION CORPORATION | KNOXVILLE, TN | U.S. Bank, National Association |
| $150,000–350,000 | GREENWAY ENTERPRISES, INC | KNOXVILLE, TN | Simply Bank |
| $350,000–1 million | GREG COLEMAN LAW, PC | KNOXVILLE, TN | Mountain Commerce Bank |
| $1–2 million | GULF & OHIO RAILWAYS INC | KNOXVILLE, TN | Mountain Commerce Bank |
| $150,000–350,000 | H-S WHITSON CONSTRUCTION CO., INC. | KNOXVILLE, TN | Home Federal Bank of Tennessee |
| $350,000–1 million | HALLIDAY FOODS INC. | KNOXVILLE, TN | SmartBank |
| $150,000–350,000 | HARDCOAT TECHNOLOGIES, LLC | KNOXVILLE, TN | Pinnacle Bank |
| $150,000–350,000 | HARMONY FOOD SERVICES TEXAS, LLC | KNOXVILLE, TN | Regions Bank |