| $150,000–350,000 | SHEARER HILLS BAPTIST CHURCH | SAN ANTONIO, TX | Lone Star Capital Bank, National Association |
| $150,000–350,000 | SHELTON & VALADEZ PC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SHELTON PRESORT, INC. | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | SHEPHERD LIVING HOSPICE LLC | SAN ANTONIO, TX | Zions Bank, A Division of |
| $350,000–1 million | SHEPHERD OF THE HILLS LUTHERAN CHURCH | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SHEPHERD RETAIL, INC. | SAN ANTONIO, TX | SouthTrust Bank, National Association |
| $150,000–350,000 | SHERRILL UNIVERSAL CITY CORRAL | SAN ANTONIO, TX | Newtek Small Business Finance, Inc. |
| $1–2 million | SHIRLEY MOTOR COMPANY, INC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SHISHA CAFE | SAN ANTONIO, TX | BBVA USA |
| $150,000–350,000 | SHORT-LINE CORPORATION | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SHOWER DOORS TODAY, LLC | SAN ANTONIO, TX | BBVA USA |
| $150,000–350,000 | SHURMED EMERGENCY MEDICAL SERVICE LLC | SAN ANTONIO, TX | Customers Bank |
| $150,000–350,000 | SHWEIKI MEDIA, INC. | SAN ANTONIO, TX | Newtek Small Business Finance, Inc. |
| $150,000–350,000 | SI - CREEKSIDE, LTD. | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | SIGMA CORE, LLC | SAN ANTONIO, TX | Wallis Bank |
| $150,000–350,000 | SIGMA MENTAL HEALTH URGENT CARE, LLC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SIGNAL HOME HEALTH CARE, LLC | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | SIGNATURE PARTNERS LTD. | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | SILO RESTAURANT, INC. | SAN ANTONIO, TX | Bank OZK |
| $1–2 million | SILOTECH GROUP INC | SAN ANTONIO, TX | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | SIMEM AMERICA CORPORATION | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SIMONIS ENTERPRISES LLC | SAN ANTONIO, TX | Riverview Bank |
| $150,000–350,000 | SIMPLYFRESCO LLC | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | SINCLAIR LAND SURVEYING, INC. | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SINCLAIR SERVICE ASSESSMENTS, INC | SAN ANTONIO, TX | Zions Bank, A Division of |
| $350,000–1 million | SISTEMA INFANTIL TELETONUSA | SAN ANTONIO, TX | Frost Bank |
| $1–2 million | SITTERLE HOMES, LTD. | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | SIXRSIG LLC | SAN ANTONIO, TX | Idaho First Bank |
| $350,000–1 million | SIZZLING IN SAN ANTONIO | SAN ANTONIO, TX | Hancock Whitney Bank |
| $150,000–350,000 | SIZZLING ON LA CANTERA, LLA | SAN ANTONIO, TX | Hancock Whitney Bank |
| $150,000–350,000 | SKELTON ENTERPRISES INC. | SAN ANTONIO, TX | Jefferson Bank |
| $150,000–350,000 | SKIN REJUVENATION CLINIQUE, IN | SAN ANTONIO, TX | Lone Star National Bank |
| $150,000–350,000 | SKYE ENGINEERING, INC | SAN ANTONIO, TX | PlainsCapital Bank |
| $150,000–350,000 | SKYNET TELECOM, LLC | SAN ANTONIO, TX | Texas Republic Bank, National Association |
| $150,000–350,000 | SLANKARD PRODUCE COMPANY INC | SAN ANTONIO, TX | Wells Fargo Bank, National Association |
| $350,000–1 million | SLATTERY PERKINS RAMIREZ, P.C. | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | SLEEP THERAPY & RESEARCH CENTER, LLC | SAN ANTONIO, TX | BBVA USA |
| $150,000–350,000 | SLEEPONE HEALTHCARE SERVICES, LLC | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | SLUDGENET SOLIDS AND FLUIDS DISPOSAL, LLC | SAN ANTONIO, TX | Plains State Bank |
| $150,000–350,000 | SMART THOMAS LLC | SAN ANTONIO, TX | Riverview Bank |
| $150,000–350,000 | SMILE KINGS BANDERA PLLC | SAN ANTONIO, TX | Bank of America, National Association |
| $150,000–350,000 | SMILE KINGS DENTAL & ORTHODONTICS PLLC | SAN ANTONIO, TX | Bank of America, National Association |
| $150,000–350,000 | SMITH & SHEDD FAMILY PET HOSPITAL, PA | SAN ANTONIO, TX | Texas Heritage Bank |
| $150,000–350,000 | SMITH PRINT II, INCORPORATED | SAN ANTONIO, TX | Vantage Bank Texas |
| $350,000–1 million | SMITHERS MERCHANT BUILDERS LP | SAN ANTONIO, TX | IBERIABANK |
| $150,000–350,000 | SMOKE & OAK BARBEQUE LLC | SAN ANTONIO, TX | Zions Bank, A Division of |
| $150,000–350,000 | SMOKE KING INC DBA CLUB HUMIDOR | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | SNELL & ASSOCIATES LAND SURVEYORS INC | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SNIP & FERENCE PA | SAN ANTONIO, TX | The Bank of San Antonio |
| $150,000–350,000 | SNL ALAMO CNT LLC | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | SNL STAFFING SOLUTIONS INC | SAN ANTONIO, TX | Security Service FCU |
| $350,000–1 million | SOCOMA, INC. | SAN ANTONIO, TX | BMO Harris Bank National Association |
| $350,000–1 million | SOFT TOUCH HOME CARE INC | SAN ANTONIO, TX | Vantage Bank Texas |
| $350,000–1 million | SOL SCHWARTZ & ASSOCIATES, P.C. | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SOLA-LITE, LLC | SAN ANTONIO, TX | Third Coast Bank SSB |
| $150,000–350,000 | SOLAR ELECTRIC TEXAS | SAN ANTONIO, TX | Wells Fargo Bank, National Association |
| $150,000–350,000 | SOLDIERS' ANGELS | SAN ANTONIO, TX | Bank of America, National Association |
| $150,000–350,000 | SOLID BORDER INC | SAN ANTONIO, TX | Bank of America, National Association |
| $150,000–350,000 | SOLIMA PEOPLE LLC | SAN ANTONIO, TX | Bank of America, National Association |
| $150,000–350,000 | SOLUTIO ENVIRONMENTAL, INC. | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $5–10 million | SOLUTIONS SHARED SERVICES | SAN ANTONIO, TX | Wells Fargo Bank, National Association |
| $150,000–350,000 | SOMBRERO CAPITAL LLC | SAN ANTONIO, TX | Veritex Community Bank |
| $150,000–350,000 | SONATEST INC | SAN ANTONIO, TX | Wells Fargo Bank, National Association |
| $150,000–350,000 | SONTERRA DERMATOLOGY, PLLC | SAN ANTONIO, TX | Frost Bank |
| $2–5 million | SONTERRA MEDICAL MANAGEMENT GROUP, INC. | SAN ANTONIO, TX | Zions Bank, A Division of |
| $150,000–350,000 | SONTERRA STATION, L.P. | SAN ANTONIO, TX | Zions Bank, A Division of |
| $150,000–350,000 | SOU-TIER, INC. | SAN ANTONIO, TX | The Bank of San Antonio |
| $150,000–350,000 | SOUND HOLDINGS LLC | SAN ANTONIO, TX | Bank of America, National Association |
| $150,000–350,000 | SOURCE POWER LLC | SAN ANTONIO, TX | TransPecos Banks, SSB. |
| $350,000–1 million | SOUTH ALAMO MEDICAL GROUP PA | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SOUTH CENTRAL TEXAS MANAGEMENT, INC. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SOUTH PARK FAMILY DENTAL CARE LLC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SOUTH TEXAS ALLERGY & ASTHMA MEDICAL PROFESSIONALS PLLC | SAN ANTONIO, TX | Zions Bank, A Division of |
| $150,000–350,000 | SOUTH TEXAS CONTINUUM OF CARE SPECIALISTS, PLLC | SAN ANTONIO, TX | Zions Bank, A Division of |
| $150,000–350,000 | SOUTH TEXAS DRYWALL & CONSTRUCTION INC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SOUTH TEXAS ENGINEERING, INC. | SAN ANTONIO, TX | Cross River Bank |
| $150,000–350,000 | SOUTH TEXAS ENT CONSULTANTS, PA | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SOUTH TEXAS HERBS INC. | SAN ANTONIO, TX | PlainsCapital Bank |
| $150,000–350,000 | SOUTH TEXAS LIQUID TERMINAL, INC | SAN ANTONIO, TX | PlainsCapital Bank |
| $5–10 million | SOUTH TEXAS ONCOLOGY & HEMATOLOGY PLLC | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SOUTH TEXAS ORTHOPEDIC SPECIALTY GROUP, PLLC | SAN ANTONIO, TX | Spirit of Texas Bank, SSB |
| $150,000–350,000 | SOUTH TEXAS PATHOLOGY ASSOCIATES, LLP | SAN ANTONIO, TX | Frost Bank |
| $2–5 million | SOUTH TEXAS PIZZA, INC | SAN ANTONIO, TX | Signature Bank |
| $150,000–350,000 | SOUTH TEXAS PRESS INC. | SAN ANTONIO, TX | Vantage Bank Texas |
| $2–5 million | SOUTH TEXAS RADIOLOGY GROUP, P.A. | SAN ANTONIO, TX | Zions Bank, A Division of |
| $350,000–1 million | SOUTH TEXAS SIDING, INC | SAN ANTONIO, TX | Cross River Bank |
| $150,000–350,000 | SOUTH TEXAS SKIN CANCER CENTER LLC | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SOUTH TEXAS SPINAL CLINIC, PA | SAN ANTONIO, TX | The Bank of San Antonio |
| $150,000–350,000 | SOUTH TEXAS VISION ASSOCIATES PA | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SOUTHEAST SNF LLC | SAN ANTONIO, TX | Renasant Bank |
| $150,000–350,000 | SOUTHEAST SOUTH TEXAS CENTER FOR PEDIATRIC CARE, PA | SAN ANTONIO, TX | Frost Bank |
| $1–2 million | SOUTHERN WEALTH MANAGEMENT LLP | SAN ANTONIO, TX | Texas Community Bank |
| $350,000–1 million | SOUTHSIDE CHILDREN'S DENTAL CENTER PC | SAN ANTONIO, TX | Frost Bank |
| $2–5 million | SOUTHWAY MAC HAIK FORD LTD | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | SOUTHWEST BAKING CO. LLC | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $350,000–1 million | SOUTHWEST CHILDREN'S CENTER, P.A. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST COMPANIES LTD. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST IMMUNODIAGNOSTICS, INC. | SAN ANTONIO, TX | Zions Bank, A Division of |
| $150,000–350,000 | SOUTHWEST PAIN CLINIC PA | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | SOUTHWEST SCHOOL OF ART | SAN ANTONIO, TX | Frost Bank |