| $1–2 million | SOUTHWEST SIGN GROUP, INC. | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $2–5 million | SOUTHWEST TEXAS EQUIPMENT DISTRIBUTORS, INC. | SAN ANTONIO, TX | Frost Bank |
| $5–10 million | SOUTHWESTERN MOTOR TRANSPORT, INC | SAN ANTONIO, TX | BBVA USA |
| $350,000–1 million | SPECTRUM LIGHTING INC. SAN ANTONIO | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SPEECH AND LANGUAGE CENTER AT STONE OAK | SAN ANTONIO, TX | BBVA USA |
| $350,000–1 million | SPEECH SPECIALISTS OF SAN ANTONIO PC | SAN ANTONIO, TX | Texas Champion Bank |
| $150,000–350,000 | SPEED-E'Z PHYSICIAN EXCHANGE, INC. | SAN ANTONIO, TX | Spirit of Texas Bank, SSB |
| $150,000–350,000 | SPEEDWAY ERECTION SERVICE COMPANY | SAN ANTONIO, TX | Prosperity Bank |
| $2–5 million | SPFM, L.P. | SAN ANTONIO, TX | Bank of America, National Association |
| $150,000–350,000 | SPHERE MANAGEMENT GROUP | SAN ANTONIO, TX | Readycap Lending, LLC |
| $150,000–350,000 | SPIGEL PROPERTIES, LLC | SAN ANTONIO, TX | PlainsCapital Bank |
| $350,000–1 million | SPINDLETOP PAIN MANAGEMENT COMPANY INC. | SAN ANTONIO, TX | BBVA USA |
| $150,000–350,000 | SPIRE MEDICAL MANAGEMENT INC | SAN ANTONIO, TX | BBVA USA |
| $150,000–350,000 | SPIRE RISK MANAGEMENT LLC | SAN ANTONIO, TX | Lone Star National Bank |
| $350,000–1 million | SPM PAYROLL SERVICES, LLC | SAN ANTONIO, TX | Newtek Small Business Finance, Inc. |
| $350,000–1 million | SPORTS MEDICINE ASSOCIATES OF SAN ANTONIO, PA | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | SRO ASSOCIATES, INC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SSG HOTEL, LLC | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | ST LUKE | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | ST LUKE CATHOLIC SCHOOL | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | ST MARK THE EVANGELIST CATHOLIC CHURCH | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | ST MARY MAGDALEN CATHOLIC SCHOOL | SAN ANTONIO, TX | Jefferson Bank |
| $150,000–350,000 | ST PAUL LUTHERAN CHILD DEVELOPMENT CENTE | SAN ANTONIO, TX | Bank of America, National Association |
| $150,000–350,000 | ST PETER PRINCE OF THE APOSTLES CHURCH & SCHOOL | SAN ANTONIO, TX | International Bank of Commerce |
| $150,000–350,000 | ST. ANDREW'S UNITED METHODIST CHURCH OF SAN ANTONIO, INC | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | ST. ANTHONY CATHOLIC SCHOOL | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | ST. GEORGE EPISCOPAL DAY SCHOOL, INC. | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | ST. GERARD CATHOLIC HIGH SCHOOL | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | ST. GREGORY THE GREAT CATHOLIC SCHOOL | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | ST. JAMES THE APOSTLE CATHOLIC SCHOOL | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | ST. JUSTE MANAGEMENT CORP. | SAN ANTONIO, TX | Pacific Premier Bank |
| $350,000–1 million | ST. LUKE'S EPISCOPAL SCHOOL OF SAN ANTONIO | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | ST. MARK HOME HEALTH CARE, LLC | SAN ANTONIO, TX | Commerce Bank |
| $150,000–350,000 | ST. MARK'S EPISCOPAL CHURCH OF SAN ANTONIO | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | ST. MATTHEW CATHOLIC SCHOOL | SAN ANTONIO, TX | Jefferson Bank |
| $1–2 million | ST. PETER - ST. JOSEPH CHILDREN'S HOME | SAN ANTONIO, TX | Jefferson Bank |
| $350,000–1 million | STABILITY STAFFING AND CONSULTING LLC | SAN ANTONIO, TX | Bank of America, National Association |
| $350,000–1 million | STAFF POWER GLOBAL, LLC | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $5–10 million | STAGG RESTAURANTS, LLC | SAN ANTONIO, TX | Citizens Bank, National Association |
| $150,000–350,000 | STALWART CONTRACTING, LLC | SAN ANTONIO, TX | Generations Community FCU |
| $150,000–350,000 | STAR MANUFACTURING LTD | SAN ANTONIO, TX | Broadway National Bank |
| $1–2 million | STAR SHUTTLE, INC. | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | STAR TEAM INTENSIVE CARE AND HOSPITALIST | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | STARCAP MARKETING LLC | SAN ANTONIO, TX | Jefferson Bank |
| $150,000–350,000 | STARFIRE SPRINKLER SERVICES, INC. | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | STATE STREET PRODUCE, INC | SAN ANTONIO, TX | Bank of America, National Association |
| $150,000–350,000 | STATEWIDE DISTRIBUTING, INC. | SAN ANTONIO, TX | Bank of America, National Association |
| $150,000–350,000 | STEAM CLEANING SOLUTIONS LLC | SAN ANTONIO, TX | Bank of America, National Association |
| $350,000–1 million | STEELHEAD, INC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | STELLAR GTC, LLC | SAN ANTONIO, TX | Jefferson Bank |
| $150,000–350,000 | STEMBIOSYS, INC. | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | STEPHEN MILLER MD PA | SAN ANTONIO, TX | The Bank of San Antonio |
| $150,000–350,000 | STEVE M EDWARDS DDS PA | SAN ANTONIO, TX | Vantage Bank Texas |
| $150,000–350,000 | STEVEN A DAVIS, MD PA | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | STIRISTA, LLC | SAN ANTONIO, TX | American Bank, National Association |
| $150,000–350,000 | STMA BUSINESS LLC | SAN ANTONIO, TX | Wallis Bank |
| $350,000–1 million | STONE OAK FAMILY DOCTORS, P.A. | SAN ANTONIO, TX | Broadway National Bank |
| $150,000–350,000 | STONE OAK PEDIATRIC DENTISTRY | SAN ANTONIO, TX | BBVA USA |
| $150,000–350,000 | STONE OAK PEDIATRICS, PA | SAN ANTONIO, TX | Zions Bank, A Division of |
| $150,000–350,000 | STONE OAK SURGERY CENTER LLC. | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | STONE OAK VILLAS I LTD. | SAN ANTONIO, TX | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | STONE OAK VILLAS II LTD | SAN ANTONIO, TX | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | STONE WERKS @ RIM, LLC | SAN ANTONIO, TX | Lone Star Capital Bank, National Association |
| $350,000–1 million | STONE WERKS GRILLE @ CULEBRA, LLC | SAN ANTONIO, TX | Lone Star Capital Bank, National Association |
| $350,000–1 million | STONE WERKS GRILLE @ HEIGHTS, LLC | SAN ANTONIO, TX | Lone Star Capital Bank, National Association |
| $350,000–1 million | STONE WERKS GRILLE @ VINEYARD, LLC | SAN ANTONIO, TX | Lone Star Capital Bank, National Association |
| $350,000–1 million | STONEBRIDGE ALLIANCE, LLC | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | STONEBROOK MANOR SNF LLC | SAN ANTONIO, TX | Renasant Bank |
| $350,000–1 million | STOUFFER & ASSOCIATES, LLP | SAN ANTONIO, TX | Broadway National Bank |
| $1–2 million | STOUT EXCAVATING GROUP, LLC | SAN ANTONIO, TX | Security Financial Bank |
| $150,000–350,000 | STOUT'S PIZZA CO., LLC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | STRAIGHT LINE MANAGEMENT LLC | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | STRAITLINE PUMPS LLC | SAN ANTONIO, TX | Bank OZK |
| $150,000–350,000 | STRAITLINE RENTALS LLC | SAN ANTONIO, TX | Bank OZK |
| $150,000–350,000 | STRAITLINE WELL SERVICES LLC | SAN ANTONIO, TX | Bank OZK |
| $350,000–1 million | STRATTON REHABILITATION CLINIC, INC. | SAN ANTONIO, TX | Vantage Bank Texas |
| $350,000–1 million | STREAMLINE INNOVATIONS, INC. | SAN ANTONIO, TX | Texas Capital Bank, National Association |
| $350,000–1 million | STRUCTURAL ENGINEERING ASSOCIATES INC | SAN ANTONIO, TX | Frost Bank |
| $350,000–1 million | STUART A TERRY MD PA | SAN ANTONIO, TX | International Bank of Commerce |
| $1–2 million | SUAREZ BROS CRANE AND HEAVY HAUL | SAN ANTONIO, TX | MetaBank, National Association |
| $150,000–350,000 | SUBLIME CUSTOM STONE, LLC | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SUMMIT CHILDRENS CLINIC, P.A. | SAN ANTONIO, TX | Broadway National Bank |
| $350,000–1 million | SUMMIT CHRISTIAN CENTER | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $150,000–350,000 | SUMMIT HME, INC. | SAN ANTONIO, TX | The Bank of San Antonio |
| $150,000–350,000 | SUN ACTION TRACKERS LLC | SAN ANTONIO, TX | Zions Bank, A Division of |
| $350,000–1 million | SUNBELT DESIGN & DEVELOPMENT I | SAN ANTONIO, TX | Comerica Bank |
| $150,000–350,000 | SUNBELT MILL SUPPLY INC | SAN ANTONIO, TX | Security State Bank |
| $150,000–350,000 | SUPERIOR HOME HEALTH OF EAGLE PASS LLC | SAN ANTONIO, TX | International Bank of Commerce |
| $150,000–350,000 | SUPERIOR ROOFING & CONSTRUCTIO | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SUPREME MEAT PURVEYORS | SAN ANTONIO, TX | Frost Bank |
| $150,000–350,000 | SURF SAN ANTONIO, INC. | SAN ANTONIO, TX | TexStar National Bank |
| $5–10 million | SURLEAN MEAT COMPANY | SAN ANTONIO, TX | JPMorgan Chase Bank, National Association |
| $2–5 million | SUSHI ZUSHI OF TEXAS, LLC | SAN ANTONIO, TX | Arizona Bank & Trust |
| $350,000–1 million | SUSHIHANA JAPANESE RESTAURANT LLC | SAN ANTONIO, TX | Texas Capital Bank, National Association |
| $150,000–350,000 | SUSTAINABLE SECURITY SOLUTIONS INC | SAN ANTONIO, TX | Zions Bank, A Division of |
| $150,000–350,000 | SW DIAGNOSTIC CENTER P.A. | SAN ANTONIO, TX | International Bank of Commerce |
| $150,000–350,000 | SWAP-O-RAMA, INC. | SAN ANTONIO, TX | SouthTrust Bank, National Association |
| $150,000–350,000 | SWIPETRACK SOLUTIONS, LLC | SAN ANTONIO, TX | Readycap Lending, LLC |
| $1–2 million | SWSD LIMITED PARTNERSHIP | SAN ANTONIO, TX | PlainsCapital Bank |
| $150,000–350,000 | SWT QUALITY FASTENERS, INC.DBA QUALITY FASTNERS | SAN ANTONIO, TX | Lone Star Capital Bank, National Association |