| $350,000–1 million | 1 OPAL, INC. | PANAMA CITY, FL | First National Bank Northwest Florida |
| $150,000–350,000 | 10 TUPELO, INC. | PANAMA CITY, FL | Regions Bank |
| $350,000–1 million | 814 SAND, INC | PANAMA CITY, FL | Centennial Bank |
| $1–2 million | AADVANTAGE RELOCATION INC. | PANAMA CITY, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | AAG ELECTRIC MOTORS & PUMPS, INC. | PANAMA CITY, FL | Hancock Whitney Bank |
| $150,000–350,000 | ACE HOME & GARDEN CENTER OF BAY COUNTY, LLC | PANAMA CITY, FL | Trustmark National Bank |
| $1–2 million | ADE OF PANAMA CITY, INC | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | AFFORDABLE BODY SHOP, INC. | PANAMA CITY, FL | Hancock Whitney Bank |
| $350,000–1 million | AHMED M. KATOOT LLC | PANAMA CITY, FL | First Federal Bank |
| $150,000–350,000 | ALL AMERICAN A/C, INC. | PANAMA CITY, FL | Innovations FCU |
| $2–5 million | AMBIENT AIR CORPORATION | PANAMA CITY, FL | Regions Bank |
| $350,000–1 million | ANCHORAGE CHILDREN'S HOME OF BAY COUNTY, INC. | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | ANDERSON CONSTRUCTION COMPANY OF NORTH FLORIDA | PANAMA CITY, FL | MidSouth Bank |
| $150,000–350,000 | ANESTHESIA UNLIMITED, INC. | PANAMA CITY, FL | BancorpSouth Bank |
| $350,000–1 million | APARTMENT ADVANTAGE GROUP LLC | PANAMA CITY, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | ART CONSTRUCTION OF NW FL, LLC | PANAMA CITY, FL | BancorpSouth Bank |
| $150,000–350,000 | B&S LIQUORS INC | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | BALDWIN DENTAL, INC. | PANAMA CITY, FL | Regions Bank |
| $150,000–350,000 | BARRON & REDDING, P.A. | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | BAUMAN CHIROPRACTIC CLINIC OF NORTHWEST FLORIDA, P.A. | PANAMA CITY, FL | BancorpSouth Bank |
| $150,000–350,000 | BAY ARTHRITIS INSTITUTE INC | PANAMA CITY, FL | Community Bank of Mississippi |
| $150,000–350,000 | BAY COUNTY HEALTHCARE SERVICES, LLC | PANAMA CITY, FL | Regions Bank |
| $150,000–350,000 | BAY POINT IMPROVEMENT ASSOCIATION INC | PANAMA CITY, FL | Trustmark National Bank |
| $350,000–1 million | BAY RADIOLOGY ASSOCIATES PL | PANAMA CITY, FL | Trustmark National Bank |
| $350,000–1 million | BCL CIVIL CONTRACTORS, INC | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | BEACHES CONSTRUCTION COMPANY, LLC | PANAMA CITY, FL | Innovations FCU |
| $1–2 million | BILL CRAMER CHEVROLET, CADILLAC, BUICK, GMC, INC | PANAMA CITY, FL | MidSouth Bank |
| $350,000–1 million | BLUE DIAMOND COMMERCIAL COATINGS, INC. | PANAMA CITY, FL | SmartBank |
| $350,000–1 million | BRAIN AND SPINE, L.L.C. | PANAMA CITY, FL | BancorpSouth Bank |
| $150,000–350,000 | BRANNAN ALUMINUM, INC. | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | BREAK-N-GROUND, LLC | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | BROADBAND TELE COMMUNICATIONS, INC | PANAMA CITY, FL | MidSouth Bank |
| $150,000–350,000 | BROWARD HALL, AGENCY, INC. | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | BUCHANAN & HARPER, INC. | PANAMA CITY, FL | BancorpSouth Bank |
| $350,000–1 million | BURKE BLUE HUTCHISON SMITH ZIMMERMAN BURKE HENRY & MASTERS, P. A. | PANAMA CITY, FL | Regions Bank |
| $2–5 million | BY THE SEA RESORTS INC. | PANAMA CITY, FL | Synovus Bank |
| $150,000–350,000 | BYRD ENTERPRISE & LAND DEVELOPMENT, INC. | PANAMA CITY, FL | First Federal Bank |
| $150,000–350,000 | BYRIDER-PCB, INC. | PANAMA CITY, FL | First Financial Bank |
| $150,000–350,000 | C-MILES CONSTRUCTION, INC. | PANAMA CITY, FL | Hancock Whitney Bank |
| $150,000–350,000 | C4 GROUP LLC | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | CATO ENTERPRISES, INC. | PANAMA CITY, FL | First Federal Bank |
| $150,000–350,000 | CENTENNIAL ROOFING CORP. | PANAMA CITY, FL | Hancock Whitney Bank |
| $150,000–350,000 | CHARTER SENIOR LIVING PANAMA CITY, LLC | PANAMA CITY, FL | Midwest Regional Bank |
| $150,000–350,000 | CHEF DEE'S CATERING INC. | PANAMA CITY, FL | Hancock Whitney Bank |
| $350,000–1 million | CHEMICAL ADDICTIONS RECOVERY EFFORT, INC. | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | CHIPOLA MANOR, LIMITED | PANAMA CITY, FL | BancorpSouth Bank |
| $150,000–350,000 | CLASSIC CARPET CLEANERS OF BAY COUNTY, INC | PANAMA CITY, FL | MidSouth Bank |
| $150,000–350,000 | CLASSIC FLOORS, INC | PANAMA CITY, FL | MidSouth Bank |
| $150,000–350,000 | COASTAL HELICOPTERS, INC. | PANAMA CITY, FL | BancorpSouth Bank |
| $350,000–1 million | COASTAL PARASAIL, INC. | PANAMA CITY, FL | BancorpSouth Bank |
| $150,000–350,000 | COASTAL PLUMBING OF BAY COUNTY II, LLC | PANAMA CITY, FL | Hancock Whitney Bank |
| $150,000–350,000 | COASTALMED OF FLORIDA, LLC | PANAMA CITY, FL | BancorpSouth Bank |
| $350,000–1 million | COMMUNITY CHARTER ACADEMY, INC. | PANAMA CITY, FL | BancorpSouth Bank |
| $150,000–350,000 | COMMUNITY-BASED OPTIONS, INC. | PANAMA CITY, FL | Regions Bank |
| $150,000–350,000 | CONTEGO ENVIRONMENTAL LLC | PANAMA CITY, FL | Centennial Bank |
| $150,000–350,000 | COQUI DISPOSAL SERVICES, LLC | PANAMA CITY, FL | First Bank of the Lake |
| $150,000–350,000 | CURRAHEE INSPECTION SERVICES LLC | PANAMA CITY, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $150,000–350,000 | DAYSTAR CLEANING, INC. | PANAMA CITY, FL | Hancock Whitney Bank |
| $350,000–1 million | DEBEST PIZZA, INC. | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | DEER POINT TIMBER PRODUCTS INC | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | DERMATOLOGY ASSOCIATES OF BAY COUNTY, P.A. | PANAMA CITY, FL | Regions Bank |
| $2–5 million | DERMATOLOGY SOLUTIONS GROUP, LLC | PANAMA CITY, FL | Hancock Whitney Bank |
| $350,000–1 million | DESTINY SERVICES INC | PANAMA CITY, FL | Cadence Bank, National Association |
| $350,000–1 million | DIGESTIVE DISEASES CENTER OF FLORIDA, PLLC | PANAMA CITY, FL | BancorpSouth Bank |
| $150,000–350,000 | DIGITRAX, INC. | PANAMA CITY, FL | Truist Bank d/b/a Branch Banking & Trust Co |
| $350,000–1 million | DJ ENTERPRISES OF PANAMA CITY INC. | PANAMA CITY, FL | Centennial Bank |
| $150,000–350,000 | DUNES OF PANAMA MANAGEMENT ASSOCIATION | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | E.P. CONSULTANTS, INC. | PANAMA CITY, FL | Centennial Bank |
| $350,000–1 million | EARLY EDUCATION AND CARE, INC. | PANAMA CITY, FL | First Federal Bank |
| $350,000–1 million | EASTERN INDUSTRIES INC. | PANAMA CITY, FL | BancorpSouth Bank |
| $350,000–1 million | ECONFINA CARDIOLOGY GROUP, PA | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | EL JALISCO PANAMA CITY INC. | PANAMA CITY, FL | Centennial Bank |
| $150,000–350,000 | EMERALD COAST AIR, LLC | PANAMA CITY, FL | Innovations FCU |
| $350,000–1 million | EMERALD COAST AUTO SALES, INC. | PANAMA CITY, FL | Troy Bank & Trust Company |
| $150,000–350,000 | EMERALD COAST DENTAL SPA, INC. | PANAMA CITY, FL | Live Oak Banking Company |
| $350,000–1 million | EMERALD COAST HAIR CARE INC. | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | EMERALD COAST PEDIATRICS AND ADOLESCENTS INC | PANAMA CITY, FL | Regions Bank |
| $150,000–350,000 | EMERALD COAST RECYCLING LLC | PANAMA CITY, FL | BancorpSouth Bank |
| $350,000–1 million | EMERALD COAST STRIPING, LLC | PANAMA CITY, FL | BancorpSouth Bank |
| $150,000–350,000 | EMERALD FALLS, INC | PANAMA CITY, FL | MidSouth Bank |
| $1–2 million | ENTERA BRANDING AND CONSULTING LLC | PANAMA CITY, FL | Cogent Bank |
| $150,000–350,000 | ERIC R CLAUSSEN, DMD, PA | PANAMA CITY, FL | Hancock Whitney Bank |
| $350,000–1 million | FIRST BAPTIST CHURCH, INC., OF PANAMA CITY | PANAMA CITY, FL | Trustmark National Bank |
| $350,000–1 million | FIRST SERVICE CORPORATION OF PANAMA CITY, INC. | PANAMA CITY, FL | First Federal Bank |
| $150,000–350,000 | FIRST UNITED METHODIST CHURCH | PANAMA CITY, FL | Hancock Whitney Bank |
| $150,000–350,000 | FITZPATRICK ENTERPRISES INC | PANAMA CITY, FL | Renasant Bank |
| $150,000–350,000 | FIVE AND TEN LLC | PANAMA CITY, FL | Centennial Bank |
| $150,000–350,000 | FLOORING DEPOT OF PANAMA CITY, INC | PANAMA CITY, FL | Trustmark National Bank |
| $1–2 million | FLORIDA THERAPY SERVICES, INC | PANAMA CITY, FL | Regions Bank |
| $350,000–1 million | FOOD FOR LESS PC, INC. | PANAMA CITY, FL | Regions Bank |
| $150,000–350,000 | FOWHAND FURNITURE INC | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | FRITZ INVESTMENTS | PANAMA CITY, FL | Hancock Whitney Bank |
| $2–5 million | GAC CONTRACTORS, INC | PANAMA CITY, FL | Trustmark National Bank |
| $350,000–1 million | GCPC, INC. | PANAMA CITY, FL | Community Bank of Mississippi |
| $150,000–350,000 | GORTEMOLLER ENGINEERING, INC. | PANAMA CITY, FL | BancorpSouth Bank |
| $350,000–1 million | GREASE PRO, INC. | PANAMA CITY, FL | Trustmark National Bank |
| $150,000–350,000 | GREG ABRAMS SEAFOOD | PANAMA CITY, FL | Hancock Whitney Bank |
| $150,000–350,000 | GREINER ENTERPRISES LLC | PANAMA CITY, FL | Trustmark National Bank |
| $350,000–1 million | GULF COAST CHILDRENS ADVOCACY CENTER INC | PANAMA CITY, FL | First Federal Bank |
| $150,000–350,000 | GULF COAST PLUMBING, INC | PANAMA CITY, FL | Trustmark National Bank |